GREMLIN Database
GLTP - Proton glutamate symport protein
UniProt: P39817 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 414 (390)
Sequences: 6249 (3727)
Seq/√Len: 188.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_D142_R4.6211.00
167_E171_K3.7241.00
164_K167_E3.3131.00
93_N324_Q3.2381.00
91_L224_G3.1491.00
15_V196_L3.0851.00
182_K185_Q3.0661.00
131_I150_F3.0511.00
72_K396_E2.9711.00
50_F152_A2.8891.00
54_V173_F2.8191.00
31_R35_D2.7891.00
273_D276_E2.7421.00
268_L289_V2.7311.00
36_G132_I2.7191.00
8_Q189_V2.6801.00
19_I196_L2.6651.00
281_P398_A2.5451.00
50_F54_V2.5251.00
168_P175_S2.5091.00
276_E282_K2.4771.00
96_K99_V2.4391.00
33_V197_A2.4381.00
51_S176_T2.4291.00
320_T323_Q2.4051.00
281_P393_S2.3251.00
155_F179_I2.3201.00
255_F383_P2.2861.00
222_F376_A2.2841.00
163_G166_S2.2221.00
4_L7_F2.1931.00
219_G223_L2.1841.00
76_W388_A2.1461.00
80_I236_V2.1151.00
134_T138_D2.1101.00
254_L274_R2.0881.00
126_Q130_D2.0661.00
91_L227_L2.0561.00
238_L241_Q2.0151.00
72_K395_W2.0101.00
169_V172_F1.9871.00
10_L14_A1.9061.00
225_L376_A1.8841.00
18_V22_F1.8841.00
92_A309_I1.8761.00
12_A196_L1.8601.00
95_L220_T1.8591.00
280_C390_I1.8581.00
311_L362_G1.8471.00
90_L94_V1.8411.00
168_P171_K1.8151.00
275_M386_A1.8121.00
144_D147_A1.8111.00
59_G174_E1.8101.00
86_G90_L1.8071.00
273_D277_K1.7951.00
370_D377_R1.7951.00
51_S180_M1.7691.00
159_A179_I1.7651.00
44_I187_V1.7551.00
169_V175_S1.7381.00
227_L231_V1.7371.00
71_I75_I1.7341.00
97_P313_Q1.7181.00
169_V179_I1.6981.00
95_L223_L1.6941.00
240_F394_K1.6821.00
161_G182_K1.6761.00
165_A178_Q1.6731.00
12_A16_G1.6671.00
68_S396_E1.6661.00
212_L216_K1.6631.00
250_M278_Y1.6611.00
318_D322_S1.6611.00
137_I140_M1.6501.00
280_C393_S1.6371.00
288_V389_C1.6301.00
251_I386_A1.6161.00
92_A306_V1.6161.00
311_L358_L1.5651.00
271_L386_A1.5321.00
91_L220_T1.5201.00
374_D378_T1.5121.00
136_I151_F1.5111.00
215_F219_G1.4991.00
246_E249_K1.4981.00
225_L380_V1.4971.00
36_G129_L1.4871.00
224_G302_L1.4861.00
137_I141_A1.4641.00
42_K134_T1.4551.00
237_G387_I1.4531.00
58_A170_M1.4491.00
315_F362_G1.4431.00
161_G186_I1.4331.00
172_F175_S1.4301.00
250_M277_K1.4281.00
255_F379_G1.4081.00
272_M285_V1.4031.00
19_I23_F1.4011.00
130_D144_D1.4001.00
265_E340_A1.3961.00
35_D39_R1.3771.00
39_R134_T1.3681.00
7_F11_I1.3611.00
174_E178_Q1.3581.00
50_F140_M1.3571.00
132_I150_F1.3381.00
281_P284_V1.3361.00
158_A183_L1.3231.00
393_S399_F1.3191.00
321_L325_L1.3141.00
102_D316_Q1.3111.00
