GREMLIN Database
PTTBC - PTS system trehalose-specific EIIBC component
UniProt: P39794 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 470 (442)
Sequences: 3991 (2257)
Seq/√Len: 107.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_D45_M4.4021.00
416_Y452_I3.9971.00
409_S456_V3.7601.00
314_G411_G3.6721.00
6_K10_Q3.5871.00
362_A458_F3.4121.00
242_A278_S3.3151.00
269_I273_L3.2201.00
35_L41_V3.2041.00
38_E57_S3.1221.00
12_V78_L3.0061.00
7_S49_I2.8741.00
14_A42_D2.8721.00
44_E47_D2.8311.00
416_Y445_A2.8301.00
246_L270_T2.8281.00
176_G190_G2.7991.00
43_Q62_F2.7721.00
412_L456_V2.6091.00
37_D40_K2.5561.00
405_I464_Y2.4831.00
5_N9_R2.4541.00
257_T265_V2.4281.00
54_G65_V2.4281.00
50_D371_K2.4221.00
356_Q396_N2.4191.00
77_E80_K2.3741.00
100_M105_R2.3661.00
22_A36_I2.3411.00
18_A83_G2.3031.00
33_F64_V2.2981.00
177_W191_I2.2791.00
252_F256_R2.2751.00
416_Y420_Q2.2361.00
14_A49_I2.2151.00
253_L269_I2.1911.00
447_A451_A2.1911.00
335_L343_T2.1841.00
43_Q47_D2.1791.00
43_Q57_S2.1611.00
14_A45_M2.1551.00
245_M277_A2.1531.00
5_N77_E2.1491.00
254_T262_Q2.1281.00
420_Q445_A2.1271.00
77_E81_E2.1111.00
33_F78_L2.1021.00
299_S303_S2.0681.00
177_W187_P2.0521.00
24_A78_L2.0491.00
15_V33_F2.0221.00
173_A195_V2.0191.00
12_V82_T1.9611.00
367_V372_Q1.9381.00
10_Q49_I1.9371.00
24_A33_F1.9371.00
9_R81_E1.9171.00
11_I46_L1.9071.00
261_I265_V1.8831.00
313_G410_S1.8471.00
109_T183_F1.8351.00
130_I134_L1.8021.00
23_A34_A1.7561.00
404_I408_V1.7551.00
369_D372_Q1.7371.00
358_S457_P1.7371.00
459_A463_A1.7291.00
417_I449_G1.7271.00
358_S454_L1.7031.00
26_H75_Y1.6941.00
405_I460_G1.6861.00
248_K251_V1.6761.00
10_Q13_E1.6761.00
364_M377_L1.6731.00
46_L49_I1.6561.00
310_L415_M1.6441.00
253_L257_T1.6321.00
248_K252_F1.6281.00
445_A448_I1.6221.00
360_A391_A1.6131.00
361_L380_G1.6121.00
288_A292_V1.6091.00
392_I403_F1.6081.00
173_A191_I1.5981.00
128_M165_G1.5941.00
460_G464_Y1.5931.00
357_G383_A1.5931.00
342_G423_L1.5731.00
399_Y402_P1.5721.00
185_G243_S1.5701.00
75_Y79_V1.5701.00
241_L286_T1.5651.00
45_M48_Q1.5511.00
9_R13_E1.5511.00
405_I409_S1.5471.00
309_G414_G1.5441.00
134_L139_I1.5301.00
11_I66_I1.5291.00
456_V460_G1.5201.00
244_Y247_A1.5191.00
181_K187_P1.5011.00
15_V35_L1.4841.00
8_A78_L1.4801.00
455_I459_A1.4781.00
56_F65_V1.4781.00
265_V269_I1.4641.00
249_I274_T1.4571.00
318_A407_M1.4571.00
291_N295_S1.4491.00
108_K182_R1.4401.00
292_V296_G1.4291.00
366_I465_A1.4121.00
102_P105_R1.4031.00
314_G318_A1.4011.00
399_Y466_R1.3811.00
21_I84_I1.3771.00
310_L411_G1.3691.00
24_A79_V1.3661.00
317_S353_N1.3571.00
12_V81_E1.3571.00
177_W188_L1.3561.00
179_A244_Y1.3330.99
372_Q399_Y1.3310.99
126_L268_P1.3240.99
180_V243_S1.3180.99
244_Y248_K1.2930.99
102_P106_A1.2930.99
363_M367_V1.2880.99
249_I273_L1.2790.99
