GREMLIN Database
TOP1 - DNA topoisomerase 1
UniProt: P39814 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 691 (589)
Sequences: 6246 (3694)
Seq/√Len: 152.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_E225_K5.2501.00
273_K366_D4.1651.00
183_N507_Q3.9501.00
180_K511_D3.7981.00
584_S601_N3.7811.00
240_K438_E3.6521.00
254_F262_E3.6121.00
76_K106_C3.3021.00
220_S223_D3.2751.00
296_I374_I3.2451.00
372_K376_E3.1981.00
535_H540_N3.1601.00
189_E451_Q3.0791.00
239_E396_T3.0361.00
245_E387_V2.9841.00
387_V411_F2.9591.00
247_K387_V2.8801.00
65_K69_T2.8381.00
243_K389_D2.8351.00
365_R369_R2.7821.00
396_T399_G2.7441.00
172_L487_I2.7311.00
115_K119_K2.5911.00
45_D48_Q2.5701.00
393_V436_L2.5701.00
235_Q441_T2.5401.00
225_K229_S2.5191.00
106_C127_M2.5121.00
189_E453_F2.5021.00
120_E124_H2.4431.00
179_E459_R2.4391.00
280_Q367_Q2.4331.00
269_F369_R2.4321.00
485_D489_R2.4181.00
586_M607_N2.3651.00
391_M408_K2.3601.00
437_Q440_D2.3501.00
194_D205_E2.3451.00
389_D410_K2.3281.00
249_N385_P2.3261.00
263_A370_L2.3181.00
175_I493_V2.3091.00
272_K276_M2.2531.00
4_Y76_K2.2461.00
245_E410_K2.2311.00
49_N548_D2.2151.00
229_S232_K2.1931.00
28_K67_L2.1921.00
240_K394_D2.1911.00
278_A296_I2.1641.00
176_I502_P2.1251.00
542_E545_K2.1241.00
199_K440_D2.0871.00
234_N398_N2.0771.00
412_S416_K2.0591.00
56_T64_L2.0491.00
230_Q400_L2.0301.00
579_C582_C2.0171.00
30_S94_L2.0121.00
388_L409_V2.0101.00
190_Y452_H2.0091.00
272_K485_D2.0041.00
79_L91_A1.9871.00
319_D324_K1.9641.00
386_A409_V1.9521.00
173_R177_D1.9461.00
188_E219_N1.9451.00
26_K74_A1.9401.00
237_T441_T1.9391.00
580_E607_N1.9291.00
406_G434_P1.9251.00
532_D549_N1.9191.00
28_K66_E1.9121.00
578_D585_P1.8941.00
116_D120_E1.8911.00
599_C605_C1.8831.00
368_M372_K1.8751.00
128_I133_V1.8691.00
245_E389_D1.8641.00
581_L606_R1.8641.00
187_P453_F1.8491.00
81_A91_A1.8391.00
197_F206_A1.8361.00
236_Y395_L1.8351.00
246_R390_T1.8301.00
269_F277_I1.8081.00
536_V546_I1.7891.00
206_A395_L1.7881.00
488_Q495_L1.7801.00
247_K385_P1.7671.00
221_E451_Q1.7661.00
61_G65_K1.7591.00
131_D539_G1.7581.00
394_D401_T1.7501.00
193_I224_V1.7281.00
5_L71_A1.7141.00
582_C599_C1.7141.00
268_N498_K1.6981.00
192_T452_H1.6831.00
579_C599_C1.6831.00
180_K184_D1.6681.00
4_Y78_Y1.6671.00
69_T73_K1.6641.00
177_D181_E1.6601.00
313_E351_S1.6551.00
196_T446_D1.6471.00
486_T490_R1.6411.00
269_F366_D1.6231.00
179_E502_P1.6141.00
28_K70_A1.6101.00
130_M134_D1.6041.00
196_T205_E1.6031.00
582_C605_C1.6031.00
394_D403_R1.6011.00
389_D408_K1.5961.00
236_Y397_N1.5931.00
208_F400_L1.5921.00
262_E265_R1.5861.00
58_R61_G1.5851.00
219_N223_D1.5741.00
