GREMLIN Database
TRER - Trehalose operon transcriptional repressor
UniProt: P39796 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (192)
Sequences: 25286 (20268)
Seq/√Len: 1462.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_K26_E4.0701.00
16_Q21_R3.9611.00
14_A55_N3.4411.00
16_Q37_Q3.3271.00
10_Y51_M3.3141.00
59_Q69_L2.9051.00
181_V184_P2.7031.00
12_D16_Q2.6011.00
9_I40_T2.5821.00
31_E42_R2.5611.00
60_K66_S2.4971.00
61_I64_K2.4591.00
10_Y55_N2.3701.00
9_I38_Y2.2461.00
27_I67_V2.2131.00
15_Q19_G2.1831.00
12_D38_Y2.0151.00
10_Y14_A1.9761.00
64_K67_V1.9261.00
53_A60_K1.8531.00
130_R138_I1.8471.00
47_K50_H1.8231.00
14_A18_E1.7741.00
33_E37_Q1.7111.00
32_H36_A1.6831.00
186_T189_D1.6481.00
12_D15_Q1.6361.00
16_Q22_W1.6171.00
108_S111_I1.5881.00
53_A58_I1.5801.00
14_A57_Y1.5781.00
31_E46_R1.5711.00
186_T190_R1.5681.00
8_T12_D1.5651.00
30_S33_E1.5491.00
34_L45_V1.5461.00
58_I66_S1.5421.00
49_L58_I1.5411.00
184_P188_E1.5211.00
126_V142_D1.4891.00
61_I67_V1.4451.00
17_I68_V1.4211.00
96_K131_K1.4201.00
5_K8_T1.4201.00
50_H60_K1.4051.00
127_I130_R1.3951.00
176_A184_P1.3671.00
126_V130_R1.3541.00
51_M54_Q1.3321.00
24_A70_N1.3281.00
40_T45_V1.3091.00
50_H54_Q1.3041.00
33_E36_A1.2971.00
22_W68_V1.2961.00
174_S178_K1.2761.00
98_T131_K1.2721.00
59_Q67_V1.2651.00
187_D191_E1.2611.00
6_F51_M1.2531.00
125_E141_K1.2531.00
182_A186_T1.2311.00
50_H53_A1.2131.00
92_G96_K1.2121.00
16_Q20_G1.1801.00
120_D123_I1.1791.00
105_E125_E1.1661.00
113_K116_R1.1631.00
136_H147_K1.1491.00
27_I65_G1.1461.00
139_L143_Y1.1431.00
102_F105_E1.1371.00
51_M55_N1.1361.00
18_E57_Y1.1341.00
89_Q92_G1.1321.00
61_I65_G1.1201.00
101_K104_L1.1191.00
89_Q96_K1.1111.00
118_N121_D1.1091.00
171_L175_Y1.1041.00
111_I143_Y1.0991.00
162_Y166_E1.0941.00
89_Q93_K1.0911.00
22_W26_E1.0911.00
101_K105_E1.0851.00
16_Q38_Y1.0821.00
127_I131_K1.0751.00
86_E90_T1.0561.00
49_L66_S1.0501.00
25_E59_Q1.0301.00
161_I164_Y1.0241.00
7_I51_M1.0221.00
127_I141_K1.0191.00
93_K97_T1.0191.00
128_R177_Q1.0051.00
138_I142_D0.9961.00
87_L91_L0.9781.00
129_S141_K0.9741.00
139_L189_D0.9711.00
172_S188_E0.9601.00
161_I165_I0.9551.00
163_E167_G0.9551.00
190_R194_D0.9531.00
103_G125_E0.9511.00
63_G66_S0.9501.00
27_I30_S0.9481.00
7_I11_K0.9471.00
97_T100_H0.9471.00
11_K14_A0.9331.00
93_K96_K0.9311.00
107_P112_Q0.9291.00
175_Y179_E0.9261.00
107_P111_I0.9261.00
109_E113_K0.9251.00
196_R199_D0.9241.00
47_K51_M0.9091.00
13_I34_L0.8981.00
41_S44_T0.8981.00
153_T156_I0.8971.00
80_G135_E0.8961.00
6_F10_Y0.8891.00
110_L113_K0.8891.00
101_K125_E0.8821.00
125_E170_G0.8781.00
89_Q95_T0.8741.00
160_S163_E0.8691.00
103_G106_P0.8651.00
91_L95_T0.8651.00
90_T93_K0.8641.00
152_L155_E0.8631.00
110_L114_Q0.8611.00
152_L156_I0.8581.00
179_E184_P0.8571.00
85_K88_A0.8531.00
184_P187_D0.8451.00
5_K44_T0.8421.00
127_I188_E0.8421.00
96_K100_H0.8381.00
124_W174_S0.8301.00
100_H104_L0.8301.00
132_I138_I0.8261.00
175_Y178_K0.8231.00
145_F148_H0.8231.00
49_L53_A0.8221.00
104_L108_S0.8191.00
117_A121_D0.8181.00
34_L49_L0.8171.00
85_K89_Q0.8161.00
74_M77_P0.8151.00
111_I114_Q0.8141.00
28_L58_I0.8121.00
89_Q94_E0.8121.00
105_E108_S0.8041.00
