PBPA - BACSU - GREMLIN Contacts

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PBPA - Penicillin-binding protein 1A/1B

UniProt:	P39793	Sequences: MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLILFVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDEIPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLLSHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDLSKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKVAVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDKLDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTIKPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIPALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGNNGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVPGVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSLSAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLTEYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQSVDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDKKDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDNNNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	914 (717)
Sequences:	1029 (844)
Seq/√Len:	31.5

ECOLI - PBPB PBPC PBPA
BACSU - PBPA PBPF PBPG PBPD YQGF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
267_D	271_N	6.344	1.00
206_G	217_D	6.057	1.00
300_F	326_T	5.074	1.00
600_V	609_A	4.251	1.00
107_V	205_I	4.212	1.00
260_K	267_D	4.154	1.00
80_Y	322_K	4.107	1.00
215_V	225_Q	4.069	1.00
105_D	109_E	3.977	1.00
545_F	684_Y	3.877	1.00
437_I	447_R	3.802	1.00
355_T	496_P	3.673	1.00
548_T	602_Y	3.598	1.00
260_K	270_Y	3.585	1.00
129_R	132_G	3.558	1.00
380_Y	615_G	3.505	1.00
523_F	527_T	3.504	1.00
542_Y	655_S	3.385	1.00
109_E	264_F	3.333	1.00
266_S	269_Q	3.274	1.00
572_G	599_F	3.260	1.00
541_D	655_S	3.251	1.00
500_A	609_A	3.247	1.00
356_L	608_A	3.246	1.00
402_I	550_M	3.190	1.00
100_I	186_D	3.050	1.00
662_E	675_T	3.035	1.00
108_K	186_D	2.959	1.00
120_Y	186_D	2.935	1.00
439_M	550_M	2.820	1.00
82_K	328_D	2.813	1.00
100_I	108_K	2.796	1.00
322_K	522_E	2.791	1.00
249_E	253_N	2.782	1.00
489_G	493_G	2.770	1.00
685_F	691_P	2.740	1.00
506_F	547_I	2.738	1.00
339_M	352_G	2.726	1.00
560_G	563_A	2.709	1.00
542_Y	656_V	2.699	1.00
416_S	453_K	2.675	1.00
490_G	493_G	2.670	1.00
324_Y	520_S	2.606	1.00
105_D	108_K	2.601	1.00
106_V	226_A	2.597	1.00
359_T	607_T	2.594	1.00
440_R	549_D	2.583	1.00
501_G	515_P	2.534	1.00
80_Y	324_Y	2.489	0.99
78_T	86_E	2.486	0.99
122_H	180_E	2.473	0.99
106_V	109_E	2.471	0.99
206_G	218_L	2.461	0.99
84_G	519_K	2.449	0.99
652_K	658_E	2.426	0.99
363_E	516_H	2.420	0.99
356_L	643_V	2.395	0.99
430_D	447_R	2.393	0.99
409_T	546_M	2.390	0.99
569_E	647_S	2.381	0.99
552_K	649_S	2.360	0.99
661_V	671_A	2.319	0.99
228_T	248_A	2.316	0.99
358_D	361_N	2.307	0.99
79_I	87_I	2.288	0.99
99_S	102_E	2.276	0.99
434_L	447_R	2.272	0.99
501_G	512_Y	2.260	0.99
108_K	120_Y	2.210	0.99
118_R	126_D	2.201	0.99
223_V	265_I	2.195	0.99
100_I	190_E	2.154	0.98
235_S	238_A	2.146	0.98
549_D	552_K	2.143	0.98
499_M	600_V	2.138	0.98
335_L	366_A	2.123	0.98
354_V	639_L	2.117	0.98
449_I	453_K	2.097	0.98
488_F	493_G	2.068	0.98
669_K	693_T	2.061	0.98
224_E	276_V	2.048	0.98
441_Y	445_Q	2.047	0.98
511_T	537_S	2.027	0.98
78_T	322_K	2.012	0.98
470_L	539_M	2.000	0.97
412_Q	436_P	1.993	0.97
202_A	211_E	1.993	0.97
268_S	272_K	1.984	0.97
487_G	490_G	1.978	0.97
364_V	517_F	1.968	0.97
