GREMLIN Database
PROB - Glutamate 5-kinase 1
UniProt: P39820 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (358)
Sequences: 2514 (1537)
Seq/√Len: 81.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_R43_E4.6751.00
316_V355_I4.4481.00
281_I316_V4.2551.00
243_D248_R3.9961.00
283_A319_P3.8801.00
52_V143_L3.5921.00
8_V34_I3.4461.00
12_S53_A3.3621.00
335_I354_V3.3441.00
286_E318_G3.3131.00
76_A98_G3.2731.00
279_I314_V3.1921.00
318_G321_G3.1221.00
322_V325_K3.1041.00
45_I159_I3.0811.00
120_I132_I3.0691.00
301_V354_V2.9261.00
198_L221_Q2.8381.00
278_E305_N2.8181.00
175_D185_K2.8081.00
189_Y255_G2.8041.00
38_K127_G2.7841.00
172_G186_R2.7831.00
315_E322_V2.7771.00
280_I303_G2.7651.00
341_K345_E2.6091.00
336_M339_K2.5781.00
229_K256_D2.5441.00
14_S235_G2.5031.00
190_L254_I2.4941.00
276_S312_A2.4391.00
31_V89_Q2.4141.00
237_G243_D2.3951.00
278_E317_R2.3871.00
173_L190_L2.3241.00
177_N180_E2.3071.00
106_D112_R2.2701.00
165_M241_L2.2491.00
281_I286_E2.2381.00
38_K95_L2.1461.00
67_T70_G2.1381.00
190_L252_T2.1131.00
287_E291_H2.0061.00
286_E323_I1.9991.00
281_I289_M1.9811.00
233_G240_K1.9781.00
171_N234_T1.9771.00
176_A183_E1.9651.00
280_I305_N1.9161.00
116_A158_L1.9091.00
329_H359_D1.8721.00
278_E315_E1.8701.00
302_V319_P1.8611.00
229_K253_Y1.8551.00
280_I319_P1.8481.00
10_I46_L1.8301.00
95_L129_I1.8171.00
338_A346_L1.8021.00
191_P255_G1.7631.00
35_S95_L1.7301.00
70_G122_E1.7171.00
176_A184_A1.7041.00
284_G288_A1.6881.00
32_Q92_Q1.6811.00
34_I44_M1.6751.00
6_I42_H1.6721.00
334_E348_F1.6541.00
314_V328_T1.6391.00
33_A239_Q1.6341.00
224_L230_V1.6311.00
12_S208_V1.6161.00
32_Q93_Y1.6091.00
28_R89_Q1.6081.00
284_G300_G1.6041.00
34_I46_L1.5721.00
40_A246_D1.5611.00
10_I30_H1.5370.99
349_E352_F1.5360.99
90_F97_P1.4870.99
313_V327_Q1.4530.99
84_Q88_N1.4480.99
7_V161_A1.4030.99
31_V90_F1.4030.99
27_I85_Q1.4030.99
36_V242_A1.3900.99
309_P331_S1.3720.99
100_I137_S1.3570.99
285_A296_L1.3540.99
28_R92_Q1.3540.99
202_G206_S1.3530.99
110_R114_R1.3510.99
8_V241_L1.3480.99
178_P184_A1.3400.99
152_S164_L1.3330.99
286_E290_I1.3320.99
180_E183_E1.3200.98
284_G297_L1.3100.98
150_M218_L1.3030.98
167_L233_G1.2990.98
287_E292_N1.2930.98
174_Y178_P1.2820.98
3_K42_H1.2820.98
282_D300_G1.2790.98
80_T83_M1.2760.98
90_F129_I1.2570.98
64_R71_K1.2480.98
334_E337_E1.2450.98
164_L230_V1.2430.98
283_A286_E1.2370.98
156_S228_V1.2320.98
285_A300_G1.2200.97
34_I129_I1.2100.97
150_M222_T1.2010.97
119_T123_L1.1930.97
324_G360_W1.1870.97
22_I54_A1.1780.97
298_P346_L1.1770.97
340_G343_S1.1760.97
59_L74_A1.1760.97
46_L86_Y1.1730.97
89_Q92_Q1.1660.97
231_F244_I1.1660.97
122_E125_E1.1620.96
187_F200_Y1.1540.96
28_R32_Q1.1440.96
326_G355_I1.1400.96
186_R249_G1.1360.96
297_L300_G1.1290.96
239_Q243_D1.1200.96
304_V335_I1.1200.96
187_F190_L1.1180.96
24_E88_N1.1180.96
38_K129_I1.1160.96
