MPR - BACSU - GREMLIN Contacts

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MPR - Extracellular metalloprotease

UniProt:	P39790	Sequences: MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSNTGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERTRISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTITAAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTNSSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYSDTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	313 (245)
Sequences:	1339 (1042)
Seq/√Len:	66.6

ECOLI - YDGD
BACSU - MPR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
227_S	273_R	6.869	1.00
133_G	141_V	5.236	1.00
135_L	205_P	5.012	1.00
142_V	282_A	3.829	1.00
140_T	198_A	3.678	1.00
178_T	200_K	3.443	1.00
115_T	129_Y	3.278	1.00
163_P	205_P	3.098	1.00
134_F	214_Y	2.998	1.00
173_G	211_W	2.977	1.00
162_A	174_T	2.923	1.00
143_T	148_V	2.825	1.00
131_C	147_C	2.477	1.00
113_R	230_T	2.468	1.00
261_D	294_N	2.457	1.00
114_A	163_P	2.438	1.00
230_T	272_Y	2.388	1.00
134_F	282_A	2.353	1.00
184_K	310_W	2.312	1.00
255_K	288_N	2.286	1.00
214_Y	272_Y	2.279	1.00
214_Y	282_A	2.165	1.00
148_V	197_G	2.156	1.00
261_D	296_G	2.137	1.00
229_V	262_T	2.133	1.00
194_Y	303_V	2.119	1.00
229_V	286_H	2.098	1.00
146_H	267_S	2.014	1.00
193_N	254_Y	1.854	1.00
135_L	163_P	1.827	1.00
135_L	141_V	1.812	1.00
161_A	177_G	1.808	1.00
110_F	280_Q	1.801	1.00
114_A	133_G	1.782	1.00
117_Q	129_Y	1.713	1.00
193_N	252_E	1.645	0.99
114_A	141_V	1.624	0.99
146_H	286_H	1.616	0.99
179_M	200_K	1.592	0.99
140_T	200_K	1.581	0.99
176_S	202_N	1.559	0.99
112_Y	215_R	1.539	0.99
262_T	294_N	1.527	0.99
139_N	204_S	1.505	0.99
110_F	230_T	1.486	0.99
177_G	199_I	1.468	0.98
66_Y	69_T	1.446	0.98
59_A	63_S	1.441	0.98
261_D	289_G	1.423	0.98
162_A	165_R	1.414	0.98
144_A	285_I	1.408	0.98
143_T	197_G	1.383	0.98
163_P	211_W	1.378	0.98
50_D	53_K	1.375	0.98
146_H	289_G	1.371	0.98
161_A	199_I	1.364	0.97
55_Q	61_Q	1.335	0.97
183_V	194_Y	1.327	0.97
262_T	286_H	1.325	0.97
181_Y	310_W	1.311	0.97
227_S	283_I	1.311	0.97
178_T	202_N	1.303	0.97
56_T	59_A	1.299	0.97
304_F	308_Q	1.274	0.96
175_Y	202_N	1.268	0.96
134_F	285_I	1.252	0.96
53_K	57_S	1.251	0.96
254_Y	303_V	1.250	0.96
256_L	271_V	1.246	0.96
227_S	293_Y	1.233	0.95
117_Q	168_S	1.226	0.95
288_N	295_L	1.216	0.95
108_T	210_G	1.203	0.95
289_G	296_G	1.201	0.95
93_S	96_I	1.201	0.95
