GREMLIN Database
END3 - Endonuclease III
UniProt: P39788 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (199)
Sequences: 8434 (5317)
Seq/√Len: 376.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_D111_E3.9301.00
61_R64_D3.5021.00
195_R198_E3.2471.00
96_M100_D3.1691.00
190_K195_R2.6831.00
58_K72_E2.6781.00
96_M116_P2.5801.00
107_R133_V2.4871.00
73_L91_Q2.4161.00
91_Q95_K2.4001.00
15_G173_D2.3621.00
58_K76_D2.3191.00
75_Q78_K2.2391.00
109_R113_V2.2341.00
101_Y114_K2.2261.00
63_E98_I2.0671.00
29_N32_E2.0081.00
202_L208_G2.0031.00
38_A93_L1.9741.00
69_P72_E1.9271.00
95_K99_E1.9251.00
60_K64_D1.8921.00
159_L163_K1.8641.00
89_N92_K1.8541.00
92_K116_P1.8261.00
70_L74_Q1.8171.00
85_N89_N1.7971.00
70_L91_Q1.7911.00
15_G176_V1.7641.00
63_E67_A1.7301.00
100_D114_K1.7201.00
35_V90_I1.6881.00
31_F62_P1.6591.00
13_K203_S1.6231.00
143_E161_V1.6221.00
53_K57_Q1.5971.00
111_E114_K1.5771.00
98_I103_G1.5571.00
152_C164_T1.5281.00
59_Y76_D1.5001.00
59_Y68_V1.4961.00
31_F94_S1.4941.00
28_S32_E1.4911.00
109_R135_A1.4841.00
43_C47_L1.4841.00
9_F204_L1.4831.00
54_T57_Q1.4631.00
92_K95_K1.4281.00
21_A26_V1.4261.00
104_E107_R1.4211.00
32_E56_F1.3991.00
85_N88_K1.3891.00
109_R127_V1.3781.00
162_E166_M1.3681.00
173_D176_V1.3611.00
149_L201_L1.3471.00
120_R162_E1.3341.00
54_T76_D1.3281.00
74_Q83_Y1.3241.00
68_V73_L1.3051.00
151_I206_R1.3031.00
107_R131_F1.2921.00
149_L204_L1.2891.00
183_F187_Y1.2831.00
113_V120_R1.2731.00
43_C80_I1.2451.00
47_L50_R1.2321.00
40_S45_D1.2201.00
96_M114_K1.2141.00
169_V177_T1.2121.00
96_M101_Y1.2071.00
9_F12_D1.2021.00
71_E74_Q1.1871.00
14_I18_F1.1781.00
161_V165_L1.1721.00
146_S165_L1.1691.00
70_L88_K1.1601.00
13_K17_M1.1571.00
127_V133_V1.1481.00
50_R53_K1.1281.00
176_V180_R1.1201.00
34_V38_A1.1191.00
93_L115_L1.1141.00
92_K96_M1.1141.00
155_K159_L1.1041.00
97_I105_V1.0991.00
30_P130_A1.0951.00
65_Y73_L1.0861.00
162_E165_L1.0821.00
69_P91_Q1.0821.00
112_L127_V1.0701.00
132_G175_S1.0681.00
188_H200_P1.0621.00
100_D111_E1.0581.00
11_L15_G1.0571.00
34_V126_V1.0511.00
10_C201_L1.0511.00
24_E187_Y1.0431.00
35_V56_F1.0391.00
101_Y111_E1.0381.00
44_T47_L1.0381.00
70_L87_A1.0371.00
12_D16_D1.0351.00
196_C205_C1.0081.00
9_F13_K0.9971.00
32_E52_T0.9921.00
127_V135_A0.9821.00
31_F65_Y0.9791.00
52_T56_F0.9781.00
49_N53_K0.9681.00
70_L95_K0.9661.00
154_W161_V0.9621.00
65_Y94_S0.9591.00
136_I166_M0.9481.00
189_C199_C0.9451.00
17_M200_P0.9441.00
163_K166_M0.9411.00
201_L204_L0.9411.00
171_K174_W0.9381.00
166_M169_V0.9351.00
93_L96_M0.9351.00
189_C196_C0.9341.00
184_F188_H0.9301.00
157_S160_E0.9301.00
46_A50_R0.9271.00
62_P98_I0.9161.00
88_K92_K0.9071.00
27_H32_E0.9021.00
128_S137_A0.8941.00
66_L94_S0.8941.00
13_K200_P0.8851.00
13_K16_D0.8801.00
18_F183_F0.8791.00
34_V93_L0.8781.00
93_L97_I0.8741.00
128_S178_H0.8731.00
147_K161_V0.8701.00
146_S181_L0.8691.00
184_F200_P0.8681.00
72_E76_D0.8661.00
41_A122_T0.8571.00
26_V53_K0.8501.00
134_P171_K0.8451.00
110_D113_V0.8391.00
21_A24_E0.8301.00
159_L162_E0.8291.00
66_L98_I0.8221.00
160_E164_T0.8211.00
51_V54_T0.8191.00
177_T181_L0.8161.00
35_V93_L0.8081.00
54_T79_S0.8021.00
37_V126_V0.8011.00
164_T167_R0.8011.00
68_V72_E0.7971.00
127_V131_F0.7941.00
62_P105_V0.7891.00
47_L79_S0.7851.00