579_C605_C1.5691.00
496_D501_V1.5671.00
468_T472_R1.5561.00
528_K532_D1.5531.00
585_P600_S1.5521.00
238_V395_L1.5501.00
108_V122_F1.5371.00
241_V393_V1.5361.00
226_E230_Q1.5281.00
239_E401_T1.5221.00
548_D552_T1.5211.00
267_L369_R1.5151.00
218_L227_I1.5131.00
380_A418_Y1.5041.00
387_V410_K1.5021.00
198_L445_K1.4941.00
392_S405_N1.4911.00
375_W379_V1.4861.00
223_D226_E1.4781.00
141_I547_I1.4761.00
196_T448_E1.4761.00
386_A415_M1.4721.00
64_L97_S1.4681.00
131_D134_D1.4651.00
308_N338_E1.4551.00
488_Q500_F1.4471.00
6_V122_F1.4381.00
555_E559_K1.4371.00
204_F395_L1.4341.00
228_L449_P1.4301.00
218_L224_V1.4231.00
41_Q53_K1.4191.00
532_D541_T1.4121.00
237_T396_T1.4101.00
163_S490_R1.3961.00
577_E586_M1.3861.00
263_A373_L1.3801.00
306_I381_S1.3801.00
280_Q284_G1.3751.00
224_V449_P1.3661.00
88_E92_W1.3661.00
560_K564_E1.3621.00
197_F395_L1.3611.00
173_R514_M1.3591.00
222_A226_E1.3581.00
459_R502_P1.3571.00
26_K70_A1.3501.00
228_L232_K1.3411.00
180_K183_N1.3401.00
406_G433_L1.3371.00
50_F548_D1.3341.00
243_K391_M1.3291.00
6_V25_Y1.3241.00
276_M280_Q1.3181.00
78_Y125_P1.3161.00
494_A503_T1.3121.00
364_G367_Q1.3101.00
351_S354_R1.3081.00
62_P66_E1.3041.00
277_I366_D1.2981.00
18_E26_K1.2921.00
325_E416_K1.2901.00
163_S168_Q1.2901.00
109_V126_R1.2861.00
203_T445_K1.2841.00
225_K228_L1.2831.00
31_M60_K1.2811.00
206_A404_A1.2781.00
535_H541_T1.2711.00
455_Q458_P1.2701.00
89_A136_Q1.2641.00
545_K548_D1.2581.00
326_F412_S1.2581.00
395_L442_V1.2521.00
197_F236_Y1.2511.00
396_T401_T1.2501.00
35_R97_S1.2481.00
194_D207_S1.2451.00
176_I510_L1.2441.00
248_R415_M1.2431.00
468_T471_E1.2431.00
234_N397_N1.2351.00
284_G367_Q1.2311.00
36_D140_R1.2281.00
230_Q398_N1.2281.00
577_E609_K1.2261.00
532_D535_H1.2251.00
384_A411_F1.2181.00
17_I27_V1.2181.00
84_D343_A1.2171.00
531_R535_H1.2091.00
316_A320_Q1.2061.00
62_P65_K1.2051.00
95_A105_D1.2001.00
273_K276_M1.1981.00
581_L607_N1.1931.00
212_N399_G1.1921.00
365_R368_M1.1921.00
199_K202_E1.1871.00
315_A319_D1.1831.00
179_E183_N1.1831.00
388_L407_S1.1821.00
4_Y24_K1.1791.00
352_V379_V1.1771.00
65_K68_K1.1711.00
194_D450_E1.1711.00
135_A537_E1.1631.00
77_V100_L1.1611.00
584_S600_S1.1551.00
16_T19_R1.1511.00
493_V500_F1.1501.00
231_L397_N1.1471.00
444_S447_I1.1461.00
71_A77_V1.1431.00
221_E449_P1.1421.00
575_A585_P1.1411.00
269_F370_L1.1381.00
180_K507_Q1.1341.00
269_F273_K1.1331.00
231_L447_I1.1271.00
116_D309_T1.1241.00
195_G236_Y1.1231.00
390_T405_N1.1110.99
192_T207_S1.1080.99
296_I299_M1.1040.99
574_Y585_P1.1040.99
597_L611_I1.1020.99
534_D537_E1.1010.99
295_L363_L1.0980.99
199_K442_V1.0980.99
180_K514_M1.0940.99
588_Y611_I1.0920.99
