GREMLIN Database
MPR - Extracellular metalloprotease
UniProt: P39790 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (245)
Sequences: 1339 (1042)
Seq/√Len: 66.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_S273_R6.8691.00
133_G141_V5.2361.00
135_L205_P5.0121.00
142_V282_A3.8291.00
140_T198_A3.6781.00
178_T200_K3.4431.00
115_T129_Y3.2781.00
163_P205_P3.0981.00
134_F214_Y2.9981.00
173_G211_W2.9771.00
162_A174_T2.9231.00
143_T148_V2.8251.00
131_C147_C2.4771.00
113_R230_T2.4681.00
261_D294_N2.4571.00
114_A163_P2.4381.00
230_T272_Y2.3881.00
134_F282_A2.3531.00
184_K310_W2.3121.00
255_K288_N2.2861.00
214_Y272_Y2.2791.00
214_Y282_A2.1651.00
148_V197_G2.1561.00
261_D296_G2.1371.00
229_V262_T2.1331.00
194_Y303_V2.1191.00
229_V286_H2.0981.00
146_H267_S2.0141.00
193_N254_Y1.8541.00
135_L163_P1.8271.00
135_L141_V1.8121.00
161_A177_G1.8081.00
110_F280_Q1.8011.00
114_A133_G1.7821.00
117_Q129_Y1.7131.00
193_N252_E1.6450.99
114_A141_V1.6240.99
146_H286_H1.6160.99
179_M200_K1.5920.99
140_T200_K1.5810.99
176_S202_N1.5590.99
112_Y215_R1.5390.99
262_T294_N1.5270.99
139_N204_S1.5050.99
110_F230_T1.4860.99
177_G199_I1.4680.98
66_Y69_T1.4460.98
59_A63_S1.4410.98
261_D289_G1.4230.98
162_A165_R1.4140.98
144_A285_I1.4080.98
143_T197_G1.3830.98
163_P211_W1.3780.98
50_D53_K1.3750.98
146_H289_G1.3710.98
161_A199_I1.3640.97
55_Q61_Q1.3350.97
183_V194_Y1.3270.97
262_T286_H1.3250.97
181_Y310_W1.3110.97
227_S283_I1.3110.97
178_T202_N1.3030.97
56_T59_A1.2990.97
304_F308_Q1.2740.96
175_Y202_N1.2680.96
134_F285_I1.2520.96
53_K57_S1.2510.96
254_Y303_V1.2500.96
256_L271_V1.2460.96
227_S293_Y1.2330.95
117_Q168_S1.2260.95
288_N295_L1.2160.95
108_T210_G1.2030.95
289_G296_G1.2010.95
93_S96_I1.2010.95
148_V180_F1.1990.95
144_A267_S1.1940.95
58_K61_Q1.1940.95
194_Y254_Y1.1910.94
165_R172_Y1.1890.94
254_Y301_N1.1880.94
69_T72_T1.1840.94
201_L205_P1.1830.94
80_Q83_L1.1790.94
286_H289_G1.1770.94
50_D55_Q1.1520.93
55_Q59_A1.1500.93
258_Y294_N1.1420.93
132_T269_S1.1200.92
272_Y288_N1.1150.92
138_P207_N1.1060.92
144_A269_S1.1050.92
196_Y303_V1.1040.92
196_Y297_T1.0960.92
243_S298_R1.0950.92
261_D264_G1.0910.91
139_N200_K1.0880.91
116_V161_A1.0720.91
252_E255_K1.0540.90
135_L207_N1.0500.90
94_S97_G1.0470.90
65_P73_S1.0470.90
215_R280_Q1.0380.89
108_T166_N1.0350.89
112_Y280_Q1.0330.89
68_G72_T1.0290.89
137_N140_T1.0280.89
250_S292_S1.0280.89
55_Q58_K1.0270.89
285_I297_T1.0260.89
207_N213_G1.0210.88
141_V201_L1.0200.88
241_M293_Y1.0140.88
229_V260_T1.0130.88
297_T303_V1.0130.88
61_Q64_A1.0100.88
51_A57_S1.0040.88
82_E85_K1.0020.88
59_A62_V0.9990.87
175_Y205_P0.9830.87
95_I239_G0.9820.86
