GREMLIN Database
PBPA - Penicillin-binding protein 1A/1B
UniProt: P39793 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 914 (717)
Sequences: 1029 (844)
Seq/√Len: 31.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_D271_N6.3441.00
206_G217_D6.0571.00
300_F326_T5.0741.00
600_V609_A4.2511.00
107_V205_I4.2121.00
260_K267_D4.1541.00
80_Y322_K4.1071.00
215_V225_Q4.0691.00
105_D109_E3.9771.00
545_F684_Y3.8771.00
437_I447_R3.8021.00
355_T496_P3.6731.00
548_T602_Y3.5981.00
260_K270_Y3.5851.00
129_R132_G3.5581.00
380_Y615_G3.5051.00
523_F527_T3.5041.00
542_Y655_S3.3851.00
109_E264_F3.3331.00
266_S269_Q3.2741.00
572_G599_F3.2601.00
541_D655_S3.2511.00
500_A609_A3.2471.00
356_L608_A3.2461.00
402_I550_M3.1901.00
100_I186_D3.0501.00
662_E675_T3.0351.00
108_K186_D2.9591.00
120_Y186_D2.9351.00
439_M550_M2.8201.00
82_K328_D2.8131.00
100_I108_K2.7961.00
322_K522_E2.7911.00
249_E253_N2.7821.00
489_G493_G2.7701.00
685_F691_P2.7401.00
506_F547_I2.7381.00
339_M352_G2.7261.00
560_G563_A2.7091.00
542_Y656_V2.6991.00
416_S453_K2.6751.00
490_G493_G2.6701.00
324_Y520_S2.6061.00
105_D108_K2.6011.00
106_V226_A2.5971.00
359_T607_T2.5941.00
440_R549_D2.5831.00
501_G515_P2.5341.00
80_Y324_Y2.4890.99
78_T86_E2.4860.99
122_H180_E2.4730.99
106_V109_E2.4710.99
206_G218_L2.4610.99
84_G519_K2.4490.99
652_K658_E2.4260.99
363_E516_H2.4200.99
356_L643_V2.3950.99
430_D447_R2.3930.99
409_T546_M2.3900.99
569_E647_S2.3810.99
552_K649_S2.3600.99
661_V671_A2.3190.99
228_T248_A2.3160.99
358_D361_N2.3070.99
79_I87_I2.2880.99
99_S102_E2.2760.99
434_L447_R2.2720.99
501_G512_Y2.2600.99
108_K120_Y2.2100.99
118_R126_D2.2010.99
223_V265_I2.1950.99
100_I190_E2.1540.98
235_S238_A2.1460.98
549_D552_K2.1430.98
499_M600_V2.1380.98
335_L366_A2.1230.98
354_V639_L2.1170.98
449_I453_K2.0970.98
488_F493_G2.0680.98
669_K693_T2.0610.98
224_E276_V2.0480.98
441_Y445_Q2.0470.98
511_T537_S2.0270.98
78_T322_K2.0120.98
470_L539_M2.0000.97
412_Q436_P1.9930.97
202_A211_E1.9930.97
268_S272_K1.9840.97
487_G490_G1.9780.97
364_V517_F1.9680.97
270_Y274_K1.9650.97
388_P489_G1.9580.97
695_S698_Y1.9300.97
104_P218_L1.9030.97
660_T680_K1.9020.97
356_L639_L1.8990.97
152_Q172_E1.8980.97
570_V603_T1.8970.97
401_V454_A1.8870.96
113_A264_F1.8870.96
662_E695_S1.8820.96
447_R450_P1.8690.96
398_Y451_A1.8490.96
569_E649_S1.8320.96
427_R431_R1.8300.96
304_V325_T1.8160.96
359_T507_G1.8100.95
82_K365_R1.7990.95
98_V103_I1.7880.95
81_D85_K1.7790.95
388_P392_I1.7560.95
114_T254_I1.7470.94
253_N274_K1.7460.94
359_T504_S1.7430.94
395_I467_A1.7390.94
257_S270_Y1.7380.94
413_I454_A1.7210.94
