GREMLIN Database
LICT - Transcription antiterminator LicT
UniProt: P39805 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (264)
Sequences: 3683 (3195)
Seq/√Len: 196.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_K147_S4.4991.00
84_Q135_E4.1761.00
251_E257_K3.0711.00
229_L264_L3.0061.00
189_H245_K2.9861.00
187_K193_E2.9081.00
233_K240_Y2.9041.00
106_Q110_K2.8181.00
233_K260_S2.8041.00
239_A271_E2.7861.00
181_E253_E2.5861.00
76_E143_K2.5641.00
243_T267_T2.3821.00
41_E47_V2.3261.00
134_K153_A2.3151.00
100_H159_H2.1761.00
185_I249_Y2.1671.00
186_V204_F2.1591.00
14_V22_L2.1011.00
43_R47_V2.0701.00
214_R262_E2.0621.00
8_N16_N2.0581.00
77_I136_A2.0511.00
21_E33_K1.9761.00
12_I15_V1.9731.00
218_G256_H1.9351.00
247_Q263_L1.9231.00
80_Y139_M1.9151.00
243_T263_L1.9101.00
180_Q201_Y1.8501.00
244_K260_S1.8071.00
12_I16_N1.8011.00
239_A243_T1.7951.00
80_Y135_E1.7761.00
131_A134_K1.7221.00
186_V270_I1.6931.00
81_A136_A1.6851.00
119_L154_G1.6261.00
9_N12_I1.6231.00
134_K150_E1.6191.00
190_F242_C1.6051.00
40_D43_R1.5941.00
8_N15_V1.5871.00
197_E273_V1.5861.00
182_I246_I1.5711.00
8_N12_I1.5531.00
244_K263_L1.5521.00
108_N149_P1.5381.00
186_V242_C1.5351.00
239_A270_I1.5341.00
27_R31_F1.5281.00
108_N148_L1.5281.00
184_S188_Y1.5251.00
231_T235_K1.5221.00
207_H269_H1.5161.00
137_L141_K1.4921.00
241_E244_K1.4921.00
248_T251_E1.4891.00
247_Q266_L1.4671.00
43_R107_R1.4361.00
16_N20_K1.4291.00
96_S159_H1.4171.00
67_P70_C1.4171.00
28_G45_E1.4141.00
226_D264_L1.3991.00
81_A132_I1.3831.00
200_H273_V1.3791.00
11_V16_N1.3711.00
183_L201_Y1.3681.00
211_F215_L1.3621.00
222_E261_D1.3581.00
212_A216_F1.3511.00
38_D41_E1.3421.00
24_V27_R1.3381.00
70_C74_S1.3251.00
133_G153_A1.3201.00
243_T247_Q1.3161.00
29_L41_E1.3121.00
9_N16_N1.3051.00
194_F270_I1.3051.00
78_I98_T1.2891.00
105_I109_Q1.2751.00
129_E157_A1.2721.00
20_K31_F1.2641.00
13_S16_N1.2641.00
82_K89_L1.2561.00
92_S96_S1.2531.00
96_S100_H1.2531.00
77_I81_A1.2511.00
229_L260_S1.2461.00
232_V267_T1.2421.00
44_I47_V1.2401.00
137_L153_A1.2361.00
73_V144_T1.2261.00
11_V15_V1.2221.00
73_V143_K1.1991.00
194_F273_V1.1981.00
221_M265_Y1.1901.00
186_V243_T1.1891.00
149_P152_E1.1691.00
227_F261_D1.1571.00
42_A45_E1.1561.00
18_Q22_L1.1541.00
240_Y267_T1.1381.00
230_D234_E1.1371.00
130_F153_A1.1311.00
208_L211_F1.1161.00
244_K248_T1.1091.00
70_C102_N1.1021.00
32_Q40_D1.1001.00
201_Y205_V1.0961.00
211_F259_T1.0861.00
20_K24_V1.0861.00
41_E45_E1.0751.00
12_I17_E1.0711.00
211_F258_L1.0711.00
33_K37_D1.0691.00
94_Y98_T1.0651.00
135_E138_V1.0601.00
175_I212_A1.0581.00
185_I188_Y1.0551.00
80_Y84_Q1.0511.00
74_S78_I1.0471.00
37_D43_R1.0431.00
8_N11_V1.0381.00
105_I148_L1.0371.00
130_F157_A1.0301.00
261_D264_L1.0291.00
243_T270_I1.0221.00
240_Y260_S1.0151.00
243_T266_L1.0031.00
37_D41_E1.0021.00
102_N106_Q0.9991.00
70_C105_I0.9981.00
