GREMLIN Database
YPPC - Uncharacterized protein YppC
UniProt: P39791 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (307)
Sequences: 200 (169)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_R104_H4.9521.00
50_A100_L4.4990.99
117_L122_V4.0840.99
152_N205_A4.0520.99
106_S114_F3.7540.98
114_F134_W3.6700.97
155_Q160_Q3.1750.94
50_A154_I3.1270.94
224_L228_F3.0220.92
106_S112_P2.9090.91
37_F44_I2.9070.91
52_F232_L2.9010.91
13_L120_F2.7910.89
88_A185_V2.6390.86
238_T243_D2.4760.82
106_S134_W2.3680.79
100_L154_I2.2930.76
126_M133_F2.2650.75
88_A231_F2.2370.74
41_H104_H2.2230.74
106_S115_H2.1920.73
85_Y157_P2.1910.73
48_L52_F2.1640.72
59_W66_G2.1590.72
50_A199_V2.1310.71
26_D259_R2.1260.70
74_R288_R2.0970.69
172_I308_L2.0860.69
52_F187_F2.0570.68
105_W109_V1.9870.65
96_A146_L1.9810.65
112_P134_W1.9640.64
90_W267_H1.9290.63
59_W301_Y1.9070.62
148_I159_I1.8950.61
45_K139_T1.8340.58
182_F307_Q1.8200.58
107_K218_L1.8010.57
145_A275_D1.7980.57
50_A96_A1.7870.56
35_K51_S1.7770.56
148_I278_H1.7570.55
39_D233_H1.7540.55
129_E141_R1.7470.55
26_D264_E1.7420.54
66_G70_Q1.7330.54
44_I90_W1.7120.53
50_A147_I1.6770.52
148_I152_N1.6750.51
13_L296_E1.6160.49
231_F304_K1.6070.48
154_I158_I1.6040.48
177_S237_H1.5860.47
45_K57_A1.5850.47
23_K33_A1.5530.46
52_F244_M1.5360.45
21_K47_S1.5290.45
10_R162_P1.5250.45
237_H243_D1.5120.44
105_W180_F1.4960.43
23_K218_L1.4750.42
177_S200_K1.4730.42
102_L174_F1.4710.42
68_L312_F1.4600.42
38_Y244_M1.4470.41
37_F134_W1.4430.41
112_P218_L1.4410.41
14_S74_R1.4340.41
145_A186_I1.4320.41
308_L312_F1.4080.40
62_T258_L1.4070.40
51_S262_Y1.4030.39
245_E262_Y1.3750.38
70_Q78_Q1.3730.38
51_S305_K1.3710.38
32_N35_K1.3700.38
157_P245_E1.3700.38
48_L232_L1.3680.38
72_G311_L1.3620.38
52_F228_F1.3500.37
112_P115_H1.3420.37
85_Y262_Y1.3320.36
114_F120_F1.3290.36
305_K309_H1.3270.36
13_L107_K1.3260.36
100_L147_I1.3000.35
25_A264_E1.2940.35
198_S304_K1.2900.35
50_A152_N1.2790.34
96_A147_I1.2640.34
147_I154_I1.2550.33
37_F104_H1.2300.32
65_K261_C1.2260.32
48_L120_F1.2130.32
108_R201_R1.2080.31
112_P131_T1.1980.31
29_S57_A1.1940.31
87_R91_L1.1940.31
106_S120_F1.1910.31
49_L215_L1.1890.31
59_W70_Q1.1750.30
200_K211_L1.1750.30
48_L248_I1.1550.29
8_A137_R1.1530.29
23_K191_N1.1450.29
29_S143_M1.1250.28
226_S268_S1.1230.28
17_E159_I1.1220.28
181_H198_S1.1200.28
104_H122_V1.1170.28
29_S259_R1.1160.28
104_H107_K1.1150.28
90_W169_F1.1100.28
65_K78_Q1.1010.27