148_V	180_F	1.199	0.95
144_A	267_S	1.194	0.95
58_K	61_Q	1.194	0.95
194_Y	254_Y	1.191	0.94
165_R	172_Y	1.189	0.94
254_Y	301_N	1.188	0.94
69_T	72_T	1.184	0.94
201_L	205_P	1.183	0.94
80_Q	83_L	1.179	0.94
286_H	289_G	1.177	0.94
50_D	55_Q	1.152	0.93
55_Q	59_A	1.150	0.93
258_Y	294_N	1.142	0.93
132_T	269_S	1.120	0.92
272_Y	288_N	1.115	0.92
138_P	207_N	1.106	0.92
144_A	269_S	1.105	0.92
196_Y	303_V	1.104	0.92
196_Y	297_T	1.096	0.92
243_S	298_R	1.095	0.92
261_D	264_G	1.091	0.91
139_N	200_K	1.088	0.91
116_V	161_A	1.072	0.91
252_E	255_K	1.054	0.90
135_L	207_N	1.050	0.90
94_S	97_G	1.047	0.90
65_P	73_S	1.047	0.90
215_R	280_Q	1.038	0.89
108_T	166_N	1.035	0.89
112_Y	280_Q	1.033	0.89
68_G	72_T	1.029	0.89
137_N	140_T	1.028	0.89
250_S	292_S	1.028	0.89
55_Q	58_K	1.027	0.89
285_I	297_T	1.026	0.89
207_N	213_G	1.021	0.88
141_V	201_L	1.020	0.88
241_M	293_Y	1.014	0.88
229_V	260_T	1.013	0.88
297_T	303_V	1.013	0.88
61_Q	64_A	1.010	0.88
51_A	57_S	1.004	0.88
82_E	85_K	1.002	0.88
59_A	62_V	0.999	0.87
175_Y	205_P	0.983	0.87
95_I	239_G	0.982	0.86
146_H	195_D	0.976	0.86
113_R	132_T	0.972	0.86
267_S	289_G	0.966	0.86
52_T	57_S	0.961	0.85
53_K	56_T	0.960	0.85
132_T	233_P	0.959	0.85
58_K	62_V	0.941	0.84
236_K	259_T	0.933	0.84
70_G	74_K	0.933	0.84
61_Q	76_L	0.932	0.83
65_P	68_G	0.924	0.83
97_G	269_S	0.917	0.82
54_N	58_K	0.917	0.82
146_H	265_C	0.916	0.82
55_Q	60_D	0.915	0.82
222_P	227_S	0.914	0.82
132_T	146_H	0.909	0.82
113_R	272_Y	0.902	0.81
113_R	270_P	0.902	0.81
159_I	199_I	0.893	0.81
59_A	64_A	0.892	0.81
236_K	239_G	0.876	0.79
146_H	269_S	0.876	0.79
67_E	70_G	0.870	0.79
67_E	71_K	0.870	0.79
56_T	60_D	0.868	0.79
141_V	161_A	0.867	0.79
79_G	82_E	0.865	0.79
72_T	81_T	0.865	0.79
112_Y	217_T	0.859	0.78
264_G	294_N	0.855	0.78
50_D	60_D	0.852	0.78
97_G	144_A	0.851	0.77
107_T	210_G	0.848	0.77
57_S	60_D	0.847	0.77
187_T	190_K	0.839	0.76
97_G	267_S	0.837	0.76
112_Y	272_Y	0.831	0.76
233_P	266_Q	0.831	0.76
132_T	144_A	0.830	0.76
132_T	289_G	0.830	0.76
61_Q	67_E	0.828	0.76
63_S	69_T	0.828	0.76
66_Y	72_T	0.827	0.75
196_Y	299_V	0.826	0.75
269_S	294_N	0.812	0.74
117_Q	159_I	0.811	0.74
267_S	286_H	0.806	0.74
83_L	86_N	0.806	0.74
246_K	257_T	0.806	0.74
97_G	265_C	0.805	0.73
74_K	78_G	0.803	0.73
56_T	61_Q	0.802	0.73
110_F	140_T	0.797	0.73
135_L	201_L	0.795	0.73
53_K	58_K	0.795	0.73
132_T	266_Q	0.795	0.73
62_V	67_E	0.793	0.72
118_L	130_G	0.787	0.72