179_M182_I0.9971.00
38_D43_R0.9961.00
127_K130_F0.9951.00
179_M205_V0.9861.00
243_T246_I0.9830.99
38_D42_A0.9820.99
141_K144_T0.9800.99
240_Y244_K0.9750.99
93_I163_A0.9720.99
75_E95_V0.9670.99
85_L135_E0.9660.99
138_V147_S0.9650.99
82_K85_L0.9650.99
101_I156_I0.9650.99
24_V31_F0.9620.99
137_L156_I0.9600.99
229_L240_Y0.9600.99
81_A160_I0.9530.99
72_E75_E0.9510.99
70_C73_V0.9460.99
182_I249_Y0.9460.99
133_G157_A0.9440.99
226_D261_D0.9370.99
113_D149_P0.9340.99
232_V264_L0.9340.99
187_K194_F0.9320.99
133_G136_A0.9240.99
264_L267_T0.9230.99
246_I249_Y0.9160.99
9_N15_V0.9160.99
130_F134_K0.9160.99
73_V139_M0.9120.99
242_C246_I0.9100.99
134_K138_V0.9050.99
135_E139_M0.8970.99
211_F214_R0.8970.99
119_L155_F0.8930.99
140_V148_L0.8920.99
181_E249_Y0.8920.99
130_F154_G0.8900.99
17_E20_K0.8840.99
77_I139_M0.8830.99
249_Y253_E0.8800.99
72_E76_E0.8780.99
181_E184_S0.8730.99
182_I270_I0.8650.99
203_R272_R0.8640.99
240_Y243_T0.8610.99
247_Q258_L0.8590.99
101_I140_V0.8590.99
89_L160_I0.8580.99
125_L150_E0.8540.99
206_T210_F0.8530.99
128_D131_A0.8530.99
204_F266_L0.8510.99
186_V190_F0.8510.99
75_E94_Y0.8460.98
265_Y269_H0.8440.98
163_A211_F0.8430.98
74_S101_I0.8420.98
185_I189_H0.8390.98
269_H272_R0.8340.98
187_K197_E0.8320.98
157_A161_V0.8310.98
185_I246_I0.8310.98
87_K268_I0.8310.98
178_V182_I0.8300.98
246_I270_I0.8300.98
136_A139_M0.8260.98
8_N13_S0.8190.98
28_G31_F0.8180.98
141_K148_L0.8150.98
39_V43_R0.8130.98
212_A254_Y0.8130.98
177_K253_E0.8130.98
100_H104_A0.8110.98
253_E256_H0.8090.98
160_I164_E0.8080.98
73_V77_I0.8070.98
179_M183_L0.8070.98
57_E60_K0.8050.98
199_L203_R0.8000.98
41_E46_K0.7990.98
79_S94_Y0.7960.98
189_H242_C0.7940.98
8_N17_E0.7900.98
227_F231_T0.7880.98
116_N122_T0.7860.98
115_K151_D0.7830.98
239_A267_T0.7740.97
238_R241_E0.7710.97
12_I39_V0.7690.97
81_A139_M0.7670.97
116_N154_G0.7660.97
152_E265_Y0.7650.97
179_M208_L0.7630.97
23_V27_R0.7600.97
250_I254_Y0.7580.97
11_V155_F0.7540.97
172_I176_T0.7510.97
109_Q145_G0.7480.97
171_N174_N0.7460.97
203_R273_V0.7420.97
137_L140_V0.7370.96
215_L256_H0.7360.96
133_G160_I0.7290.96
87_K164_E0.7290.96
238_R243_T0.7270.96
31_F34_K0.7240.96
43_R46_K0.7220.96
75_E79_S0.7210.96
231_T234_E0.7210.96
210_F213_Q0.7200.96
106_Q109_Q0.7120.96
248_T252_R0.7120.96
90_N164_E0.7100.96
122_T154_G0.7090.96
85_L132_I0.7070.95
104_A108_N0.7030.95
35_S38_D0.7030.95
176_T205_V0.7010.95
271_E274_V0.7000.95
25_M31_F0.7000.95
66_I102_N0.6980.95
109_Q138_V0.6970.95
227_F235_K0.6970.95
227_F264_L0.6910.95
178_V208_L0.6900.95
50_L55_V0.6900.95
240_Y263_L0.6840.95
169_M172_I0.6810.94
83_L86_G0.6800.94
39_V47_V0.6770.94
81_A135_E0.6770.94
200_H204_F0.6770.94
20_K27_R0.6770.94
74_S98_T0.6750.94
41_E44_I0.6720.94
136_A160_I0.6720.94
239_A274_V0.6700.94
79_S82_K0.6670.94
139_M142_N0.6570.93
78_I136_A0.6570.93
209_K213_Q0.6540.93
