GREMLIN Database
CHEW - Chemotaxis protein CheW
UniProt: P39802 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (140)
Sequences: 5263 (3813)
Seq/√Len: 322.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_E132_R3.8151.00
109_E128_K3.2891.00
80_I91_G3.0531.00
30_S54_R2.9071.00
10_K102_T2.7911.00
103_V127_V2.7031.00
48_C62_D2.5731.00
15_M96_E2.5401.00
29_K84_A2.5111.00
48_C65_K2.4741.00
108_I125_Q2.3891.00
48_C93_I2.3681.00
104_H107_E2.3491.00
27_Q140_N2.2551.00
60_V80_I2.0851.00
83_I92_W2.0341.00
65_K71_E1.9961.00
124_E138_D1.9881.00
64_R95_D1.9711.00
34_W37_P1.9411.00
52_N55_G1.9181.00
9_E24_S1.7151.00
56_V89_E1.6491.00
15_M98_N1.6061.00
45_P65_K1.5571.00
17_N64_R1.5141.00
72_Y75_T1.5091.00
20_E98_N1.5081.00
52_N57_V1.4851.00
74_I78_T1.4711.00
121_V141_A1.4501.00
33_K79_R1.4451.00
75_T78_T1.4261.00
7_T105_E1.4191.00
34_W80_I1.4051.00
29_K89_E1.3951.00
11_M136_I1.3701.00
24_S124_E1.3441.00
13_V20_E1.3291.00
60_V91_G1.3271.00
48_C74_I1.3241.00
123_I135_N1.3091.00
129_Q132_R1.3011.00
24_S27_Q1.3011.00
14_F81_I1.2931.00
51_I80_I1.2831.00
108_I136_I1.2751.00
9_E105_E1.2641.00
58_T82_I1.2411.00
23_I83_I1.2231.00
29_K56_V1.2211.00
15_M18_G1.1891.00
62_D65_K1.1701.00
107_E129_Q1.1351.00
37_P60_V1.1171.00
138_D141_A1.1091.00
62_D71_E1.1041.00
28_V81_I1.1041.00
78_T93_I1.0961.00
11_M103_V1.0931.00
12_I81_I1.0801.00
34_W93_I1.0741.00
13_V101_I1.0701.00
63_L142_V1.0381.00
11_M127_V1.0381.00
74_I93_I1.0041.00
13_V98_N0.9981.00
35_Q80_I0.9931.00
12_I79_R0.9921.00
22_A136_I0.9841.00
127_V136_I0.9811.00
23_I139_A0.9641.00
51_I60_V0.9591.00
17_N69_L0.9551.00
8_G102_T0.9541.00
86_R140_N0.9511.00
83_I139_A0.9441.00
22_A127_V0.9411.00
62_D66_R0.9391.00
53_L82_I0.9371.00
22_A134_L0.9271.00
13_V99_D0.9231.00
12_I31_I0.9191.00
13_V134_L0.9171.00
7_T104_H0.9111.00
64_R69_L0.9041.00
15_M20_E0.8781.00
14_F23_I0.8751.00
63_L92_W0.8681.00
27_Q124_E0.8581.00
47_I61_I0.8461.00
46_Y66_R0.8371.00
34_W79_R0.8351.00
37_P51_I0.8341.00
84_A89_E0.8271.00
81_I94_V0.8261.00
32_E80_I0.8241.00
111_A123_I0.8241.00
64_R70_P0.8191.00
16_V63_L0.8161.00
47_I59_P0.8151.00
80_I93_I0.8091.00
8_G104_H0.8061.00
8_G105_E0.8041.00
32_E35_Q0.8001.00
30_S97_A0.7991.00
40_V43_V0.7911.00
92_W139_A0.7881.00
141_A145_K0.7871.00
10_K25_V0.7811.00
78_T95_D0.7771.00
11_M22_A0.7771.00
7_T106_S0.7761.00
32_E56_V0.7761.00
112_P115_V0.7610.99
32_E53_L0.7470.99
40_V50_V0.7470.99
21_Y67_L0.7400.99
117_K120_D0.7380.99
42_G45_P0.7280.99
128_K133_L0.7270.99
40_V114_G0.7200.99
12_I126_I0.7180.99
72_Y95_D0.7170.99
125_Q136_I0.7150.99
38_T57_V0.7140.99
94_V97_A0.7090.99
141_A144_D0.7070.99
27_Q139_A0.6980.99
62_D72_Y0.6910.99
38_T41_P0.6910.99
69_L72_Y0.6890.99
43_V47_I0.6850.99
103_V108_I0.6830.99
137_I142_V0.6810.99
33_K133_L0.6800.99
32_E97_A0.6790.99
58_T89_E0.6780.99
44_E61_I0.6720.99
13_V22_A0.6700.99
126_I133_L0.6660.99
9_E124_E0.6620.99
7_T45_P0.6620.99
25_V100_V0.6540.98
37_P80_I0.6450.98
15_M101_I0.6450.98
43_V46_Y0.6380.98
135_N138_D0.6360.98
118_D121_V0.6360.98
82_I89_E0.6310.98
58_T91_G0.6270.98
23_I92_W0.6270.98
48_C71_E0.6270.98
21_Y119_T0.6250.98
108_I127_V0.6200.98
110_S125_Q0.6160.98
16_V90_V0.6120.98
113_E120_D0.6080.98
128_K131_N0.5990.97
66_R146_E0.5990.97
35_Q51_I0.5900.97
11_M105_E0.5780.97
27_Q85_Y0.5760.97
50_V135_N0.5700.96
25_V32_E0.5660.96
79_R96_E0.5660.96
111_A115_V0.5640.96
18_G106_S0.5610.96
46_Y65_K0.5590.96
32_E58_T0.5590.96
18_G72_Y0.5570.96
52_N128_K0.5560.96
14_F30_S0.5560.96
95_D100_V0.5560.96
70_P74_I0.5540.96
57_V81_I0.5520.96
107_E130_E0.5460.95
28_V109_E0.5450.95
16_V122_S0.5440.95
37_P82_I0.5440.95
64_R71_E0.5420.95
20_E134_L0.5410.95
64_R72_Y0.5390.95
59_P78_T0.5390.95
57_V135_N0.5360.95
26_T29_K0.5340.95
34_W78_T0.5320.95
87_D106_S0.5320.95
12_I33_K0.5300.95
39_R43_V0.5300.95
25_V61_I0.5250.94
25_V31_I0.5230.94
18_G45_P0.5230.94
53_L87_D0.5220.94
70_P130_E0.5220.94
66_R145_K0.5170.94
54_R91_G0.5160.94
129_Q134_L0.5160.94
8_G101_I0.5150.94
12_I94_V0.5110.93
40_V55_G0.5110.93
18_G131_N0.5100.93
12_I53_L0.5090.93
13_V122_S0.5080.93
63_L94_V0.5070.93
68_N120_D0.5070.93
121_V145_K0.5040.93
38_T52_N0.5020.93
115_V120_D0.5010.93
34_W74_I0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ho9A 1 1 100 0.186 Contact Map
2qdlA 1 0.9744 100 0.199 Contact Map
4jpbW 1 0.8974 100 0.229 Contact Map
1b3qA 2 0.8526 99.4 0.571 Contact Map
1knxA 5 0.9679 6.8 0.93 Contact Map
2xheA 1 0.3397 4.4 0.936 Contact Map
3ll7A 1 0.5897 4.3 0.936 Contact Map
3fanA 2 0.3718 4.1 0.937 Contact Map
1ko7A 3 0.8526 3.7 0.938 Contact Map
4otmA 2 0.5897 3.4 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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