245_M282_I1.2770.99
415_M419_S1.2710.99
159_M227_V1.2670.99
409_S457_P1.2620.99
458_F462_Y1.2620.99
70_T259_E1.2570.99
309_G415_M1.2530.99
416_Y448_I1.2510.99
412_L452_I1.2400.99
193_L271_L1.2360.99
14_A46_L1.2290.99
262_Q266_V1.2290.99
344_F347_P1.2240.99
38_E60_G1.2240.99
408_V460_G1.2100.99
190_G194_G1.2030.99
350_A446_F1.2020.99
46_L62_F1.1980.99
461_T465_A1.1960.99
175_I236_V1.1950.99
362_A462_Y1.1940.99
21_I82_T1.1910.99
274_T278_S1.1900.99
185_G246_L1.1770.99
163_I275_G1.1770.99
416_Y449_G1.1700.99
296_G299_S1.1650.99
66_I70_T1.1580.99
12_V21_I1.1550.99
178_S188_L1.1520.98
245_M274_T1.1460.98
46_L52_V1.1370.98
141_F153_W1.1360.98
7_S51_V1.1340.98
365_F458_F1.1290.98
5_N81_E1.1250.98
380_G384_Y1.1180.98
293_L319_L1.1150.98
8_A81_E1.1140.98
309_G418_S1.1070.98
319_L328_F1.1070.98
184_G251_V1.1060.98
180_V190_G1.1040.98
10_Q45_M1.1020.98
351_L417_I1.1010.98
124_A167_A1.1000.98
392_I406_A1.0940.98
252_F255_K1.0940.98
243_S247_A1.0940.98
66_I74_V1.0910.98
281_I285_I1.0890.98
253_L266_V1.0830.98
237_L241_L1.0790.98
6_K9_R1.0790.98
127_L164_A1.0750.98
114_F236_V1.0710.98
180_V187_P1.0690.98
79_V84_I1.0680.98
306_A419_S1.0660.97
401_F465_A1.0640.97
306_A415_M1.0600.97
194_G239_I1.0570.97
196_M275_G1.0540.97
405_I461_T1.0520.97
186_N250_E1.0480.97
179_A240_L1.0420.97
78_L82_T1.0410.97
165_G169_T1.0400.97
18_A82_T1.0400.97
297_L344_F1.0380.97
409_S413_A1.0340.97
180_V185_G1.0300.97
117_I171_L1.0220.97
78_L81_E1.0190.97
358_S362_A1.0180.97
49_I52_V1.0170.97
193_L274_T1.0150.97
355_A406_A1.0130.97
227_V280_I1.0110.97
378_T382_S1.0080.96
70_T73_K1.0070.96
142_S153_W1.0040.96
28_V387_I1.0040.96
183_F244_Y1.0030.96
5_N80_K1.0030.96
112_D182_R0.9990.96
452_I456_V0.9990.96
413_A452_I0.9980.96
131_N157_A0.9940.96
361_L365_F0.9930.96
417_I422_V0.9930.96
396_N402_P0.9890.96
292_V295_S0.9880.96
298_I302_G0.9870.96
94_K97_E0.9860.96
247_A251_V0.9830.96
286_T290_G0.9830.96
350_A434_G0.9820.96
193_L239_I0.9810.96
109_T113_I0.9800.96
133_I137_E0.9750.96
166_T195_V0.9740.96
76_A80_K0.9740.96
359_A396_N0.9730.96
22_A34_A0.9710.96
289_I292_V0.9670.96
72_N76_A0.9660.95
55_S62_F0.9630.95
117_I178_S0.9630.95
359_A406_A0.9620.95
7_S11_I0.9600.95
428_G437_S0.9570.95
179_A183_F0.9570.95
170_F200_P0.9490.95
38_E62_F0.9470.95
367_V468_K0.9420.95
413_A453_V0.9400.95
442_Y445_A0.9400.95
185_G190_G0.9380.95
358_S384_Y0.9360.95
11_I49_I0.9340.95
99_N105_R0.9330.95
401_F467_F0.9310.94
304_F307_L0.9290.94
316_Y348_M0.9210.94
8_A77_E0.9200.94
183_F247_A0.9180.94
57_S62_F0.9180.94
13_E45_M0.9150.94
444_G448_I0.9140.94
285_I289_I0.9120.94
92_V96_S0.9110.94
156_L159_M0.9080.94
175_I239_I0.9060.94
237_L286_T0.9050.94
174_L192_V0.8990.93
435_I447_A0.8990.93
176_G239_I0.8950.93
310_L412_L0.8950.93
