GREMLIN Database
XTMB - PBSX phage terminase large subunit
UniProt: P39786 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (372)
Sequences: 2619 (2101)
Seq/√Len: 108.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_R231_R5.5931.00
279_V403_A4.5321.00
207_E211_K4.0021.00
51_A118_L3.7701.00
281_L407_A3.1811.00
224_Y229_K3.1301.00
36_T151_T3.0801.00
120_W151_T2.9901.00
124_C150_C2.9541.00
372_V376_L2.8711.00
29_G140_R2.8381.00
28_Y138_R2.7471.00
198_T201_D2.6811.00
162_Y167_R2.6281.00
289_Y364_F2.6271.00
350_R405_W2.5721.00
395_T398_P2.4961.00
122_E151_T2.4461.00
129_Y133_K2.3821.00
309_E312_E2.3751.00
28_Y227_A2.3731.00
26_G30_S2.3601.00
90_Q98_R2.3381.00
322_A340_M2.3161.00
121_I127_V2.3161.00
372_V404_I2.2831.00
207_E210_V2.2581.00
28_Y137_G2.2501.00
139_L148_M2.1931.00
221_P225_R2.1741.00
44_L51_A2.1521.00
371_N374_Y2.1431.00
266_G407_A2.1251.00
301_M309_E2.0921.00
209_Y213_L2.0881.00
129_Y164_H2.0851.00
294_W313_F2.0061.00
132_F150_C1.9791.00
43_K118_L1.9681.00
52_L116_I1.9681.00
55_R61_H1.8931.00
240_L401_L1.8841.00
294_W368_R1.8721.00
279_V372_V1.8661.00
200_N229_K1.8561.00
295_E369_C1.8431.00
244_E247_P1.8411.00
26_G32_K1.8341.00
285_P288_K1.7981.00
347_P350_R1.7841.00
291_Y364_F1.7691.00
245_V248_H1.7561.00
200_N210_V1.7461.00
297_Y371_N1.7381.00
294_W316_T1.7341.00
56_E131_G1.7211.00
15_F39_K1.7161.00
196_H231_R1.7061.00
310_L320_I1.6941.00
324_S345_K1.6921.00
21_Y192_T1.6871.00
111_K227_A1.6761.00
376_L401_L1.6571.00
124_C161_T1.6551.00
129_Y163_R1.6311.00
61_H101_F1.6141.00
244_E248_H1.6121.00
214_D224_Y1.6071.00
263_F293_Y1.5931.00
273_E399_H1.5491.00
312_E316_T1.5431.00
25_V196_H1.5341.00
211_K215_G1.5321.00
289_Y362_K1.5261.00
44_L99_I1.5141.00
292_I372_V1.5101.00
121_I135_L1.5011.00
297_Y400_T1.4851.00
260_K282_A1.4741.00
308_E336_Q1.4731.00
347_P351_L1.4531.00
309_E313_F1.4411.00
307_A336_Q1.4351.00
211_K214_D1.4341.00
279_V292_I1.4291.00
242_Q245_V1.4271.00
271_F330_I1.4241.00
85_L90_Q1.4181.00
154_P230_G1.4011.00
304_D332_Y1.3801.00
351_L379_L1.3791.00
265_T280_R1.3751.00
50_T98_R1.3721.00
376_L404_I1.3671.00
17_W22_Q1.3651.00
26_G153_N1.3641.00
354_T404_I1.3601.00
27_G199_A1.3551.00
44_L97_S1.3421.00
255_I258_I1.3291.00
55_R64_S1.3280.99
22_Q149_I1.3170.99
331_Q335_Q1.3100.99
276_N306_T1.3070.99
225_R229_K1.3040.99
242_Q246_L1.2950.99
119_I148_M1.2940.99
277_A400_T1.2930.99
134_E137_G1.2760.99
25_V194_Y1.2640.99
269_F328_K1.2560.99
394_F398_P1.2540.99
200_N214_D1.2510.99
26_G230_G1.2510.99
85_L88_P1.2460.99
248_H358_K1.2380.99
266_G281_L1.2340.99
220_D223_L1.2310.99
20_T212_Q1.2280.99
116_I119_I1.2240.99
308_E312_E1.2230.99
303_D328_K1.2140.99
304_D308_E1.2140.99
121_I124_C1.2050.99
245_V249_D1.2050.99
41_V69_F1.1930.99
265_T314_I1.1880.99
162_Y232_F1.1850.99
298_Q301_M1.1790.99
209_Y212_Q1.1780.99
281_L292_I1.1740.99
292_I404_I1.1720.99
39_K43_K1.1720.99
350_R353_Y1.1650.99
243_F248_H1.1560.99
296_Y309_E1.1540.99
52_L102_K1.1490.99
206_P209_Y1.1410.98
34_Y68_L1.1320.98
301_M305_R1.1280.98
280_R317_Q1.1270.98
302_T359_R1.1250.98
339_R342_G1.1240.98
121_I150_C1.1230.98
30_S197_S1.1210.98
61_H65_T1.1150.98
379_L393_E1.1150.98