75_E164_F1.0990.27
115_H235_V1.0990.27
68_L78_Q1.0930.27
111_K137_R1.0920.27
60_S183_N1.0920.27
171_T214_Q1.0910.27
107_K135_H1.0910.27
26_D189_S1.0740.26
32_N236_P1.0730.26
216_S255_S1.0670.26
167_N248_I1.0640.26
51_S216_S1.0550.26
26_D57_A1.0530.26
44_I267_H1.0490.26
44_I292_P1.0470.25
220_F256_P1.0450.25
187_F228_F1.0370.25
255_S262_Y1.0360.25
36_A205_A1.0350.25
104_H261_C1.0340.25
199_V243_D1.0230.25
84_A211_L1.0170.24
48_L177_S1.0160.24
68_L169_F1.0150.24
97_Y135_H1.0080.24
85_Y88_A1.0070.24
16_I47_S1.0040.24
12_L28_I1.0000.24
70_Q108_R0.9990.24
62_T296_E0.9920.24
107_K230_H0.9890.24
84_A189_S0.9880.24
45_K216_S0.9870.23
51_S245_E0.9860.23
85_Y185_V0.9850.23
57_A199_V0.9810.23
100_L199_V0.9800.23
48_L201_R0.9800.23
8_A144_Y0.9790.23
157_P262_Y0.9780.23
45_K262_Y0.9770.23
245_E255_S0.9770.23
153_T157_P0.9660.23
164_F168_V0.9640.23
68_L218_L0.9640.23
41_H107_K0.9600.23
100_L146_L0.9580.23
157_P184_T0.9550.22
85_Y216_S0.9550.22
14_S236_P0.9480.22
66_G301_Y0.9470.22
216_S249_G0.9460.22
161_N174_F0.9440.22
73_L104_H0.9430.22
104_H218_L0.9390.22
83_L164_F0.9380.22
162_P223_E0.9370.22
85_Y246_K0.9340.22
113_L237_H0.9340.22
87_R162_P0.9330.22
38_Y171_T0.9270.22
8_A218_L0.9230.21
186_I222_P0.9230.21
243_D258_L0.9200.21
245_E304_K0.9190.21
66_G174_F0.9170.21
181_H211_L0.9160.21
84_A153_T0.9140.21
43_E133_F0.9130.21
195_Y231_F0.9100.21
81_F231_F0.9060.21
39_D170_D0.9030.21
180_F301_Y0.9020.21
94_S98_P0.8980.21
229_Y263_P0.8970.21
104_H117_L0.8950.21
71_L309_H0.8890.20
141_R181_H0.8890.20
107_K197_I0.8870.20
26_D84_A0.8840.20
164_F313_A0.8760.20
12_L40_R0.8740.20
111_K186_I0.8720.20
13_L115_H0.8700.20
210_R214_Q0.8690.20
110_G268_S0.8690.20
74_R79_K0.8650.20
102_L270_D0.8590.20
136_E173_P0.8580.20
29_S225_F0.8570.20
41_H111_K0.8560.20
57_A211_L0.8560.20
242_F251_T0.8520.19
94_S153_T0.8510.19
90_W186_I0.8510.19
186_I277_F0.8500.19
94_S270_D0.8440.19
126_M275_D0.8430.19
51_S157_P0.8420.19
29_S244_M0.8390.19
259_R267_H0.8340.19
253_R280_K0.8280.19
192_G228_F0.8240.19
84_A245_E0.8240.19
48_L224_L0.8240.19
186_I282_K0.8240.19
44_I159_I0.8230.19
142_L209_I0.8210.19
45_K171_T0.8210.19
59_W286_F0.8200.19
215_L232_L0.8180.18
176_L307_Q0.8150.18
181_H307_Q0.8140.18
51_S249_G0.8090.18
84_A262_Y0.8050.18
300_W307_Q0.8040.18
14_S18_R0.8030.18
90_W181_H0.8010.18
182_F214_Q0.8010.18
10_R186_I0.8010.18
111_K170_D0.7990.18
297_L311_L0.7980.18
44_I129_E0.7950.18
216_S262_Y0.7930.18
