GREMLIN Database
FLGK - Flagellar hook-associated protein 1
UniProt: P39810 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 507 (459)
Sequences: 2482 (2028)
Seq/√Len: 94.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_N206_G4.0231.00
45_E71_K3.8461.00
198_E208_Y3.7911.00
14_A484_A3.7121.00
344_R356_D3.6351.00
215_I234_N3.5531.00
180_V218_L3.3971.00
210_Q213_L3.3591.00
75_R212_D3.1141.00
204_P208_Y3.0711.00
173_L301_L2.9501.00
179_D217_K2.9491.00
44_L68_V2.8411.00
215_I236_L2.7931.00
17_A68_V2.7871.00
348_T352_E2.7681.00
183_L214_L2.7601.00
170_K308_Y2.5941.00
473_N476_Q2.5461.00
185_S254_S2.4991.00
24_T42_V2.4681.00
180_V301_L2.4181.00
217_K220_S2.3931.00
456_D460_Q2.3781.00
105_M162_L2.3421.00
131_L144_V2.2991.00
339_F406_L2.2991.00
17_A44_L2.2961.00
449_E453_N2.2541.00
41_R76_I2.2481.00
21_A44_L2.2311.00
492_D496_D2.2051.00
180_V184_L2.1541.00
127_S147_K2.1521.00
384_S387_A2.1401.00
159_S325_L2.1031.00
123_S147_K2.0851.00
43_S72_S2.0421.00
226_V236_L2.0331.00
221_M300_S2.0241.00
198_E204_P2.0151.00
134_N137_E2.0091.00
177_V181_N1.9761.00
128_L144_V1.9721.00
176_T300_S1.9571.00
187_L215_I1.9551.00
222_V238_S1.9411.00
166_Q325_L1.9351.00
370_G374_K1.9341.00
213_L217_K1.9301.00
94_Y303_G1.9111.00
184_L238_S1.9051.00
338_A341_E1.8981.00
152_A156_N1.8871.00
25_T474_M1.8841.00
187_L218_L1.8771.00
188_N245_I1.8651.00
306_E319_G1.8461.00
173_L305_I1.8311.00
11_A488_V1.8221.00
97_T303_G1.8171.00
187_L214_L1.8141.00
128_L406_L1.8031.00
227_S237_A1.7881.00
98_K320_V1.7671.00
92_A445_A1.7541.00
400_N404_T1.7461.00
25_T473_N1.7331.00
124_F148_G1.7311.00
183_L218_L1.7301.00
96_D100_K1.7291.00
343_H357_F1.7241.00
187_L190_L1.7171.00
188_N252_K1.7111.00
128_L339_F1.7031.00
468_D481_Y1.6981.00
47_T66_T1.6971.00
29_V467_L1.6871.00
388_N391_F1.6721.00
92_A452_L1.6571.00
85_Y452_L1.6511.00
180_V221_M1.6331.00
367_P370_G1.6211.00
99_A442_N1.6181.00
184_L245_I1.6061.00
43_S74_E1.6041.00
104_Q168_N1.5971.00
236_L245_I1.5921.00
22_L474_M1.5891.00
229_N233_G1.5861.00
176_T301_L1.5821.00
186_Q214_L1.5741.00
184_L252_K1.5701.00
379_D383_D1.5671.00
215_I224_I1.5641.00
95_Y441_A1.5631.00
383_D386_G1.5561.00
137_E140_A1.5551.00
180_V255_L1.5551.00
226_V234_N1.5381.00
120_V154_T1.5381.00
186_Q210_Q1.5351.00
442_N446_S1.5061.00
438_A442_N1.5051.00
82_D459_R1.5041.00
36_G213_L1.5041.00
342_V402_N1.4971.00
183_L217_K1.4921.00
99_A438_A1.4871.00