455_F460_K1.7190.94
469_G536_K1.7120.94
545_F653_P1.7080.94
258_L262_Q1.6940.93
522_E528_K1.6940.93
513_N535_S1.6910.93
387_Q577_T1.6890.93
245_P248_A1.6830.93
711_G716_Y1.6800.93
419_T425_P1.6760.93
555_V570_V1.6760.93
113_A262_Q1.6740.93
222_T276_V1.6590.93
414_D436_P1.6430.92
571_A602_Y1.6420.92
111_F198_F1.6400.92
331_A366_A1.6400.92
661_V685_F1.6350.92
184_S187_E1.6170.92
120_Y189_L1.6170.92
409_T550_M1.6140.92
378_F384_T1.6090.92
308_I323_I1.6010.91
205_I229_L1.5970.91
469_G538_A1.5890.91
358_D363_E1.5860.91
440_R683_E1.5810.91
439_M454_A1.5790.91
224_E252_R1.5770.91
357_L500_A1.5770.91
355_T497_L1.5750.91
198_F205_I1.5730.91
357_L607_T1.5590.90
271_N274_K1.5190.89
402_I546_M1.5150.89
210_E214_G1.5110.89
269_Q272_K1.5050.89
404_N462_T1.5030.88
406_K542_Y1.5020.88
335_L354_V1.5010.88
102_E219_S1.5000.88
223_V273_A1.4880.88
675_T695_S1.4840.88
304_V307_E1.4760.88
388_P494_V1.4600.87
54_V58_V1.4540.87
97_Y190_E1.4510.87
152_Q160_L1.4470.86
555_V599_F1.4420.86
665_S691_P1.4410.86
111_F230_A1.4380.86
399_G506_F1.4330.86
512_Y515_P1.4320.86
245_P249_E1.4300.86
407_W439_M1.4150.85
661_V691_P1.4080.85
334_K338_L1.4060.85
246_D249_E1.4020.85
392_I396_L1.3990.85
434_L445_Q1.3960.84
518_V521_I1.3960.84
339_M368_G1.3910.84
470_L505_A1.3910.84
568_V644_D1.3880.84
267_D270_Y1.3760.84
160_L175_L1.3740.83
193_L198_F1.3700.83
400_P466_F1.3680.83
462_T465_D1.3590.83
258_L261_K1.3580.83
100_I120_Y1.3570.83
466_F539_M1.3470.82
671_A691_P1.3470.82
277_A280_D1.3430.82
197_Y201_R1.3360.82
308_I518_V1.3340.82
504_S607_T1.3330.82
178_Q182_N1.3310.81
80_Y86_E1.3280.81
198_F229_L1.3210.81
545_F652_K1.3140.81
178_Q181_R1.3140.81
506_F602_Y1.3120.80
733_A736_A1.3120.80
637_A641_A1.3110.80
420_Y426_I1.3090.80
117_A258_L1.3060.80
114_T258_L1.3060.80
444_A553_T1.3050.80
434_L437_I1.3050.80
662_E698_Y1.2920.79
440_R553_T1.2870.79
560_G599_F1.2790.79
125_I130_I1.2700.78
444_A557_T1.2670.78
386_A596_D1.2660.78
260_K271_N1.2630.78
501_G607_T1.2550.77
466_F470_L1.2510.77
183_Y191_M1.2430.77
249_E278_V1.2390.76
704_E715_K1.2310.76
56_F170_V1.2310.76
488_F491_N1.2310.76
298_S303_E1.2280.76
658_E684_Y1.2180.75
556_K564_Q1.2170.75
467_A472_L1.2170.75
407_W454_A1.2070.75
271_N275_K1.2060.75
300_F519_K1.2060.75
303_E517_F1.2050.74
472_L494_V1.2030.74
189_L193_L1.2020.74
402_I439_M1.2010.74
140_D144_A1.1980.74
155_V179_L1.1960.74
166_L170_V1.1940.74
100_I103_I1.1870.73
392_I397_D1.1860.73
365_R606_Y1.1840.73
670_L692_S1.1770.73
109_E186_D1.1740.72
324_Y522_E1.1730.72
171_Q175_L1.1690.72
741_V747_S1.1680.72
44_L48_G1.1670.72