283_A287_E1.1100.95
239_Q242_A1.1050.95
192_E195_P1.1010.95
36_V39_K1.0890.95
317_R322_V1.0800.95
275_I315_E1.0710.94
332_S336_M1.0710.94
307_S332_S1.0700.94
295_S356_H1.0700.94
105_N109_K1.0650.94
21_S57_S1.0650.94
71_K210_T1.0600.94
303_G339_K1.0540.94
293_G357_R1.0520.94
233_G244_I1.0490.94
171_N174_Y1.0470.94
100_I120_I1.0460.94
3_K163_Q1.0460.94
29_E32_Q1.0460.94
6_I245_L1.0440.94
330_Y338_A1.0400.93
59_L77_V1.0310.93
173_L187_F1.0270.93
196_E201_A1.0260.93
58_S87_M1.0240.93
223_A230_V1.0240.93
285_A288_A1.0240.93
36_V40_A1.0200.93
282_D285_A1.0190.93
105_N112_R1.0160.93
198_L217_L1.0140.93
218_L222_T1.0080.92
12_S21_S1.0040.92
33_A240_K1.0030.92
176_A182_P1.0030.92
280_I317_R1.0000.92
298_P340_G0.9980.92
284_G295_S0.9980.92
240_K243_D0.9960.92
304_V308_F0.9870.92
56_F65_P0.9860.92
46_L129_I0.9850.91
110_R268_W0.9850.91
10_I34_I0.9800.91
298_P343_S0.9800.91
10_I15_L0.9720.91
171_N237_G0.9590.90
316_V324_G0.9560.90
16_T23_D0.9550.90
150_M215_S0.9530.90
13_S209_G0.9510.90
266_R293_G0.9500.90
12_S152_S0.9470.90
56_F74_A0.9440.90
195_P198_L0.9350.89
30_H86_Y0.9310.89
197_L200_Y0.9300.89
301_V335_I0.9290.89
54_A81_L0.9250.89
329_H353_E0.9250.89
196_E199_G0.9230.89
242_A246_D0.9200.88
195_P199_G0.9190.88
38_K44_M0.9180.88
295_S300_G0.9170.88
140_V144_T0.9160.88
234_T237_G0.9150.88
163_Q229_K0.9130.88
282_D297_L0.9060.88
27_I31_V0.8990.87
4_Q42_H0.8950.87
98_G123_L0.8940.87
343_S346_L0.8830.86
201_A204_A0.8820.86
15_L22_I0.8810.86
170_I174_Y0.8810.86
23_D236_S0.8810.86
314_V355_I0.8800.86
102_L116_A0.8800.86
72_Q115_N0.8770.86
74_A77_V0.8750.86
172_G232_I0.8650.85
16_T54_A0.8580.85
85_Q89_Q0.8520.84
13_S169_D0.8470.84
124_L130_P0.8460.84
278_E314_V0.8420.84
119_T137_S0.8380.83
37_L42_H0.8380.83
315_E325_K0.8350.83
307_S336_M0.8330.83
275_I325_K0.8320.83
165_M244_I0.8290.83
93_Y97_P0.8270.82
8_V167_L0.8260.82
285_A295_S0.8240.82
168_T254_I0.8120.81
66_V131_I0.8100.81
288_A300_G0.8090.81
120_I124_L0.8060.81
204_A209_G0.8060.81
27_I89_Q0.8000.80
231_F253_Y0.8000.80
356_H360_W0.7990.80
330_Y348_F0.7980.80
169_D178_P0.7960.80
170_I179_N0.7960.80
6_I37_L0.7940.80
290_I321_G0.7930.80
13_S210_T0.7910.80
52_V71_K0.7880.79
177_N184_A0.7870.79
56_F64_R0.7860.79
224_L254_I0.7850.79
279_I339_K0.7760.78
273_S313_V0.7740.78
31_V35_S0.7730.78
163_Q253_Y0.7730.78
339_K343_S0.7700.78
214_K218_L0.7680.78
338_A343_S0.7650.77
331_S334_E0.7650.77
14_S26_K0.7620.77
87_M97_P0.7620.77
179_N205_G0.7580.77
61_Y74_A0.7570.77
282_D295_S0.7530.76
230_V254_I0.7520.76
45_I132_I0.7510.76
157_G228_V0.7500.76
232_I254_I0.7480.76
355_I360_W0.7420.75
39_K95_L0.7420.75
35_S93_Y0.7410.75
67_T122_E0.7380.75
280_I283_A0.7350.74
286_E319_P0.7340.74
294_S299_A0.7330.74
200_Y217_L0.7320.74
177_N202_G0.7270.74
69_K118_A0.7270.74
80_T270_Q0.7240.73
157_G267_Q0.7210.73
202_G205_G0.7210.73