270_Y	274_K	1.965	0.97
388_P	489_G	1.958	0.97
695_S	698_Y	1.930	0.97
104_P	218_L	1.903	0.97
660_T	680_K	1.902	0.97
356_L	639_L	1.899	0.97
152_Q	172_E	1.898	0.97
570_V	603_T	1.897	0.97
401_V	454_A	1.887	0.96
113_A	264_F	1.887	0.96
662_E	695_S	1.882	0.96
447_R	450_P	1.869	0.96
398_Y	451_A	1.849	0.96
569_E	649_S	1.832	0.96
427_R	431_R	1.830	0.96
304_V	325_T	1.816	0.96
359_T	507_G	1.810	0.95
82_K	365_R	1.799	0.95
98_V	103_I	1.788	0.95
81_D	85_K	1.779	0.95
388_P	392_I	1.756	0.95
114_T	254_I	1.747	0.94
253_N	274_K	1.746	0.94
359_T	504_S	1.743	0.94
395_I	467_A	1.739	0.94
257_S	270_Y	1.738	0.94
413_I	454_A	1.721	0.94
455_F	460_K	1.719	0.94
469_G	536_K	1.712	0.94
545_F	653_P	1.708	0.94
258_L	262_Q	1.694	0.93
522_E	528_K	1.694	0.93
513_N	535_S	1.691	0.93
387_Q	577_T	1.689	0.93
245_P	248_A	1.683	0.93
711_G	716_Y	1.680	0.93
419_T	425_P	1.676	0.93
555_V	570_V	1.676	0.93
113_A	262_Q	1.674	0.93
222_T	276_V	1.659	0.93
414_D	436_P	1.643	0.92
571_A	602_Y	1.642	0.92
111_F	198_F	1.640	0.92
331_A	366_A	1.640	0.92
661_V	685_F	1.635	0.92
184_S	187_E	1.617	0.92
120_Y	189_L	1.617	0.92
409_T	550_M	1.614	0.92
378_F	384_T	1.609	0.92
308_I	323_I	1.601	0.91
205_I	229_L	1.597	0.91
469_G	538_A	1.589	0.91
358_D	363_E	1.586	0.91
440_R	683_E	1.581	0.91
439_M	454_A	1.579	0.91
224_E	252_R	1.577	0.91
357_L	500_A	1.577	0.91
355_T	497_L	1.575	0.91
198_F	205_I	1.573	0.91
357_L	607_T	1.559	0.90
271_N	274_K	1.519	0.89
402_I	546_M	1.515	0.89
210_E	214_G	1.511	0.89
269_Q	272_K	1.505	0.89
404_N	462_T	1.503	0.88
406_K	542_Y	1.502	0.88
335_L	354_V	1.501	0.88
102_E	219_S	1.500	0.88
223_V	273_A	1.488	0.88
675_T	695_S	1.484	0.88
304_V	307_E	1.476	0.88
388_P	494_V	1.460	0.87
54_V	58_V	1.454	0.87
97_Y	190_E	1.451	0.87
152_Q	160_L	1.447	0.86
555_V	599_F	1.442	0.86
665_S	691_P	1.441	0.86
111_F	230_A	1.438	0.86
399_G	506_F	1.433	0.86
512_Y	515_P	1.432	0.86
245_P	249_E	1.430	0.86
407_W	439_M	1.415	0.85
661_V	691_P	1.408	0.85
334_K	338_L	1.406	0.85
246_D	249_E	1.402	0.85
392_I	396_L	1.399	0.85
434_L	445_Q	1.396	0.84
518_V	521_I	1.396	0.84
339_M	368_G	1.391	0.84
470_L	505_A	1.391	0.84
568_V	644_D	1.388	0.84
267_D	270_Y	1.376	0.84
160_L	175_L	1.374	0.83
193_L	198_F	1.370	0.83
400_P	466_F	1.368	0.83
462_T	465_D	1.359	0.83
258_L	261_K	1.358	0.83
100_I	120_Y	1.357	0.83
466_F	539_M	1.347	0.82
671_A	691_P	1.347	0.82
277_A	280_D	1.343	0.82
197_Y	201_R	1.336	0.82
308_I	518_V	1.334	0.82
504_S	607_T	1.333	0.82
178_Q	182_N	1.331	0.81
80_Y	86_E	1.328	0.81
198_F	229_L	1.321	0.81
545_F	652_K	1.314	0.81
178_Q	181_R	1.314	0.81
506_F	602_Y	1.312	0.80
733_A	736_A	1.312	0.80
637_A	641_A	1.311	0.80
420_Y	426_I	1.309	0.80
117_A	258_L	1.306	0.80
114_T	258_L	1.306	0.80
444_A	553_T	1.305	0.80
434_L	437_I	1.305	0.80
662_E	698_Y	1.292	0.79
440_R	553_T	1.287	0.79
560_G	599_F	1.279	0.79
125_I	130_I	1.270	0.78
444_A	557_T	1.267	0.78
386_A	596_D	1.266	0.78
260_K	271_N	1.263	0.78
501_G	607_T	1.255	0.77
466_F	470_L	1.251	0.77
183_Y	191_M	1.243	0.77
249_E	278_V	1.239	0.76
704_E	715_K	1.231	0.76
56_F	170_V	1.231	0.76
488_F	491_N	1.231	0.76
298_S	303_E	1.228	0.76
658_E	684_Y	1.218	0.75
556_K	564_Q	1.217	0.75
467_A	472_L	1.217	0.75
407_W	454_A	1.207	0.75
271_N	275_K	1.206	0.75
300_F	519_K	1.206	0.75
303_E	517_F	1.205	0.74
472_L	494_V	1.203	0.74
189_L	193_L	1.202	0.74
402_I	439_M	1.201	0.74
140_D	144_A	1.198	0.74
155_V	179_L	1.196	0.74