12_L21_K0.7930.18
94_S143_M0.7870.18
38_Y199_V0.7860.18
41_H168_V0.7830.18
170_D303_H0.7790.17
181_H200_K0.7790.17
73_L82_F0.7790.17
186_I315_E0.7780.17
26_D262_Y0.7760.17
51_S85_Y0.7750.17
132_R137_R0.7740.17
156_T292_P0.7730.17
122_V273_K0.7720.17
147_I223_E0.7700.17
249_G262_Y0.7680.17
176_L184_T0.7670.17
62_T255_S0.7670.17
200_K224_L0.7660.17
157_P255_S0.7650.17
25_A204_K0.7630.17
37_F267_H0.7610.17
28_I187_F0.7590.17
174_F235_V0.7570.17
10_R206_E0.7560.17
101_L113_L0.7540.17
25_A128_E0.7530.17
20_T36_A0.7520.17
10_R277_F0.7520.17
157_P216_S0.7500.17
165_K310_A0.7450.17
138_N251_T0.7440.17
218_L277_F0.7400.16
79_K182_F0.7380.16
61_M243_D0.7380.16
85_Y305_K0.7370.16
229_Y266_I0.7340.16
136_E172_I0.7330.16
177_S189_S0.7330.16
157_P285_F0.7300.16
59_W239_G0.7270.16
291_L301_Y0.7270.16
82_F113_L0.7270.16
51_S118_H0.7260.16
202_F212_G0.7230.16
104_H177_S0.7190.16
225_F284_T0.7180.16
27_N30_R0.7170.16
27_N34_Y0.7170.16
30_R34_Y0.7170.16
78_Q229_Y0.7140.16
156_T228_F0.7090.16
75_E233_H0.7090.16
82_F180_F0.7080.16
96_A100_L0.7070.16
265_L282_K0.7070.16
285_F310_A0.7050.16
21_K111_K0.7050.16
182_F300_W0.7030.16
218_L289_E0.7000.15
148_I273_K0.7000.15
90_W304_K0.6990.15
309_H312_F0.6990.15
216_S264_E0.6980.15
181_H300_W0.6970.15
72_G315_E0.6960.15
216_S245_E0.6950.15
154_I197_I0.6920.15
181_H304_K0.6910.15
87_R153_T0.6900.15
37_F41_H0.6900.15
194_F220_F0.6850.15
36_A162_P0.6840.15
154_I176_L0.6820.15
97_Y110_G0.6800.15
35_K232_L0.6780.15
32_N36_A0.6780.15
189_S216_S0.6760.15
84_A157_P0.6750.15
19_Q135_H0.6700.15
75_E290_E0.6680.15
50_A88_A0.6660.15
26_D82_F0.6650.15
88_A222_P0.6610.15
44_I186_I0.6570.14
17_E189_S0.6570.14
302_L311_L0.6560.14
18_R156_T0.6510.14
105_W108_R0.6510.14
195_Y228_F0.6500.14
9_I48_L0.6470.14
57_A96_A0.6460.14
172_I186_I0.6450.14
82_F238_T0.6420.14
124_Q137_R0.6420.14
70_Q204_K0.6420.14
81_F304_K0.6410.14
48_L110_G0.6400.14
25_A139_T0.6400.14
66_G255_S0.6400.14
62_T107_K0.6390.14
230_H293_K0.6370.14
145_A162_P0.6360.14
170_D203_S0.6350.14
182_F298_T0.6350.14
26_D51_S0.6340.14
23_K35_K0.6340.14
90_W141_R0.6330.14
66_G298_T0.6310.14
22_M29_S0.6310.14
246_K314_V0.6290.14
36_A137_R0.6290.14
129_E189_S0.6280.14
123_S275_D0.6280.14
17_E132_R0.6250.14
8_A296_E0.6230.14
232_L246_K0.6230.14
120_F148_I0.6170.14
166_K213_K0.6170.14
37_F167_N0.6160.14
201_R207_E0.6160.14
233_H248_I0.6160.14
129_E245_E0.6150.14
241_R276_W0.6100.13
87_R123_S0.6080.13