249_I253_L0.8940.93
35_L62_F0.8930.93
106_A109_T0.8890.93
402_P405_I0.8890.93
365_F461_T0.8890.93
358_S453_V0.8880.93
356_Q406_A0.8860.93
366_I466_R0.8850.93
65_V393_F0.8850.93
176_G243_S0.8840.93
259_E262_Q0.8810.93
288_A291_N0.8800.93
364_M376_S0.8800.93
282_I286_T0.8790.93
113_I240_L0.8740.92
369_D373_K0.8720.92
141_F154_A0.8720.92
422_V449_G0.8690.92
462_Y465_A0.8690.92
24_A82_T0.8680.92
352_S356_Q0.8660.92
359_A402_P0.8660.92
205_A220_W0.8660.92
194_G270_T0.8650.92
412_L416_Y0.8620.92
176_G194_G0.8610.92
354_I357_G0.8600.92
43_Q55_S0.8590.92
10_Q14_A0.8580.92
163_I196_M0.8580.92
444_G447_A0.8570.92
198_V233_Q0.8570.92
10_Q50_D0.8560.92
98_K101_N0.8550.92
363_M395_V0.8500.91
245_M249_I0.8500.91
420_Q452_I0.8490.91
363_M376_S0.8480.91
364_M373_K0.8470.91
15_V62_F0.8440.91
309_G313_G0.8440.91
383_A388_T0.8440.91
318_A403_F0.8400.91
254_T266_V0.8370.91
453_V457_P0.8370.91
372_Q468_K0.8350.91
26_H71_V0.8290.90
372_Q395_V0.8270.90
47_D398_R0.8260.90
257_T261_I0.8230.90
97_E105_R0.8220.90
207_G210_A0.8220.90
98_K102_P0.8210.90
6_K50_D0.8140.89
309_G348_M0.8120.89
313_G414_G0.8120.89
138_G142_S0.8110.89
402_P461_T0.8110.89
184_G190_G0.8110.89
165_G199_H0.8100.89
173_A194_G0.8100.89
355_A359_A0.8070.89
45_M49_I0.8030.89
337_G340_L0.8020.89
174_L195_V0.8010.89
222_L280_I0.7990.89
241_L282_I0.7990.89
314_G407_M0.7960.88
277_A282_I0.7960.88
43_Q46_L0.7950.88
41_V55_S0.7920.88
370_E373_K0.7920.88
395_V399_Y0.7890.88
11_I14_A0.7870.88
454_L457_P0.7870.88
9_R18_A0.7810.87
351_L413_A0.7810.87
232_Y238_P0.7800.87
131_N164_A0.7800.87
416_Y419_S0.7800.87
103_L106_A0.7780.87
124_A166_T0.7770.87
95_A98_K0.7760.87
451_A455_I0.7740.87
44_E48_Q0.7710.87
315_F407_M0.7700.87
39_S42_D0.7670.86
396_N406_A0.7640.86
41_V62_F0.7640.86
239_I243_S0.7640.86
38_E43_Q0.7640.86
356_Q359_A0.7640.86
328_F332_D0.7590.86
92_V95_A0.7580.86
98_K105_R0.7540.86
452_I455_I0.7530.85
46_L64_V0.7530.85
174_L191_I0.7500.85
176_G191_I0.7480.85
36_I40_K0.7470.85
73_K259_E0.7460.85
363_M402_P0.7420.85
185_G250_E0.7420.85
11_I15_V0.7370.84
366_I462_Y0.7340.84
314_G404_I0.7320.84
167_A174_L0.7310.84
361_L458_F0.7300.84
345_L349_L0.7290.84
258_P261_I0.7270.83
375_L379_S0.7260.83
401_F466_R0.7250.83
192_V196_M0.7250.83
261_I385_L0.7230.83
334_Q337_G0.7210.83
383_A391_A0.7210.83
351_L453_V0.7210.83
384_Y432_V0.7150.82
19_E36_I0.7140.82
356_Q391_A0.7120.82
257_T266_V0.7110.82
47_D55_S0.7090.82
369_D468_K0.7090.82
405_I408_V0.7090.82
426_S437_S0.7070.82
257_T269_I0.7070.82
108_K112_D0.7060.82
79_V82_T0.7060.82
299_S305_A0.7050.82
40_K48_Q0.7030.81
221_N226_E0.7030.81
12_V15_V0.7020.81
109_T244_Y0.7010.81
19_E40_K0.6990.81
166_T196_M0.6970.81
409_S460_G0.6950.81
334_Q339_K0.6950.81
388_T391_A0.6950.81
5_N73_K0.6940.81
