PROB - BACSU - GREMLIN Contacts

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PROB - Glutamate 5-kinase 1

UniProt:	P39820	Sequences: MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEMILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILLTRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIHADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLLATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPISGEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEEIMEAKGKRSDELDFEKTFEVIHRNDWVNVKD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	365 (358)
Sequences:	2514 (1537)
Seq/√Len:	81.2

ECOLI - PROB
BACSU - PROB PROJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_R	43_E	4.675	1.00
316_V	355_I	4.448	1.00
281_I	316_V	4.255	1.00
243_D	248_R	3.996	1.00
283_A	319_P	3.880	1.00
52_V	143_L	3.592	1.00
8_V	34_I	3.446	1.00
12_S	53_A	3.362	1.00
335_I	354_V	3.344	1.00
286_E	318_G	3.313	1.00
76_A	98_G	3.273	1.00
279_I	314_V	3.192	1.00
318_G	321_G	3.122	1.00
322_V	325_K	3.104	1.00
45_I	159_I	3.081	1.00
120_I	132_I	3.069	1.00
301_V	354_V	2.926	1.00
198_L	221_Q	2.838	1.00
278_E	305_N	2.818	1.00
175_D	185_K	2.808	1.00
189_Y	255_G	2.804	1.00
38_K	127_G	2.784	1.00
172_G	186_R	2.783	1.00
315_E	322_V	2.777	1.00
280_I	303_G	2.765	1.00
341_K	345_E	2.609	1.00
336_M	339_K	2.578	1.00
229_K	256_D	2.544	1.00
14_S	235_G	2.503	1.00
190_L	254_I	2.494	1.00
276_S	312_A	2.439	1.00
31_V	89_Q	2.414	1.00
237_G	243_D	2.395	1.00
278_E	317_R	2.387	1.00
173_L	190_L	2.324	1.00
177_N	180_E	2.307	1.00
106_D	112_R	2.270	1.00
165_M	241_L	2.249	1.00
281_I	286_E	2.238	1.00
38_K	95_L	2.146	1.00
67_T	70_G	2.138	1.00
190_L	252_T	2.113	1.00
287_E	291_H	2.006	1.00
286_E	323_I	1.999	1.00
281_I	289_M	1.981	1.00
233_G	240_K	1.978	1.00
171_N	234_T	1.977	1.00
176_A	183_E	1.965	1.00
280_I	305_N	1.916	1.00
116_A	158_L	1.909	1.00
329_H	359_D	1.872	1.00
278_E	315_E	1.870	1.00
302_V	319_P	1.861	1.00
229_K	253_Y	1.855	1.00
280_I	319_P	1.848	1.00
10_I	46_L	1.830	1.00
95_L	129_I	1.817	1.00
338_A	346_L	1.802	1.00
191_P	255_G	1.763	1.00
35_S	95_L	1.730	1.00
70_G	122_E	1.717	1.00
176_A	184_A	1.704	1.00
284_G	288_A	1.688	1.00
32_Q	92_Q	1.681	1.00
34_I	44_M	1.675	1.00
6_I	42_H	1.672	1.00
334_E	348_F	1.654	1.00
314_V	328_T	1.639	1.00
33_A	239_Q	1.634	1.00
224_L	230_V	1.631	1.00
12_S	208_V	1.616	1.00
32_Q	93_Y	1.609	1.00
28_R	89_Q	1.608	1.00
284_G	300_G	1.604	1.00
34_I	46_L	1.572	1.00
40_A	246_D	1.561	1.00
10_I	30_H	1.537	0.99
349_E	352_F	1.536	0.99
90_F	97_P	1.487	0.99
313_V	327_Q	1.453	0.99
84_Q	88_N	1.448	0.99
7_V	161_A	1.403	0.99
31_V	90_F	1.403	0.99
27_I	85_Q	1.403	0.99
36_V	242_A	1.390	0.99
309_P	331_S	1.372	0.99
100_I	137_S	1.357	0.99