116_A155_V0.7190.73
145_F215_S0.7190.73
265_T359_D0.7180.73
144_T150_M0.7180.73
255_G312_A0.7170.73
45_I274_P0.7170.73
188_D249_G0.7170.73
157_G226_L0.7160.72
189_Y253_Y0.7160.72
61_Y65_P0.7130.72
73_A123_L0.7120.72
284_G299_A0.7100.72
117_Y121_M0.7090.72
309_P312_A0.7090.72
56_F71_K0.7080.72
144_T210_T0.7080.72
23_D26_K0.7060.71
43_E127_G0.7040.71
115_N140_V0.7040.71
288_A297_L0.7020.71
4_Q162_D0.6940.70
107_F116_A0.6940.70
185_K246_D0.6940.70
243_D250_D0.6930.70
23_D54_A0.6920.70
24_E28_R0.6910.70
17_N23_D0.6890.70
333_E336_M0.6890.70
76_A137_S0.6890.70
16_T53_A0.6880.69
283_A318_G0.6840.69
304_V336_M0.6840.69
70_G126_R0.6840.69
41_G94_S0.6830.69
72_Q142_E0.6830.69
102_L155_V0.6820.69
280_I302_V0.6780.68
156_S164_L0.6770.68
215_S230_V0.6740.68
280_I314_V0.6680.67
296_L300_G0.6680.67
163_Q231_F0.6670.67
281_I323_I0.6660.67
217_L232_I0.6650.67
279_I316_V0.6630.67
117_Y160_H0.6630.67
53_A208_V0.6610.66
298_P350_K0.6610.66
193_I197_L0.6600.66
218_L221_Q0.6600.66
26_K168_T0.6600.66
217_L254_I0.6590.66
105_N111_E0.6590.66
5_R121_M0.6580.66
142_E284_G0.6540.66
304_V332_S0.6540.66
52_V68_I0.6530.65
329_H351_T0.6530.65
328_T331_S0.6530.65
355_I362_N0.6530.65
43_E125_E0.6510.65
275_I322_V0.6510.65
16_T22_I0.6480.65
51_A74_A0.6470.65
20_G206_S0.6470.65
140_V223_A0.6430.64
222_T230_V0.6430.64
84_Q87_M0.6420.64
286_E316_V0.6380.64
353_E356_H0.6380.64
107_F154_L0.6370.64
197_L201_A0.6340.63
351_T359_D0.6320.63
346_L352_F0.6290.63
40_A287_E0.6280.62
12_S168_T0.6270.62
131_I331_S0.6270.62
305_N360_W0.6250.62
25_A28_R0.6240.62
301_V347_D0.6240.62
289_M315_E0.6210.62
98_G157_G0.6210.62
173_L232_I0.6200.61
289_M296_L0.6200.61
142_E282_D0.6190.61
343_S352_F0.6180.61
298_P330_Y0.6180.61
152_S269_I0.6160.61
335_I339_K0.6160.61
285_A294_S0.6150.61
282_D288_A0.6130.61
338_A341_K0.6130.61
63_S66_V0.6120.60
265_T327_Q0.6110.60
288_A292_N0.6090.60
304_V339_K0.6090.60
299_A349_E0.6080.60
109_K112_R0.6070.60
169_D174_Y0.6040.59
25_A32_Q0.6020.59
288_A296_L0.6010.59
299_A340_G0.6000.59
89_Q97_P0.6000.59
223_A228_V0.5990.59
15_L168_T0.5980.59
293_G356_H0.5980.59
196_E200_Y0.5970.59
243_D247_G0.5960.58
86_Y206_S0.5960.58
339_K345_E0.5950.58
204_A207_K0.5910.58
241_L244_I0.5900.58
22_I85_Q0.5900.58
143_L233_G0.5890.58
303_G336_M0.5890.58
114_R117_Y0.5880.57
266_R356_H0.5860.57
115_N118_A0.5860.57
39_K88_N0.5860.57
29_E239_Q0.5850.57
61_Y70_G0.5850.57
107_F145_F0.5840.57
76_A96_T0.5830.57
168_T230_V0.5830.57
80_T87_M0.5820.57
169_D184_A0.5790.56
254_I272_H0.5770.56
39_K185_K0.5770.56
145_F154_L0.5760.56
22_I46_L0.5760.56
239_Q246_D0.5750.56
116_A177_N0.5740.56
12_S209_G0.5740.56
108_S154_L0.5730.55
280_I304_V0.5720.55
289_M362_N0.5690.55
263_N266_R0.5670.55
32_Q36_V0.5650.54
343_S348_F0.5650.54
146_G210_T0.5650.54
293_G297_L0.5630.54
44_M185_K0.5630.54
240_K250_D0.5620.54
