GREMLIN Database
YVYG - Uncharacterized protein YvyG
UniProt: P39808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 160 (155)
Sequences: 393 (334)
Seq/√Len: 26.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_H49_Y4.3051.00
11_K90_E3.7081.00
14_C101_V3.5221.00
35_K38_E3.1801.00
25_E104_R3.0391.00
28_T32_K2.9581.00
13_L17_H2.8001.00
21_L108_V2.7811.00
14_C97_S2.4970.99
26_E45_K2.4560.99
14_C18_E2.4040.99
27_K46_E2.3990.99
16_L52_A2.2370.98
116_T123_I2.0600.97
24_S105_L1.9780.96
24_S109_N1.9730.96
19_H52_A1.9190.95
32_K132_P1.9080.95
6_I67_F1.8660.94
125_I128_D1.6850.90
99_S102_L1.5810.87
81_A85_G1.5160.84
18_E97_S1.5100.84
9_Q56_T1.5090.84
26_E38_E1.5010.84
25_E108_V1.4830.83
21_L101_V1.4810.83
122_F126_S1.4440.81
128_D156_F1.4310.81
7_I94_L1.4070.80
132_P158_S1.4020.79
10_L112_N1.3810.78
31_L116_T1.3530.77
131_V155_L1.3510.77
38_E41_N1.3430.76
77_S110_E1.3090.74
53_I138_N1.2940.73
7_I159_K1.2860.73
75_T118_D1.2830.73
50_I130_L1.2800.73
21_L42_I1.2780.73
28_T108_V1.2180.69
54_T78_A1.2140.69
65_S86_S1.2110.68
17_H158_S1.2050.68
72_E102_L1.2020.68
14_C94_L1.1960.67
30_A39_L1.1890.67
116_T120_L1.1790.66
101_V143_I1.1520.64
111_M114_Q1.1520.64
28_T121_Q1.1470.64
55_Q59_D1.1470.64
77_S118_D1.1430.64
13_L51_Q1.1420.64
16_L79_C1.1400.64
121_Q125_I1.1390.63
95_Y99_S1.1340.63
28_T47_Q1.1120.62
11_K18_E1.1110.61
3_A6_I1.1050.61
30_A42_I1.1030.61
86_S89_E1.0920.60
88_K91_L1.0890.60
83_T136_N1.0810.59
104_R119_A1.0780.59
32_K158_S1.0780.59
18_E104_R1.0730.59
31_L110_E1.0700.59
8_E36_T1.0660.58
73_N90_E1.0570.58
32_K125_I1.0520.57
10_L76_I1.0430.57
23_L120_L1.0390.56
54_T101_V1.0280.55
3_A79_C1.0270.55
21_L24_S1.0260.55
37_K40_S1.0180.55
43_L71_S1.0180.55
20_L154_K0.9940.53
89_E93_Q0.9830.52
65_S123_I0.9780.52
24_S108_V0.9720.51
34_G41_N0.9680.51
117_R120_L0.9670.51
105_L119_A0.9620.51
124_S157_D0.9610.50
40_S127_Y0.9600.50
41_N45_K0.9530.50
50_I138_N0.9520.50
40_S44_T0.9480.49
64_T68_L0.9450.49
29_E33_A0.9440.49
32_K108_V0.9420.49
47_Q109_N0.9410.49
97_S104_R0.9210.47
121_Q132_P0.9190.47
130_L145_A0.8930.45
57_E64_T0.8890.45
30_A38_E0.8860.45
32_K121_Q0.8820.45
16_L49_Y0.8820.45
75_T80_I0.8790.44
47_Q68_L0.8730.44
8_E12_R0.8710.44
16_L116_T0.8700.44
65_S152_K0.8680.43
57_E60_R0.8670.43
25_E89_E0.8500.42
21_L157_D0.8490.42
18_E93_Q0.8480.42
9_Q63_T0.8400.41
127_Y132_P0.8380.41
55_Q132_P0.8380.41
17_H68_L0.8380.41
110_E149_K0.8340.41
49_Y53_I0.8290.41
111_M155_L0.8290.41
53_I123_I0.8210.40
44_T138_N0.8180.40
119_A132_P0.8160.40
67_F152_K0.8160.40
137_F157_D0.8130.39
4_K87_E0.8030.39