166_L	170_V	1.194	0.74
100_I	103_I	1.187	0.73
392_I	397_D	1.186	0.73
365_R	606_Y	1.184	0.73
670_L	692_S	1.177	0.73
109_E	186_D	1.174	0.72
324_Y	522_E	1.173	0.72
171_Q	175_L	1.169	0.72
741_V	747_S	1.168	0.72
44_L	48_G	1.167	0.72
496_P	500_A	1.163	0.72
708_K	711_G	1.159	0.71
710_S	720_N	1.156	0.71
111_F	193_L	1.154	0.71
209_A	213_F	1.153	0.71
426_I	452_L	1.150	0.71
441_Y	444_A	1.149	0.71
554_A	559_T	1.148	0.71
341_G	344_V	1.145	0.71
601_G	636_F	1.141	0.70
418_Y	453_K	1.141	0.70
59_M	170_V	1.139	0.70
661_V	683_E	1.139	0.70
33_L	38_L	1.137	0.70
685_F	689_T	1.133	0.70
116_D	122_H	1.132	0.70
331_A	643_V	1.122	0.69
403_E	543_T	1.117	0.69
501_G	504_S	1.116	0.69
399_G	470_L	1.113	0.68
150_I	196_I	1.113	0.68
118_R	122_H	1.108	0.68
130_I	134_L	1.105	0.68
64_P	171_Q	1.105	0.68
456_Q	483_Y	1.105	0.68
422_N	452_L	1.103	0.68
157_N	162_H	1.098	0.67
335_L	368_G	1.096	0.67
316_P	321_L	1.094	0.67
96_T	524_N	1.094	0.67
606_Y	643_V	1.092	0.67
107_V	198_F	1.091	0.67
107_V	111_F	1.091	0.67
454_A	458_V	1.086	0.66
127_P	130_I	1.086	0.66
741_V	745_S	1.085	0.66
156_K	168_R	1.082	0.66
49_V	52_G	1.078	0.66
410_Y	661_V	1.078	0.66
429_W	445_Q	1.074	0.66
742_D	748_E	1.071	0.65
655_S	687_K	1.067	0.65
596_D	613_G	1.065	0.65
707_A	715_K	1.065	0.65
552_K	569_E	1.064	0.65
206_G	209_A	1.060	0.64
98_V	218_L	1.059	0.64
34_F	37_T	1.055	0.64
180_E	188_I	1.053	0.64
520_S	530_D	1.048	0.64
688_G	692_S	1.043	0.63
209_A	229_L	1.036	0.63
420_Y	483_Y	1.035	0.63
22_P	26_K	1.034	0.63
712_L	716_Y	1.031	0.62
98_V	206_G	1.030	0.62
321_L	529_L	1.030	0.62
455_F	463_A	1.030	0.62
418_Y	456_Q	1.028	0.62
548_T	571_A	1.028	0.62
742_D	752_S	1.027	0.62
412_Q	438_S	1.025	0.62
222_T	226_A	1.021	0.62
397_D	486_G	1.018	0.61
307_E	518_V	1.017	0.61
413_I	450_P	1.017	0.61
19_S	23_K	1.017	0.61
671_A	680_K	1.015	0.61
155_V	383_Q	1.014	0.61
410_Y	668_A	1.011	0.61
413_I	439_M	1.004	0.60
152_Q	168_R	1.004	0.60
257_S	274_K	1.001	0.60
710_S	716_Y	1.001	0.60
640_I	644_D	1.000	0.60
437_I	442_A	0.997	0.60
98_V	102_E	0.996	0.60
252_R	277_A	0.995	0.60
747_S	753_S	0.992	0.59
418_Y	426_I	0.991	0.59
595_R	617_N	0.990	0.59
41_L	45_F	0.990	0.59
708_K	716_Y	0.990	0.59
126_D	129_R	0.990	0.59
660_T	682_T	0.985	0.59
726_S	731_G	0.980	0.58
407_W	411_E	0.980	0.58
136_A	145_E	0.977	0.58
570_V	636_F	0.975	0.58
672_G	675_T	0.973	0.58
308_I	521_I	0.972	0.58
109_E	120_Y	0.972	0.58
606_Y	644_D	0.972	0.58
225_Q	276_V	0.969	0.57
326_T	519_K	0.968	0.57
459_G	462_T	0.968	0.57
334_K	642_D	0.966	0.57
86_E	89_E	0.965	0.57
748_E	752_S	0.964	0.57
642_D	645_D	0.964	0.57
429_W	594_A	0.961	0.57
315_D	319_D	0.961	0.57
388_P	488_F	0.960	0.57
443_L	547_I	0.957	0.56
665_S	685_F	0.955	0.56
223_V	256_L	0.953	0.56
750_Q	753_S	0.952	0.56
458_V	462_T	0.951	0.56
660_T	663_K	0.950	0.56
475_T	498_T	0.950	0.56
200_P	211_E	0.949	0.56
180_E	320_G	0.944	0.55
554_A	572_G	0.941	0.55
297_Y	333_D	0.940	0.55
661_V	665_S	0.938	0.55
688_G	694_V	0.937	0.55
691_P	698_Y	0.936	0.55
753_S	759_I	0.935	0.55
353_G	380_Y	0.933	0.55
708_K	715_K	0.931	0.54
33_L	37_T	0.930	0.54
430_D	434_L	0.928	0.54
336_D	340_D	0.924	0.54
38_L	43_I	0.922	0.54
56_F	60_V	0.922	0.54
60_V	63_A	0.921	0.54
354_V	608_A	0.921	0.54
550_M	571_A	0.920	0.54
391_T	499_M	0.918	0.53
539_M	543_T	0.917	0.53
665_S	668_A	0.916	0.53
117_A	262_Q	0.916	0.53
707_A	710_S	0.915	0.53
406_K	540_S	0.914	0.53