496_P500_A1.1630.72
708_K711_G1.1590.71
710_S720_N1.1560.71
111_F193_L1.1540.71
209_A213_F1.1530.71
426_I452_L1.1500.71
441_Y444_A1.1490.71
554_A559_T1.1480.71
341_G344_V1.1450.71
601_G636_F1.1410.70
418_Y453_K1.1410.70
59_M170_V1.1390.70
661_V683_E1.1390.70
33_L38_L1.1370.70
685_F689_T1.1330.70
116_D122_H1.1320.70
331_A643_V1.1220.69
403_E543_T1.1170.69
501_G504_S1.1160.69
399_G470_L1.1130.68
150_I196_I1.1130.68
118_R122_H1.1080.68
130_I134_L1.1050.68
64_P171_Q1.1050.68
456_Q483_Y1.1050.68
422_N452_L1.1030.68
157_N162_H1.0980.67
335_L368_G1.0960.67
316_P321_L1.0940.67
96_T524_N1.0940.67
606_Y643_V1.0920.67
107_V198_F1.0910.67
107_V111_F1.0910.67
454_A458_V1.0860.66
127_P130_I1.0860.66
741_V745_S1.0850.66
156_K168_R1.0820.66
49_V52_G1.0780.66
410_Y661_V1.0780.66
429_W445_Q1.0740.66
742_D748_E1.0710.65
655_S687_K1.0670.65
596_D613_G1.0650.65
707_A715_K1.0650.65
552_K569_E1.0640.65
206_G209_A1.0600.64
98_V218_L1.0590.64
34_F37_T1.0550.64
180_E188_I1.0530.64
520_S530_D1.0480.64
688_G692_S1.0430.63
209_A229_L1.0360.63
420_Y483_Y1.0350.63
22_P26_K1.0340.63
712_L716_Y1.0310.62
98_V206_G1.0300.62
321_L529_L1.0300.62
455_F463_A1.0300.62
418_Y456_Q1.0280.62
548_T571_A1.0280.62
742_D752_S1.0270.62
412_Q438_S1.0250.62
222_T226_A1.0210.62
397_D486_G1.0180.61
307_E518_V1.0170.61
413_I450_P1.0170.61
19_S23_K1.0170.61
671_A680_K1.0150.61
155_V383_Q1.0140.61
410_Y668_A1.0110.61
413_I439_M1.0040.60
152_Q168_R1.0040.60
257_S274_K1.0010.60
710_S716_Y1.0010.60
640_I644_D1.0000.60
437_I442_A0.9970.60
98_V102_E0.9960.60
252_R277_A0.9950.60
747_S753_S0.9920.59
418_Y426_I0.9910.59
595_R617_N0.9900.59
41_L45_F0.9900.59
708_K716_Y0.9900.59
126_D129_R0.9900.59
660_T682_T0.9850.59
726_S731_G0.9800.58
407_W411_E0.9800.58
136_A145_E0.9770.58
570_V636_F0.9750.58
672_G675_T0.9730.58
308_I521_I0.9720.58
109_E120_Y0.9720.58
606_Y644_D0.9720.58
225_Q276_V0.9690.57
326_T519_K0.9680.57
459_G462_T0.9680.57
334_K642_D0.9660.57
86_E89_E0.9650.57
748_E752_S0.9640.57
642_D645_D0.9640.57
429_W594_A0.9610.57
315_D319_D0.9610.57
388_P488_F0.9600.57
443_L547_I0.9570.56
665_S685_F0.9550.56
223_V256_L0.9530.56
750_Q753_S0.9520.56
458_V462_T0.9510.56
660_T663_K0.9500.56
475_T498_T0.9500.56
200_P211_E0.9490.56
180_E320_G0.9440.55
554_A572_G0.9410.55
297_Y333_D0.9400.55
661_V665_S0.9380.55
688_G694_V0.9370.55
691_P698_Y0.9360.55
753_S759_I0.9350.55
353_G380_Y0.9330.55
708_K715_K0.9310.54
33_L37_T0.9300.54
430_D434_L0.9280.54
336_D340_D0.9240.54
38_L43_I0.9220.54
56_F60_V0.9220.54
60_V63_A0.9210.54
354_V608_A0.9210.54
550_M571_A0.9200.54
391_T499_M0.9180.53
