GREMLIN Database
FLGM - Negative regulator of flagellin synthesis
UniProt: P39809 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 88 (85)
Sequences: 179 (155)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_H79_K4.2501.00
13_P20_K2.8100.98
57_K60_Q2.7390.97
42_E61_L2.3330.93
82_I86_K2.2350.92
56_E60_Q2.1250.89
8_T65_I1.9890.86
80_N85_Y1.7310.77
71_K77_I1.6220.72
24_Q43_M1.5330.68
26_T39_Q1.5260.67
44_Q79_K1.5190.67
34_I69_S1.4770.65
66_E71_K1.4650.64
57_K61_L1.4630.64
45_H64_Q1.4400.63
73_D76_H1.4060.61
74_A77_I1.3530.58
45_H81_M1.3340.57
11_V56_E1.3100.55
72_V81_M1.3100.55
41_K56_E1.2920.54
41_K45_H1.2920.54
56_E79_K1.2790.53
10_S67_N1.2700.53
49_A65_I1.2410.51
15_Q29_Q1.2240.50
43_M69_S1.2180.50
9_Q83_N1.2170.50
28_A43_M1.2140.49
72_V83_N1.2010.49
35_E38_S1.1990.49
81_M86_K1.1660.47
17_N51_T1.1530.46
31_Q77_I1.1350.45
38_S61_L1.1320.45
15_Q46_A1.1310.44
66_E73_D1.1210.44
57_K69_S1.0990.43
7_G11_V1.0940.42
35_E85_Y1.0900.42
67_N71_K1.0810.42
13_P54_R1.0800.42
72_V77_I1.0620.40
9_Q80_N1.0360.39
81_M85_Y1.0260.38
38_S41_K1.0210.38
61_L64_Q1.0100.38
3_I28_A1.0030.37
15_Q39_Q0.9780.36
74_A79_K0.9760.36
44_Q75_N0.9680.35
43_M72_V0.9540.34
4_N84_F0.9520.34
3_I33_K0.9420.34
17_N34_I0.9400.34
64_Q75_N0.9330.33
6_F47_S0.8980.32
59_A63_A0.8970.31
49_A52_G0.8970.31
9_Q39_Q0.8960.31
18_Y41_K0.8710.30
8_T44_Q0.8700.30
48_D51_T0.8670.30
25_K84_F0.8670.30
44_Q83_N0.8560.29
11_V85_Y0.8350.28
2_K61_L0.8220.28
10_S48_D0.8220.28
19_D53_S0.8210.28
67_N76_H0.8130.27
7_G82_I0.8100.27
15_Q73_D0.8060.27
4_N19_D0.8020.27
23_V62_K0.8020.27
43_M51_T0.7870.26
46_A51_T0.7770.26
3_I70_Y0.7720.25
43_M77_I0.7650.25
31_Q69_S0.7620.25
11_V57_K0.7540.25
2_K84_F0.7520.25
57_K65_I0.7450.24
58_I73_D0.7400.24
8_T15_Q0.7350.24
21_Q80_N0.7240.23
20_K23_V0.7240.23
8_T39_Q0.7240.23
22_A39_Q0.7190.23
20_K80_N0.7120.23
60_Q63_A0.7070.23
36_I41_K0.6920.22
24_Q77_I0.6910.22
2_K7_G0.6890.22
67_N72_V0.6880.22
5_Q8_T0.6820.22
2_K12_N0.6810.22
58_I75_N0.6810.22
28_A53_S0.6810.22
75_N85_Y0.6800.22
46_A49_A0.6780.21
13_P48_D0.6770.21
12_N62_K0.6640.21
26_T65_I0.6610.21
69_S85_Y0.6590.21
38_S77_I0.6340.20
25_K53_S0.6130.19
72_V80_N0.6020.19
29_Q42_E0.5900.18
24_Q53_S0.5840.18
61_L66_E0.5740.18
21_Q47_S0.5670.17
22_A33_K0.5650.17
71_K74_A0.5620.17
56_E77_I0.5540.17
60_Q64_Q0.5510.17
10_S46_A0.5470.17
6_F9_Q0.5450.17
39_Q44_Q0.5420.17
8_T76_H0.5280.16
51_T86_K0.5190.16
28_A75_N0.5170.16
34_I80_N0.5170.16
2_K65_I0.5160.16
28_A63_A0.5080.15
16_K79_K0.5070.15
27_V58_I0.5050.15
25_K60_Q0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rp3B 1 0.8977 99.7 0.447 Contact Map
2r1fA 4 0.2841 7.9 0.924 Contact Map
4iilA 1 0.7955 6.8 0.927 Contact Map
4iiwA 4 0.6705 6.3 0.927 Contact Map
1b0zA 4 0.4318 6.3 0.927 Contact Map
2flqA 2 0.6705 5.8 0.929 Contact Map
3h35A 3 0.0227 5.3 0.93 Contact Map
3lpzA 1 0.4091 4.7 0.932 Contact Map
4d0kA 1 0 4.4 0.933 Contact Map
2p61A 1 0.5455 4.3 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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