596_D	611_W	0.914	0.53
28_R	31_G	0.914	0.53
568_V	605_Q	0.913	0.53
400_P	543_T	0.913	0.53
163_Q	225_Q	0.911	0.53
399_G	539_M	0.906	0.52
387_Q	491_N	0.905	0.52
554_A	599_F	0.904	0.52
537_S	541_D	0.902	0.52
420_Y	424_K	0.902	0.52
437_I	450_P	0.901	0.52
371_R	614_M	0.901	0.52
489_G	577_T	0.900	0.52
716_Y	721_Q	0.899	0.52
200_P	237_T	0.896	0.52
399_G	547_I	0.896	0.52
197_Y	240_N	0.895	0.51
260_K	263_G	0.894	0.51
325_T	458_V	0.893	0.51
725_L	735_F	0.892	0.51
555_V	560_G	0.888	0.51
81_D	329_T	0.885	0.51
723_L	727_W	0.884	0.51
474_L	498_T	0.883	0.51
740_S	745_S	0.883	0.51
331_A	365_R	0.879	0.50
452_L	486_G	0.878	0.50
710_S	715_K	0.873	0.50
77_S	323_I	0.873	0.50
672_G	695_S	0.872	0.50
114_T	154_V	0.869	0.49
662_E	665_S	0.869	0.49
433_Y	449_I	0.869	0.49
750_Q	755_K	0.866	0.49
364_V	367_I	0.866	0.49
112_I	264_F	0.864	0.49
369_A	379_N	0.863	0.49
305_M	317_S	0.861	0.49
29_K	33_L	0.861	0.49
57_A	61_S	0.861	0.49
78_T	89_E	0.859	0.49
106_V	223_V	0.859	0.49
152_Q	320_G	0.858	0.48
740_S	743_G	0.857	0.48
125_I	599_F	0.857	0.48
229_L	395_I	0.855	0.48
114_T	255_V	0.855	0.48
137_N	173_V	0.851	0.48
728_N	731_G	0.851	0.48
421_S	483_Y	0.850	0.48
151_T	155_V	0.849	0.48
442_A	450_P	0.848	0.48
750_Q	756_E	0.847	0.48
70_K	73_T	0.844	0.47
317_S	321_L	0.842	0.47
105_D	112_I	0.842	0.47
367_I	517_F	0.841	0.47
754_A	759_I	0.840	0.47
723_L	735_F	0.838	0.47
755_K	758_V	0.838	0.47
661_V	670_L	0.837	0.47
112_I	120_Y	0.837	0.47
130_I	175_L	0.836	0.47
662_E	668_A	0.836	0.47
231_G	248_A	0.835	0.47
107_V	226_A	0.835	0.47
355_T	500_A	0.835	0.47
507_G	602_Y	0.833	0.46
228_T	241_P	0.831	0.46
636_F	640_I	0.827	0.46
736_A	743_G	0.826	0.46
84_G	330_K	0.825	0.46
707_A	714_V	0.824	0.46
401_V	413_I	0.823	0.46
604_P	650_F	0.822	0.46
504_S	512_Y	0.819	0.45
106_V	269_Q	0.819	0.45
221_L	226_A	0.819	0.45
206_G	210_E	0.818	0.45
725_L	737_V	0.816	0.45
260_K	274_K	0.815	0.45
479_V	485_I	0.815	0.45
711_G	715_K	0.813	0.45
160_L	164_K	0.813	0.45
686_V	690_A	0.811	0.45
166_L	254_I	0.809	0.45
160_L	171_Q	0.808	0.44
696_K	699_E	0.807	0.44
79_I	90_V	0.807	0.44
488_F	492_D	0.806	0.44
111_F	150_I	0.806	0.44
612_T	629_Q	0.804	0.44
565_V	568_V	0.804	0.44
733_A	737_V	0.801	0.44
403_E	540_S	0.800	0.44
329_T	333_D	0.799	0.44
137_N	145_E	0.799	0.44
657_V	685_F	0.796	0.43
750_Q	757_A	0.795	0.43
708_K	712_L	0.795	0.43
160_L	172_E	0.794	0.43
661_V	688_G	0.793	0.43
307_E	516_H	0.793	0.43
482_A	493_G	0.792	0.43
516_H	531_L	0.792	0.43
540_S	543_T	0.790	0.43
17_K	20_P	0.789	0.43
231_G	255_V	0.788	0.43
231_G	254_I	0.786	0.43
744_G	751_N	0.784	0.43
100_I	112_I	0.783	0.42
739_Q	743_G	0.783	0.42
555_V	572_G	0.782	0.42
129_R	409_T	0.781	0.42
392_I	490_G	0.780	0.42
421_S	456_Q	0.779	0.42
200_P	240_N	0.778	0.42
412_Q	437_I	0.778	0.42
684_Y	691_P	0.778	0.42
196_I	205_I	0.777	0.42
704_E	708_K	0.777	0.42
680_K	685_F	0.777	0.42
335_L	352_G	0.777	0.42
683_E	689_T	0.776	0.42
727_W	737_V	0.775	0.42
130_I	147_G	0.774	0.42
685_F	690_A	0.773	0.42
744_G	750_Q	0.770	0.41
554_A	560_G	0.770	0.41
378_F	615_G	0.770	0.41
60_V	174_W	0.769	0.41
753_S	757_A	0.768	0.41
668_A	671_A	0.767	0.41
685_F	688_G	0.767	0.41
709_L	714_V	0.767	0.41
84_G	219_S	0.766	0.41
670_L	685_F	0.765	0.41
193_L	205_I	0.765	0.41
218_L	226_A	0.763	0.41
443_L	450_P	0.763	0.41
64_P	175_L	0.763	0.41
179_L	323_I	0.763	0.41
276_V	281_E	0.763	0.41
505_A	539_M	0.761	0.41