495_L500_F1.0860.99
254_F377_R1.0850.99
119_K123_K1.0840.99
108_V125_P1.0810.99
588_Y595_K1.0810.99
171_A469_L1.0760.99
31_M63_V1.0760.99
601_N604_D1.0680.99
236_Y442_V1.0680.99
502_P507_Q1.0660.99
243_K435_D1.0650.99
172_L506_G1.0640.99
110_F121_S1.0630.99
120_E123_K1.0630.99
209_F403_R1.0610.99
586_M597_L1.0590.99
193_I227_I1.0580.99
196_T203_T1.0570.99
262_E373_L1.0570.99
487_I493_V1.0560.99
590_M595_K1.0540.99
138_A543_W1.0500.99
466_V484_L1.0480.99
198_L443_L1.0450.99
134_D543_W1.0440.99
305_R342_D1.0370.99
257_S477_P1.0350.99
262_E266_K1.0340.99
138_A547_I1.0340.99
88_E128_I1.0340.99
311_V315_A1.0330.99
263_A274_T1.0330.99
52_P141_I1.0290.99
277_I370_L1.0290.99
191_W451_Q1.0270.99
163_S486_T1.0250.99
436_L440_D1.0250.99
193_I447_I1.0230.99
63_V66_E1.0180.99
261_Q467_K1.0170.99
315_A327_L1.0100.99
269_F274_T1.0050.99
193_I228_L1.0040.99
36_D57_I1.0030.99
326_F411_F1.0020.99
191_W221_E1.0010.99
12_A16_T1.0000.99
231_L402_F0.9990.99
232_K446_D0.9940.99
460_Y468_T0.9940.99
227_I400_L0.9930.99
112_E117_A0.9930.99
461_T499_R0.9920.99
20_Y115_K0.9900.99
56_T59_G0.9890.99
580_E609_K0.9890.99
395_L404_A0.9870.99
182_I459_R0.9830.99
198_L203_T0.9830.99
459_R501_V0.9790.99
262_E377_R0.9780.99
236_Y444_S0.9740.99
366_D369_R0.9730.99
181_E460_Y0.9690.99
412_S419_V0.9680.99
273_K277_I0.9650.98
580_E586_M0.9630.98
92_W128_I0.9590.98
235_Q443_L0.9580.98
195_G397_N0.9580.98
334_A337_N0.9580.98
316_A319_D0.9570.98
100_L103_N0.9570.98
192_T450_E0.9560.98
259_L274_T0.9530.98
545_K549_N0.9500.98
204_F436_L0.9490.98
34_V97_S0.9490.98
150_I164_A0.9480.98
419_V422_K0.9430.98
248_R414_F0.9380.98
392_S403_R0.9350.98
270_R273_K0.9320.98
174_L468_T0.9310.98
44_V141_I0.9280.98
556_K560_K0.9240.98
225_K449_P0.9240.98
577_E597_L0.9230.98
462_E495_L0.9210.98
168_Q486_T0.9200.98
331_R334_A0.9190.98
598_A605_C0.9170.98
605_C608_T0.9160.98
49_N544_V0.9160.98
121_S125_P0.9160.98
176_I507_Q0.9160.98
271_A500_F0.9150.98
104_S127_M0.9140.98
279_Q283_E0.9110.98
112_E307_S0.9090.98
314_A378_F0.9030.98
608_T611_I0.9020.98
168_Q490_R0.9020.98
384_A387_V0.9000.98
391_M406_G0.8940.98
488_Q493_V0.8930.98
559_K562_E0.8920.97
284_G295_L0.8910.97
134_D542_E0.8910.97
218_L223_D0.8880.97
11_P31_M0.8880.97
76_K104_S0.8880.97
178_R181_E0.8860.97
204_F404_A0.8860.97
96_H99_D0.8850.97
469_L483_T0.8810.97
28_K63_V0.8800.97
282_Y299_M0.8790.97
228_L447_I0.8770.97
598_A603_P0.8770.97
57_I60_K0.8750.97
195_G447_I0.8750.97
271_A481_A0.8740.97
528_K531_R0.8710.97
237_T439_G0.8650.97
238_V393_V0.8630.97
259_L278_A0.8620.97
238_V442_V0.8620.97
549_N552_T0.8600.97
598_A601_N0.8580.97