490_L494_L1.4821.00
41_R74_E1.4791.00
282_S285_I1.4731.00
78_D462_M1.4691.00
387_A391_F1.4681.00
381_I389_I1.4661.00
189_S193_Q1.4651.00
445_A449_E1.4551.00
155_F331_M1.4541.00
184_L244_S1.4471.00
190_L194_I1.4421.00
179_D221_M1.4411.00
18_Q21_A1.4270.99
208_Y228_Y1.4250.99
89_N219_S1.4220.99
18_Q44_L1.4150.99
146_R149_Q1.4140.99
343_H406_L1.4010.99
337_K341_E1.4000.99
155_F332_A1.3940.99
77_R82_D1.3890.99
176_T221_M1.3860.99
117_L158_I1.3810.99
228_Y234_N1.3780.99
7_G491_Q1.3750.99
371_A374_K1.3700.99
125_W410_L1.3680.99
229_N235_A1.3620.99
27_N40_Q1.3620.99
103_S106_E1.3580.99
302_L306_E1.3520.99
101_A307_S1.3480.99
460_Q464_A1.3430.99
484_A487_M1.3310.99
372_A375_I1.3080.99
151_V155_F1.3080.99
86_R215_I1.3070.99
481_Y485_A1.3020.99
85_Y455_A1.2990.99
86_R216_D1.2960.99
173_L308_Y1.2950.99
92_A449_E1.2950.99
184_L222_V1.2930.99
14_A18_Q1.2850.99
22_L494_L1.2820.99
408_N411_T1.2750.99
185_S189_S1.2620.99
172_E304_F1.2600.99
224_I236_L1.2590.99
124_F151_V1.2570.99
92_A96_D1.2500.99
35_D217_K1.2450.99
274_D278_G1.2430.99
195_A233_G1.2420.99
383_D387_A1.2370.99
245_I252_K1.2340.99
130_E133_N1.2340.99
14_A487_M1.2280.98
47_T69_Q1.2190.98
127_S144_V1.2180.98
89_N220_S1.2130.98
179_D183_L1.2060.98
174_N178_L1.2040.98
17_A70_G1.2000.98
329_D332_A1.1990.98
9_E13_R1.1950.98
448_T452_L1.1950.98
169_L307_S1.1950.98
11_A487_M1.1940.98
192_K196_Q1.1900.98
433_E437_E1.1810.98
453_N457_I1.1790.98
346_G402_N1.1690.98
31_N34_T1.1640.98
160_E164_N1.1570.98
403_A407_A1.1560.98
20_A23_S1.1520.98
480_A484_A1.1500.98
119_S123_S1.1470.98
15_L481_Y1.1440.98
163_T325_L1.1410.98
9_E12_R1.1410.98
159_S163_T1.1390.98
413_K425_D1.1330.97
99_A103_S1.1280.97
99_A445_A1.1190.97
190_L214_L1.1120.97
148_G357_F1.1100.97
381_I388_N1.1100.97
177_V255_L1.1070.97
180_V222_V1.1040.97
218_L236_L1.1030.97
183_L221_M1.0980.97
155_F375_I1.0960.97
327_D330_N1.0890.97
148_G152_A1.0830.97
307_S321_Y1.0820.97
216_D459_R1.0800.97
342_V345_N1.0760.96
320_V323_E1.0750.96
22_L477_F1.0710.96
170_K309_G1.0700.96
18_Q480_A1.0700.96
85_Y216_D1.0680.96
219_S224_I1.0640.96
40_Q209_D1.0560.96
20_A70_G1.0490.96
333_L337_K1.0470.96
338_A412_G1.0410.96
381_I387_A1.0400.96
59_K62_G1.0390.96
305_I308_Y1.0380.96
193_Q196_Q1.0360.96
329_D370_G1.0350.96
81_L462_M1.0290.95
356_D359_D1.0270.95
159_S373_G1.0210.95
158_I328_L1.0200.95
98_K306_E1.0200.95
81_L458_N1.0120.95
243_V246_E1.0040.95