109_R124_N0.7821.00
128_S175_S0.7811.00
206_R209_Q0.7801.00
188_H198_E0.7761.00
147_K152_C0.7761.00
27_H33_L0.7731.00
137_A178_H0.7711.00
109_R133_V0.7701.00
136_I174_W0.7651.00
8_E12_D0.7641.00
165_L169_V0.7601.00
109_R123_A0.7601.00
118_V122_T0.7561.00
54_T58_K0.7541.00
105_V112_L0.7501.00
153_R157_S0.7461.00
72_E75_Q0.7451.00
163_K167_R0.7411.00
143_E147_K0.7371.00
33_L130_A0.7341.00
138_V161_V0.7321.00
160_E163_K0.7311.00
154_W157_S0.7241.00
14_I179_H0.7171.00
124_N136_I0.7161.00
50_R54_T0.7141.00
129_V175_S0.7121.00
66_L95_K0.7040.99
47_L80_I0.7000.99
90_I94_S0.6980.99
145_V184_F0.6980.99
166_M174_W0.6950.99
155_K158_V0.6860.99
12_D15_G0.6830.99
196_C199_C0.6830.99
8_E173_D0.6800.99
66_L91_Q0.6760.99
63_E103_G0.6750.99
59_Y72_E0.6730.99
37_V129_V0.6680.99
32_E60_K0.6680.99
15_G180_R0.6630.99
46_A49_N0.6620.99
37_V122_T0.6620.99
184_F187_Y0.6600.99
11_L176_V0.6570.99
13_K204_L0.6570.99
66_L69_P0.6510.99
39_L48_V0.6510.99
173_D180_R0.6470.99
204_L208_G0.6460.99
98_I101_Y0.6450.99
68_V91_Q0.6440.99
120_R124_N0.6410.99
194_P205_C0.6390.99
128_S135_A0.6370.99
18_F184_F0.6330.99
118_V123_A0.6250.99
97_I103_G0.6240.99
22_E25_L0.6240.99
76_D79_S0.6240.99
189_C205_C0.6240.99
21_A183_F0.6230.99
59_Y73_L0.6210.99
62_P94_S0.6190.99
112_L126_V0.6190.99
48_V80_I0.6170.99
164_T168_K0.6140.99
148_R194_P0.6130.99
10_C180_R0.6120.99
107_R111_E0.6100.99
109_R120_R0.6090.99
126_V130_A0.6090.99
120_R159_L0.6090.99
39_L80_I0.6050.98
170_P174_W0.6050.98
202_L207_E0.6020.98
154_W160_E0.5980.98
87_A91_Q0.5960.98
87_A90_I0.5950.98
32_E65_Y0.5940.98
35_V38_A0.5930.98
113_V123_A0.5900.98
135_A174_W0.5900.98
108_D127_V0.5840.98
74_Q87_A0.5830.98
202_L209_Q0.5800.98
142_V181_L0.5800.98
11_L173_D0.5780.98
135_A166_M0.5780.98
124_N162_E0.5760.98
38_A90_I0.5760.98
18_F21_A0.5750.98
114_K127_V0.5710.98
64_D67_A0.5700.98
122_T126_V0.5680.98
129_V179_H0.5680.98
73_L77_I0.5650.98
95_K98_I0.5650.98
8_E172_E0.5590.97
136_I177_T0.5570.97
51_V80_I0.5560.97
104_E131_F0.5550.97
190_K193_S0.5540.97
136_I169_V0.5520.97
96_M115_L0.5510.97
112_L118_V0.5510.97
148_R196_C0.5480.97
138_V142_V0.5480.97
118_V126_V0.5470.97
165_L177_T0.5470.97
24_E183_F0.5470.97
9_F203_S0.5450.97
34_V97_I0.5430.97
60_K68_V0.5410.97
23_C129_V0.5410.97
29_N60_K0.5400.97
146_S149_L0.5380.97
60_K65_Y0.5370.97
158_V162_E0.5290.96
14_I180_R0.5280.96
140_T191_A0.5280.96
29_N33_L0.5260.96
15_G19_P0.5230.96
36_A52_T0.5210.96
18_F176_V0.5210.96
124_N137_A0.5200.96
149_L206_R0.5140.96
197_A202_L0.5120.96
30_P131_F0.5120.96
67_A98_I0.5110.96
138_V143_E0.5100.96
162_E169_V0.5090.96
174_W178_H0.5070.96
11_L169_V0.5070.96
154_W164_T0.5060.95
165_L168_K0.5050.95
155_K160_E0.5050.95
50_R79_S0.5030.95
136_I165_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kg2A 1 0.9909 100 0.185 Contact Map
3fspA 1 0.9909 100 0.186 Contact Map
1ornA 1 0.9772 100 0.194 Contact Map
2abkA 1 0.9635 100 0.195 Contact Map
4unfA 1 0.9543 100 0.196 Contact Map
4uobA 1 0.9863 100 0.202 Contact Map
3n5nX 1 0.9909 100 0.203 Contact Map
1keaA 2 0.9589 100 0.221 Contact Map
1pu6A 1 0.8539 100 0.34 Contact Map
3s6iA 1 0.8265 100 0.462 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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