138_A536_V0.8570.97
149_K555_E0.8560.97
588_Y597_L0.8550.97
591_G594_G0.8540.97
41_Q48_Q0.8510.97
40_S48_Q0.8510.97
56_T97_S0.8490.97
38_P55_I0.8490.97
243_K408_K0.8460.97
388_L415_M0.8440.96
226_E229_S0.8430.96
26_K73_K0.8430.96
461_T464_R0.8420.96
176_I180_K0.8400.96
541_T545_K0.8380.96
244_K390_T0.8350.96
230_Q399_G0.8340.96
581_L586_M0.8330.96
197_F402_F0.8310.96
393_V435_D0.8290.96
252_L304_T0.8270.96
579_C598_A0.8260.96
83_P111_N0.8250.96
92_W133_V0.8250.96
243_K438_E0.8230.96
589_K596_F0.8220.96
241_V436_L0.8220.96
370_L374_I0.8160.96
5_L74_A0.8140.96
513_I521_I0.8110.96
83_P118_I0.8100.96
35_R96_H0.8090.96
363_L367_Q0.8090.96
92_W130_M0.8070.95
263_A267_L0.8030.95
271_A462_E0.7990.95
35_R64_L0.7990.95
6_V80_A0.7990.95
495_L498_K0.7980.95
577_E607_N0.7980.95
596_F608_T0.7980.95
409_V415_M0.7970.95
280_Q364_G0.7970.95
34_V64_L0.7960.95
559_K563_S0.7960.95
42_M145_L0.7940.95
558_V562_E0.7940.95
197_F444_S0.7930.95
470_E477_P0.7910.95
246_R388_L0.7910.95
112_E309_T0.7900.95
25_Y78_Y0.7880.95
158_V512_L0.7880.95
179_E507_Q0.7870.95
71_A98_L0.7870.95
504_E508_I0.7860.95
71_A95_A0.7860.95
541_T549_N0.7850.95
529_M546_I0.7850.95
174_L472_R0.7850.95
77_V103_N0.7830.95
482_P486_T0.7830.95
38_P53_K0.7830.95
271_A485_D0.7810.95
255_T304_T0.7800.95
185_F454_T0.7800.95
578_D583_S0.7770.94
284_G362_V0.7770.94
95_A100_L0.7770.94
197_F397_N0.7750.94
463_A466_V0.7740.94
257_S466_V0.7690.94
195_G402_F0.7680.94
140_R144_R0.7670.94
79_L88_E0.7650.94
603_P607_N0.7650.94
552_T555_E0.7650.94
204_F442_V0.7640.94
486_T489_R0.7600.94
19_R115_K0.7580.94
77_V95_A0.7560.94
311_V314_A0.7560.94
376_E419_V0.7550.94
166_R526_T0.7540.94
197_F442_V0.7540.94
156_K562_E0.7530.93
323_G326_F0.7530.93
409_V412_S0.7520.93
607_N611_I0.7520.93
582_C600_S0.7510.93
386_A412_S0.7510.93
188_E217_P0.7510.93
246_R386_A0.7500.93
16_T294_G0.7490.93
114_T117_A0.7480.93
271_A466_V0.7460.93
239_E394_D0.7460.93
313_E316_A0.7450.93
83_P109_V0.7440.93
275_M481_A0.7430.93
586_M599_C0.7420.93
251_A265_R0.7410.93
259_L370_L0.7400.93
544_V548_D0.7390.93
576_G585_P0.7380.93
12_A282_Y0.7360.93
315_A328_G0.7350.93
607_N610_P0.7350.93
15_K19_R0.7350.93
78_Y122_F0.7340.93
587_V598_A0.7290.92
169_S513_I0.7270.92
266_K420_E0.7260.92
426_M429_K0.7250.92
6_V21_L0.7250.92
303_S341_Q0.7240.92
586_M611_I0.7220.92
130_M133_V0.7220.92
322_Y326_F0.7220.92
190_Y454_T0.7210.92
231_L236_Y0.7210.92
364_G368_M0.7170.92
295_L354_R0.7150.92
70_A73_K0.7130.92
242_T438_E0.7130.92
196_T445_K0.7130.92
68_K72_K0.7120.91
587_V600_S0.7100.91
579_C600_S0.7090.91
10_S13_K0.7080.91
242_T392_S0.7070.91
8_V13_K0.7060.91
