GREMLIN Database
YITT - UPF0750 membrane protein YitT
UniProt: P39803 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (268)
Sequences: 3717 (2696)
Seq/√Len: 164.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_I87_L5.6301.00
207_K210_E4.9971.00
227_P236_Q3.8781.00
228_A239_M3.7331.00
213_E217_G3.4411.00
206_K237_K3.3611.00
205_T211_I3.1521.00
17_L95_F2.8941.00
114_F176_L2.6751.00
201_A252_L2.6641.00
37_F65_L2.5651.00
229_K234_N2.4881.00
214_A255_I2.3641.00
229_K238_E2.3361.00
226_V239_M2.2901.00
205_T208_A2.2831.00
214_A218_K2.2271.00
44_L48_V2.1831.00
209_D213_E2.1781.00
199_L269_Q2.1081.00
227_P238_E2.0741.00
223_I231_A2.0351.00
9_L87_L1.9981.00
15_G122_G1.9251.00
13_I91_L1.9231.00
8_K84_Y1.9171.00
20_A95_F1.9051.00
24_N99_L1.9011.00
90_A94_L1.8861.00
221_R248_E1.8781.00
19_N92_T1.8551.00
167_G175_A1.8421.00
21_A25_L1.8341.00
59_G97_G1.8091.00
187_R191_A1.8091.00
22_G119_S1.8021.00
11_I129_Y1.7871.00
126_T133_T1.7171.00
212_K231_A1.7061.00
152_G190_D1.7041.00
44_L61_L1.6871.00
167_G172_W1.6861.00
256_V263_A1.6591.00
30_A111_N1.6331.00
223_I240_M1.6291.00
225_T240_M1.6291.00
215_I252_L1.6281.00
206_K235_E1.6131.00
171_G174_K1.6041.00
107_D177_Y1.6031.00
48_V55_Y1.6011.00
208_A238_E1.5931.00
256_V265_T1.5511.00
206_K262_K1.5401.00
8_K129_Y1.5381.00
124_G192_I1.5071.00
229_K236_Q1.4991.00
71_I75_L1.4991.00
219_M252_L1.4961.00
212_K234_N1.4941.00
109_L180_V1.4671.00
214_A259_V1.4581.00
241_I266_N1.4301.00
200_T268_V1.4211.00
209_D234_N1.4101.00
81_F132_S1.3941.00
202_M241_I1.3921.00
212_K225_T1.3691.00
24_N100_P1.3681.00
157_I161_I1.3581.00
40_V44_L1.3461.00
161_I165_T1.3371.00
15_G126_T1.3311.00
12_V88_S1.3241.00
17_L99_L1.3221.00
21_A99_L1.3201.00
244_I252_L1.3151.00
163_I182_L1.2981.00
67_I71_I1.2971.00
59_G93_T1.2751.00
37_F69_V1.2741.00
27_L115_G1.2741.00
62_L96_M1.2681.00
228_A237_K1.2641.00
31_D174_K1.2641.00
262_K276_F1.2591.00
57_S97_G1.2591.00
120_A124_G1.2451.00
215_I242_I1.2431.00
210_E259_V1.2381.00
156_F186_T1.1991.00
77_V81_F1.1941.00
200_T266_N1.1811.00
140_A155_F1.1751.00
73_G82_T1.1751.00
22_G122_G1.1691.00
83_V87_L1.1691.00
183_Y187_R1.1641.00
16_A91_L1.1631.00
160_G164_L1.1571.00
12_V131_A1.1521.00
74_W79_K1.1511.00
202_M268_V1.1501.00
200_T270_T1.1491.00
203_I256_V1.1371.00
9_L84_Y1.1341.00
22_G118_I1.1311.00
117_V188_V1.1301.00
253_E272_G1.1261.00
225_T238_E1.1231.00
214_A258_E1.1221.00
249_L267_I1.1201.00
216_Y231_A1.1121.00
63_F93_T1.1101.00
70_G89_V1.1081.00
201_A249_L1.0951.00
112_A116_G1.0931.00
108_I174_K1.0901.00
260_D263_A1.0771.00
28_I58_T1.0720.99
59_G63_F1.0650.99
56_I61_L1.0550.99
212_K223_I1.0510.99
110_L114_F1.0480.99
74_W82_T1.0440.99
224_T228_A1.0400.99
9_L13_I1.0400.99
255_I258_E1.0290.99
91_L95_F1.0280.99
87_L91_L1.0150.99
215_I221_R1.0140.99
230_G233_T1.0120.99
40_V165_T1.0120.99
7_K11_I1.0110.99
107_D173_E1.0100.99
