GREMLIN Database
RECU - Holliday junction resolvase RecU
UniProt: P39792 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 206 (168)
Sequences: 776 (541)
Seq/√Len: 41.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_N189_Y4.3031.00
118_D122_E3.6961.00
143_Q178_P3.5991.00
143_Q169_K3.5901.00
35_L137_I3.1941.00
116_F136_V3.0991.00
63_I81_F2.9221.00
188_D191_S2.8201.00
39_L137_I2.7561.00
50_Q129_A2.6261.00
138_I172_L2.5771.00
125_K157_D2.5181.00
47_L126_Q2.4741.00
141_F169_K2.4421.00
168_R171_E2.4201.00
125_K153_F2.3901.00
40_N89_Y2.3341.00
158_R171_E2.0450.99
143_Q173_E2.0140.99
148_E151_K2.0120.99
147_L152_L1.9820.99
96_R197_Y1.9500.99
93_Y194_E1.9340.99
128_K153_F1.8760.99
87_T99_D1.8400.98
158_R168_R1.8040.98
54_I98_I1.7420.98
134_C149_A1.6940.97
151_K154_Y1.6490.97
149_A153_F1.6260.96
50_Q126_Q1.6220.96
128_K150_D1.6090.96
171_E175_T1.5980.96
144_V187_I1.5940.96
148_E177_Y1.5900.96
145_Y178_P1.5710.95
124_M149_A1.5710.95
164_R168_R1.5640.95
156_W163_G1.5530.95
38_D186_R1.5520.95
177_Y192_I1.5320.95
106_K140_A1.4910.94
141_F145_Y1.4850.94
99_D123_H1.4420.93
125_K129_A1.4160.92
101_E136_V1.4150.92
94_K194_E1.3990.92
122_E125_K1.3970.92
50_Q130_Q1.3910.92
179_I192_I1.3820.91
168_R172_L1.3740.91
62_Q82_K1.3630.91
39_L102_A1.3540.90
108_K141_F1.3530.90
87_T123_H1.3170.89
124_M134_C1.3070.89
147_L151_K1.2960.88
118_D160_E1.2760.88
153_F157_D1.2570.87
42_T185_P1.2220.85
128_K149_A1.2110.85
169_K178_P1.2060.84
64_V84_S1.1840.83
47_L53_V1.1830.83
113_L155_F1.1740.83
111_F138_I1.1370.81
64_V80_Y1.1300.80
169_K173_E1.1200.80
122_E126_Q1.1090.79
38_D144_V1.0690.76
179_I188_D1.0610.76
108_K140_A1.0350.74
137_I179_I1.0320.74
44_K48_T1.0140.72
67_H77_K1.0110.72
182_G185_P0.9940.71
51_I94_K0.9560.68
94_K130_Q0.9540.68
51_I190_I0.9470.67
54_I190_I0.9440.67
54_I189_Y0.9410.67
34_T38_D0.9380.66
62_Q69_P0.9350.66
53_V130_Q0.9220.65
57_K90_N0.9130.64
98_I133_I0.9070.64
53_V127_V0.9030.63
151_K175_T0.8940.63
41_E44_K0.8930.63
144_V169_K0.8910.62
65_N77_K0.8840.62
137_I193_I0.8730.61
61_V76_I0.8700.61
177_Y195_Q0.8680.60
47_L55_H0.8670.60
35_L179_I0.8630.60
28_Y31_R0.8580.59
160_E195_Q0.8530.59
49_N184_A0.8510.59
97_Y123_H0.8370.58
113_L156_W0.8270.57
128_K148_E0.8240.56
148_E197_Y0.8210.56
116_F138_I0.8110.55
65_N82_K0.8090.55
92_I130_Q0.8030.54
151_K155_F0.7970.54
35_L142_D0.7930.53
121_I152_L0.7920.53
42_T192_I0.7720.52
121_I156_W0.7700.51
98_I193_I0.7700.51
112_P115_N0.7670.51
81_F117_H0.7580.50
147_L176_A0.7510.50
147_L171_E0.7490.49
28_Y39_L0.7450.49
62_Q80_Y0.7450.49
78_E99_D0.7420.49
170_D173_E0.7410.49
182_G191_S0.7360.48
64_V79_A0.7350.48
75_V134_C0.7340.48
57_K86_T0.7330.48
192_I195_Q0.7300.48
144_V178_P0.7280.47
85_S119_H0.7270.47
158_R162_N0.7250.47
50_Q65_N0.7250.47
66_V90_N0.7220.47
118_D150_D0.7170.46
66_V78_E0.7090.46
49_N131_D0.7070.45