146_H195_D0.9760.86
113_R132_T0.9720.86
267_S289_G0.9660.86
52_T57_S0.9610.85
53_K56_T0.9600.85
132_T233_P0.9590.85
58_K62_V0.9410.84
236_K259_T0.9330.84
70_G74_K0.9330.84
61_Q76_L0.9320.83
65_P68_G0.9240.83
97_G269_S0.9170.82
54_N58_K0.9170.82
146_H265_C0.9160.82
55_Q60_D0.9150.82
222_P227_S0.9140.82
132_T146_H0.9090.82
113_R272_Y0.9020.81
113_R270_P0.9020.81
159_I199_I0.8930.81
59_A64_A0.8920.81
236_K239_G0.8760.79
146_H269_S0.8760.79
67_E70_G0.8700.79
67_E71_K0.8700.79
56_T60_D0.8680.79
141_V161_A0.8670.79
79_G82_E0.8650.79
72_T81_T0.8650.79
112_Y217_T0.8590.78
264_G294_N0.8550.78
50_D60_D0.8520.78
97_G144_A0.8510.77
107_T210_G0.8480.77
57_S60_D0.8470.77
187_T190_K0.8390.76
97_G267_S0.8370.76
112_Y272_Y0.8310.76
233_P266_Q0.8310.76
132_T144_A0.8300.76
132_T289_G0.8300.76
61_Q67_E0.8280.76
63_S69_T0.8280.76
66_Y72_T0.8270.75
196_Y299_V0.8260.75
269_S294_N0.8120.74
117_Q159_I0.8110.74
267_S286_H0.8060.74
83_L86_N0.8060.74
246_K257_T0.8060.74
97_G265_C0.8050.73
74_K78_G0.8030.73
56_T61_Q0.8020.73
110_F140_T0.7970.73
135_L201_L0.7950.73
53_K58_K0.7950.73
132_T266_Q0.7950.73
62_V67_E0.7930.72
118_L130_G0.7870.72
258_Y265_C0.7850.72
58_K64_A0.7830.71
289_G294_N0.7820.71
68_G74_K0.7790.71
50_D54_N0.7790.71
113_R129_Y0.7780.71
70_G73_S0.7760.71
60_D64_A0.7740.70
233_P263_Y0.7730.70
163_P175_Y0.7720.70
273_R283_I0.7720.70
51_A61_Q0.7710.70
270_P293_Y0.7700.70
80_Q84_E0.7680.70
270_P283_I0.7640.69
107_T166_N0.7640.69
144_A195_D0.7630.69
193_N255_K0.7620.69
270_P294_N0.7580.69
66_Y73_S0.7520.68
53_K61_Q0.7460.68
64_A69_T0.7460.68
55_Q62_V0.7410.67
71_K74_K0.7400.67
57_S69_T0.7390.67
54_N65_P0.7370.67
54_N61_Q0.7340.66
166_N172_Y0.7320.66
100_E110_F0.7320.66
52_T56_T0.7310.66
60_D63_S0.7280.66
63_S70_G0.7280.66
208_T211_W0.7210.65
63_S71_K0.7200.65
61_Q65_P0.7200.65
52_T59_A0.7190.65
163_P173_G0.7120.64
63_S66_Y0.7100.64
161_A299_V0.7000.63
262_T296_G0.6980.62
56_T65_P0.6970.62
51_A54_N0.6940.62
289_G293_Y0.6900.62
140_T181_Y0.6890.61
51_A56_T0.6890.61
241_M249_R0.6860.61
113_R255_K0.6860.61
258_Y296_G0.6860.61
50_D68_G0.6850.61
239_G264_G0.6840.61
133_G161_A0.6830.61
115_T130_G0.6810.61
50_D58_K0.6770.60
64_A71_K0.6750.60
60_D66_Y0.6730.60
64_A67_E0.6730.60
65_P69_T0.6720.60
198_A306_N0.6690.59
207_N211_W0.6690.59
159_I177_G0.6680.59
247_P251_A0.6620.58
64_A72_T0.6580.58
263_Y266_Q0.6550.58
217_T261_D0.6530.57
64_A74_K0.6520.57
53_K60_D0.6520.57
145_G272_Y0.6470.57
159_I227_S0.6470.57
78_G84_E0.6460.57
68_G73_S0.6460.57
258_Y261_D0.6440.56
69_T73_S0.6420.56
136_V142_V0.6360.55
205_P213_G0.6350.55
57_S63_S0.6350.55
193_N288_N0.6330.55
60_D67_E0.6320.55
113_R140_T0.6310.55