245_F249_K1.3111.00
162_I166_S1.3111.00
49_V145_L1.3041.00
57_A153_I1.3001.00
220_T306_V1.2981.00
43_M151_F1.2891.00
168_P172_F1.2881.00
73_T288_V1.2861.00
236_V391_V1.2821.00
55_I173_F1.2801.00
229_L380_V1.2691.00
393_S397_K1.2691.00
24_P204_G1.2661.00
284_V393_S1.2501.00
167_E170_M1.2431.00
294_S297_C1.2381.00
155_F176_T1.2271.00
218_V369_V1.2271.00
251_I383_P1.2241.00
308_C327_M1.2221.00
213_P216_K1.2181.00
44_I184_T1.2171.00
89_L324_Q1.2061.00
243_K246_E1.2001.00
158_A186_I1.1991.00
318_D323_Q1.1791.00
13_L199_M1.1791.00
154_L183_L1.1771.00
271_L289_V1.1761.00
201_A205_Q1.1731.00
186_I190_T1.1731.00
105_H108_K1.1681.00
327_M356_V1.1671.00
258_A378_T1.1671.00
159_A169_V1.1601.00
153_I157_V1.1461.00
90_L93_N1.1411.00
31_R201_A1.1401.00
230_F234_P1.1401.00
346_L367_A1.1371.00
77_F288_V1.1371.00
216_K219_G1.1321.00
185_Q273_D1.1311.00
123_D126_Q1.1191.00
102_D105_H1.1181.00
102_D106_L1.1141.00
247_V251_I1.1131.00
393_S398_A1.1111.00
303_Y370_D1.1081.00
237_G242_I1.1081.00
65_K283_R1.1081.00
46_V148_V1.1071.00
180_M184_T1.1011.00
267_I271_L1.0991.00
162_I175_S1.0951.00
75_I79_V1.0941.00
275_M289_V1.0911.00
253_D277_K1.0861.00
8_Q12_A1.0861.00
298_D335_S1.0831.00
23_F26_F1.0811.00
268_L293_L1.0811.00
51_S55_I1.0691.00
80_I298_D1.0681.00
242_I399_F1.0641.00
231_V234_P1.0611.00
36_G40_L1.0581.00
33_V190_T1.0561.00
86_G328_M1.0561.00
241_Q394_K1.0511.00
271_L382_V1.0471.00
69_L284_V1.0451.00
62_S65_K1.0441.00
162_I179_I1.0431.00
262_T371_R1.0341.00
119_D122_V1.0331.00
275_M280_C1.0331.00
233_F236_V1.0311.00
238_L243_K1.0301.00
26_F30_L1.0291.00
171_K175_S1.0291.00
53_I149_I1.0281.00
18_V21_H1.0211.00
138_D141_A1.0191.00
280_C285_V1.0141.00
98_G313_Q1.0121.00
394_K397_K1.0121.00
325_L329_L1.0111.00
190_T193_I1.0091.00
212_L215_F1.0071.00
79_V83_L1.0030.99
300_S345_S1.0010.99
231_V235_L1.0010.99
303_Y377_R0.9970.99
228_I232_L0.9940.99
150_F154_L0.9890.99
88_G305_S0.9880.99
14_A18_V0.9830.99
25_D28_M0.9750.99
218_V372_V0.9750.99
209_E212_L0.9730.99
171_K174_E0.9640.99
169_V173_F0.9610.99
182_K186_I0.9610.99
91_L95_L0.9600.99
68_S72_K0.9570.99
249_K252_W0.9560.99
242_I246_E0.9540.99
82_T86_G0.9530.99
86_G325_L0.9510.99
78_E82_T0.9490.99
296_N385_H0.9480.99
15_V19_I0.9450.99
216_K313_Q0.9440.99
321_L324_Q0.9410.99
250_M274_R0.9390.99
163_G167_E0.9380.99
342_P374_D0.9370.99
250_M254_L0.9190.99
19_I200_A0.9180.99
223_L226_F0.9100.99
89_L93_N0.9090.99
34_G198_L0.9080.99
259_F375_M0.9070.99
154_L186_I0.9050.99