57_K123_H0.7070.45
58_P117_H0.7040.45
136_V172_L0.7030.45
163_G166_S0.7000.45
87_T97_Y0.6870.44
72_S75_V0.6860.43
179_I191_S0.6820.43
122_E160_E0.6820.43
76_I80_Y0.6810.43
148_E196_L0.6780.43
122_E131_D0.6750.42
42_T127_V0.6750.42
38_D197_Y0.6740.42
45_Y185_P0.6690.42
49_N154_Y0.6680.42
39_L169_K0.6670.42
155_F175_T0.6660.42
55_H90_N0.6640.41
158_R163_G0.6630.41
160_E180_S0.6620.41
98_I136_V0.6610.41
40_N61_V0.6610.41
170_D174_E0.6610.41
31_R102_A0.6610.41
106_K139_S0.6600.41
61_V84_S0.6590.41
182_G187_I0.6560.41
35_L187_I0.6550.41
127_V134_C0.6490.40
144_V179_I0.6470.40
182_G188_D0.6400.39
76_I79_A0.6400.39
92_I127_V0.6400.39
26_P50_Q0.6380.39
48_T182_G0.6360.39
183_Y186_R0.6360.39
30_N183_Y0.6350.39
155_F171_E0.6320.39
177_Y197_Y0.6300.38
59_T81_F0.6250.38
157_D161_K0.6250.38
186_R197_Y0.6230.38
63_I97_Y0.6220.38
28_Y124_M0.6210.38
26_P29_S0.6180.37
77_K81_F0.6160.37
71_R75_V0.6140.37
26_P136_V0.6070.36
43_N54_I0.6050.36
144_V181_L0.6050.36
148_E191_S0.6040.36
32_G36_E0.6020.36
121_I136_V0.6000.36
93_Y127_V0.6000.36
75_V78_E0.5930.35
90_N123_H0.5930.35
114_Q128_K0.5910.35
81_F104_E0.5860.35
161_K187_I0.5830.34
30_N59_T0.5820.34
142_D160_E0.5800.34
35_L104_E0.5800.34
104_E117_H0.5800.34
89_Y102_A0.5790.34
64_V71_R0.5790.34
61_V79_A0.5780.34
112_P166_S0.5770.34
26_P131_D0.5760.34
181_L185_P0.5750.34
86_T119_H0.5720.33
53_V126_Q0.5700.33
154_Y161_K0.5690.33
152_L181_L0.5680.33
169_K185_P0.5680.33
57_K66_V0.5660.33
48_T195_Q0.5650.33
33_M59_T0.5630.33
85_S123_H0.5610.33
138_I174_E0.5600.32
140_A174_E0.5600.32
122_E154_Y0.5590.32
31_R115_N0.5580.32
57_K85_S0.5460.31
116_F157_D0.5460.31
92_I131_D0.5450.31
65_N170_D0.5450.31
172_L176_A0.5440.31
70_K124_M0.5420.31
154_Y174_E0.5400.31
87_T90_N0.5400.31
137_I147_L0.5370.31
122_E141_F0.5350.30
44_K153_F0.5330.30
57_K84_S0.5320.30
142_D195_Q0.5280.30
121_I149_A0.5280.30
64_V112_P0.5250.30
54_I92_I0.5240.30
96_R195_Q0.5240.30
59_T85_S0.5220.29
45_Y49_N0.5210.29
55_H124_M0.5210.29
34_T48_T0.5190.29
58_P79_A0.5190.29
70_K84_S0.5170.29
44_K126_Q0.5170.29
170_D191_S0.5140.29
29_S137_I0.5140.29
64_V81_F0.5130.29
158_R174_E0.5130.29
90_N99_D0.5120.29
184_A196_L0.5120.29
101_E197_Y0.5100.28
31_R119_H0.5100.28
92_I195_Q0.5080.28
160_E191_S0.5080.28
128_K196_L0.5070.28
59_T86_T0.5050.28
62_Q87_T0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zp7A 2 0.7621 100 0.079 Contact Map
2fcoA 2 0.7476 100 0.107 Contact Map
4qbnA 2 0.4466 61.9 0.945 Contact Map
2wcwA 2 0.6165 59.5 0.946 Contact Map
4qboA 2 0.4417 46 0.95 Contact Map
2eo0A 2 0.6019 30.5 0.955 Contact Map
1hh1A 2 0.5583 29.1 0.956 Contact Map
2bykB 1 0.4466 26.8 0.956 Contact Map
1ob8A 1 0.5922 26.6 0.956 Contact Map
4csrA 1 0.4272 14.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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