14_S273_S0.5600.54
222_T271_F0.5600.54
202_G217_L0.5600.54
173_L217_L0.5580.54
8_V46_L0.5580.54
14_S244_I0.5580.54
21_S138_T0.5580.54
295_S357_R0.5580.54
132_I182_P0.5580.54
7_V47_I0.5580.54
26_K29_E0.5570.53
169_D205_G0.5550.53
168_T197_L0.5550.53
193_I217_L0.5550.53
312_A335_I0.5550.53
52_V83_M0.5530.53
302_V317_R0.5530.53
342_R345_E0.5520.53
332_S344_D0.5520.53
61_Y64_R0.5500.52
104_R150_M0.5500.52
282_D293_G0.5500.52
195_P281_I0.5490.52
104_R272_H0.5480.52
35_S39_K0.5460.52
13_S205_G0.5460.52
293_G326_G0.5460.52
121_M125_E0.5450.52
16_T52_V0.5450.52
167_L240_K0.5430.52
266_R358_N0.5420.51
307_S333_E0.5410.51
104_R154_L0.5410.51
68_I349_E0.5410.51
27_I255_G0.5400.51
83_M152_S0.5400.51
15_L57_S0.5400.51
178_P182_P0.5390.51
31_V86_Y0.5370.51
20_G30_H0.5370.51
36_V236_S0.5360.51
284_G343_S0.5360.51
340_G346_L0.5330.50
267_Q272_H0.5330.50
186_R189_Y0.5330.50
39_K93_Y0.5320.50
225_S262_V0.5310.50
43_E124_L0.5310.50
142_E297_L0.5280.50
180_E261_S0.5280.50
324_G355_I0.5250.49
112_R293_G0.5250.49
113_Y157_G0.5240.49
288_A294_S0.5240.49
174_Y184_A0.5240.49
142_E300_G0.5240.49
309_P349_E0.5240.49
292_N305_N0.5240.49
22_I129_I0.5230.49
267_Q271_F0.5230.49
46_L269_I0.5230.49
346_L349_E0.5230.49
180_E328_T0.5230.49
330_Y340_G0.5220.49
141_E144_T0.5220.49
228_V335_I0.5210.49
337_E341_K0.5200.49
205_G210_T0.5200.49
110_R265_T0.5190.48
33_A242_A0.5180.48
197_L209_G0.5170.48
316_V360_W0.5170.48
55_G86_Y0.5170.48
173_L254_I0.5160.48
73_A119_T0.5160.48
48_T86_Y0.5160.48
294_S357_R0.5160.48
27_I86_Y0.5160.48
127_G160_H0.5140.48
58_S81_L0.5140.48
288_A295_S0.5140.48
285_A297_L0.5140.48
298_P354_V0.5140.48
266_R326_G0.5130.48
100_I116_A0.5130.48
175_D187_F0.5120.48
194_T197_L0.5120.48
102_L353_E0.5110.47
81_L87_M0.5100.47
51_A131_I0.5100.47
197_L221_Q0.5100.47
293_G360_W0.5090.47
201_A206_S0.5080.47
35_S165_M0.5080.47
32_Q200_Y0.5070.47
26_K166_I0.5070.47
281_I296_L0.5060.47
70_G125_E0.5050.47
203_S214_K0.5050.47
268_W308_F0.5050.47
69_K111_E0.5050.47
284_G296_L0.5040.46
225_S257_K0.5040.46
188_D323_I0.5030.46
48_T224_L0.5030.46
46_L97_P0.5030.46
30_H217_L0.5020.46
183_E257_K0.5020.46
26_K31_V0.5020.46
61_Y77_V0.5020.46
179_N184_A0.5010.46
35_S38_K0.5010.46
64_R159_I0.5010.46
296_L308_F0.5000.46
15_L27_I0.5000.46
56_F208_V0.5000.46
33_A37_L0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j5vA 2 0.8767 100 0.261 Contact Map
4q1tA 4 0.9425 100 0.272 Contact Map
2akoA 2 0.6575 100 0.595 Contact Map
3d40A 2 0.6438 100 0.648 Contact Map
3ll9A 2 0.6301 100 0.65 Contact Map
1e19A 2 0.6658 100 0.658 Contact Map
2e9yA 2 0.6685 100 0.662 Contact Map
1z9dA 5 0.6329 100 0.665 Contact Map
4axsA 2 0.6548 100 0.669 Contact Map
3nwyA 5 0.6301 100 0.673 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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