285_A	296_L	1.354	0.99
28_R	92_Q	1.354	0.99
202_G	206_S	1.353	0.99
110_R	114_R	1.351	0.99
8_V	241_L	1.348	0.99
178_P	184_A	1.340	0.99
152_S	164_L	1.333	0.99
286_E	290_I	1.332	0.99
180_E	183_E	1.320	0.98
284_G	297_L	1.310	0.98
150_M	218_L	1.303	0.98
167_L	233_G	1.299	0.98
287_E	292_N	1.293	0.98
174_Y	178_P	1.282	0.98
3_K	42_H	1.282	0.98
282_D	300_G	1.279	0.98
80_T	83_M	1.276	0.98
90_F	129_I	1.257	0.98
64_R	71_K	1.248	0.98
334_E	337_E	1.245	0.98
164_L	230_V	1.243	0.98
283_A	286_E	1.237	0.98
156_S	228_V	1.232	0.98
285_A	300_G	1.220	0.97
34_I	129_I	1.210	0.97
150_M	222_T	1.201	0.97
119_T	123_L	1.193	0.97
324_G	360_W	1.187	0.97
22_I	54_A	1.178	0.97
298_P	346_L	1.177	0.97
340_G	343_S	1.176	0.97
59_L	74_A	1.176	0.97
46_L	86_Y	1.173	0.97
89_Q	92_Q	1.166	0.97
231_F	244_I	1.166	0.97
122_E	125_E	1.162	0.96
187_F	200_Y	1.154	0.96
28_R	32_Q	1.144	0.96
326_G	355_I	1.140	0.96
186_R	249_G	1.136	0.96
297_L	300_G	1.129	0.96
239_Q	243_D	1.120	0.96
304_V	335_I	1.120	0.96
187_F	190_L	1.118	0.96
24_E	88_N	1.118	0.96
38_K	129_I	1.116	0.96
283_A	287_E	1.110	0.95
239_Q	242_A	1.105	0.95
192_E	195_P	1.101	0.95
36_V	39_K	1.089	0.95
317_R	322_V	1.080	0.95
275_I	315_E	1.071	0.94
332_S	336_M	1.071	0.94
307_S	332_S	1.070	0.94
295_S	356_H	1.070	0.94
105_N	109_K	1.065	0.94
21_S	57_S	1.065	0.94
71_K	210_T	1.060	0.94
303_G	339_K	1.054	0.94
293_G	357_R	1.052	0.94
233_G	244_I	1.049	0.94
171_N	174_Y	1.047	0.94
100_I	120_I	1.046	0.94
3_K	163_Q	1.046	0.94
29_E	32_Q	1.046	0.94
6_I	245_L	1.044	0.94
330_Y	338_A	1.040	0.93
59_L	77_V	1.031	0.93
173_L	187_F	1.027	0.93
196_E	201_A	1.026	0.93
58_S	87_M	1.024	0.93
223_A	230_V	1.024	0.93
285_A	288_A	1.024	0.93
36_V	40_A	1.020	0.93
282_D	285_A	1.019	0.93
105_N	112_R	1.016	0.93
198_L	217_L	1.014	0.93
218_L	222_T	1.008	0.92
12_S	21_S	1.004	0.92
33_A	240_K	1.003	0.92
176_A	182_P	1.003	0.92
280_I	317_R	1.000	0.92
298_P	340_G	0.998	0.92
284_G	295_S	0.998	0.92
240_K	243_D	0.996	0.92
304_V	308_F	0.987	0.92
56_F	65_P	0.986	0.92
46_L	129_I	0.985	0.91
110_R	268_W	0.985	0.91
10_I	34_I	0.980	0.91
298_P	343_S	0.980	0.91
10_I	15_L	0.972	0.91
171_N	237_G	0.959	0.90
316_V	324_G	0.956	0.90
16_T	23_D	0.955	0.90
150_M	215_S	0.953	0.90
13_S	209_G	0.951	0.90
266_R	293_G	0.950	0.90
12_S	152_S	0.947	0.90
56_F	74_A	0.944	0.90
195_P	198_L	0.935	0.89
30_H	86_Y	0.931	0.89
197_L	200_Y	0.930	0.89
301_V	335_I	0.929	0.89
54_A	81_L	0.925	0.89
329_H	353_E	0.925	0.89
196_E	199_G	0.923	0.89
242_A	246_D	0.920	0.88
195_P	199_G	0.919	0.88
38_K	44_M	0.918	0.88
295_S	300_G	0.917	0.88
140_V	144_T	0.916	0.88
234_T	237_G	0.915	0.88
163_Q	229_K	0.913	0.88
282_D	297_L	0.906	0.88
27_I	31_V	0.899	0.87
4_Q	42_H	0.895	0.87
98_G	123_L	0.894	0.87
