GREMLIN Database
YVYF - Uncharacterized protein YvyF
UniProt: P39807 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (122)
Sequences: 406 (346)
Seq/√Len: 31.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_A16_K3.7951.00
53_R57_E3.2061.00
78_H94_R3.1661.00
9_K29_E3.0451.00
91_T101_A2.9321.00
33_S36_T2.7341.00
40_F46_N2.7201.00
87_E97_K2.6031.00
30_E64_L2.3080.99
76_I94_R2.1710.99
83_A92_S2.1670.98
69_I75_Q2.1590.98
118_A121_I2.0110.98
88_R105_D1.9990.97
14_F17_T1.9870.97
4_L13_L1.9110.97
12_A25_A1.8860.96
58_T68_F1.8270.96
34_F37_V1.7680.95
14_F64_L1.6450.92
108_D120_K1.6360.92
50_T88_R1.6180.92
49_S54_I1.5940.91
34_F68_F1.5420.90
36_T60_V1.4940.88
85_P92_S1.4930.88
16_K19_L1.4760.87
65_I93_I1.4050.85
50_T82_L1.4030.85
39_K112_H1.3730.83
9_K22_V1.3690.83
21_T67_K1.3590.83
42_R85_P1.3590.83
121_I124_E1.3520.82
61_E66_L1.3510.82
7_C10_C1.3460.82
75_Q94_R1.3430.82
34_F38_Y1.3270.81
6_N11_N1.3140.80
4_L15_L1.2990.80
38_Y74_I1.2800.79
115_H118_A1.2580.77
3_E48_Q1.2570.77
37_V98_F1.2540.77
69_I76_I1.2450.77
51_L66_L1.2140.75
40_F57_E1.2020.74
48_Q79_L1.1840.73
69_I84_Y1.1740.72
38_Y79_L1.1500.71
61_E101_A1.1420.70
24_Q36_T1.1390.70
47_R84_Y1.1150.68
47_R80_P1.0980.67
45_E123_K1.0770.65
64_L67_K1.0750.65
117_D120_K1.0690.65
41_L48_Q1.0660.65
75_Q79_L1.0500.63
64_L69_I1.0400.63
122_E125_N1.0140.61
23_C26_C1.0010.60
37_V54_I0.9950.59
100_K104_S0.9770.58
33_S64_L0.9640.57
52_S62_E0.9610.57
49_S110_M0.9570.56
41_L46_N0.9510.56
113_L117_D0.9450.55
35_E75_Q0.9350.54
37_V97_K0.8890.51
110_M125_N0.8880.51
51_L59_G0.8820.50
65_I71_Q0.8700.49
14_F22_V0.8620.49
24_Q70_R0.8620.49
42_R84_Y0.8600.48
35_E94_R0.8510.48
42_R45_E0.8500.48
60_V73_R0.8430.47
68_F72_K0.8380.47
20_Q72_K0.8300.46
32_K35_E0.8210.45
40_F53_R0.8190.45
34_F101_A0.8190.45
13_L27_I0.8130.45
40_F52_S0.8130.45
20_Q42_R0.8040.44
8_P59_G0.8030.44
57_E115_H0.8020.44
21_T77_T0.7900.43
54_I92_S0.7890.43
35_E106_I0.7740.42
69_I94_R0.7720.41
31_E35_E0.7710.41
41_L74_I0.7680.41
9_K70_R0.7650.41
38_Y47_R0.7570.40
100_K111_D0.7560.40
22_V31_E0.7490.40
71_Q93_I0.7480.39
54_I76_I0.7350.38
120_K123_K0.7280.38
29_E32_K0.7260.38
124_E127_K0.7240.38
72_K103_Q0.7140.37
37_V60_V0.7130.37
52_S56_E0.7050.36
10_C23_C0.6700.34
7_C23_C0.6700.34
7_C26_C0.6700.34
10_C26_C0.6700.34
25_A48_Q0.6690.34
9_K68_F0.6630.33
119_L123_K0.6620.33
5_A13_L0.6610.33
30_E62_E0.6590.33
79_L82_L0.6550.33
103_Q106_I0.6520.32
86_C102_C0.6500.32
99_C102_C0.6500.32
86_C89_C0.6500.32
89_C99_C0.6500.32
89_C102_C0.6500.32
86_C99_C0.6500.32
80_P84_Y0.6410.32
24_Q27_I0.6380.31
36_T68_F0.6340.31
112_H115_H0.6330.31
72_K76_I0.6250.30
53_R87_E0.6220.30
115_H127_K0.6180.30
40_F62_E0.6160.30
65_I111_D0.6150.30
117_D123_K0.6110.29
16_K54_I0.6090.29
3_E61_E0.6000.29
119_L122_E0.6000.29
79_L98_F0.5980.29
12_A112_H0.5960.28
19_L96_G0.5960.28
50_T118_A0.5950.28
4_L114_N0.5940.28
120_K126_S0.5840.28
107_K126_S0.5800.27
49_S53_R0.5750.27
45_E48_Q0.5720.27
20_Q39_K0.5720.27
14_F42_R0.5680.27
101_A121_I0.5670.27
38_Y97_K0.5600.26
42_R47_R0.5540.26
52_S59_G0.5520.26
30_E69_I0.5390.25
36_T59_G0.5360.25
52_S98_F0.5360.25
104_S108_D0.5350.25
123_K127_K0.5320.24
19_L108_D0.5310.24
37_V47_R0.5310.24
101_A105_D0.5300.24
40_F119_L0.5270.24
101_A104_S0.5270.24
8_P106_I0.5240.24
24_Q63_E0.5200.24
30_E63_E0.5200.24
12_A24_Q0.5200.24
13_L22_V0.5170.24
13_L24_Q0.5160.23
30_E68_F0.5120.23
42_R69_I0.5120.23
82_L107_K0.5100.23
35_E103_Q0.5080.23
15_L51_L0.5030.23
105_D109_Q0.5020.23
14_F19_L0.5020.23
108_D115_H0.5000.23
26_C99_C0.5000.23
23_C102_C0.5000.23
23_C89_C0.5000.23
26_C102_C0.5000.23
23_C99_C0.5000.23
26_C86_C0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o9xA 2 0.6619 90.9 0.893 Contact Map
3qt1I 1 0.2878 88.2 0.899 Contact Map
1twfI 1 0.7194 86.1 0.902 Contact Map
3h0gI 1 0.6403 86.1 0.902 Contact Map
1y02A 1 0.4604 78.5 0.91 Contact Map
4c2mI 1 0.7338 77.2 0.911 Contact Map
3u6pA 1 0.5036 76.4 0.912 Contact Map
2og0A 1 0.3525 74.7 0.913 Contact Map
2gmgA 1 0.2878 73.5 0.914 Contact Map
4awxB 1 0.4245 69.5 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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