274_D277_T1.0000.95
27_N49_Y0.9960.95
179_D182_S0.9940.95
275_N278_G0.9930.94
347_V353_Q0.9880.94
334_E416_I0.9860.94
319_G323_E0.9790.94
25_T477_F0.9780.94
151_V335_F0.9770.94
409_V423_V0.9760.94
82_D216_D0.9720.94
452_L456_D0.9710.94
324_M437_E0.9680.94
215_I226_V0.9670.94
145_A388_N0.9660.94
247_I250_K0.9640.94
21_A477_F0.9640.94
187_L194_I0.9640.94
45_E69_Q0.9620.93
384_S388_N0.9620.93
42_V70_G0.9560.93
486_R489_T0.9550.93
189_S192_K0.9550.93
386_G389_I0.9540.93
176_T179_D0.9530.93
85_Y89_N0.9470.93
123_S126_N0.9460.93
108_V165_V0.9450.93
21_A42_V0.9440.93
96_D445_A0.9390.93
381_I391_F0.9370.93
329_D372_A0.9370.93
39_R470_E0.9370.93
182_S186_Q0.9350.93
334_E338_A0.9350.93
187_L236_L0.9340.92
124_F339_F0.9320.92
95_Y448_T0.9220.92
496_D500_N0.9170.92
404_T408_N0.9160.92
6_M10_T0.9150.92
198_E232_G0.9130.92
379_D387_A0.9100.91
213_L216_D0.9080.91
348_T355_G0.9020.91
479_H482_N0.9020.91
220_S300_S0.9010.91
366_E369_K0.8990.91
163_T373_G0.8970.91
40_Q205_N0.8950.91
489_T492_D0.8940.91
367_P371_A0.8930.91
162_L321_Y0.8920.91
85_Y456_D0.8910.91
22_L25_T0.8910.91
77_R459_R0.8910.91
303_G307_S0.8900.91
163_T166_Q0.8900.91
88_Q455_A0.8850.90
214_L221_M0.8830.90
366_E370_G0.8820.90
94_Y306_E0.8800.90
27_N46_A0.8790.90
402_N405_K0.8790.90
148_G358_F0.8780.90
38_T75_R0.8770.90
8_L12_R0.8760.90
339_F357_F0.8760.90
365_T371_A0.8750.90
387_A392_S0.8730.90
32_A467_L0.8710.90
82_D86_R0.8680.89
97_T300_S0.8670.89
122_N126_N0.8650.89
111_E116_G0.8630.89
455_A458_N0.8620.89
345_N402_N0.8610.89
8_L491_Q0.8590.89
467_L471_M0.8530.89
383_D389_I0.8520.89
490_L493_E0.8510.88
185_S252_K0.8490.88
145_A381_I0.8490.88
326_S330_N0.8460.88
40_Q206_G0.8430.88
180_V187_L0.8390.88
102_L320_V0.8390.88
124_F128_L0.8380.88
486_R492_D0.8380.88
293_E296_S0.8370.88
309_G319_G0.8370.88
106_E438_A0.8360.88
235_A246_E0.8330.87
284_S287_D0.8300.87
177_V301_L0.8270.87
95_Y444_L0.8250.87
130_E140_A0.8240.87
145_A377_V0.8210.87
165_V307_S0.8200.87
197_V204_P0.8160.86
448_T451_Q0.8160.86
35_D456_D0.8150.86
141_R349_K0.8130.86
309_G322_P0.8110.86
383_D391_F0.8110.86
71_K74_E0.8100.86
79_I83_Y0.8100.86
192_K250_K0.8090.86
132_S403_A0.8080.86
50_F66_T0.8070.86
473_N477_F0.8060.86
141_R346_G0.8040.85
348_T353_Q0.8000.85
132_S404_T0.7980.85
26_A487_M0.7960.85
343_H389_I0.7940.85
402_N406_L0.7930.85
182_S440_E0.7900.84
303_G306_E0.7900.84
348_T351_G0.7890.84
7_G495_L0.7890.84
35_D213_L0.7880.84