304_L349_L0.9000.99
334_T352_T0.9000.99
157_V161_G0.8950.99
274_R277_K0.8940.99
139_V151_F0.8940.99
275_M285_V0.8920.99
87_L227_L0.8920.99
267_I270_Q0.8900.99
122_V126_Q0.8900.99
26_F29_A0.8900.99
309_I324_Q0.8880.99
235_L238_L0.8870.99
234_P248_L0.8870.99
39_R42_K0.8850.99
232_L236_V0.8830.99
315_F361_E0.8790.99
254_L271_L0.8780.99
155_F183_L0.8750.99
221_V373_M0.8710.99
152_A156_G0.8700.99
303_Y373_M0.8650.99
264_T381_N0.8620.98
254_L267_I0.8620.98
44_I183_L0.8610.98
19_I30_L0.8600.98
55_I174_E0.8540.98
297_C385_H0.8540.98
124_F128_I0.8520.98
226_F230_F0.8510.98
234_P238_L0.8480.98
185_Q189_V0.8470.98
222_F226_F0.8450.98
136_I143_N0.8440.98
51_S173_F0.8420.98
166_S175_S0.8410.98
200_A204_G0.8400.98
29_A32_P0.8390.98
221_V306_V0.8380.98
218_V373_M0.8380.98
233_F237_G0.8330.98
223_L227_L0.8300.98
69_L392_V0.8290.98
196_L200_A0.8270.98
23_F30_L0.8240.98
257_I267_I0.8240.98
54_V159_A0.8200.98
350_L363_V0.8180.98
30_L200_A0.8170.98
252_W256_L0.8160.98
346_L363_V0.8140.98
30_L197_A0.8130.98
257_I270_Q0.8120.98
247_V386_A0.8110.98
177_A181_F0.8080.98
35_D129_L0.8070.98
257_I261_T0.8060.98
19_I26_F0.8050.98
120_K123_D0.7970.97
394_K399_F0.7960.97
54_V155_F0.7960.97
307_S366_I0.7960.97
217_L306_V0.7900.97
159_A173_F0.7900.97
319_M323_Q0.7830.97
293_L385_H0.7820.97
91_L94_V0.7780.97
64_K67_G0.7770.97
165_A171_K0.7750.97
136_I139_V0.7720.97
393_S400_R0.7670.97
172_F176_T0.7670.97
60_S69_L0.7650.97
88_G306_V0.7630.97
126_Q129_L0.7630.97
102_D108_K0.7620.97
40_L132_I0.7620.97
284_V288_V0.7590.97
191_A194_G0.7580.97
217_L373_M0.7570.97
103_L106_L0.7570.97
262_T374_D0.7560.97
52_T177_A0.7550.96
140_M151_F0.7540.96
34_G194_G0.7520.96
9_I191_A0.7520.96
217_L366_I0.7500.96
295_L336_K0.7470.96
304_L346_L0.7450.96
23_F200_A0.7450.96
63_M157_V0.7450.96
123_D127_M0.7450.96
122_V130_D0.7450.96
254_L270_Q0.7430.96
97_P100_G0.7410.96
125_K129_L0.7400.96
271_L385_H0.7390.96
258_A382_V0.7380.96
37_F191_A0.7380.96
37_F190_T0.7340.96
96_K313_Q0.7320.96
166_S170_M0.7320.96
65_K68_S0.7300.96
151_F155_F0.7280.96
346_L373_M0.7210.95
135_N151_F0.7210.95
91_L223_L0.7210.95
308_C352_T0.7210.95
54_V152_A0.7200.95
241_Q244_Y0.7190.95
217_L303_Y0.7190.95
150_F190_T0.7190.95
25_D204_G0.7150.95
291_S295_L0.7130.95
29_A33_V0.7130.95
4_L8_Q0.7120.95
106_L109_K0.7070.95
80_I84_V0.7070.95
237_G240_F0.7060.95
220_T223_L0.7020.95
136_I141_A0.7000.95
214_M217_L0.6990.95
73_T392_V0.6980.95
88_G302_L0.6970.95
224_G306_V0.6970.95