336_D	369_A	0.759	0.41
568_V	606_Y	0.757	0.40
711_G	719_D	0.757	0.40
568_V	647_S	0.756	0.40
234_Q	255_V	0.756	0.40
43_I	246_D	0.755	0.40
497_L	517_F	0.754	0.40
716_Y	719_D	0.753	0.40
756_E	759_I	0.753	0.40
254_I	257_S	0.753	0.40
22_P	25_G	0.753	0.40
118_R	129_R	0.752	0.40
350_M	631_V	0.751	0.40
692_S	700_K	0.750	0.40
440_R	685_F	0.750	0.40
413_I	453_K	0.749	0.40
571_A	650_F	0.749	0.40
701_E	704_E	0.748	0.40
665_S	695_S	0.748	0.40
630_K	633_K	0.748	0.40
686_V	691_P	0.747	0.40
711_G	714_V	0.746	0.40
418_Y	431_R	0.746	0.40
231_G	545_F	0.744	0.39
716_Y	727_W	0.743	0.39
232_M	671_A	0.741	0.39
158_S	195_R	0.740	0.39
671_A	685_F	0.740	0.39
716_Y	726_S	0.740	0.39
63_A	174_W	0.739	0.39
200_P	203_Y	0.739	0.39
59_M	198_F	0.738	0.39
160_L	163_Q	0.738	0.39
210_E	551_L	0.738	0.39
709_L	713_N	0.738	0.39
232_M	504_S	0.738	0.39
553_T	557_T	0.737	0.39
125_I	173_V	0.737	0.39
709_L	712_L	0.736	0.39
668_A	691_P	0.734	0.39
723_L	729_Y	0.734	0.39
97_Y	103_I	0.733	0.39
272_K	441_Y	0.733	0.39
125_I	269_Q	0.732	0.38
351_Q	370_G	0.730	0.38
105_D	264_F	0.730	0.38
257_S	260_K	0.730	0.38
316_P	320_G	0.726	0.38
545_F	656_V	0.724	0.38
30_K	34_F	0.723	0.38
112_I	117_A	0.722	0.38
209_A	217_D	0.721	0.38
229_L	325_T	0.721	0.38
405_K	411_E	0.721	0.38
577_T	617_N	0.721	0.38
410_Y	685_F	0.720	0.38
298_S	302_E	0.720	0.38
110_A	230_A	0.720	0.38
747_S	752_S	0.720	0.38
391_T	572_G	0.718	0.37
746_Y	749_I	0.718	0.37
90_V	305_M	0.717	0.37
605_Q	644_D	0.717	0.37
703_K	711_G	0.716	0.37
225_Q	281_E	0.713	0.37
55_T	59_M	0.713	0.37
235_S	247_K	0.713	0.37
751_N	758_V	0.712	0.37
217_D	220_K	0.712	0.37
389_G	596_D	0.712	0.37
330_K	337_E	0.711	0.37
735_F	749_I	0.711	0.37
612_T	632_A	0.711	0.37
473_G	498_T	0.710	0.37
82_K	85_K	0.710	0.37
102_E	348_E	0.710	0.37
551_L	602_Y	0.710	0.37
214_G	283_V	0.709	0.37
403_E	466_F	0.708	0.37
741_V	746_Y	0.708	0.37
692_S	697_T	0.707	0.37
449_I	452_L	0.707	0.37
449_I	469_G	0.707	0.37
427_R	433_Y	0.706	0.36
739_Q	742_D	0.706	0.36
675_T	698_Y	0.705	0.36
737_V	749_I	0.703	0.36
75_Y	203_Y	0.702	0.36
426_I	483_Y	0.702	0.36
683_E	688_G	0.702	0.36
368_G	639_L	0.700	0.36
113_A	163_Q	0.699	0.36
686_V	689_T	0.699	0.36
732_D	737_V	0.699	0.36
723_L	737_V	0.698	0.36
130_I	152_Q	0.698	0.36
190_E	242_V	0.696	0.36
418_Y	449_I	0.695	0.36
455_F	486_G	0.694	0.36
254_I	263_G	0.694	0.36
50_V	54_V	0.693	0.35
398_Y	415_D	0.691	0.35
752_S	755_K	0.691	0.35
451_A	611_W	0.691	0.35
306_K	383_Q	0.691	0.35
131_G	135_V	0.690	0.35
455_F	485_I	0.690	0.35
394_P	443_L	0.690	0.35
22_P	46_V	0.690	0.35
394_P	506_F	0.689	0.35
134_L	137_N	0.689	0.35
62_D	167_K	0.689	0.35
388_P	499_M	0.689	0.35
321_L	497_L	0.689	0.35
415_D	596_D	0.689	0.35
713_N	720_N	0.689	0.35
371_R	400_P	0.688	0.35
705_E	717_D	0.687	0.35
735_F	738_K	0.686	0.35
707_A	711_G	0.685	0.35
300_F	327_L	0.684	0.35
154_V	191_M	0.684	0.35
199_S	237_T	0.684	0.35
198_F	234_Q	0.681	0.35
151_T	180_E	0.680	0.35
693_T	696_K	0.679	0.34
707_A	716_Y	0.679	0.34
355_T	366_A	0.679	0.34
118_R	121_E	0.678	0.34
309_D	315_D	0.678	0.34
398_Y	443_L	0.676	0.34
42_L	46_V	0.676	0.34
326_T	363_E	0.675	0.34
43_I	46_V	0.675	0.34
366_A	639_L	0.675	0.34
424_K	452_L	0.674	0.34
599_F	636_F	0.674	0.34
664_G	679_K	0.674	0.34
388_P	498_T	0.673	0.34
58_V	61_S	0.673	0.34
738_K	743_G	0.672	0.34
114_T	234_Q	0.671	0.34
269_Q	534_K	0.671	0.34
601_G	632_A	0.671	0.34