14_A30_A0.7880.84
193_Q207_L0.7880.84
40_Q46_A0.7880.84
414_I423_V0.7850.84
164_N168_N0.7850.84
109_L324_M0.7820.84
10_T13_R0.7800.84
125_W409_V0.7800.84
479_H492_D0.7790.84
166_Q322_P0.7780.84
188_N247_I0.7780.84
169_L304_F0.7770.84
410_L424_L0.7750.83
79_I228_Y0.7740.83
99_A441_A0.7740.83
101_A169_L0.7730.83
343_H355_G0.7720.83
210_Q240_E0.7700.83
38_T209_D0.7690.83
194_I207_L0.7680.83
329_D333_L0.7650.83
326_S329_D0.7620.82
33_N480_A0.7610.82
98_K303_G0.7610.82
466_S469_E0.7590.82
416_I419_K0.7580.82
141_R343_H0.7570.82
191_N245_I0.7570.82
358_F367_P0.7530.82
130_E143_V0.7520.81
25_T29_V0.7510.81
221_M301_L0.7480.81
121_L331_M0.7440.81
149_Q153_E0.7440.81
128_L403_A0.7430.81
89_N93_G0.7410.81
472_T475_I0.7380.80
165_V321_Y0.7370.80
350_S355_G0.7370.80
228_Y232_G0.7340.80
379_D382_I0.7340.80
97_T101_A0.7340.80
331_M335_F0.7340.80
155_F159_S0.7330.80
156_N372_A0.7330.80
332_A372_A0.7330.80
491_Q494_L0.7300.80
224_I431_I0.7290.79
280_V305_I0.7280.79
400_N403_A0.7260.79
118_N122_N0.7250.79
38_T212_D0.7240.79
165_V168_N0.7220.79
98_K441_A0.7220.79
336_A370_G0.7220.79
372_A377_V0.7210.79
90_N219_S0.7210.79
421_T425_D0.7190.78
374_K381_I0.7180.78
376_K379_D0.7170.78
369_K374_K0.7120.78
256_G284_S0.7110.78
123_S167_S0.7100.78
140_A143_V0.7100.78
486_R498_V0.7080.77
108_V161_S0.7050.77
378_A387_A0.7040.77
78_D100_K0.7020.77
331_M427_Y0.6980.76
145_A387_A0.6980.76
385_K388_N0.6960.76
94_Y98_K0.6940.76
350_S358_F0.6940.76
459_R463_S0.6930.76
39_R469_E0.6920.76
19_Q23_S0.6900.76
388_N392_S0.6890.75
38_T206_G0.6890.75
148_G151_V0.6870.75
164_N167_S0.6860.75
374_K387_A0.6860.75
235_A243_V0.6850.75
145_A382_I0.6840.75
13_R47_T0.6830.75
97_T304_F0.6820.75
389_I392_S0.6810.75
153_E157_Y0.6810.75
347_V394_T0.6780.74
191_N247_I0.6770.74
345_N405_K0.6730.74
381_I385_K0.6720.74
51_P62_G0.6720.74
37_Y465_V0.6720.74
380_S387_A0.6710.74
144_V148_G0.6690.73
143_V147_K0.6680.73
39_R76_I0.6680.73
102_L438_A0.6680.73
280_V284_S0.6670.73
88_Q91_S0.6620.73
393_L396_A0.6600.72
142_S145_A0.6580.72
474_M478_Q0.6550.72
161_S164_N0.6540.72
198_E228_Y0.6520.71
408_N412_G0.6510.71
485_A492_D0.6500.71
187_L204_P0.6490.71
77_R216_D0.6490.71
401_A405_K0.6460.71
338_A423_V0.6450.71
177_V257_T0.6450.71
274_D279_L0.6430.70
7_G26_A0.6420.70
174_N257_T0.6410.70
94_Y302_L0.6410.70
377_V382_I0.6380.70
344_R355_G0.6370.70
237_A243_V0.6360.70
88_Q448_T0.6360.70