39_R130_D0.6960.94
87_L232_L0.6930.94
221_V225_L0.6910.94
246_E250_M0.6900.94
16_G200_A0.6900.94
140_M147_A0.6880.94
247_V390_I0.6860.94
28_M204_G0.6850.94
58_A160_A0.6840.94
139_V143_N0.6840.94
164_K171_K0.6810.94
155_F169_V0.6800.94
100_G103_L0.6800.94
218_V222_F0.6780.94
350_L354_N0.6760.94
191_A261_T0.6760.94
159_A170_M0.6750.94
217_L225_L0.6750.94
330_V355_A0.6740.93
324_Q328_M0.6730.93
127_M133_P0.6710.93
24_P28_M0.6690.93
308_C312_A0.6680.93
82_T332_V0.6650.93
338_I348_V0.6640.93
193_I197_A0.6630.93
8_Q193_I0.6630.93
26_F204_G0.6620.93
62_S70_G0.6600.93
180_M187_V0.6600.93
178_Q182_K0.6540.92
326_L356_V0.6520.92
167_E172_F0.6510.92
127_M130_D0.6500.92
162_I178_Q0.6480.92
331_L348_V0.6480.92
87_L224_G0.6450.92
75_I78_E0.6450.92
54_V176_T0.6440.92
322_S325_L0.6420.92
118_T121_V0.6410.92
84_V228_I0.6400.92
195_V342_P0.6380.92
228_I302_L0.6380.92
328_M331_L0.6360.91
175_S178_Q0.6350.91
65_K70_G0.6350.91
293_L297_C0.6320.91
217_L307_S0.6310.91
68_S71_I0.6310.91
63_M70_G0.6310.91
336_K385_H0.6300.91
78_E336_K0.6290.91
93_N321_L0.6290.91
77_F388_A0.6280.91
228_I298_D0.6250.91
174_E177_A0.6240.91
340_A343_S0.6240.91
175_S179_I0.6230.91
242_I400_R0.6230.91
184_T259_F0.6220.90
46_V140_M0.6200.90
318_D321_L0.6190.90
312_A317_V0.6180.90
322_S326_L0.6180.90
77_F385_H0.6180.90
65_K398_A0.6150.90
239_I391_V0.6150.90
40_L154_L0.6150.90
391_V395_W0.6140.90
304_L338_I0.6140.90
135_N139_V0.6120.90
251_I271_L0.6100.90
282_K286_S0.6090.90
106_L110_D0.6090.90
232_L238_L0.6090.90
242_I250_M0.6080.89
297_C338_I0.6080.89
247_V278_Y0.6010.89
304_L308_C0.6000.89
16_G20_G0.5990.89
129_L132_I0.5980.89
262_T266_T0.5980.89
24_P27_G0.5960.89
170_M174_E0.5950.88
234_P237_G0.5940.88
163_G170_M0.5940.88
230_F235_L0.5920.88
326_L330_V0.5920.88
33_V193_I0.5920.88
328_M332_V0.5900.88
36_G150_F0.5900.88
48_I149_I0.5900.88
389_C393_S0.5890.88
130_D133_P0.5890.88
289_V389_C0.5870.88
162_I182_K0.5870.88
249_K253_D0.5850.88
48_I180_M0.5830.87
238_L244_Y0.5830.87
83_L86_G0.5810.87
300_S338_I0.5790.87
298_D384_G0.5780.87
278_Y390_I0.5750.87
129_L133_P0.5750.87
40_L187_V0.5740.87
19_I22_F0.5730.87
265_E293_L0.5730.87
237_G391_V0.5720.86
169_V176_T0.5720.86
194_G198_L0.5710.86
27_G204_G0.5710.86
55_I59_G0.5700.86
159_A166_S0.5690.86
345_S352_T0.5680.86
149_I315_F0.5670.86
104_S108_K0.5670.86
11_I15_V0.5660.86
300_S304_L0.5660.86
270_Q273_D0.5640.86
305_S331_L0.5620.85
182_K189_V0.5620.85
95_L216_K0.5610.85
13_L195_V0.5600.85