229_L233_K0.6530.93
241_E245_K0.6510.93
207_H265_Y0.6480.93
236_Y271_E0.6470.93
190_F194_F0.6450.93
174_N177_K0.6440.93
117_A158_L0.6440.93
108_N113_D0.6430.93
194_F200_H0.6410.92
203_R269_H0.6400.92
221_M261_D0.6400.92
12_I30_A0.6390.92
53_K56_S0.6390.92
114_I152_E0.6390.92
62_L69_E0.6390.92
197_E200_H0.6340.92
79_S83_L0.6330.92
52_N55_V0.6320.92
180_Q184_S0.6290.92
74_S77_I0.6270.92
9_N13_S0.6270.92
10_N13_S0.6270.92
231_T236_Y0.6220.91
116_N121_E0.6200.91
108_N152_E0.6200.91
233_K264_L0.6190.91
190_F193_E0.6170.91
107_R155_F0.6160.91
250_I256_H0.6130.91
176_T201_Y0.6130.91
100_H152_E0.6100.91
244_K247_Q0.6040.90
184_S195_N0.6030.90
105_I140_V0.6010.90
140_V144_T0.6000.90
212_A256_H0.5960.90
226_D263_L0.5960.90
250_I258_L0.5950.89
242_C270_I0.5940.89
226_D230_D0.5940.89
184_S187_K0.5930.89
77_I80_Y0.5920.89
229_L261_D0.5900.89
80_Y132_I0.5890.89
183_L187_K0.5890.89
237_H267_T0.5880.89
183_L270_I0.5840.89
213_Q217_N0.5820.88
116_N151_D0.5820.88
59_F95_V0.5800.88
175_I205_V0.5800.88
89_L93_I0.5790.88
92_S163_A0.5790.88
62_L66_I0.5780.88
134_K147_S0.5770.88
25_M30_A0.5760.88
19_G22_L0.5750.88
81_A85_L0.5750.88
183_L186_V0.5740.88
197_E269_H0.5730.88
100_H203_R0.5720.88
151_D154_G0.5700.87
67_P118_L0.5690.87
162_N210_F0.5680.87
190_F246_I0.5660.87
34_K38_D0.5660.87
138_V142_N0.5640.87
17_E24_V0.5630.87
183_L200_H0.5630.87
199_L210_F0.5630.87
85_L129_E0.5600.86
211_F269_H0.5580.86
185_I245_K0.5570.86
36_G40_D0.5560.86
130_F150_E0.5560.86
139_M143_K0.5510.86
182_I243_T0.5480.85
103_F107_R0.5470.85
167_E234_E0.5470.85
107_R152_E0.5460.85
121_E154_G0.5460.85
85_L89_L0.5450.85
127_K157_A0.5440.85
230_D233_K0.5440.85
77_I140_V0.5430.85
178_V254_Y0.5410.85
116_N156_I0.5400.84
24_V39_V0.5400.84
15_V19_G0.5380.84
232_V268_I0.5370.84
199_L204_F0.5340.84
12_I24_V0.5330.84
129_E161_V0.5320.84
18_Q23_V0.5320.84
49_T92_S0.5290.83
133_G156_I0.5290.83
130_F161_V0.5270.83
30_A126_Y0.5250.83
130_F133_G0.5240.83
76_E80_Y0.5230.83
10_N17_E0.5220.82
93_I211_F0.5220.82
206_T261_D0.5220.82
243_T256_H0.5140.81
155_F227_F0.5140.81
162_N211_F0.5120.81
24_V29_L0.5110.81
241_E248_T0.5110.81
69_E143_K0.5100.81
240_Y271_E0.5100.81
70_C109_Q0.5080.81
105_I146_V0.5070.81
89_L92_S0.5050.80
178_V249_Y0.5030.80
27_R180_Q0.5020.80
102_N271_E0.5010.80
49_T64_Y0.5010.80
198_S202_Y0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r6iA 2 0.9675 100 0.335 Contact Map
1h99A 2 0.7942 100 0.382 Contact Map
3sqnA 2 0.9278 100 0.457 Contact Map
3rioA 1 0.5993 99.9 0.577 Contact Map
3ufeA 2 0.3863 99.8 0.681 Contact Map
1auuA 2 0.1986 93.6 0.903 Contact Map
1l1cA 2 0.1986 93.4 0.904 Contact Map
3nufA 2 0.426 89.6 0.913 Contact Map
1wtyA 4 0.2238 12 0.954 Contact Map
1wwpA 2 0.2238 9 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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