240_S256_P0.6060.13
248_I308_L0.6050.13
76_R204_K0.6030.13
197_I214_Q0.6020.13
198_S305_K0.6000.13
73_L164_F0.5990.13
270_D281_I0.5990.13
198_S224_L0.5990.13
112_P182_F0.5980.13
300_W303_H0.5970.13
70_Q174_F0.5960.13
185_V306_R0.5930.13
250_I264_E0.5920.13
192_G300_W0.5910.13
270_D273_K0.5900.13
68_L193_F0.5890.13
231_F298_T0.5880.13
110_G292_P0.5870.13
18_R170_D0.5860.13
51_S304_K0.5860.13
69_F180_F0.5840.13
91_L102_L0.5840.13
94_S176_L0.5800.13
248_I251_T0.5800.13
41_H80_W0.5780.13
31_T34_Y0.5780.13
27_N31_T0.5780.13
181_H298_T0.5780.13
102_L165_K0.5760.13
11_K97_Y0.5740.13
12_L135_H0.5740.13
112_P223_E0.5730.13
135_H242_F0.5730.13
82_F243_D0.5720.13
137_R142_L0.5720.13
146_L177_S0.5720.13
15_R19_Q0.5690.13
36_A118_H0.5680.13
187_F244_M0.5660.13
16_I20_T0.5640.13
159_I178_D0.5630.13
145_A286_F0.5620.12
38_Y286_F0.5620.12
40_R298_T0.5620.12
252_K314_V0.5620.12
82_F177_S0.5610.12
23_K97_Y0.5600.12
295_I305_K0.5580.12
174_F237_H0.5580.12
87_R161_N0.5560.12
185_V304_K0.5560.12
178_D187_F0.5550.12
12_L16_I0.5530.12
51_S195_Y0.5530.12
20_T301_Y0.5530.12
13_L190_S0.5460.12
185_V231_F0.5450.12
178_D301_Y0.5450.12
88_A263_P0.5430.12
137_R194_F0.5400.12
67_S142_L0.5390.12
246_K262_Y0.5380.12
45_K128_E0.5370.12
71_L120_F0.5370.12
166_K201_R0.5360.12
138_N277_F0.5350.12
183_N297_L0.5350.12
68_L158_I0.5350.12
194_F217_Q0.5340.12
37_F200_K0.5340.12
72_G186_I0.5340.12
69_F217_Q0.5310.12
211_L300_W0.5310.12
157_P246_K0.5300.12
14_S39_D0.5290.12
37_F301_Y0.5280.12
158_I256_P0.5280.12
107_K113_L0.5260.12
148_I205_A0.5250.12
13_L248_I0.5230.12
232_L240_S0.5230.12
13_L39_D0.5200.12
82_F271_G0.5180.12
157_P264_E0.5180.12
152_N282_K0.5180.12
81_F145_A0.5170.12
221_K267_H0.5160.12
19_Q112_P0.5160.12
10_R81_F0.5140.12
143_M216_S0.5140.12
74_R281_I0.5110.12
206_E285_F0.5100.12
69_F199_V0.5100.12
10_R40_R0.5080.11
236_P286_F0.5050.11
50_A143_M0.5030.11
302_L305_K0.5010.11
286_F296_E0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t06A 1 0.1375 9.6 0.983 Contact Map
2y9mA 1 0.1812 9.3 0.983 Contact Map
3wctA 2 0.3906 6.3 0.984 Contact Map
3g46A 2 0.3781 5.3 0.985 Contact Map
2dt7B 1 0.2469 5.1 0.985 Contact Map
3upsA 2 0.2094 4.3 0.985 Contact Map
2zs0A 2 0.3719 4.2 0.985 Contact Map
1ow5A 1 0.0625 3.7 0.986 Contact Map
3wctB 3 0.3875 3.6 0.986 Contact Map
4lctA 2 0.2156 3.3 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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