GREMLIN Database
SMF - Protein smf
UniProt: P39813 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (277)
Sequences: 4265 (3385)
Seq/√Len: 203.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_G183_N4.1851.00
219_S246_Q3.8541.00
176_Q203_E3.4131.00
150_S182_E3.3541.00
274_K285_E2.7451.00
148_L187_A2.7271.00
113_K145_V2.5981.00
256_S259_D2.5391.00
169_G190_M2.4491.00
167_T190_M2.4351.00
101_A195_I2.3711.00
251_F285_E2.2301.00
129_V253_V2.2061.00
267_K271_Q2.1991.00
115_G225_V2.1881.00
232_E263_G2.1121.00
138_C165_G2.0961.00
129_V257_L2.0871.00
130_V134_T2.0571.00
158_A189_H2.0561.00
119_T122_P2.0191.00
76_N84_Q2.0101.00
101_A197_L1.9611.00
122_P152_I1.9391.00
130_V228_V1.8921.00
116_I156_S1.8901.00
131_N162_K1.8651.00
178_I187_A1.8571.00
181_R184_L1.8351.00
154_G186_L1.8321.00
77_T98_V1.8281.00
116_I134_T1.8171.00
155_M159_A1.8091.00
88_W223_E1.7961.00
232_E267_K1.7951.00
130_V159_A1.7831.00
230_G234_S1.7821.00
212_P238_I1.7821.00
79_P82_S1.7681.00
187_A196_L1.7661.00
76_N101_A1.7351.00
115_G222_S1.7211.00
70_Y75_I1.7031.00
189_H193_H1.6861.00
136_E279_A1.6811.00
100_F201_P1.6811.00
170_V221_L1.6771.00
122_P127_K1.6351.00
270_Q277_W1.6331.00
123_T229_Q1.5941.00
219_S239_T1.5821.00
184_L188_D1.5811.00
200_H213_M1.5761.00
134_T159_A1.5691.00
102_K191_A1.5321.00
92_I246_Q1.5311.00
134_T138_C1.5001.00
127_K155_M1.4991.00
252_A265_P1.4971.00
224_G251_F1.4941.00
225_V243_A1.4781.00
25_W34_L1.4721.00
18_S97_A1.4511.00
123_T261_Y1.4511.00
114_I226_I1.4111.00
64_P68_A1.3991.00
107_L195_I1.3751.00
104_D166_R1.3741.00
159_A163_A1.3571.00
263_G277_W1.3491.00
75_I102_K1.3431.00
69_A73_Q1.3431.00
189_H192_K1.3361.00
222_S225_V1.3321.00
175_F198_S1.3301.00
157_H167_T1.3161.00
170_V217_I1.3141.00
185_Q189_H1.3121.00
199_E216_R1.2971.00
226_I276_I1.2841.00
243_A250_V1.2831.00
185_Q188_D1.2831.00
255_G262_A1.2791.00
190_M194_H1.2781.00
270_Q281_D1.2751.00
101_A105_M1.2731.00
171_I196_L1.2721.00
13_I17_L1.2661.00
207_Q210_H1.2621.00
143_V166_R1.2591.00
81_S90_K1.2531.00
29_D33_S1.2421.00
200_H210_H1.2421.00
226_I253_V1.2391.00
220_G246_Q1.2341.00
252_A269_I1.2251.00
267_K270_Q1.2251.00
135_K162_K1.2231.00
78_I101_A1.2191.00
168_I195_I1.2151.00
114_I144_I1.2071.00
269_I275_A1.2031.00
104_D108_L1.2021.00
162_K189_H1.1991.00
117_V240_A1.1991.00
14_N17_L1.1981.00
138_C163_A1.1971.00
19_P23_L1.1971.00
87_F90_K1.1961.00
266_I277_W1.1921.00
131_N158_A1.1881.00
173_G178_I1.1821.00
144_I156_S1.1681.00
110_K143_V1.1661.00
114_I137_I1.1661.00
249_E286_L1.1661.00
68_A71_R1.1621.00
148_L196_L1.1621.00
148_L169_G1.1601.00
65_R68_A1.1481.00
276_I282_I1.1441.00
226_I282_I1.1421.00
133_L226_I1.1391.00
143_V168_I1.1371.00
224_G276_I1.1351.00
228_V253_V1.1271.00
115_G218_I1.1081.00
35_T38_V1.1031.00
238_I242_Q1.0911.00
172_A210_H1.0831.00
152_I228_V1.0771.00
125_Y257_L1.0761.00
113_K143_V1.0761.00
154_G158_A1.0711.00
27_K30_P1.0681.00
92_I220_G1.0651.00
142_W283_F1.0541.00
69_A75_I1.0471.00