559_T	599_F	0.670	0.34
696_K	701_E	0.670	0.34
275_K	330_K	0.669	0.34
60_V	64_P	0.669	0.34
257_S	261_K	0.667	0.34
195_R	218_L	0.667	0.34
400_P	463_A	0.666	0.33
340_D	472_L	0.666	0.33
747_S	756_E	0.665	0.33
125_I	176_S	0.664	0.33
608_A	639_L	0.664	0.33
715_K	719_D	0.664	0.33
122_H	613_G	0.664	0.33
378_F	577_T	0.664	0.33
742_D	751_N	0.664	0.33
351_Q	380_Y	0.663	0.33
79_I	301_V	0.663	0.33
52_G	170_V	0.663	0.33
392_I	499_M	0.663	0.33
167_K	171_Q	0.662	0.33
740_S	753_S	0.660	0.33
709_L	716_Y	0.660	0.33
652_K	656_V	0.659	0.33
143_G	147_G	0.659	0.33
744_G	749_I	0.657	0.33
610_V	635_I	0.657	0.33
256_L	270_Y	0.657	0.33
300_F	304_V	0.657	0.33
751_N	754_A	0.656	0.33
557_T	561_Q	0.655	0.33
716_Y	725_L	0.655	0.33
170_V	173_V	0.652	0.32
424_K	483_Y	0.652	0.32
378_F	383_Q	0.652	0.32
511_T	535_S	0.651	0.32
714_V	718_K	0.651	0.32
546_M	656_V	0.650	0.32
708_K	714_V	0.649	0.32
601_G	640_I	0.648	0.32
388_P	493_G	0.647	0.32
755_K	759_I	0.646	0.32
118_R	132_G	0.645	0.32
597_S	612_T	0.644	0.32
459_G	463_A	0.644	0.32
749_I	757_A	0.643	0.32
725_L	729_Y	0.643	0.32
551_L	564_Q	0.642	0.32
753_S	758_V	0.642	0.32
101_D	534_K	0.641	0.32
752_S	756_E	0.641	0.32
152_Q	155_V	0.641	0.32
753_S	756_E	0.641	0.32
56_F	59_M	0.640	0.32
665_S	671_A	0.640	0.32
742_D	747_S	0.639	0.32
701_E	728_N	0.637	0.31
709_L	719_D	0.637	0.31
145_E	560_G	0.637	0.31
138_F	218_L	0.635	0.31
300_F	309_D	0.635	0.31
578_N	595_R	0.635	0.31
95_R	175_L	0.635	0.31
33_L	229_L	0.634	0.31
703_K	708_K	0.633	0.31
704_E	707_A	0.632	0.31
351_Q	371_R	0.632	0.31
391_T	614_M	0.632	0.31
337_E	642_D	0.631	0.31
199_S	212_F	0.631	0.31
489_G	492_D	0.630	0.31
594_A	629_Q	0.630	0.31
278_V	281_E	0.629	0.31
743_G	750_Q	0.628	0.31
301_V	609_A	0.628	0.31
307_E	636_F	0.628	0.31
400_P	493_G	0.628	0.31
46_V	50_V	0.626	0.31
717_D	730_D	0.626	0.31
720_N	723_L	0.625	0.31
130_I	173_V	0.624	0.31
386_A	614_M	0.623	0.30
711_G	724_T	0.623	0.30
721_Q	726_S	0.621	0.30
307_E	497_L	0.621	0.30
327_L	443_L	0.620	0.30
360_K	395_I	0.620	0.30
682_T	691_P	0.620	0.30
408_S	546_M	0.620	0.30
501_G	514_E	0.619	0.30
220_K	637_A	0.619	0.30
225_Q	676_P	0.619	0.30
214_G	501_G	0.617	0.30
324_Y	519_K	0.617	0.30
639_L	643_V	0.616	0.30
85_K	275_K	0.614	0.30
708_K	726_S	0.613	0.30
443_L	451_A	0.613	0.30
355_T	607_T	0.612	0.30
46_V	219_S	0.612	0.30
734_T	738_K	0.610	0.30
719_D	724_T	0.610	0.30
83_N	329_T	0.609	0.29
438_S	454_A	0.609	0.29
750_Q	754_A	0.609	0.29
705_E	718_K	0.608	0.29
733_A	743_G	0.607	0.29
670_L	691_P	0.606	0.29
454_A	543_T	0.606	0.29
79_I	629_Q	0.605	0.29
248_A	252_R	0.605	0.29
683_E	691_P	0.604	0.29
101_D	733_A	0.603	0.29
42_L	551_L	0.603	0.29
744_G	758_V	0.603	0.29
17_K	135_V	0.602	0.29
494_V	499_M	0.602	0.29
40_T	504_S	0.602	0.29
127_P	131_G	0.601	0.29
316_P	323_I	0.601	0.29
487_G	491_N	0.600	0.29
78_T	96_T	0.599	0.29
722_S	735_F	0.598	0.29
684_Y	689_T	0.598	0.29
116_D	613_G	0.598	0.29
721_Q	730_D	0.598	0.29
320_G	526_G	0.598	0.29
745_S	751_N	0.597	0.29
718_K	733_A	0.597	0.29
665_S	688_G	0.597	0.29
723_L	749_I	0.595	0.29
179_L	483_Y	0.594	0.28
101_D	135_V	0.594	0.28
205_I	233_P	0.593	0.28
748_E	753_S	0.593	0.28
437_I	483_Y	0.593	0.28
386_A	613_G	0.592	0.28
135_V	717_D	0.592	0.28
370_G	380_Y	0.592	0.28
335_L	339_M	0.591	0.28
382_T	452_L	0.591	0.28
719_D	726_S	0.591	0.28
244_N	301_V	0.591	0.28
404_N	466_F	0.590	0.28
268_S	754_A	0.590	0.28