117_L154_T0.6350.69
103_S442_N0.6350.69
329_D334_E0.6350.69
50_F62_G0.6350.69
211_R228_Y0.6350.69
298_K302_L0.6340.69
34_T213_L0.6340.69
446_S449_E0.6330.69
372_A384_S0.6330.69
138_E349_K0.6330.69
378_A381_I0.6320.69
120_V151_V0.6290.69
305_I309_G0.6280.69
75_R209_D0.6270.68
320_V437_E0.6270.68
359_D378_A0.6270.68
344_R350_S0.6270.68
95_Y486_R0.6260.68
476_Q479_H0.6240.68
173_L257_T0.6220.68
414_I422_S0.6190.67
116_G119_S0.6170.67
342_V406_L0.6160.67
82_D212_D0.6160.67
327_D430_L0.6140.67
493_E497_K0.6130.67
124_F332_A0.6120.67
24_T473_N0.6120.67
216_D220_S0.6110.66
127_S131_L0.6100.66
366_E371_A0.6080.66
492_D497_K0.6070.66
44_L70_G0.6060.66
103_S107_G0.6060.66
11_A14_A0.6040.66
89_N216_D0.6030.65
17_A69_Q0.6020.65
330_N334_E0.5980.65
284_S288_T0.5980.65
147_K150_A0.5980.65
277_T322_P0.5970.65
27_N65_G0.5950.64
485_A497_K0.5930.64
126_N130_E0.5920.64
482_N497_K0.5900.64
332_A336_A0.5900.64
323_E327_D0.5900.64
348_T354_G0.5890.64
10_T30_A0.5880.64
93_G97_T0.5870.63
180_V427_Y0.5870.63
142_S146_R0.5860.63
84_Q104_Q0.5860.63
153_E156_N0.5860.63
171_A175_T0.5850.63
21_A131_L0.5800.62
467_L479_H0.5790.62
236_L244_S0.5790.62
41_R473_N0.5780.62
368_A374_K0.5780.62
75_R208_Y0.5780.62
148_G377_V0.5780.62
149_Q382_I0.5770.62
89_N452_L0.5760.62
132_S135_T0.5740.62
109_L434_L0.5740.62
471_M495_L0.5740.62
389_I402_N0.5730.62
367_P374_K0.5710.61
152_A377_V0.5700.61
14_A86_R0.5700.61
132_S400_N0.5690.61
40_Q477_F0.5690.61
342_V409_V0.5690.61
10_T14_A0.5690.61
346_G358_F0.5690.61
134_N140_A0.5680.61
25_T144_V0.5680.61
20_A73_V0.5680.61
10_T66_T0.5680.61
96_D220_S0.5670.61
45_E74_E0.5670.61
176_T304_F0.5660.61
74_E78_D0.5650.60
176_T180_V0.5640.60
210_Q214_L0.5640.60
385_K389_I0.5620.60
49_Y206_G0.5620.60
486_R500_N0.5620.60
303_G479_H0.5600.60
80_F84_Q0.5600.60
226_V232_G0.5590.60
64_M328_L0.5580.60
139_S142_S0.5580.60
15_L170_K0.5580.60
384_S389_I0.5580.60
458_N461_Q0.5570.59
122_N410_L0.5570.59
307_S320_V0.5560.59
81_L455_A0.5560.59
128_L407_A0.5560.59
330_N426_Y0.5560.59
101_A304_F0.5560.59
411_T414_I0.5550.59
34_T480_A0.5530.59
471_M494_L0.5520.59
30_A484_A0.5510.59
208_Y234_N0.5510.59
12_R480_A0.5490.58
177_V280_V0.5490.58
38_T463_S0.5490.58
416_I426_Y0.5490.58
40_Q469_E0.5480.58
381_I390_A0.5470.58
145_A378_A0.5470.58
327_D493_E0.5470.58
187_L211_R0.5460.58
461_Q466_S0.5460.58
91_S94_Y0.5460.58
391_F399_D0.5450.58
147_K439_Q0.5450.58