267_I293_L0.5600.85
319_M327_M0.5600.85
12_A200_A0.5590.85
77_F228_I0.5590.85
267_I382_V0.5580.85
19_I27_G0.5580.85
340_A344_G0.5580.85
71_I74_I0.5560.85
233_F238_L0.5560.85
280_C389_C0.5560.85
105_H109_K0.5550.85
381_N385_H0.5540.85
308_C311_L0.5530.85
104_S107_A0.5530.85
100_G213_P0.5530.85
272_M289_V0.5520.84
343_S347_V0.5520.84
275_M385_H0.5520.84
119_D123_D0.5500.84
83_L87_L0.5500.84
159_A175_S0.5490.84
100_G216_K0.5480.84
55_I170_M0.5480.84
41_I257_I0.5470.84
5_I8_Q0.5450.84
284_V398_A0.5440.84
117_Y120_K0.5440.84
40_L190_T0.5440.84
362_G365_I0.5440.84
43_M183_L0.5440.84
216_K220_T0.5430.83
323_Q326_L0.5430.83
196_L207_G0.5420.83
191_A195_V0.5410.83
238_L245_F0.5410.83
335_S347_V0.5410.83
158_A162_I0.5400.83
224_G228_I0.5400.83
219_G222_F0.5390.83
279_G400_R0.5380.83
167_E175_S0.5370.83
283_R398_A0.5350.83
281_P285_V0.5350.83
96_K309_I0.5340.82
390_I399_F0.5320.82
89_L328_M0.5320.82
69_L396_E0.5300.82
162_I165_A0.5300.82
359_P362_G0.5300.82
258_A374_D0.5290.82
188_M191_A0.5270.82
13_L375_M0.5260.82
307_S370_D0.5250.81
166_S179_I0.5240.81
77_F292_G0.5240.81
64_K161_G0.5240.81
36_G190_T0.5230.81
338_I345_S0.5230.81
84_V302_L0.5230.81
83_L232_L0.5220.81
301_S332_V0.5220.81
229_L233_F0.5220.81
292_G389_C0.5210.81
27_G201_A0.5200.81
80_I295_L0.5200.81
327_M331_L0.5170.80
88_G303_Y0.5160.80
371_R375_M0.5160.80
303_Y307_S0.5160.80
85_L332_V0.5160.80
133_P137_I0.5150.80
45_V365_I0.5140.80
12_A215_F0.5140.80
141_A144_D0.5130.80
247_V383_P0.5130.80
39_R129_L0.5130.80
127_M131_I0.5130.80
104_S110_D0.5120.80
128_I132_I0.5100.80
214_M225_L0.5100.80
258_A379_G0.5100.80
135_N138_D0.5090.79
233_F248_L0.5090.79
369_V373_M0.5090.79
144_D148_V0.5070.79
311_L315_F0.5060.79
388_A391_V0.5060.79
22_F123_D0.5060.79
299_G380_V0.5040.79
311_L348_V0.5030.79
258_A267_I0.5030.79
45_V344_G0.5020.78
91_L219_G0.5020.78
31_R205_Q0.5010.78
300_S344_G0.5010.78
350_L360_A0.5010.78
66_M70_G0.5000.78
73_T287_F0.5000.78
251_I255_F0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.9275 100 0.047 Contact Map
4czbA 2 0.6498 32.9 0.965 Contact Map
3zuxA 1 0.3527 22.8 0.967 Contact Map
4n7wA 2 0.3671 22.2 0.967 Contact Map
4cz8A 2 0.6498 13.3 0.971 Contact Map
4bwzA 2 0.6208 10.4 0.972 Contact Map
2zy9A 2 0.2367 5.8 0.975 Contact Map
3kuuA 5 0.3502 5.3 0.975 Contact Map
1scfA 4 0 4.7 0.976 Contact Map
3rlbA 1 0.3478 4.1 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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