539_M543_T0.9170.53
665_S668_A0.9160.53
117_A262_Q0.9160.53
707_A710_S0.9150.53
406_K540_S0.9140.53
596_D611_W0.9140.53
28_R31_G0.9140.53
568_V605_Q0.9130.53
400_P543_T0.9130.53
163_Q225_Q0.9110.53
399_G539_M0.9060.52
387_Q491_N0.9050.52
554_A599_F0.9040.52
537_S541_D0.9020.52
420_Y424_K0.9020.52
437_I450_P0.9010.52
371_R614_M0.9010.52
489_G577_T0.9000.52
716_Y721_Q0.8990.52
200_P237_T0.8960.52
399_G547_I0.8960.52
197_Y240_N0.8950.51
260_K263_G0.8940.51
325_T458_V0.8930.51
725_L735_F0.8920.51
555_V560_G0.8880.51
81_D329_T0.8850.51
723_L727_W0.8840.51
474_L498_T0.8830.51
740_S745_S0.8830.51
331_A365_R0.8790.50
452_L486_G0.8780.50
710_S715_K0.8730.50
77_S323_I0.8730.50
672_G695_S0.8720.50
114_T154_V0.8690.49
662_E665_S0.8690.49
433_Y449_I0.8690.49
750_Q755_K0.8660.49
364_V367_I0.8660.49
112_I264_F0.8640.49
369_A379_N0.8630.49
305_M317_S0.8610.49
29_K33_L0.8610.49
57_A61_S0.8610.49
78_T89_E0.8590.49
106_V223_V0.8590.49
152_Q320_G0.8580.48
740_S743_G0.8570.48
125_I599_F0.8570.48
229_L395_I0.8550.48
114_T255_V0.8550.48
137_N173_V0.8510.48
728_N731_G0.8510.48
421_S483_Y0.8500.48
151_T155_V0.8490.48
442_A450_P0.8480.48
750_Q756_E0.8470.48
70_K73_T0.8440.47
317_S321_L0.8420.47
105_D112_I0.8420.47
367_I517_F0.8410.47
754_A759_I0.8400.47
723_L735_F0.8380.47
755_K758_V0.8380.47
661_V670_L0.8370.47
112_I120_Y0.8370.47
130_I175_L0.8360.47
662_E668_A0.8360.47
231_G248_A0.8350.47
107_V226_A0.8350.47
355_T500_A0.8350.47
507_G602_Y0.8330.46
228_T241_P0.8310.46
636_F640_I0.8270.46
736_A743_G0.8260.46
84_G330_K0.8250.46
707_A714_V0.8240.46
401_V413_I0.8230.46
604_P650_F0.8220.46
504_S512_Y0.8190.45
106_V269_Q0.8190.45
221_L226_A0.8190.45
206_G210_E0.8180.45
725_L737_V0.8160.45
260_K274_K0.8150.45
479_V485_I0.8150.45
711_G715_K0.8130.45
160_L164_K0.8130.45
686_V690_A0.8110.45
166_L254_I0.8090.45
160_L171_Q0.8080.44
696_K699_E0.8070.44
79_I90_V0.8070.44
488_F492_D0.8060.44
111_F150_I0.8060.44
612_T629_Q0.8040.44
565_V568_V0.8040.44
733_A737_V0.8010.44
403_E540_S0.8000.44
329_T333_D0.7990.44
137_N145_E0.7990.44
657_V685_F0.7960.43
750_Q757_A0.7950.43
708_K712_L0.7950.43
160_L172_E0.7940.43
661_V688_G0.7930.43
307_E516_H0.7930.43
482_A493_G0.7920.43
516_H531_L0.7920.43
540_S543_T0.7900.43
17_K20_P0.7890.43
231_G255_V0.7880.43
231_G254_I0.7860.43
744_G751_N0.7840.43
100_I112_I0.7830.42
739_Q743_G0.7830.42
555_V572_G0.7820.42
129_R409_T0.7810.42
392_I490_G0.7800.42
421_S456_Q0.7790.42
200_P240_N0.7780.42
412_Q437_I0.7780.42
684_Y691_P0.7780.42
196_I205_I0.7770.42
704_E708_K0.7770.42
680_K685_F0.7770.42
335_L352_G0.7770.42