258_Y	265_C	0.785	0.72
58_K	64_A	0.783	0.71
289_G	294_N	0.782	0.71
68_G	74_K	0.779	0.71
50_D	54_N	0.779	0.71
113_R	129_Y	0.778	0.71
70_G	73_S	0.776	0.71
60_D	64_A	0.774	0.70
233_P	263_Y	0.773	0.70
163_P	175_Y	0.772	0.70
273_R	283_I	0.772	0.70
51_A	61_Q	0.771	0.70
270_P	293_Y	0.770	0.70
80_Q	84_E	0.768	0.70
270_P	283_I	0.764	0.69
107_T	166_N	0.764	0.69
144_A	195_D	0.763	0.69
193_N	255_K	0.762	0.69
270_P	294_N	0.758	0.69
66_Y	73_S	0.752	0.68
53_K	61_Q	0.746	0.68
64_A	69_T	0.746	0.68
55_Q	62_V	0.741	0.67
71_K	74_K	0.740	0.67
57_S	69_T	0.739	0.67
54_N	65_P	0.737	0.67
54_N	61_Q	0.734	0.66
166_N	172_Y	0.732	0.66
100_E	110_F	0.732	0.66
52_T	56_T	0.731	0.66
60_D	63_S	0.728	0.66
63_S	70_G	0.728	0.66
208_T	211_W	0.721	0.65
63_S	71_K	0.720	0.65
61_Q	65_P	0.720	0.65
52_T	59_A	0.719	0.65
163_P	173_G	0.712	0.64
63_S	66_Y	0.710	0.64
161_A	299_V	0.700	0.63
262_T	296_G	0.698	0.62
56_T	65_P	0.697	0.62
51_A	54_N	0.694	0.62
289_G	293_Y	0.690	0.62
140_T	181_Y	0.689	0.61
51_A	56_T	0.689	0.61
241_M	249_R	0.686	0.61
113_R	255_K	0.686	0.61
258_Y	296_G	0.686	0.61
50_D	68_G	0.685	0.61
239_G	264_G	0.684	0.61
133_G	161_A	0.683	0.61
115_T	130_G	0.681	0.61
50_D	58_K	0.677	0.60
64_A	71_K	0.675	0.60
60_D	66_Y	0.673	0.60
64_A	67_E	0.673	0.60
65_P	69_T	0.672	0.60
198_A	306_N	0.669	0.59
207_N	211_W	0.669	0.59
159_I	177_G	0.668	0.59
247_P	251_A	0.662	0.58
64_A	72_T	0.658	0.58
263_Y	266_Q	0.655	0.58
217_T	261_D	0.653	0.57
64_A	74_K	0.652	0.57
53_K	60_D	0.652	0.57
145_G	272_Y	0.647	0.57
159_I	227_S	0.647	0.57
78_G	84_E	0.646	0.57
68_G	73_S	0.646	0.57
258_Y	261_D	0.644	0.56
69_T	73_S	0.642	0.56
136_V	142_V	0.636	0.55
205_P	213_G	0.635	0.55
57_S	63_S	0.635	0.55
193_N	288_N	0.633	0.55
60_D	67_E	0.632	0.55
113_R	140_T	0.631	0.55
62_V	69_T	0.631	0.55
72_T	75_S	0.629	0.55
181_Y	198_A	0.626	0.54
140_T	310_W	0.625	0.54
67_E	72_T	0.623	0.54
54_N	62_V	0.623	0.54
68_G	77_Y	0.620	0.54
265_C	286_H	0.618	0.53
116_V	133_G	0.617	0.53
83_L	87_I	0.615	0.53
227_S	271_V	0.615	0.53
54_N	88_Q	0.614	0.53
81_T	84_E	0.614	0.53
145_G	182_S	0.614	0.53
93_S	97_G	0.613	0.53
256_L	283_I	0.610	0.52
65_P	72_T	0.608	0.52
270_P	288_N	0.607	0.52
235_D	239_G	0.607	0.52
163_P	183_V	0.604	0.52
307_I	311_A	0.604	0.52
58_K	63_S	0.604	0.52
81_T	85_K	0.603	0.52
149_Y	205_P	0.603	0.52
140_T	311_A	0.601	0.51
298_R	301_N	0.601	0.51
140_T	227_S	0.600	0.51
242_W	245_T	0.597	0.51