62_V69_T0.6310.55
72_T75_S0.6290.55
181_Y198_A0.6260.54
140_T310_W0.6250.54
67_E72_T0.6230.54
54_N62_V0.6230.54
68_G77_Y0.6200.54
265_C286_H0.6180.53
116_V133_G0.6170.53
83_L87_I0.6150.53
227_S271_V0.6150.53
54_N88_Q0.6140.53
81_T84_E0.6140.53
145_G182_S0.6140.53
93_S97_G0.6130.53
256_L283_I0.6100.52
65_P72_T0.6080.52
270_P288_N0.6070.52
235_D239_G0.6070.52
163_P183_V0.6040.52
307_I311_A0.6040.52
58_K63_S0.6040.52
81_T85_K0.6030.52
149_Y205_P0.6030.52
140_T311_A0.6010.51
298_R301_N0.6010.51
140_T227_S0.6000.51
242_W245_T0.5970.51
136_V293_Y0.5950.51
82_E87_I0.5940.50
202_N205_P0.5940.50
136_V307_I0.5930.50
51_A55_Q0.5910.50
59_A88_Q0.5900.50
195_D287_T0.5880.50
166_N232_F0.5870.50
65_P75_S0.5850.49
50_D59_A0.5840.49
233_P267_S0.5820.49
271_V296_G0.5810.49
51_A65_P0.5760.48
76_L79_G0.5750.48
73_S80_Q0.5740.48
156_A177_G0.5740.48
175_Y201_L0.5730.48
181_Y200_K0.5700.48
227_S256_L0.5690.48
286_H296_G0.5650.47
262_T289_G0.5630.47
97_G146_H0.5610.47
265_C289_G0.5590.46
263_Y269_S0.5570.46
50_D64_A0.5560.46
182_S197_G0.5550.46
222_P273_R0.5540.46
95_I197_G0.5530.46
53_K59_A0.5530.46
140_T273_R0.5530.46
57_S65_P0.5510.45
111_P213_G0.5500.45
233_P265_C0.5500.45
69_T74_K0.5490.45
132_T195_D0.5480.45
117_Q165_R0.5480.45
269_S286_H0.5460.45
68_G80_Q0.5440.45
51_A64_A0.5420.44
267_S287_T0.5410.44
308_Q311_A0.5400.44
62_V65_P0.5400.44
144_A289_G0.5390.44
51_A58_K0.5370.44
55_Q65_P0.5360.44
97_G266_Q0.5350.44
75_S88_Q0.5340.43
66_Y79_G0.5340.43
195_D233_P0.5300.43
60_D65_P0.5290.43
57_S66_Y0.5270.43
65_P79_G0.5270.43
269_S289_G0.5260.42
134_F229_V0.5250.42
145_G297_T0.5250.42
108_T112_Y0.5250.42
79_G85_K0.5230.42
116_V199_I0.5230.42
94_S269_S0.5230.42
223_V242_W0.5190.42
148_V159_I0.5190.42
72_T82_E0.5190.42
114_A140_T0.5180.42
52_T55_Q0.5180.42
133_G304_F0.5170.41
58_K67_E0.5170.41
216_T304_F0.5160.41
74_K77_Y0.5160.41
135_L216_T0.5130.41
60_D69_T0.5120.41
107_T118_L0.5120.41
64_A70_G0.5110.41
274_N280_Q0.5100.41
164_G168_S0.5090.41
164_G211_W0.5080.40
54_N60_D0.5050.40
95_I235_D0.5050.40
175_Y204_S0.5050.40
195_D266_Q0.5020.40
113_R282_A0.5020.40
59_A65_P0.5000.40
80_Q85_K0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nzqA 1 0.8179 100 0.328 Contact Map
3nxpA 1 0.8179 100 0.331 Contact Map
2xxlA 1 0.8307 100 0.333 Contact Map
4kkdA 1 0.9329 100 0.333 Contact Map
2bdyA 1 0.754 100 0.335 Contact Map
2f83A 2 0.9105 100 0.338 Contact Map
2b9lA 1 0.8243 100 0.341 Contact Map
2xrcA 2 0.7093 100 0.349 Contact Map
2vntA 1 0.6997 100 0.349 Contact Map
2olgA 1 0.738 100 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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