76_F80_G0.8001.00
35_T45_V0.7971.00
183_E189_D0.7911.00
88_A132_I0.7911.00
108_S112_Q0.7811.00
119_L123_I0.7811.00
124_W128_R0.7811.00
9_I12_D0.7801.00
189_D192_L0.7771.00
25_E70_N0.7761.00
24_A69_L0.7721.00
104_L107_P0.7711.00
92_G97_T0.7591.00
160_S165_I0.7581.00
31_E60_K0.7541.00
112_Q117_A0.7541.00
183_E187_D0.7501.00
185_C195_L0.7481.00
140_D143_Y0.7471.00
11_K15_Q0.7411.00
6_F47_K0.7341.00
102_F108_S0.7341.00
173_I189_D0.7211.00
109_E112_Q0.7191.00
16_Q19_G0.7181.00
112_Q115_L0.7171.00
96_K134_G0.7171.00
108_S114_Q0.7161.00
136_H139_L0.7101.00
84_F88_A0.7091.00
101_K108_S0.7081.00
188_E191_E0.7071.00
21_R37_Q0.7031.00
104_L146_R0.7011.00
107_P110_L0.7001.00
75_Q79_S0.6931.00
166_E172_S0.6911.00
13_I22_W0.6901.00
9_I45_V0.6871.00
195_L199_D0.6851.00
86_E194_D0.6841.00
98_T103_G0.6831.00
36_A39_G0.6801.00
94_E97_T0.6791.00
32_H35_T0.6781.00
12_D37_Q0.6741.00
95_T98_T0.6711.00
172_S184_P0.6691.00
173_I188_E0.6691.00
115_L118_N0.6691.00
99_V103_G0.6681.00
103_G107_P0.6671.00
22_W28_L0.6631.00
91_L94_E0.6591.00
86_E89_Q0.6571.00
189_D193_L0.6541.00
171_L174_S0.6521.00
164_Y167_G0.6511.00
49_L60_K0.6491.00
102_F106_P0.6491.00
172_S175_Y0.6471.00
84_F87_L0.6441.00
187_D190_R0.6431.00
129_S145_F0.6411.00
160_S164_Y0.6381.00
191_E195_L0.6381.00
93_K133_D0.6371.00
35_T38_Y0.6341.00
113_K117_A0.6321.00
96_K99_V0.6291.00
163_E166_E0.6261.00
121_D147_K0.6211.00
107_P117_A0.6211.00
146_R150_P0.6201.00
183_E186_T0.6191.00
101_K127_I0.6151.00
10_Y48_A0.6151.00
131_K134_G0.6141.00
185_C193_L0.6111.00
132_I137_V0.6111.00
185_C190_R0.6101.00
76_F79_S0.6091.00
90_T96_K0.6091.00
38_Y45_V0.6081.00
92_G95_T0.6081.00
119_L122_D0.6081.00
95_T99_V0.6081.00
29_P37_Q0.6071.00
94_E186_T0.6061.00
162_Y165_I0.6041.00
154_K157_C0.6031.00
176_A181_V0.5981.00
101_K106_P0.5971.00
44_T48_A0.5951.00
34_L38_Y0.5951.00
53_A66_S0.5921.00
185_C189_D0.5921.00
95_T100_H0.5901.00
45_V58_I0.5861.00
9_I48_A0.5851.00
147_K150_P0.5831.00
126_V145_F0.5781.00
177_Q180_I0.5731.00
142_D145_F0.5681.00
141_K189_D0.5681.00
27_I64_K0.5651.00
112_Q116_R0.5651.00
126_V138_I0.5641.00
94_E98_T0.5621.00
30_S63_G0.5571.00
106_P122_D0.5521.00
43_E47_K0.5511.00
104_L122_D0.5481.00
29_P44_T0.5471.00
172_S191_E0.5421.00
97_T101_K0.5411.00
107_P121_D0.5411.00
100_H103_G0.5361.00
117_A120_D0.5321.00
35_T43_E0.5321.00
185_C199_D0.5281.00
107_P114_Q0.5201.00
107_P113_K0.5171.00
9_I13_I0.5171.00
44_T47_K0.5171.00
111_I115_L0.5141.00
184_P199_D0.5111.00
97_T130_R0.5101.00
62_R65_G0.5091.00
111_I117_A0.5061.00
122_D146_R0.5041.00
82_V85_K0.5031.00
81_L85_K0.5021.00
22_W29_P0.5011.00
7_I10_Y0.5011.00
145_F149_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0wA 2 0.9916 100 0.123 Contact Map
3f8mA 2 0.9622 100 0.149 Contact Map
2ra5A 2 0.6218 100 0.162 Contact Map
3edpA 2 0.9202 100 0.169 Contact Map
3eetA 2 0.9664 100 0.181 Contact Map
3bwgA 2 0.9622 100 0.188 Contact Map
3f8lA 2 0.6807 100 0.439 Contact Map
2di3A 2 0.8529 99.9 0.454 Contact Map
1hw1A 2 0.8529 99.9 0.455 Contact Map
4p96A 2 0.8992 99.9 0.469 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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