683_E689_T0.7760.42
727_W737_V0.7750.42
130_I147_G0.7740.42
685_F690_A0.7730.42
744_G750_Q0.7700.41
554_A560_G0.7700.41
378_F615_G0.7700.41
60_V174_W0.7690.41
753_S757_A0.7680.41
668_A671_A0.7670.41
685_F688_G0.7670.41
709_L714_V0.7670.41
84_G219_S0.7660.41
670_L685_F0.7650.41
193_L205_I0.7650.41
218_L226_A0.7630.41
443_L450_P0.7630.41
64_P175_L0.7630.41
179_L323_I0.7630.41
276_V281_E0.7630.41
505_A539_M0.7610.41
336_D369_A0.7590.41
568_V606_Y0.7570.40
711_G719_D0.7570.40
568_V647_S0.7560.40
234_Q255_V0.7560.40
43_I246_D0.7550.40
497_L517_F0.7540.40
716_Y719_D0.7530.40
756_E759_I0.7530.40
254_I257_S0.7530.40
22_P25_G0.7530.40
118_R129_R0.7520.40
350_M631_V0.7510.40
692_S700_K0.7500.40
440_R685_F0.7500.40
413_I453_K0.7490.40
571_A650_F0.7490.40
701_E704_E0.7480.40
665_S695_S0.7480.40
630_K633_K0.7480.40
686_V691_P0.7470.40
711_G714_V0.7460.40
418_Y431_R0.7460.40
231_G545_F0.7440.39
716_Y727_W0.7430.39
232_M671_A0.7410.39
158_S195_R0.7400.39
671_A685_F0.7400.39
716_Y726_S0.7400.39
63_A174_W0.7390.39
200_P203_Y0.7390.39
59_M198_F0.7380.39
160_L163_Q0.7380.39
210_E551_L0.7380.39
709_L713_N0.7380.39
232_M504_S0.7380.39
553_T557_T0.7370.39
125_I173_V0.7370.39
709_L712_L0.7360.39
668_A691_P0.7340.39
723_L729_Y0.7340.39
97_Y103_I0.7330.39
272_K441_Y0.7330.39
125_I269_Q0.7320.38
351_Q370_G0.7300.38
105_D264_F0.7300.38
257_S260_K0.7300.38
316_P320_G0.7260.38
545_F656_V0.7240.38
30_K34_F0.7230.38
112_I117_A0.7220.38
209_A217_D0.7210.38
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384_T495_S0.5460.25
500_A600_V0.5460.25
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33_L36_K0.5450.25
665_S670_L0.5450.25
197_Y203_Y0.5450.25
395_I501_G0.5450.25
50_V62_D0.5440.25
737_V757_A0.5430.25
552_K555_V0.5430.25
34_F106_V0.5420.25
103_I427_R0.5420.25
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156_K162_H0.5410.25
361_N365_R0.5410.25
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415_D613_G0.5400.25
671_A683_E0.5390.25
562_L633_K0.5380.25
100_I189_L0.5380.25
433_Y452_L0.5370.25
21_S399_G0.5370.25
212_F332_Q0.5360.25
53_A57_A0.5360.25
705_E712_L0.5350.25
263_G534_K0.5350.25
391_T471_G0.5340.25
170_V202_A0.5340.25
261_K505_A0.5330.25
429_W551_L0.5330.25
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40_T472_L0.5320.25
246_D428_D0.5320.25
114_T296_K0.5320.25
698_Y701_E0.5320.25
659_A665_S0.5320.25
101_D468_N0.5300.24
434_L449_I0.5300.24
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671_A674_N0.5290.24
303_E364_V0.5290.24
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341_G345_G0.5280.24