331_R385_P0.7060.91
402_F447_I0.7060.91
81_A88_E0.7050.91
54_Y137_Q0.7050.91
208_F218_L0.7040.91
314_A379_V0.7010.91
491_G494_A0.6950.90
28_K31_M0.6940.90
262_E418_Y0.6920.90
260_Q481_A0.6910.90
557_R560_K0.6910.90
105_D127_M0.6890.90
598_A608_T0.6890.90
337_N340_A0.6890.90
44_V50_F0.6880.90
323_G327_L0.6880.90
67_L98_L0.6880.90
574_Y577_E0.6870.90
255_T258_T0.6860.90
277_I367_Q0.6860.90
494_A501_V0.6850.90
85_R530_E0.6840.90
596_F605_C0.6840.90
38_P148_Y0.6840.90
391_M433_L0.6820.90
306_I378_F0.6800.89
383_M417_V0.6790.89
179_E182_I0.6790.89
584_S604_D0.6780.89
464_R468_T0.6760.89
530_E533_L0.6760.89
552_T556_K0.6750.89
319_D327_L0.6750.89
224_V447_I0.6750.89
195_G444_S0.6730.89
253_P335_K0.6730.89
317_F320_Q0.6730.89
173_R510_L0.6730.89
535_H538_E0.6720.89
333_P336_K0.6700.89
144_R148_Y0.6690.89
593_Y610_P0.6670.89
46_I50_F0.6670.89
312_D315_A0.6660.89
275_M299_M0.6660.89
241_V391_M0.6650.88
206_A436_L0.6650.88
393_V440_D0.6650.88
231_L234_N0.6610.88
8_V17_I0.6610.88
601_N606_R0.6610.88
227_I230_Q0.6610.88
465_L484_L0.6610.88
589_K598_A0.6610.88
406_G430_D0.6600.88
487_I491_G0.6600.88
64_L68_K0.6590.88
600_S605_C0.6580.88
306_I348_R0.6580.88
149_K558_V0.6570.88
267_L370_L0.6560.88
582_C598_A0.6550.88
597_L607_N0.6550.88
320_Q353_L0.6550.88
595_K610_P0.6530.88
197_F436_L0.6530.88
88_E91_A0.6510.87
64_L98_L0.6510.87
241_V438_E0.6500.87
369_R372_K0.6490.87
524_E528_K0.6480.87
377_R418_Y0.6480.87
309_T313_E0.6480.87
7_I91_A0.6470.87
345_E348_R0.6470.87
141_I543_W0.6460.87
134_D137_Q0.6450.87
302_D477_P0.6450.87
5_L70_A0.6420.87
575_A597_L0.6410.87
284_G363_L0.6410.87
227_I231_L0.6410.87
156_K159_K0.6410.87
305_R340_A0.6400.86
265_R421_G0.6380.86
278_A370_L0.6370.86
271_A495_L0.6370.86
472_R523_V0.6360.86
603_P606_R0.6350.86
209_F394_D0.6340.86
265_R419_V0.6340.86
576_G586_M0.6340.86
436_L442_V0.6330.86
462_E488_Q0.6320.86
582_C601_N0.6320.86
7_I77_V0.6310.86
307_S341_Q0.6300.86
42_M149_K0.6300.86
556_K559_K0.6290.86
208_F216_L0.6290.86
270_R495_L0.6290.86
17_I118_I0.6280.85
574_Y578_D0.6270.85
601_N605_C0.6270.85
313_E317_F0.6260.85
596_F599_C0.6260.85
85_R533_L0.6260.85
411_F416_K0.6240.85
162_L505_L0.6230.85
258_T261_Q0.6230.85
150_I520_I0.6210.85
250_P385_P0.6200.85
153_I558_V0.6180.85
611_I614_Q0.6160.84
603_P608_T0.6150.84
154_L513_I0.6150.84
596_F603_P0.6140.84
66_E70_A0.6140.84
245_E391_M0.6140.84
325_E387_V0.6140.84
272_K489_R0.6130.84
8_V136_Q0.6130.84
48_Q51_E0.6130.84
415_M419_V0.6110.84
519_E557_R0.6110.84
458_P499_R0.6100.84
586_M609_K0.6090.84
14_A18_E0.6090.84
550_F554_F0.6080.84
305_R337_N0.6080.84
600_S606_R0.6080.84