136_V	293_Y	0.595	0.51
82_E	87_I	0.594	0.50
202_N	205_P	0.594	0.50
136_V	307_I	0.593	0.50
51_A	55_Q	0.591	0.50
59_A	88_Q	0.590	0.50
195_D	287_T	0.588	0.50
166_N	232_F	0.587	0.50
65_P	75_S	0.585	0.49
50_D	59_A	0.584	0.49
233_P	267_S	0.582	0.49
271_V	296_G	0.581	0.49
51_A	65_P	0.576	0.48
76_L	79_G	0.575	0.48
73_S	80_Q	0.574	0.48
156_A	177_G	0.574	0.48
175_Y	201_L	0.573	0.48
181_Y	200_K	0.570	0.48
227_S	256_L	0.569	0.48
286_H	296_G	0.565	0.47
262_T	289_G	0.563	0.47
97_G	146_H	0.561	0.47
265_C	289_G	0.559	0.46
263_Y	269_S	0.557	0.46
50_D	64_A	0.556	0.46
182_S	197_G	0.555	0.46
222_P	273_R	0.554	0.46
95_I	197_G	0.553	0.46
53_K	59_A	0.553	0.46
140_T	273_R	0.553	0.46
57_S	65_P	0.551	0.45
111_P	213_G	0.550	0.45
233_P	265_C	0.550	0.45
69_T	74_K	0.549	0.45
132_T	195_D	0.548	0.45
117_Q	165_R	0.548	0.45
269_S	286_H	0.546	0.45
68_G	80_Q	0.544	0.45
51_A	64_A	0.542	0.44
267_S	287_T	0.541	0.44
308_Q	311_A	0.540	0.44
62_V	65_P	0.540	0.44
144_A	289_G	0.539	0.44
51_A	58_K	0.537	0.44
55_Q	65_P	0.536	0.44
97_G	266_Q	0.535	0.44
75_S	88_Q	0.534	0.43
66_Y	79_G	0.534	0.43
195_D	233_P	0.530	0.43
60_D	65_P	0.529	0.43
57_S	66_Y	0.527	0.43
65_P	79_G	0.527	0.43
269_S	289_G	0.526	0.42
134_F	229_V	0.525	0.42
145_G	297_T	0.525	0.42
108_T	112_Y	0.525	0.42
79_G	85_K	0.523	0.42
116_V	199_I	0.523	0.42
94_S	269_S	0.523	0.42
223_V	242_W	0.519	0.42
148_V	159_I	0.519	0.42
72_T	82_E	0.519	0.42
114_A	140_T	0.518	0.42
52_T	55_Q	0.518	0.42
133_G	304_F	0.517	0.41
58_K	67_E	0.517	0.41
216_T	304_F	0.516	0.41
74_K	77_Y	0.516	0.41
135_L	216_T	0.513	0.41
60_D	69_T	0.512	0.41
107_T	118_L	0.512	0.41
64_A	70_G	0.511	0.41
274_N	280_Q	0.510	0.41
164_G	168_S	0.509	0.41
164_G	211_W	0.508	0.40
54_N	60_D	0.505	0.40
95_I	235_D	0.505	0.40
175_Y	204_S	0.505	0.40
195_D	266_Q	0.502	0.40
113_R	282_A	0.502	0.40
59_A	65_P	0.500	0.40
80_Q	85_K	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4nzqA	1	0.8179	100	0.328	Contact Map
3nxpA	1	0.8179	100	0.331	Contact Map
2xxlA	1	0.8307	100	0.333	Contact Map
4kkdA	1	0.9329	100	0.333	Contact Map
2bdyA	1	0.754	100	0.335	Contact Map
2f83A	2	0.9105	100	0.338	Contact Map
2b9lA	1	0.8243	100	0.341	Contact Map
2xrcA	2	0.7093	100	0.349	Contact Map
2vntA	1	0.6997	100	0.349	Contact Map
2olgA	1	0.738	100	0.352	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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