6_T10_L1.0070.99
225_T231_A1.0070.99
60_T97_G1.0040.99
10_L14_I1.0040.99
77_V141_M0.9870.99
88_S131_A0.9740.99
33_Y166_A0.9670.99
252_L256_V0.9530.99
42_Q45_S0.9480.99
26_F114_F0.9460.99
266_N270_T0.9320.99
202_M226_V0.9300.99
190_D246_R0.9290.99
199_L272_G0.9290.99
5_Q8_K0.9260.98
33_Y159_N0.9160.98
11_I125_L0.9130.98
200_T241_I0.9120.98
216_Y223_I0.9070.98
143_L147_K0.9060.98
200_T243_V0.9050.98
76_K146_W0.9040.98
202_M266_N0.9000.98
61_L65_L0.8980.98
250_Y254_K0.8940.98
27_L181_T0.8920.98
16_A88_S0.8910.98
108_I112_A0.8850.98
76_K142_V0.8840.98
117_V183_Y0.8830.98
31_D46_S0.8820.98
152_G186_T0.8800.98
112_A180_V0.8780.98
152_G189_I0.8760.98
68_P71_I0.8700.98
121_V192_I0.8700.98
211_I255_I0.8690.98
72_L76_K0.8650.98
38_T96_M0.8590.98
123_I127_L0.8590.98
77_V132_S0.8420.97
216_Y222_G0.8410.97
80_S84_Y0.8400.97
245_T248_E0.8290.97
97_G100_P0.8280.97
226_V241_I0.8240.97
225_T229_K0.8230.97
185_T189_I0.8230.97
201_A256_V0.8210.97
149_K154_Y0.8210.97
43_L47_V0.8180.97
70_G85_S0.8180.97
243_V266_N0.8070.96
155_F159_N0.8060.96
214_A217_G0.8050.96
127_L141_M0.8050.96
132_S141_M0.8050.96
116_G120_A0.8050.96
60_T64_L0.8040.96
123_I189_I0.8040.96
201_A244_I0.8030.96
124_G128_K0.8000.96
33_Y178_T0.7980.96
110_L176_L0.7950.96
16_A126_T0.7940.96
17_L91_L0.7930.96
19_N122_G0.7930.96
255_I259_V0.7920.96
70_G86_I0.7910.96
7_K129_Y0.7880.96
40_V43_L0.7870.96
18_L121_V0.7850.96
64_L68_P0.7840.96
198_K242_I0.7800.96
32_V112_A0.7750.95
213_E234_N0.7740.95
143_L154_Y0.7680.95
254_K258_E0.7650.95
208_A211_I0.7600.95
69_V139_V0.7530.95
212_K216_Y0.7470.94
99_L102_T0.7470.94
63_F67_I0.7460.94
22_G26_F0.7430.94
253_E274_F0.7420.94
133_T137_D0.7400.94
165_T168_L0.7400.94
111_N173_E0.7390.94
187_R190_D0.7370.94
83_V86_I0.7360.94
157_I160_G0.7350.94
40_V65_L0.7330.94
48_V61_L0.7320.94
207_K259_V0.7310.94
16_A92_T0.7270.94
43_L165_T0.7240.94
68_P72_L0.7210.93
150_P153_T0.7200.93
156_F183_Y0.7190.93
139_V143_L0.7170.93
205_T260_D0.7170.93
136_L158_L0.7160.93
150_P190_D0.7150.93
113_V184_V0.7130.93
63_F90_A0.7130.93
70_G73_G0.7130.93
57_S60_T0.7080.93
108_I111_N0.7080.93
95_F98_I0.7070.93
69_V85_S0.7070.93
105_S173_E0.7070.93
23_L92_T0.7060.93
106_H173_E0.7030.93
221_R245_T0.7020.92
218_K255_I0.7010.92
136_L170_Q0.7000.92
19_N119_S0.6970.92
44_L65_L0.6970.92
45_S58_T0.6960.92
25_L99_L0.6920.92
23_L28_I0.6910.92
182_L186_T0.6910.92
113_V180_V0.6890.92
199_L267_I0.6880.92
211_I259_V0.6860.92
207_K260_D0.6860.92
223_I242_I0.6840.91
43_L170_Q0.6820.91
218_K251_D0.6800.91
141_M151_V0.6790.91
230_G237_K0.6780.91
222_G232_F0.6760.91
18_L118_I0.6760.91
224_T230_G0.6740.91
39_G177_Y0.6700.91
11_I14_I0.6680.91
23_L41_A0.6630.90
126_T131_A0.6600.90
41_A62_L0.6580.90
14_I18_L0.6580.90
45_S55_Y0.6540.90
201_A267_I0.6500.89
5_Q84_Y0.6490.89
218_K258_E0.6480.89
134_G137_D0.6470.89
71_I74_W0.6450.89
161_I164_L0.6440.89