30_S34_V0.6080.84
142_L529_M0.6060.83
248_R407_S0.6060.83
151_S155_W0.6050.83
122_F125_P0.6050.83
573_E595_K0.6050.83
204_F434_P0.6050.83
254_F373_L0.6040.83
534_D538_E0.6040.83
22_G119_K0.6030.83
376_E418_Y0.6020.83
81_A92_W0.6020.83
18_E23_K0.6020.83
257_S261_Q0.6010.83
248_R388_L0.6010.83
117_A121_S0.6000.83
175_I502_P0.5990.83
4_Y25_Y0.5990.83
109_V118_I0.5990.83
408_K435_D0.5990.83
95_A99_D0.5980.83
239_E438_E0.5980.83
270_R276_M0.5980.83
224_V228_L0.5950.82
83_P108_V0.5950.82
266_K418_Y0.5950.82
187_P456_P0.5950.82
63_V70_A0.5940.82
185_F457_P0.5940.82
177_D523_V0.5930.82
404_A433_L0.5930.82
148_Y151_S0.5930.82
585_P601_N0.5920.82
514_M521_I0.5920.82
71_A100_L0.5920.82
55_I58_R0.5910.82
170_V487_I0.5900.82
145_L149_K0.5900.82
194_D448_E0.5900.82
575_A578_D0.5900.82
598_A606_R0.5890.82
249_N334_A0.5890.82
193_I449_P0.5890.82
587_V599_C0.5880.82
589_K603_P0.5880.82
154_L164_A0.5870.81
583_S601_N0.5870.81
307_S310_A0.5870.81
54_Y136_Q0.5840.81
64_L94_L0.5830.81
598_A607_N0.5810.81
57_I61_G0.5810.81
317_F352_V0.5810.81
253_P346_A0.5810.81
329_G384_A0.5810.81
391_M434_P0.5800.81
577_E611_I0.5800.81
35_R92_W0.5800.81
306_I336_K0.5800.81
577_E585_P0.5800.81
117_A309_T0.5790.81
152_P155_W0.5780.80
79_L92_W0.5780.80
271_A484_L0.5770.80
133_V137_Q0.5760.80
56_T61_G0.5760.80
183_N502_P0.5760.80
8_V27_V0.5750.80
324_K328_G0.5750.80
142_L550_F0.5750.80
29_A63_V0.5750.80
81_A128_I0.5750.80
295_L506_G0.5750.80
333_P337_N0.5750.80
261_Q463_A0.5740.80
91_A128_I0.5740.80
172_L491_G0.5730.80
65_K72_K0.5730.80
542_E548_D0.5720.80
238_V436_L0.5720.80
597_L610_P0.5720.80
114_T310_A0.5720.80
174_L523_V0.5720.80
89_A93_H0.5710.80
579_C586_M0.5710.80
7_I67_L0.5700.79
154_L509_V0.5700.79
586_M603_P0.5690.79
565_M568_V0.5690.79
278_A374_I0.5680.79
193_I231_L0.5680.79
321_T416_K0.5660.79
250_P331_R0.5650.79
70_A74_A0.5650.79
306_I346_A0.5630.79
452_H455_Q0.5630.79
237_T438_E0.5620.79
5_L28_K0.5620.79
495_L499_R0.5610.78
199_K204_F0.5610.78
579_C596_F0.5600.78
308_N333_P0.5600.78
60_K63_V0.5600.78
313_E353_L0.5590.78
251_A420_E0.5580.78
212_N230_Q0.5580.78
577_E588_Y0.5580.78
322_Y327_L0.5580.78
600_S603_P0.5580.78
108_V121_S0.5580.78
199_K436_L0.5570.78
175_I271_A0.5570.78
91_A95_A0.5570.78
154_L561_A0.5570.78
312_D316_A0.5570.78
11_P279_Q0.5560.78
144_R149_K0.5560.78
547_I551_Y0.5560.78
78_Y106_C0.5550.78
328_G334_A0.5550.78
95_A128_I0.5540.78
85_R135_A0.5540.78
256_T275_M0.5540.78
352_V378_F0.5530.77
177_D514_M0.5530.77
198_L201_Q0.5530.77
275_M296_I0.5520.77
74_A103_N0.5510.77
20_Y111_N0.5510.77
586_M589_K0.5490.77
564_E567_E0.5490.77
236_Y447_I0.5480.77
