GREMLIN Database
IPI - Intracellular proteinase inhibitor
UniProt: P39804 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (102)
Sequences: 114 (93)
Seq/√Len: 9.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_G65_T4.2070.99
43_F83_D3.3240.95
46_V54_E2.6590.85
54_E57_R2.6420.84
42_K69_Q2.2750.74
46_V57_R2.1980.71
31_R63_M2.1720.70
85_W96_V2.1610.70
12_A35_F2.1140.68
47_V85_W1.8990.59
41_Q59_S1.8950.59
17_E40_G1.8460.57
45_L83_D1.7820.54
37_F92_G1.7750.54
43_F56_Y1.7380.52
26_K34_E1.7090.51
68_F76_G1.6720.49
47_V96_V1.6170.47
40_G66_Q1.5650.45
24_S98_V1.5320.43
61_E75_S1.5180.43
39_T65_T1.5070.42
21_F47_V1.5030.42
23_M45_L1.4890.41
44_E76_G1.4660.40
21_F85_W1.4310.39
44_E77_E1.3890.37
34_E49_D1.2670.32
65_T84_V1.2490.32
22_N51_E1.2290.31
70_N73_L1.2220.31
68_F78_T1.1910.29
7_V11_D1.1880.29
29_S33_I1.1850.29
49_D54_E1.1800.29
59_S73_L1.1720.29
57_R78_T1.1590.28
6_V100_F1.1540.28
37_F52_H1.1400.28
38_S58_Y1.1100.27
25_L81_F1.1080.27
68_F71_L1.1060.26
29_S102_G1.0960.26
84_V87_E1.0920.26
23_M98_V1.0880.26
24_S78_T1.0830.26
9_S32_A1.0780.26
21_F66_Q1.0520.25
9_S15_E1.0500.25
49_D53_K1.0480.25
100_F104_A1.0140.23
7_V94_Y1.0120.23
31_R76_G1.0070.23
34_E96_V0.9510.22
66_Q85_W0.9500.21
61_E90_E0.9470.21
10_I79_Y0.9430.21
25_L57_R0.9370.21
44_E55_R0.9340.21
83_D89_P0.9290.21
43_F109_Q0.9270.21
31_R46_V0.9060.20
26_K78_T0.9010.20
24_S80_D0.9010.20
49_D102_G0.8920.20
53_K59_S0.8770.19
73_L90_E0.8770.19
91_P94_Y0.8750.19
43_F89_P0.8750.19
21_F73_L0.8750.19
48_Y54_E0.8590.19
22_N76_G0.8470.19
11_D28_Q0.8410.18
6_V73_L0.8400.18
44_E48_Y0.8320.18
67_A106_N0.8290.18
53_K103_R0.8290.18
8_L44_E0.8270.18
85_W89_P0.8220.18
26_K74_E0.8160.18
100_F106_N0.8160.18
15_E86_K0.8160.18
47_V89_P0.8080.18
7_V93_T0.8070.18
23_M44_E0.8050.18
24_S58_Y0.8020.17
103_R106_N0.7960.17
35_F51_E0.7960.17
25_L56_Y0.7870.17
56_Y62_K0.7820.17
60_K100_F0.7820.17
9_S18_Q0.7760.17
33_I75_S0.7460.16
24_S100_F0.7440.16
14_Q58_Y0.7380.16
41_Q75_S0.7320.16
89_P96_V0.7210.15
38_S42_K0.7190.15
67_A107_L0.7120.15
41_Q97_K0.7110.15
22_N62_K0.7100.15
81_F98_V0.6920.15
37_F77_E0.6790.15
47_V53_K0.6700.14
75_S89_P0.6690.14
66_Q92_G0.6670.14
18_Q33_I0.6630.14
72_T93_T0.6600.14
17_E51_E0.6580.14
39_T101_K0.6580.14
66_Q69_Q0.6530.14
16_P54_E0.6500.14
40_G43_F0.6460.14
41_Q100_F0.6360.14
56_Y61_E0.6310.14
48_Y97_K0.6280.13
7_V100_F0.6280.13
16_P90_E0.6210.13
25_L32_A0.6200.13
44_E58_Y0.6090.13
8_L45_L0.6090.13
58_Y75_S0.6020.13
59_S94_Y0.5990.13
23_M104_A0.5920.13
42_K101_K0.5910.13
39_T56_Y0.5910.13
38_S63_M0.5880.13
12_A93_T0.5850.13
18_Q76_G0.5850.13
32_A70_N0.5820.13
47_V98_V0.5800.13
13_I33_I0.5780.12
23_M30_E0.5780.12
28_Q61_E0.5740.12
80_D95_E0.5670.12
60_K69_Q0.5620.12
8_L11_D0.5610.12
96_V99_T0.5530.12
25_L92_G0.5480.12
59_S99_T0.5460.12
38_S77_E0.5450.12
72_T108_K0.5430.12
55_R102_G0.5410.12
29_S85_W0.5330.12
16_P49_D0.5320.12
53_K101_K0.5240.11
45_L109_Q0.5210.11
78_T95_E0.5210.11
31_R60_K0.5120.11
67_A70_N0.5050.11
21_F37_F0.5050.11
12_A73_L0.5000.11
25_L35_F0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3isyA 1 0.9832 100 0.178 Contact Map
2x3cA 2 0.8235 96.1 0.84 Contact Map
3cfuA 1 0.916 95.3 0.849 Contact Map
2l0dA 1 0.8403 94.7 0.855 Contact Map
1xf1A 2 0.958 94.1 0.859 Contact Map
3iduA 1 0.8319 93.7 0.861 Contact Map
2kutA 1 0.8319 92 0.869 Contact Map
4lesA 1 0.8655 91.7 0.87 Contact Map
4r4gA 1 0.8824 91.6 0.87 Contact Map
3abzA 3 0.8403 90.3 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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