343_S	346_L	0.883	0.86
201_A	204_A	0.882	0.86
15_L	22_I	0.881	0.86
170_I	174_Y	0.881	0.86
23_D	236_S	0.881	0.86
314_V	355_I	0.880	0.86
102_L	116_A	0.880	0.86
72_Q	115_N	0.877	0.86
74_A	77_V	0.875	0.86
172_G	232_I	0.865	0.85
16_T	54_A	0.858	0.85
85_Q	89_Q	0.852	0.84
13_S	169_D	0.847	0.84
124_L	130_P	0.846	0.84
278_E	314_V	0.842	0.84
119_T	137_S	0.838	0.83
37_L	42_H	0.838	0.83
315_E	325_K	0.835	0.83
307_S	336_M	0.833	0.83
275_I	325_K	0.832	0.83
165_M	244_I	0.829	0.83
93_Y	97_P	0.827	0.82
8_V	167_L	0.826	0.82
285_A	295_S	0.824	0.82
168_T	254_I	0.812	0.81
66_V	131_I	0.810	0.81
288_A	300_G	0.809	0.81
120_I	124_L	0.806	0.81
204_A	209_G	0.806	0.81
27_I	89_Q	0.800	0.80
231_F	253_Y	0.800	0.80
356_H	360_W	0.799	0.80
330_Y	348_F	0.798	0.80
169_D	178_P	0.796	0.80
170_I	179_N	0.796	0.80
6_I	37_L	0.794	0.80
290_I	321_G	0.793	0.80
13_S	210_T	0.791	0.80
52_V	71_K	0.788	0.79
177_N	184_A	0.787	0.79
56_F	64_R	0.786	0.79
224_L	254_I	0.785	0.79
279_I	339_K	0.776	0.78
273_S	313_V	0.774	0.78
31_V	35_S	0.773	0.78
163_Q	253_Y	0.773	0.78
339_K	343_S	0.770	0.78
214_K	218_L	0.768	0.78
338_A	343_S	0.765	0.77
331_S	334_E	0.765	0.77
14_S	26_K	0.762	0.77
87_M	97_P	0.762	0.77
179_N	205_G	0.758	0.77
61_Y	74_A	0.757	0.77
282_D	295_S	0.753	0.76
230_V	254_I	0.752	0.76
45_I	132_I	0.751	0.76
157_G	228_V	0.750	0.76
232_I	254_I	0.748	0.76
355_I	360_W	0.742	0.75
39_K	95_L	0.742	0.75
35_S	93_Y	0.741	0.75
67_T	122_E	0.738	0.75
280_I	283_A	0.735	0.74
286_E	319_P	0.734	0.74
294_S	299_A	0.733	0.74
200_Y	217_L	0.732	0.74
177_N	202_G	0.727	0.74
69_K	118_A	0.727	0.74
80_T	270_Q	0.724	0.73
157_G	267_Q	0.721	0.73
202_G	205_G	0.721	0.73
116_A	155_V	0.719	0.73
145_F	215_S	0.719	0.73
265_T	359_D	0.718	0.73
144_T	150_M	0.718	0.73
255_G	312_A	0.717	0.73
45_I	274_P	0.717	0.73
188_D	249_G	0.717	0.73
157_G	226_L	0.716	0.72
189_Y	253_Y	0.716	0.72
61_Y	65_P	0.713	0.72
73_A	123_L	0.712	0.72
284_G	299_A	0.710	0.72
117_Y	121_M	0.709	0.72
309_P	312_A	0.709	0.72
56_F	71_K	0.708	0.72
144_T	210_T	0.708	0.72
23_D	26_K	0.706	0.71
43_E	127_G	0.704	0.71
115_N	140_V	0.704	0.71
288_A	297_L	0.702	0.71
4_Q	162_D	0.694	0.70
107_F	116_A	0.694	0.70
185_K	246_D	0.694	0.70
243_D	250_D	0.693	0.70
23_D	54_A	0.692	0.70
24_E	28_R	0.691	0.70
17_N	23_D	0.689	0.70
333_E	336_M	0.689	0.70
76_A	137_S	0.689	0.70
16_T	53_A	0.688	0.69
283_A	318_G	0.684	0.69
304_V	336_M	0.684	0.69
70_G	126_R	0.684	0.69
41_G	94_S	0.683	0.69
72_Q	142_E	0.683	0.69
102_L	155_V	0.682	0.69
280_I	302_V	0.678	0.68
156_S	164_L	0.677	0.68
215_S	230_V	0.674	0.68
280_I	314_V	0.668	0.67
296_L	300_G	0.668	0.67
163_Q	231_F	0.667	0.67
281_I	323_I	0.666	0.67
217_L	232_I	0.665	0.67
279_I	316_V	0.663	0.67
117_Y	160_H	0.663	0.67
53_A	208_V	0.661	0.66