436_I439_Q0.5430.57
166_Q309_G0.5430.57
481_Y484_A0.5430.57
131_L398_N0.5420.57
130_E137_E0.5410.57
386_G391_F0.5410.57
38_T86_R0.5410.57
336_A367_P0.5410.57
355_G358_F0.5410.57
172_E300_S0.5410.57
439_Q443_R0.5410.57
278_G284_S0.5400.57
227_S235_A0.5390.57
184_L228_Y0.5390.57
90_N298_K0.5380.57
493_E496_D0.5380.57
49_Y66_T0.5370.57
375_I379_D0.5360.57
169_L321_Y0.5350.56
322_P325_L0.5340.56
62_G202_L0.5330.56
386_G392_S0.5330.56
124_F144_V0.5330.56
404_T407_A0.5320.56
173_L304_F0.5320.56
425_D464_A0.5320.56
368_A371_A0.5310.56
180_V238_S0.5310.56
8_L126_N0.5300.56
86_R226_V0.5300.56
479_H495_L0.5290.56
88_Q489_T0.5280.55
475_I492_D0.5280.55
101_A165_V0.5270.55
217_K300_S0.5270.55
373_G377_V0.5270.55
280_V286_G0.5260.55
102_L434_L0.5260.55
468_D478_Q0.5260.55
490_L499_I0.5260.55
336_A375_I0.5250.55
324_M434_L0.5250.55
426_Y471_M0.5250.55
113_D219_S0.5240.55
366_E374_K0.5230.55
192_K195_A0.5230.55
223_D306_E0.5220.55
187_L208_Y0.5220.55
471_M479_H0.5210.54
215_I228_Y0.5210.54
416_I420_E0.5200.54
165_V169_L0.5190.54
336_A371_A0.5180.54
78_D460_Q0.5160.54
119_S423_V0.5150.54
73_V247_I0.5140.53
198_E201_G0.5140.53
152_A375_I0.5140.53
194_I204_P0.5140.53
441_A445_A0.5140.53
70_G73_V0.5130.53
231_S255_L0.5130.53
156_N160_E0.5130.53
246_E250_K0.5120.53
194_I201_G0.5120.53
375_I393_L0.5110.53
120_V123_S0.5100.53
300_S303_G0.5100.53
106_E498_V0.5100.53
187_L245_I0.5090.53
335_F338_A0.5080.53
101_A486_R0.5080.53
81_L85_Y0.5080.53
131_L432_G0.5080.53
472_T483_A0.5080.53
95_Y445_A0.5070.52
416_I480_A0.5060.52
69_Q72_S0.5060.52
44_L71_K0.5060.52
12_R472_T0.5060.52
387_A390_A0.5060.52
497_K500_N0.5050.52
256_G376_K0.5050.52
374_K379_D0.5040.52
183_L190_L0.5040.52
38_T77_R0.5040.52
235_A247_I0.5030.52
381_I386_G0.5030.52
179_D439_Q0.5020.52
153_E261_G0.5020.52
51_P63_Q0.5010.52
131_L141_R0.5010.52
251_N254_S0.5000.51
342_V405_K0.5000.51
24_T451_Q0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ut1A 1 0.6963 100 0.236 Contact Map
2d4yA 1 0.6824 100 0.379 Contact Map
3a69A 3 0.5542 99.8 0.847 Contact Map
4njlA 3 0.2406 69.9 0.967 Contact Map
1oryB 2 0.0789 53.6 0.97 Contact Map
1wyyA 3 0.2347 46.1 0.971 Contact Map
2l10A 1 0.2702 40.3 0.972 Contact Map
4bhqA 2 0.1538 21.4 0.976 Contact Map
1ykhB 1 0.2189 18.7 0.977 Contact Map
3zccA 2 0.2091 15.1 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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