274_K284_E1.0461.00
280_E284_E1.0411.00
70_Y77_T1.0341.00
125_Y129_V1.0331.00
240_A268_L1.0321.00
80_I95_P1.0301.00
68_A72_E1.0291.00
67_L71_R1.0191.00
91_S248_R1.0141.00
51_A54_N1.0111.00
75_I202_P1.0071.00
174_G206_P1.0071.00
241_Y245_E1.0061.00
175_F196_L1.0051.00
144_I160_S1.0011.00
78_I84_Q1.0011.00
277_W281_D1.0011.00
259_D262_A0.9991.00
129_V258_F0.9991.00
116_I226_I0.9951.00
89_L217_I0.9921.00
84_Q105_M0.9911.00
122_P155_M0.9911.00
188_D192_K0.9911.00
171_I175_F0.9911.00
94_D242_Q0.9871.00
87_F91_S0.9871.00
133_L279_A0.9821.00
237_L240_A0.9751.00
148_L190_M0.9681.00
177_H205_K0.9660.99
266_I275_A0.9570.99
262_A265_P0.9530.99
135_K139_R0.9500.99
30_P33_S0.9500.99
88_W91_S0.9380.99
251_F282_I0.9360.99
60_Y63_L0.9340.99
92_I95_P0.9310.99
173_G200_H0.9300.99
204_T210_H0.9290.99
172_A212_P0.9250.99
9_T66_V0.9240.99
148_L171_I0.9170.99
137_I282_I0.9150.99
77_T100_F0.9150.99
131_N155_M0.9140.99
62_K65_R0.9110.99
230_G237_L0.9100.99
66_V202_P0.9000.99
75_I175_F0.8990.99
35_T39_L0.8980.99
124_A128_Q0.8790.99
11_C14_N0.8730.99
127_K131_N0.8710.99
173_G177_H0.8640.99
132_H136_E0.8640.99
140_K283_F0.8570.99
119_T236_S0.8570.99
92_I219_S0.8490.99
135_K163_A0.8480.99
88_W113_K0.8460.99
251_F276_I0.8450.99
80_I90_K0.8450.99
138_C159_A0.8430.99
128_Q258_F0.8420.99
94_D246_Q0.8400.99
145_V222_S0.8340.99
22_L28_A0.8330.99
133_L253_V0.8310.98
266_I269_I0.8300.98
124_A127_K0.8270.98
240_A250_V0.8190.98
69_A72_E0.8190.98
88_W248_R0.8180.98
133_L276_I0.8160.98
76_N105_M0.8160.98
134_T144_I0.8130.98
79_P98_V0.8100.98
87_F109_S0.8060.98
110_K166_R0.8040.98
128_Q132_H0.8040.98
131_N159_A0.8030.98
231_K236_S0.8030.98
70_Y100_F0.8020.98
210_H213_M0.7940.98
8_L100_F0.7930.98
249_E274_K0.7890.98
278_S281_D0.7870.98
127_K158_A0.7840.98
161_I194_H0.7840.98
121_N231_K0.7830.98
119_T231_K0.7830.98
270_Q274_K0.7810.98
66_V70_Y0.7810.98
106_T109_S0.7790.98
158_A162_K0.7780.98
17_L20_S0.7710.98
59_F62_K0.7690.97
136_E139_R0.7680.97
128_Q131_N0.7670.97
244_L247_G0.7660.97
230_G265_P0.7570.97
201_P204_T0.7530.97
112_R223_E0.7510.97
117_V236_S0.7490.97
66_V69_A0.7470.97
26_W30_P0.7470.97
106_T195_I0.7460.97
267_K277_W0.7430.97
113_K222_S0.7420.97
260_P263_G0.7380.97
179_Y211_F0.7370.97
77_T101_A0.7340.97
218_I239_T0.7330.97
146_S157_H0.7310.97
171_I187_A0.7300.97
140_K280_E0.7290.97
65_R69_A0.7290.97
139_R163_A0.7280.97
70_Y202_P0.7260.96
175_F187_A0.7260.96
78_I82_S0.7220.96
145_V218_I0.7190.96
173_G206_P0.7160.96
125_Y262_A0.7160.96
126_G152_I0.7140.96
236_S240_A0.7040.96
21_L31_S0.7030.96
164_K193_H0.7000.96
13_I18_S0.6990.96
119_T261_Y0.6990.96
138_C160_S0.6980.96
102_K188_D0.6970.96
177_H203_E0.6970.96
125_Y258_F0.6960.96
39_L43_T0.6950.95
25_W42_V0.6920.95
179_Y206_P0.6900.95
126_G130_V0.6880.95
130_V155_M0.6830.95
114_I224_G0.6810.95
168_I197_L0.6790.95
80_I85_Y0.6780.95
104_D107_L0.6760.95
224_G249_E0.6760.95
251_F274_K0.6760.95
105_M108_L0.6750.95
242_Q245_E0.6730.95
215_N235_G0.6730.95
177_H187_A0.6690.94