249_I270_T0.6930.80
162_L199_H0.6930.80
290_G324_M0.6920.80
404_I407_M0.6920.80
113_I183_F0.6890.80
189_L246_L0.6880.80
7_S74_V0.6850.80
177_W181_K0.6820.79
7_S70_T0.6820.79
137_E140_F0.6800.79
464_Y468_K0.6790.79
13_E42_D0.6780.79
430_G434_G0.6780.79
27_C30_R0.6780.79
36_I84_I0.6760.79
135_T157_A0.6760.79
450_M453_V0.6750.79
425_S439_M0.6740.79
12_V18_A0.6740.79
219_V228_Q0.6730.78
15_V21_I0.6710.78
125_G129_G0.6700.78
255_K368_K0.6700.78
310_L313_G0.6690.78
76_A79_V0.6690.78
190_G243_S0.6690.78
412_L415_M0.6680.78
351_L410_S0.6670.78
317_S403_F0.6660.78
155_D221_N0.6660.78
25_T60_G0.6660.78
107_V397_L0.6660.78
28_V430_G0.6640.78
47_D54_G0.6630.77
365_F457_P0.6620.77
451_A459_A0.6620.77
203_L207_G0.6620.77
356_Q388_T0.6610.77
158_N161_N0.6600.77
8_A82_T0.6600.77
317_S392_I0.6590.77
18_A84_I0.6560.77
242_A277_A0.6540.76
322_T393_F0.6530.76
356_Q383_A0.6520.76
126_L129_G0.6520.76
33_F62_F0.6500.76
398_R402_P0.6490.76
133_I136_A0.6450.75
243_S246_L0.6450.75
363_M372_Q0.6430.75
294_T328_F0.6420.75
221_N224_G0.6420.75
202_L279_F0.6420.75
318_A322_T0.6410.75
80_K83_G0.6400.75
9_R21_I0.6400.75
31_L66_I0.6380.75
184_G250_E0.6380.75
228_Q287_F0.6370.75
113_I179_A0.6360.74
312_Y330_A0.6340.74
169_T233_Q0.6340.74
35_L57_S0.6330.74
312_Y319_L0.6330.74
250_E254_T0.6330.74
78_L83_G0.6330.74
7_S66_I0.6320.74
320_V352_S0.6320.74
315_F318_A0.6310.74
355_A409_S0.6310.74
353_N388_T0.6300.74
317_S352_S0.6280.74
422_V445_A0.6260.73
97_E100_M0.6250.73
27_C32_R0.6240.73
306_A310_L0.6230.73
129_G309_G0.6200.73
237_L321_I0.6200.73
295_S299_S0.6200.73
359_A363_M0.6190.72
119_P122_V0.6180.72
202_L206_W0.6160.72
380_G383_A0.6160.72
166_T199_H0.6150.72
166_T192_V0.6130.72
168_F171_L0.6120.72
219_V226_E0.6120.72
250_E266_V0.6110.71
128_M199_H0.6110.71
7_S10_Q0.6110.71
88_T93_K0.6100.71
345_L426_S0.6100.71
376_S380_G0.6090.71
175_I179_A0.6090.71
163_I274_T0.6080.71
180_V246_L0.6080.71
232_Y290_G0.6060.71
79_V83_G0.6050.71
237_L410_S0.6050.71
270_T274_T0.6050.71
14_A48_Q0.6040.71
133_I139_I0.6040.71
317_S356_Q0.6040.71
9_R77_E0.6020.70
156_L222_L0.6010.70
291_N339_K0.5980.70
7_S46_L0.5970.70
414_G418_S0.5970.70
287_F291_N0.5940.69
446_F450_M0.5940.69
101_N104_Q0.5940.69
40_K46_L0.5930.69
38_E41_V0.5930.69
273_L276_F0.5920.69
314_G317_S0.5920.69
54_G322_T0.5920.69
14_A41_V0.5920.69
154_A158_N0.5920.69
420_Q448_I0.5910.69
295_S298_I0.5910.69
124_A171_L0.5900.69
332_D343_T0.5880.69
185_G247_A0.5870.68
277_A281_I0.5870.68
373_K377_L0.5870.68
79_V86_E0.5860.68
232_Y283_G0.5850.68
343_T347_P0.5850.68
445_A452_I0.5830.68
128_M169_T0.5830.68
155_D220_W0.5830.68
410_S414_G0.5820.68
354_I431_G0.5810.68
435_I450_M0.5810.68
462_Y466_R0.5790.67
320_V356_Q0.5780.67
353_N406_A0.5780.67
406_A456_V0.5780.67
365_F462_Y0.5770.67