298_P	350_K	0.661	0.66
193_I	197_L	0.660	0.66
218_L	221_Q	0.660	0.66
26_K	168_T	0.660	0.66
217_L	254_I	0.659	0.66
105_N	111_E	0.659	0.66
5_R	121_M	0.658	0.66
142_E	284_G	0.654	0.66
304_V	332_S	0.654	0.66
52_V	68_I	0.653	0.65
329_H	351_T	0.653	0.65
328_T	331_S	0.653	0.65
355_I	362_N	0.653	0.65
43_E	125_E	0.651	0.65
275_I	322_V	0.651	0.65
16_T	22_I	0.648	0.65
51_A	74_A	0.647	0.65
20_G	206_S	0.647	0.65
140_V	223_A	0.643	0.64
222_T	230_V	0.643	0.64
84_Q	87_M	0.642	0.64
286_E	316_V	0.638	0.64
353_E	356_H	0.638	0.64
107_F	154_L	0.637	0.64
197_L	201_A	0.634	0.63
351_T	359_D	0.632	0.63
346_L	352_F	0.629	0.63
40_A	287_E	0.628	0.62
12_S	168_T	0.627	0.62
131_I	331_S	0.627	0.62
305_N	360_W	0.625	0.62
25_A	28_R	0.624	0.62
301_V	347_D	0.624	0.62
289_M	315_E	0.621	0.62
98_G	157_G	0.621	0.62
173_L	232_I	0.620	0.61
289_M	296_L	0.620	0.61
142_E	282_D	0.619	0.61
343_S	352_F	0.618	0.61
298_P	330_Y	0.618	0.61
152_S	269_I	0.616	0.61
335_I	339_K	0.616	0.61
285_A	294_S	0.615	0.61
282_D	288_A	0.613	0.61
338_A	341_K	0.613	0.61
63_S	66_V	0.612	0.60
265_T	327_Q	0.611	0.60
288_A	292_N	0.609	0.60
304_V	339_K	0.609	0.60
299_A	349_E	0.608	0.60
109_K	112_R	0.607	0.60
169_D	174_Y	0.604	0.59
25_A	32_Q	0.602	0.59
288_A	296_L	0.601	0.59
299_A	340_G	0.600	0.59
89_Q	97_P	0.600	0.59
223_A	228_V	0.599	0.59
15_L	168_T	0.598	0.59
293_G	356_H	0.598	0.59
196_E	200_Y	0.597	0.59
243_D	247_G	0.596	0.58
86_Y	206_S	0.596	0.58
339_K	345_E	0.595	0.58
204_A	207_K	0.591	0.58
241_L	244_I	0.590	0.58
22_I	85_Q	0.590	0.58
143_L	233_G	0.589	0.58
303_G	336_M	0.589	0.58
114_R	117_Y	0.588	0.57
266_R	356_H	0.586	0.57
115_N	118_A	0.586	0.57
39_K	88_N	0.586	0.57
29_E	239_Q	0.585	0.57
61_Y	70_G	0.585	0.57
107_F	145_F	0.584	0.57
76_A	96_T	0.583	0.57
168_T	230_V	0.583	0.57
80_T	87_M	0.582	0.57
169_D	184_A	0.579	0.56
254_I	272_H	0.577	0.56
39_K	185_K	0.577	0.56
145_F	154_L	0.576	0.56
22_I	46_L	0.576	0.56
239_Q	246_D	0.575	0.56
116_A	177_N	0.574	0.56
12_S	209_G	0.574	0.56
108_S	154_L	0.573	0.55
280_I	304_V	0.572	0.55
289_M	362_N	0.569	0.55
263_N	266_R	0.567	0.55
32_Q	36_V	0.565	0.54
343_S	348_F	0.565	0.54
146_G	210_T	0.565	0.54
293_G	297_L	0.563	0.54
44_M	185_K	0.563	0.54
240_K	250_D	0.562	0.54
14_S	273_S	0.560	0.54
222_T	271_F	0.560	0.54
202_G	217_L	0.560	0.54
173_L	217_L	0.558	0.54
8_V	46_L	0.558	0.54
14_S	244_I	0.558	0.54
21_S	138_T	0.558	0.54
295_S	357_R	0.558	0.54
132_I	182_P	0.558	0.54
7_V	47_I	0.558	0.54
26_K	29_E	0.557	0.53
169_D	205_G	0.555	0.53
168_T	197_L	0.555	0.53
193_I	217_L	0.555	0.53
312_A	335_I	0.555	0.53
52_V	83_M	0.553	0.53
302_V	317_R	0.553	0.53
342_R	345_E	0.552	0.53
332_S	344_D	0.552	0.53
61_Y	64_R	0.550	0.52
104_R	150_M	0.550	0.52