18_E22_T0.8010.39
80_I88_K0.8010.39
76_I102_L0.7980.38
7_I39_L0.7960.38
41_N48_K0.7940.38
14_C45_K0.7770.37
96_E159_K0.7750.37
47_Q136_N0.7750.37
86_S127_Y0.7700.36
53_I91_L0.7690.36
78_A81_A0.7660.36
57_E78_A0.7630.36
68_L72_E0.7590.36
37_K53_I0.7530.35
72_E78_A0.7490.35
56_T60_R0.7390.34
49_Y121_Q0.7390.34
116_T119_A0.7330.34
95_Y102_L0.7320.34
3_A107_K0.7320.34
11_K94_L0.7230.33
94_L110_E0.7190.33
79_C85_G0.7190.33
120_L135_N0.7110.32
76_I95_Y0.7100.32
36_T104_R0.7070.32
112_N116_T0.7050.32
90_E149_K0.7030.32
80_I83_T0.6980.32
16_L50_I0.6970.32
104_R116_T0.6880.31
24_S33_A0.6870.31
48_K132_P0.6830.31
59_D101_V0.6770.30
15_V67_F0.6750.30
10_L17_H0.6690.30
75_T78_A0.6690.30
79_C110_E0.6670.30
6_I76_I0.6640.29
14_C50_I0.6540.29
34_G123_I0.6470.28
11_K89_E0.6470.28
61_I65_S0.6460.28
113_R154_K0.6440.28
3_A23_L0.6440.28
105_L126_S0.6420.28
5_A66_A0.6410.28
12_R47_Q0.6410.28
45_K76_I0.6390.28
91_L156_F0.6380.28
133_K159_K0.6360.28
57_E61_I0.6320.27
64_T157_D0.6300.27
33_A94_L0.6280.27
13_L31_L0.6220.27
62_K97_S0.6210.27
36_T123_I0.6200.27
10_L47_Q0.6180.27
32_K111_M0.6170.27
59_D117_R0.6130.26
41_N62_K0.6090.26
92_E95_Y0.6070.26
35_K41_N0.6050.26
53_I127_Y0.6000.26
18_E41_N0.5970.25
114_Q135_N0.5940.25
110_E113_R0.5940.25
23_L136_N0.5880.25
87_E90_E0.5880.25
17_H53_I0.5880.25
92_E96_E0.5860.25
66_A144_K0.5860.25
13_L121_Q0.5770.24
78_A82_K0.5770.24
17_H125_I0.5730.24
25_E159_K0.5720.24
69_G157_D0.5640.24
41_N76_I0.5620.23
77_S144_K0.5590.23
141_K144_K0.5570.23
37_K154_K0.5570.23
74_N140_S0.5550.23
111_M132_P0.5550.23
50_I65_S0.5550.23
39_L47_Q0.5520.23
10_L77_S0.5500.23
119_A155_L0.5500.23
17_H132_P0.5460.23
12_R19_H0.5450.23
23_L128_D0.5440.23
130_L133_K0.5430.22
18_E29_E0.5430.22
4_K156_F0.5400.22
9_Q57_E0.5390.22
17_H32_K0.5350.22
17_H111_M0.5350.22
122_F131_V0.5350.22
67_F109_N0.5340.22
25_E154_K0.5310.22
40_S124_S0.5290.22
119_A129_M0.5260.22
100_Q104_R0.5220.21
50_I105_L0.5140.21
154_K158_S0.5130.21
104_R107_K0.5120.21
32_K35_K0.5120.21
112_N139_Y0.5040.20
4_K65_S0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3opcA 2 0.8 99.9 0.495 Contact Map
2fupA 1 0.7937 99.9 0.499 Contact Map
3a7mA 2 0.725 16.1 0.934 Contact Map
3ojaA 1 0.7312 11.5 0.938 Contact Map
3nkzA 4 0.575 9.6 0.94 Contact Map
4bwdA 2 0.3625 9.4 0.94 Contact Map
4jpsB 1 0.6687 7.9 0.943 Contact Map
2bnxA 2 0.1375 7.9 0.943 Contact Map
3vkgA 2 0.8375 6.8 0.944 Contact Map
4cg4A 2 0.9625 6 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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