421_S	578_N	0.589	0.28
199_S	232_M	0.589	0.28
599_F	640_I	0.589	0.28
727_W	735_F	0.588	0.28
741_V	749_I	0.588	0.28
670_L	683_E	0.587	0.28
244_N	365_R	0.587	0.28
711_G	727_W	0.587	0.28
741_V	751_N	0.586	0.28
178_Q	210_E	0.586	0.28
402_I	543_T	0.586	0.28
570_V	628_E	0.586	0.28
186_D	577_T	0.585	0.28
720_N	729_Y	0.585	0.28
300_F	321_L	0.584	0.28
303_E	307_E	0.584	0.28
170_V	210_E	0.584	0.28
685_F	696_K	0.583	0.28
734_T	744_G	0.583	0.28
452_L	471_G	0.583	0.28
228_T	252_R	0.583	0.28
553_T	603_T	0.582	0.28
736_A	748_E	0.582	0.28
420_Y	425_P	0.581	0.28
93_E	201_R	0.581	0.28
546_M	550_M	0.579	0.27
545_F	658_E	0.579	0.27
676_P	680_K	0.579	0.27
634_R	637_A	0.579	0.27
387_Q	488_F	0.579	0.27
104_P	129_R	0.578	0.27
53_A	266_S	0.578	0.27
563_A	570_V	0.577	0.27
64_P	95_R	0.577	0.27
45_F	67_D	0.577	0.27
232_M	237_T	0.576	0.27
690_A	694_V	0.576	0.27
466_F	543_T	0.574	0.27
739_Q	748_E	0.574	0.27
423_G	560_G	0.574	0.27
268_S	333_D	0.574	0.27
295_N	300_F	0.574	0.27
375_V	392_I	0.574	0.27
34_F	48_G	0.574	0.27
134_L	254_I	0.574	0.27
48_G	657_V	0.574	0.27
518_V	531_L	0.573	0.27
426_I	449_I	0.573	0.27
576_T	594_A	0.573	0.27
737_V	746_Y	0.572	0.27
198_F	233_P	0.572	0.27
548_T	650_F	0.571	0.27
512_Y	536_K	0.571	0.27
711_G	720_N	0.569	0.27
124_G	241_P	0.568	0.27
175_L	451_A	0.568	0.27
425_P	433_Y	0.567	0.27
397_D	487_G	0.567	0.27
73_T	195_R	0.567	0.27
220_K	618_E	0.567	0.27
126_D	248_A	0.566	0.27
702_E	707_A	0.565	0.27
551_L	612_T	0.565	0.27
47_L	323_I	0.565	0.27
656_V	684_Y	0.565	0.27
199_S	317_S	0.565	0.27
250_K	254_I	0.564	0.27
672_G	676_P	0.563	0.26
698_Y	703_K	0.563	0.26
138_F	179_L	0.563	0.26
213_F	281_E	0.563	0.26
109_E	260_K	0.563	0.26
121_E	209_A	0.562	0.26
415_D	433_Y	0.562	0.26
252_R	278_V	0.562	0.26
244_N	247_K	0.561	0.26
738_K	742_D	0.561	0.26
712_L	725_L	0.561	0.26
520_S	528_K	0.560	0.26
493_G	499_M	0.560	0.26
712_L	717_D	0.560	0.26
410_Y	691_P	0.559	0.26
684_Y	688_G	0.559	0.26
157_N	195_R	0.559	0.26
710_S	724_T	0.558	0.26
743_G	751_N	0.558	0.26
64_P	234_Q	0.558	0.26
356_L	365_R	0.558	0.26
96_T	207_K	0.557	0.26
736_A	746_Y	0.556	0.26
658_E	682_T	0.556	0.26
147_G	174_W	0.556	0.26
81_D	300_F	0.555	0.26
117_A	128_V	0.554	0.26
254_I	258_L	0.554	0.26
103_I	108_K	0.554	0.26
228_T	336_D	0.553	0.26
137_N	166_L	0.553	0.26
353_G	496_P	0.553	0.26
205_I	226_A	0.553	0.26
597_S	632_A	0.552	0.26
569_E	610_V	0.552	0.26
746_Y	754_A	0.552	0.26
396_L	467_A	0.551	0.26
706_T	714_V	0.551	0.26
155_V	172_E	0.551	0.26
354_V	610_V	0.551	0.26
173_V	198_F	0.550	0.26
266_S	709_L	0.550	0.26
139_K	328_D	0.550	0.26
220_K	307_E	0.549	0.26
77_S	397_D	0.549	0.26
482_A	485_I	0.549	0.26
487_G	535_S	0.549	0.26
193_L	196_I	0.548	0.26
82_K	329_T	0.547	0.25
429_W	447_R	0.546	0.25
193_L	630_K	0.546	0.25
384_T	495_S	0.546	0.25
500_A	600_V	0.546	0.25
429_W	444_A	0.546	0.25
97_Y	532_T	0.545	0.25
33_L	36_K	0.545	0.25
665_S	670_L	0.545	0.25
197_Y	203_Y	0.545	0.25
395_I	501_G	0.545	0.25
50_V	62_D	0.544	0.25
737_V	757_A	0.543	0.25
552_K	555_V	0.543	0.25
34_F	106_V	0.542	0.25
103_I	427_R	0.542	0.25
610_V	632_A	0.541	0.25
156_K	162_H	0.541	0.25
361_N	365_R	0.541	0.25
672_G	691_P	0.541	0.25
415_D	613_G	0.540	0.25
671_A	683_E	0.539	0.25
562_L	633_K	0.538	0.25
100_I	189_L	0.538	0.25
433_Y	452_L	0.537	0.25
21_S	399_G	0.537	0.25
212_F	332_Q	0.536	0.25
53_A	57_A	0.536	0.25
705_E	712_L	0.535	0.25