366_I401_F0.5770.67
10_Q52_V0.5760.67
14_A44_E0.5740.67
396_N403_F0.5740.67
47_D53_K0.5730.67
360_A364_M0.5700.66
118_L386_G0.5690.66
421_G441_Q0.5680.66
8_A80_K0.5670.66
405_I459_A0.5660.66
372_Q376_S0.5660.66
303_S307_L0.5660.66
408_V411_G0.5650.66
362_A461_T0.5640.65
242_A274_T0.5630.65
158_N162_L0.5630.65
7_S14_A0.5620.65
300_V311_L0.5620.65
121_I326_H0.5610.65
177_W192_V0.5600.65
34_A60_G0.5580.65
409_S412_L0.5580.65
25_T28_V0.5580.65
312_Y348_M0.5580.65
433_P436_F0.5570.64
83_G87_S0.5560.64
465_A468_K0.5540.64
357_G454_L0.5520.64
19_E78_L0.5520.64
40_K64_V0.5510.64
422_V443_W0.5500.63
161_N165_G0.5490.63
185_G270_T0.5480.63
73_K77_E0.5470.63
127_L268_P0.5470.63
28_V263_L0.5460.63
120_A192_V0.5460.63
186_N254_T0.5450.63
346_W430_G0.5450.63
10_Q80_K0.5450.63
354_I454_L0.5430.63
128_M168_F0.5420.62
363_M399_Y0.5410.62
413_A449_G0.5410.62
65_V397_L0.5400.62
313_G411_G0.5400.62
384_Y454_L0.5390.62
138_G141_F0.5390.62
245_M248_K0.5380.62
353_N380_G0.5370.62
41_V64_V0.5370.62
184_G243_S0.5370.62
333_L337_G0.5360.62
87_S96_S0.5360.62
352_S410_S0.5360.62
187_P243_S0.5350.61
65_V322_T0.5350.61
48_Q371_K0.5350.61
31_L71_V0.5340.61
333_L427_V0.5340.61
403_F406_A0.5320.61
114_F330_A0.5310.61
83_G86_E0.5300.61
324_M331_V0.5300.61
167_A171_L0.5290.61
155_D158_N0.5290.61
53_K68_Q0.5290.61
18_A81_E0.5280.60
263_L266_V0.5280.60
296_G300_V0.5270.60
246_L274_T0.5270.60
241_L244_Y0.5270.60
354_I450_M0.5260.60
135_T142_S0.5260.60
134_L140_F0.5240.60
222_L226_E0.5230.60
101_N105_R0.5220.60
429_V437_S0.5220.60
33_F41_V0.5220.60
21_I79_V0.5180.59
79_V87_S0.5170.59
113_I129_G0.5170.59
222_L225_L0.5160.59
175_I235_Q0.5140.58
359_A461_T0.5140.58
352_S388_T0.5140.58
11_I74_V0.5130.58
167_A192_V0.5130.58
25_T61_Q0.5130.58
329_L332_D0.5130.58
327_T330_A0.5130.58
402_P406_A0.5130.58
8_A74_V0.5120.58
361_L364_M0.5110.58
352_S406_A0.5110.58
204_N207_G0.5110.58
463_A468_K0.5110.58
312_Y328_F0.5110.58
360_A396_N0.5090.58
46_L54_G0.5090.58
123_T268_P0.5090.58
169_T200_P0.5080.57
53_K66_I0.5080.57
285_I288_A0.5070.57
352_S430_G0.5070.57
382_S391_A0.5060.57
363_M466_R0.5040.57
357_G380_G0.5040.57
25_T64_V0.5030.57
92_V97_E0.5030.57
317_S388_T0.5030.57
238_P283_G0.5020.57
366_I468_K0.5020.57
450_M454_L0.5010.56
360_A376_S0.5010.56
15_V49_I0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.783 100 0.654 Contact Map
3ipjA 1 0.1979 100 0.788 Contact Map
1ibaA 1 0.1638 100 0.792 Contact Map
3bp3A 1 0.1723 100 0.797 Contact Map
2h8eA 2 0.1851 63.2 0.97 Contact Map
4n8nA 1 0.1064 60.8 0.97 Contact Map
2wbmA 1 0.1872 44.2 0.973 Contact Map
1t95A 1 0.1957 34.7 0.975 Contact Map
3q9vA 1 0.1191 29.8 0.976 Contact Map
3u12A 2 0.1298 25.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0128 seconds.