282_D	293_G	0.550	0.52
195_P	281_I	0.549	0.52
104_R	272_H	0.548	0.52
35_S	39_K	0.546	0.52
13_S	205_G	0.546	0.52
293_G	326_G	0.546	0.52
121_M	125_E	0.545	0.52
16_T	52_V	0.545	0.52
167_L	240_K	0.543	0.52
266_R	358_N	0.542	0.51
307_S	333_E	0.541	0.51
104_R	154_L	0.541	0.51
68_I	349_E	0.541	0.51
27_I	255_G	0.540	0.51
83_M	152_S	0.540	0.51
15_L	57_S	0.540	0.51
178_P	182_P	0.539	0.51
31_V	86_Y	0.537	0.51
20_G	30_H	0.537	0.51
36_V	236_S	0.536	0.51
284_G	343_S	0.536	0.51
340_G	346_L	0.533	0.50
267_Q	272_H	0.533	0.50
186_R	189_Y	0.533	0.50
39_K	93_Y	0.532	0.50
225_S	262_V	0.531	0.50
43_E	124_L	0.531	0.50
142_E	297_L	0.528	0.50
180_E	261_S	0.528	0.50
324_G	355_I	0.525	0.49
112_R	293_G	0.525	0.49
113_Y	157_G	0.524	0.49
288_A	294_S	0.524	0.49
174_Y	184_A	0.524	0.49
142_E	300_G	0.524	0.49
309_P	349_E	0.524	0.49
292_N	305_N	0.524	0.49
22_I	129_I	0.523	0.49
267_Q	271_F	0.523	0.49
46_L	269_I	0.523	0.49
346_L	349_E	0.523	0.49
180_E	328_T	0.523	0.49
330_Y	340_G	0.522	0.49
141_E	144_T	0.522	0.49
228_V	335_I	0.521	0.49
337_E	341_K	0.520	0.49
205_G	210_T	0.520	0.49
110_R	265_T	0.519	0.48
33_A	242_A	0.518	0.48
197_L	209_G	0.517	0.48
316_V	360_W	0.517	0.48
55_G	86_Y	0.517	0.48
173_L	254_I	0.516	0.48
73_A	119_T	0.516	0.48
48_T	86_Y	0.516	0.48
294_S	357_R	0.516	0.48
27_I	86_Y	0.516	0.48
127_G	160_H	0.514	0.48
58_S	81_L	0.514	0.48
288_A	295_S	0.514	0.48
285_A	297_L	0.514	0.48
298_P	354_V	0.514	0.48
266_R	326_G	0.513	0.48
100_I	116_A	0.513	0.48
175_D	187_F	0.512	0.48
194_T	197_L	0.512	0.48
102_L	353_E	0.511	0.47
81_L	87_M	0.510	0.47
51_A	131_I	0.510	0.47
197_L	221_Q	0.510	0.47
293_G	360_W	0.509	0.47
201_A	206_S	0.508	0.47
35_S	165_M	0.508	0.47
32_Q	200_Y	0.507	0.47
26_K	166_I	0.507	0.47
281_I	296_L	0.506	0.47
70_G	125_E	0.505	0.47
203_S	214_K	0.505	0.47
268_W	308_F	0.505	0.47
69_K	111_E	0.505	0.47
284_G	296_L	0.504	0.46
225_S	257_K	0.504	0.46
188_D	323_I	0.503	0.46
48_T	224_L	0.503	0.46
46_L	97_P	0.503	0.46
30_H	217_L	0.502	0.46
183_E	257_K	0.502	0.46
26_K	31_V	0.502	0.46
61_Y	77_V	0.502	0.46
179_N	184_A	0.501	0.46
35_S	38_K	0.501	0.46
64_R	159_I	0.501	0.46
296_L	308_F	0.500	0.46
15_L	27_I	0.500	0.46
56_F	208_V	0.500	0.46
33_A	37_L	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j5vA	2	0.8767	100	0.261	Contact Map
4q1tA	4	0.9425	100	0.272	Contact Map
2akoA	2	0.6575	100	0.595	Contact Map
3d40A	2	0.6438	100	0.648	Contact Map
3ll9A	2	0.6301	100	0.65	Contact Map
1e19A	2	0.6658	100	0.658	Contact Map
2e9yA	2	0.6685	100	0.662	Contact Map
1z9dA	5	0.6329	100	0.665	Contact Map
4axsA	2	0.6548	100	0.669	Contact Map
3nwyA	5	0.6301	100	0.673	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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