19_P80_I0.6670.94
241_Y271_Q0.6600.94
31_S39_L0.6580.94
253_V257_L0.6560.94
125_Y256_S0.6540.94
112_R142_W0.6540.94
59_F63_L0.6530.94
42_V45_D0.6520.94
10_I55_E0.6500.94
107_L166_R0.6490.94
89_L92_I0.6470.93
15_Q97_A0.6450.93
121_N150_S0.6420.93
176_Q204_T0.6420.93
14_N209_W0.6410.93
121_N261_Y0.6390.93
227_V240_A0.6390.93
258_F263_G0.6350.93
180_P183_N0.6330.93
252_A273_A0.6270.92
34_L38_V0.6250.92
39_L42_V0.6230.92
89_L220_G0.6220.92
153_D215_N0.6200.92
30_P34_L0.6180.92
16_L20_S0.6180.92
155_M158_A0.6180.92
39_L44_R0.6170.92
265_P269_I0.6160.92
215_N218_I0.6150.92
149_A235_G0.6130.91
27_K31_S0.6130.91
85_Y100_F0.6100.91
19_P95_P0.6090.91
191_A196_L0.6080.91
160_S165_G0.6080.91
126_G228_V0.6060.91
229_Q262_A0.6060.91
61_P64_P0.6050.91
102_K175_F0.6020.91
254_P266_I0.6010.91
130_V152_I0.6010.91
84_Q106_T0.6000.91
8_L18_S0.6000.91
281_D284_E0.5970.90
122_P261_Y0.5970.90
146_S153_D0.5960.90
145_V168_I0.5950.90
149_A153_D0.5950.90
58_Q63_L0.5940.90
26_W31_S0.5940.90
211_F215_N0.5890.90
206_P210_H0.5860.90
200_H217_I0.5850.89
15_Q213_M0.5850.89
16_L19_P0.5830.89
126_G229_Q0.5810.89
117_V146_S0.5800.89
36_S40_Q0.5800.89
18_S32_M0.5800.89
175_F202_P0.5780.89
237_L268_L0.5760.89
252_A255_G0.5750.89
78_I108_L0.5740.89
252_A266_I0.5730.88
25_W31_S0.5700.88
134_T165_G0.5680.88
85_Y217_I0.5670.88
85_Y98_V0.5660.88
130_V138_C0.5650.88
270_Q275_A0.5640.88
211_F234_S0.5620.88
55_E59_F0.5620.88
85_Y90_K0.5620.88
91_S247_G0.5570.87
28_A32_M0.5560.87
27_K34_L0.5560.87
28_A31_S0.5530.87
125_Y259_D0.5510.86
149_A215_N0.5510.86
134_T141_G0.5470.86
112_R141_G0.5450.86
131_N135_K0.5450.86
187_A191_A0.5440.86
107_L143_V0.5430.86
212_P230_G0.5430.86
224_G274_K0.5430.86
146_S167_T0.5420.86
178_I196_L0.5390.85
157_H169_G0.5390.85
274_K281_D0.5380.85
49_A54_N0.5380.85
61_P68_A0.5370.85
123_T259_D0.5360.85
171_I198_S0.5360.85
224_G282_I0.5350.85
14_N18_S0.5340.85
117_V215_N0.5340.85
262_A266_I0.5330.85
134_T163_A0.5320.85
225_V228_V0.5320.85
255_G266_I0.5300.84
172_A200_H0.5270.84
41_T44_R0.5270.84
123_T126_G0.5260.84
186_L190_M0.5230.84
40_Q43_T0.5200.83
173_G187_A0.5190.83
249_E285_E0.5170.83
219_S225_V0.5170.83
25_W30_P0.5160.83
178_I184_L0.5160.83
244_L249_E0.5150.83
199_E217_I0.5150.83
136_E282_I0.5150.83
108_L168_I0.5140.83
223_E286_L0.5130.82
229_Q259_D0.5130.82
183_N186_L0.5110.82
50_A54_N0.5100.82
108_L195_I0.5060.82
225_V250_V0.5050.81
257_L266_I0.5040.81
213_M242_Q0.5040.81
120_R149_A0.5030.81
136_E280_E0.5020.81
177_H181_R0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3majA 2 0.9461 100 0.137 Contact Map
3uqzA 2 0.9428 100 0.19 Contact Map
4ljrA 2 0.7138 100 0.3 Contact Map
3quaA 2 0.5354 100 0.579 Contact Map
1rcuA 3 0.5219 100 0.64 Contact Map
2iz6A 4 0.5118 100 0.645 Contact Map
1wekA 5 0.6599 100 0.657 Contact Map
1wehA 1 0.5118 100 0.659 Contact Map
3sbxA 2 0.5354 100 0.674 Contact Map
1t35A 5 0.5488 100 0.681 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.