263_G	534_K	0.535	0.25
391_T	471_G	0.534	0.25
170_V	202_A	0.534	0.25
261_K	505_A	0.533	0.25
429_W	551_L	0.533	0.25
114_T	262_Q	0.533	0.25
40_T	472_L	0.532	0.25
246_D	428_D	0.532	0.25
114_T	296_K	0.532	0.25
698_Y	701_E	0.532	0.25
659_A	665_S	0.532	0.25
101_D	468_N	0.530	0.24
434_L	449_I	0.530	0.24
403_E	610_V	0.530	0.24
40_T	44_L	0.529	0.24
671_A	674_N	0.529	0.24
303_E	364_V	0.529	0.24
467_A	497_L	0.529	0.24
711_G	717_D	0.529	0.24
341_G	345_G	0.528	0.24
101_D	222_T	0.527	0.24
63_A	66_L	0.527	0.24
745_S	749_I	0.527	0.24
417_A	433_Y	0.526	0.24
79_I	88_A	0.526	0.24
137_N	143_G	0.526	0.24
231_G	247_K	0.525	0.24
103_I	220_K	0.525	0.24
224_E	426_I	0.525	0.24
740_S	748_E	0.525	0.24
407_W	539_M	0.524	0.24
417_A	656_V	0.524	0.24
415_D	653_P	0.524	0.24
215_V	220_K	0.523	0.24
751_N	756_E	0.523	0.24
372_N	429_W	0.523	0.24
434_L	441_Y	0.523	0.24
176_S	342_D	0.522	0.24
101_D	279_K	0.522	0.24
198_F	245_P	0.522	0.24
670_L	694_V	0.522	0.24
354_V	643_V	0.522	0.24
481_E	485_I	0.521	0.24
137_N	409_T	0.521	0.24
112_I	142_F	0.521	0.24
743_G	749_I	0.521	0.24
706_T	709_L	0.521	0.24
111_F	196_I	0.521	0.24
714_V	717_D	0.520	0.24
464_V	472_L	0.520	0.24
138_F	754_A	0.520	0.24
687_K	690_A	0.520	0.24
108_K	189_L	0.520	0.24
720_N	725_L	0.519	0.24
490_G	617_N	0.519	0.24
754_A	758_V	0.519	0.24
247_K	250_K	0.519	0.24
742_D	754_A	0.519	0.24
410_Y	683_E	0.518	0.24
703_K	710_S	0.518	0.24
45_F	325_T	0.518	0.24
688_G	691_P	0.518	0.24
396_L	486_G	0.518	0.24
749_I	759_I	0.517	0.24
732_D	748_E	0.516	0.24
319_D	639_L	0.516	0.24
752_S	757_A	0.516	0.24
746_Y	756_E	0.515	0.24
312_S	316_P	0.515	0.24
113_A	157_N	0.515	0.24
692_S	725_L	0.514	0.23
38_L	713_N	0.514	0.23
743_G	748_E	0.514	0.23
712_L	728_N	0.514	0.23
243_K	248_A	0.514	0.23
171_Q	174_W	0.513	0.23
101_D	753_S	0.513	0.23
659_A	685_F	0.513	0.23
699_E	725_L	0.512	0.23
110_A	259_M	0.512	0.23
350_M	612_T	0.512	0.23
333_D	337_E	0.512	0.23
409_T	656_V	0.512	0.23
238_A	247_K	0.512	0.23
86_E	322_K	0.511	0.23
132_G	316_P	0.511	0.23
266_S	509_N	0.511	0.23
82_K	229_L	0.511	0.23
107_V	223_V	0.510	0.23
751_N	759_I	0.510	0.23
201_R	367_I	0.510	0.23
152_Q	526_G	0.510	0.23
748_E	751_N	0.510	0.23
547_I	602_Y	0.509	0.23
455_F	470_L	0.509	0.23
717_D	726_S	0.508	0.23
103_I	304_V	0.508	0.23
733_A	738_K	0.508	0.23
472_L	519_K	0.508	0.23
40_T	43_I	0.507	0.23
177_I	269_Q	0.506	0.23
230_A	471_G	0.505	0.23
74_P	560_G	0.505	0.23
330_K	465_D	0.505	0.23
513_N	533_P	0.505	0.23
452_L	487_G	0.504	0.23
96_T	210_E	0.504	0.23
713_N	717_D	0.504	0.23
742_D	750_Q	0.504	0.23
98_V	123_H	0.503	0.23
276_V	496_P	0.503	0.23
708_K	720_N	0.503	0.23
359_T	396_L	0.502	0.23
665_S	703_K	0.502	0.23
711_G	721_Q	0.502	0.23
175_L	230_A	0.501	0.23
423_G	456_Q	0.501	0.23
751_N	755_K	0.501	0.23
50_V	58_V	0.501	0.23
467_A	501_G	0.500	0.23
709_L	715_K	0.500	0.23
381_A	438_S	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4oonA	1	0.4158	100	0.341	Contact Map
2jchA	1	0.4551	100	0.353	Contact Map
3vmaA	1	0.6543	100	0.374	Contact Map
3udfA	2	0.5284	100	0.39	Contact Map
2olvA	1	0.6532	100	0.392	Contact Map
3zg9B	1	0.4869	100	0.538	Contact Map
2y2mA	2	0.488	100	0.649	Contact Map
2v2fF	1	0.3862	100	0.705	Contact Map
3un7A	1	0.3972	100	0.714	Contact Map
2oqoA	2	0.198	100	0.723	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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