142_V146_W0.6440.89
81_F141_M0.6430.89
136_L159_N0.6430.89
125_L129_Y0.6420.89
119_S185_T0.6420.89
153_T190_D0.6380.88
251_D254_K0.6360.88
25_L29_P0.6360.88
197_M246_R0.6360.88
89_V93_T0.6360.88
84_Y130_G0.6350.88
112_A184_V0.6320.88
123_I133_T0.6300.88
254_K257_K0.6300.88
155_F189_I0.6300.88
107_D112_A0.6250.87
221_R277_F0.6240.87
85_S138_I0.6210.87
257_K274_F0.6200.87
73_G81_F0.6200.87
28_I45_S0.6200.87
204_V241_I0.6190.87
159_N277_F0.6180.87
20_A92_T0.6140.86
127_L137_D0.6110.86
164_L168_L0.6100.86
166_A175_A0.6090.86
61_L64_L0.6090.86
114_F179_L0.6080.86
208_A212_K0.6070.86
47_V68_P0.6060.86
116_G184_V0.6050.86
203_I252_L0.6050.86
194_T271_T0.6040.86
38_T92_T0.6030.85
123_I185_T0.6030.85
6_T9_L0.6010.85
205_T238_E0.5990.85
105_S108_I0.5990.85
28_I42_Q0.5970.85
163_I166_A0.5970.85
108_I177_Y0.5960.85
112_A181_T0.5960.85
209_D238_E0.5940.85
243_V270_T0.5940.85
138_I152_G0.5930.85
159_N178_T0.5890.84
45_S61_L0.5860.84
224_T264_F0.5840.84
267_I272_G0.5830.84
94_L98_I0.5830.84
44_L56_I0.5820.83
86_I89_V0.5810.83
34_A137_D0.5800.83
178_T244_I0.5790.83
147_K154_Y0.5780.83
167_G171_G0.5780.83
244_I249_L0.5750.83
199_L237_K0.5750.83
72_L142_V0.5730.82
138_I189_I0.5710.82
72_L75_L0.5700.82
221_R278_R0.5690.82
41_A241_I0.5690.82
88_S133_T0.5670.82
33_Y42_Q0.5670.82
202_M239_M0.5640.81
75_L93_T0.5640.81
84_Y178_T0.5610.81
151_V190_D0.5580.81
153_T156_F0.5580.81
48_V56_I0.5570.81
253_E257_K0.5540.80
171_G175_A0.5530.80
85_S89_V0.5500.80
105_S111_N0.5500.80
273_I278_R0.5500.80
57_S101_E0.5490.80
70_G107_D0.5490.80
264_F273_I0.5490.80
42_Q241_I0.5480.80
175_A181_T0.5460.79
19_N123_I0.5420.79
212_K238_E0.5380.78
32_V105_S0.5380.78
17_L21_A0.5370.78
41_A65_L0.5370.78
210_E213_E0.5350.78
203_I242_I0.5330.78
79_K82_T0.5320.78
42_Q46_S0.5320.78
120_A189_I0.5310.77
202_M270_T0.5300.77
58_T62_L0.5290.77
233_T262_K0.5280.77
121_V188_V0.5280.77
46_S170_Q0.5250.77
30_A176_L0.5250.77
27_L166_A0.5240.77
220_V276_F0.5230.76
170_Q174_K0.5220.76
149_K153_T0.5220.76
41_A58_T0.5210.76
64_L261_P0.5200.76
158_L162_I0.5190.76
144_A147_K0.5150.75
7_K258_E0.5150.75
127_L151_V0.5140.75
110_L183_Y0.5130.75
261_P269_Q0.5110.75
127_L193_H0.5110.75
13_I95_F0.5090.74
113_V237_K0.5080.74
141_M145_K0.5070.74
42_Q58_T0.5060.74
127_L140_A0.5060.74
144_A148_D0.5060.74
221_R264_F0.5040.74
29_P128_K0.5000.73
43_L162_I0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hluA 2 0.2607 99.9 0.695 Contact Map
3ncqA 4 0.3036 82.7 0.941 Contact Map
2eg2A 5 0.2893 82.5 0.941 Contact Map
4affA 3 0.3036 82.4 0.941 Contact Map
3t9zA 3 0.2964 82.2 0.941 Contact Map
4co3A 3 0.3 82 0.941 Contact Map
2j9cA 3 0.3107 81.5 0.942 Contact Map
4r25A 3 0.3107 81.3 0.942 Contact Map
3bzqA 3 0.3036 80.1 0.942 Contact Map
4rwwA 3 0.3 80 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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