101_D222_T0.5270.24
63_A66_L0.5270.24
745_S749_I0.5270.24
417_A433_Y0.5260.24
79_I88_A0.5260.24
137_N143_G0.5260.24
231_G247_K0.5250.24
103_I220_K0.5250.24
224_E426_I0.5250.24
740_S748_E0.5250.24
407_W539_M0.5240.24
417_A656_V0.5240.24
415_D653_P0.5240.24
215_V220_K0.5230.24
751_N756_E0.5230.24
372_N429_W0.5230.24
434_L441_Y0.5230.24
176_S342_D0.5220.24
101_D279_K0.5220.24
198_F245_P0.5220.24
670_L694_V0.5220.24
354_V643_V0.5220.24
481_E485_I0.5210.24
137_N409_T0.5210.24
112_I142_F0.5210.24
743_G749_I0.5210.24
706_T709_L0.5210.24
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687_K690_A0.5200.24
108_K189_L0.5200.24
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490_G617_N0.5190.24
754_A758_V0.5190.24
247_K250_K0.5190.24
742_D754_A0.5190.24
410_Y683_E0.5180.24
703_K710_S0.5180.24
45_F325_T0.5180.24
688_G691_P0.5180.24
396_L486_G0.5180.24
749_I759_I0.5170.24
732_D748_E0.5160.24
319_D639_L0.5160.24
752_S757_A0.5160.24
746_Y756_E0.5150.24
312_S316_P0.5150.24
113_A157_N0.5150.24
692_S725_L0.5140.23
38_L713_N0.5140.23
743_G748_E0.5140.23
712_L728_N0.5140.23
243_K248_A0.5140.23
171_Q174_W0.5130.23
101_D753_S0.5130.23
659_A685_F0.5130.23
699_E725_L0.5120.23
110_A259_M0.5120.23
350_M612_T0.5120.23
333_D337_E0.5120.23
409_T656_V0.5120.23
238_A247_K0.5120.23
86_E322_K0.5110.23
132_G316_P0.5110.23
266_S509_N0.5110.23
82_K229_L0.5110.23
107_V223_V0.5100.23
751_N759_I0.5100.23
201_R367_I0.5100.23
152_Q526_G0.5100.23
748_E751_N0.5100.23
547_I602_Y0.5090.23
455_F470_L0.5090.23
717_D726_S0.5080.23
103_I304_V0.5080.23
733_A738_K0.5080.23
472_L519_K0.5080.23
40_T43_I0.5070.23
177_I269_Q0.5060.23
230_A471_G0.5050.23
74_P560_G0.5050.23
330_K465_D0.5050.23
513_N533_P0.5050.23
452_L487_G0.5040.23
96_T210_E0.5040.23
713_N717_D0.5040.23
742_D750_Q0.5040.23
98_V123_H0.5030.23
276_V496_P0.5030.23
708_K720_N0.5030.23
359_T396_L0.5020.23
665_S703_K0.5020.23
711_G721_Q0.5020.23
175_L230_A0.5010.23
423_G456_Q0.5010.23
751_N755_K0.5010.23
50_V58_V0.5010.23
467_A501_G0.5000.23
709_L715_K0.5000.23
381_A438_S0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oonA 1 0.4158 100 0.341 Contact Map
2jchA 1 0.4551 100 0.353 Contact Map
3vmaA 1 0.6543 100 0.374 Contact Map
3udfA 2 0.5284 100 0.39 Contact Map
2olvA 1 0.6532 100 0.392 Contact Map
3zg9B 1 0.4869 100 0.538 Contact Map
2y2mA 2 0.488 100 0.649 Contact Map
2v2fF 1 0.3862 100 0.705 Contact Map
3un7A 1 0.3972 100 0.714 Contact Map
2oqoA 2 0.198 100 0.723 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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