7_I81_A0.5480.77
172_L510_L0.5480.77
35_R93_H0.5460.77
297_T345_E0.5460.77
466_V480_Y0.5460.77
175_I500_F0.5430.76
494_A504_E0.5430.76
205_E448_E0.5430.76
110_F278_A0.5430.76
4_Y75_K0.5420.76
597_L600_S0.5400.76
311_V382_Q0.5400.76
137_Q141_I0.5390.76
325_E329_G0.5390.76
101_D104_S0.5390.76
209_F212_N0.5380.76
132_L537_E0.5370.75
303_S342_D0.5360.75
10_S476_R0.5360.75
227_I447_I0.5360.75
17_I80_A0.5350.75
270_R462_E0.5350.75
605_C610_P0.5350.75
317_F379_V0.5340.75
308_N312_D0.5340.75
510_L514_M0.5340.75
599_C608_T0.5330.75
79_L128_I0.5330.75
235_Q438_E0.5320.75
21_L27_V0.5300.74
205_E431_R0.5300.74
17_I20_Y0.5300.74
541_T546_I0.5300.74
20_Y118_I0.5290.74
113_I414_F0.5290.74
573_E588_Y0.5290.74
328_G332_K0.5290.74
111_N345_E0.5280.74
207_S450_E0.5270.74
137_Q543_W0.5260.74
302_D342_D0.5260.74
482_P485_D0.5250.74
597_L609_K0.5240.74
221_E228_L0.5240.74
122_F309_T0.5230.73
586_M605_C0.5230.73
31_M62_P0.5230.73
23_K27_V0.5230.73
94_L98_L0.5220.73
277_I364_G0.5210.73
508_I511_D0.5210.73
255_T470_E0.5210.73
12_A283_E0.5210.73
58_R65_K0.5210.73
95_A127_M0.5210.73
317_F321_T0.5210.73
266_K421_G0.5190.73
260_Q275_M0.5190.73
81_A90_I0.5180.73
34_V63_V0.5180.73
548_D551_Y0.5180.73
30_S67_L0.5170.73
11_P29_A0.5170.73
13_K477_P0.5160.72
599_C603_P0.5140.72
599_C606_R0.5140.72
529_M533_L0.5140.72
582_C608_T0.5130.72
266_K419_V0.5130.72
314_A317_F0.5130.72
91_A94_L0.5120.72
31_M482_P0.5120.72
177_D180_K0.5120.72
265_R463_A0.5110.72
467_K471_E0.5110.72
591_G596_F0.5110.72
40_S55_I0.5110.72
264_A270_R0.5100.72
39_K55_I0.5090.71
294_G350_T0.5090.71
491_G503_T0.5080.71
100_L105_D0.5080.71
317_F322_Y0.5080.71
461_T497_N0.5070.71
308_N311_V0.5070.71
284_G368_M0.5070.71
11_P15_K0.5050.71
238_V241_V0.5040.71
459_R499_R0.5040.71
8_V476_R0.5040.71
578_D584_S0.5040.71
252_L305_R0.5040.71
564_E568_V0.5040.71
553_D556_K0.5030.71
484_L488_Q0.5030.71
395_L436_L0.5030.71
164_A169_S0.5030.71
14_A27_V0.5030.71
397_N447_I0.5020.70
101_D127_M0.5020.70
108_V117_A0.5020.70
89_A137_Q0.5020.70
395_L444_S0.5010.70
318_I327_L0.5010.70
610_P614_Q0.5000.70
582_C586_M0.5000.70
554_F558_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gaiA 1 0.8365 100 0.153 Contact Map
4cgyA 1 0.7829 100 0.161 Contact Map
1i7dA 1 0.7988 100 0.187 Contact Map
1mw9X 1 0.7931 100 0.202 Contact Map
4dduA 1 0.7308 100 0.275 Contact Map
1gkuB 1 0.7033 100 0.286 Contact Map
1vddA 7 0.1606 99.7 0.91 Contact Map
2fcjA 2 0.1635 98.8 0.945 Contact Map
3vdpA 2 0.1606 98.3 0.952 Contact Map
1ku9A 2 0.2113 86.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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