296_Y306_T1.1130.98
269_F322_A1.1100.98
36_T120_W1.1100.98
270_G405_W1.1080.98
243_F249_D1.1040.98
264_R411_Y1.0970.98
253_K367_D1.0940.98
269_F326_E1.0910.98
284_D291_Y1.0880.98
239_V381_Y1.0820.98
399_H405_W1.0810.98
23_F152_T1.0780.98
50_T117_S1.0780.98
332_Y335_Q1.0740.98
159_N162_Y1.0740.98
246_L249_D1.0680.98
111_K152_T1.0660.98
324_S342_G1.0660.98
41_V73_I1.0650.98
34_Y38_L1.0650.98
31_S35_H1.0590.97
70_Q86_S1.0550.97
29_G114_H1.0550.97
210_V213_L1.0480.97
346_F349_S1.0470.97
85_L92_R1.0460.97
40_I120_W1.0440.97
119_I135_L1.0440.97
49_R117_S1.0430.97
332_Y336_Q1.0370.97
10_F31_S1.0340.97
311_R315_E1.0330.97
213_L228_R1.0320.97
401_L404_I1.0310.97
82_V91_L1.0260.97
371_N400_T1.0260.97
55_R126_E1.0240.97
326_E329_S1.0210.97
20_T208_S1.0160.97
67_A98_R1.0060.97
113_V116_I0.9950.96
132_F148_M0.9930.96
65_T120_W0.9920.96
11_E16_N0.9900.96
398_P401_L0.9850.96
61_H66_F0.9850.96
198_T229_K0.9830.96
304_D335_Q0.9830.96
399_H407_A0.9820.96
19_Q193_Y0.9820.96
62_R90_Q0.9750.96
289_Y361_K0.9620.96
284_D289_Y0.9610.96
38_L76_L0.9580.95
372_V401_L0.9510.95
21_Y136_I0.9490.95
138_R227_A0.9490.95
372_V400_T0.9450.95
51_A149_I0.9450.95
152_T161_T0.9440.95
155_V226_I0.9440.95
266_G279_V0.9430.95
366_S369_C0.9400.95
382_A392_D0.9390.95
326_E330_I0.9380.95
124_C160_W0.9360.95
84_S87_S0.9340.95
37_A120_W0.9340.95
111_K153_N0.9330.95
125_S161_T0.9320.95
132_F160_W0.9290.95
267_M322_A0.9290.95
54_I127_V0.9280.95
44_L82_V0.9260.95
105_D109_K0.9210.94
157_T162_Y0.9200.94
267_M278_V0.9200.94
210_V214_D0.9180.94
365_C372_V0.9170.94
263_F317_Q0.9170.94
14_V22_Q0.9150.94
83_A92_R0.9140.94
325_A345_K0.9090.94
265_T278_V0.9090.94
55_R153_N0.8950.94
126_E155_V0.8930.93
224_Y228_R0.8920.93
17_W193_Y0.8920.93
132_F136_I0.8910.93
68_L114_H0.8910.93
243_F246_L0.8900.93
292_I403_A0.8900.93
37_A65_T0.8880.93
239_V351_L0.8840.93
379_L395_T0.8830.93
281_L403_A0.8750.93
282_A293_Y0.8730.93
280_R313_F0.8640.92
136_I148_M0.8630.92
270_G322_A0.8630.92
325_A328_K0.8600.92
340_M343_A0.8600.92
69_F91_L0.8580.92
14_V35_H0.8570.92
49_R118_L0.8550.92
53_V99_I0.8500.92
393_E398_P0.8490.92
130_E133_K0.8490.92
26_G55_R0.8480.92
269_F323_D0.8480.92
21_Y132_F0.8450.91
112_S122_E0.8450.91
398_P405_W0.8410.91
33_S65_T0.8410.91
349_S353_Y0.8410.91
93_F97_S0.8400.91
54_I104_M0.8390.91
357_V362_K0.8340.91
39_K149_I0.8340.91
307_A332_Y0.8340.91
395_T399_H0.8320.91
22_Q147_H0.8320.91
39_K118_L0.8310.91
280_R293_Y0.8270.91
137_G227_A0.8260.90
38_L72_V0.8230.90
25_V232_F0.8230.90
56_E126_E0.8220.90
240_L379_L0.8210.90
255_I366_S0.8210.90
214_D229_K0.8190.90
361_K364_F0.8190.90
391_E394_F0.8180.90
325_A330_I0.8180.90
29_G205_L0.8170.90
270_G273_E0.8130.90
402_S405_W0.8130.90
140_R202_N0.8120.90
62_R89_L0.8100.90
239_V379_L0.8070.89
159_N232_F0.8060.89
100_M116_I0.8060.89
363_I404_I0.8030.89
379_L401_L0.8030.89
208_S212_Q0.8000.89
391_E398_P0.7950.89
303_D307_A0.7950.89
375_E398_P0.7940.89
399_H406_Y0.7940.89
306_T310_L0.7910.88
153_N226_I0.7900.88
240_L354_T0.7880.88
271_F327_P0.7870.88
267_M310_L0.7850.88
125_S152_T0.7840.88
310_L318_E0.7830.88
358_K363_I0.7730.87
128_K131_G0.7700.87
274_S375_E0.7660.87
311_R336_Q0.7650.87
271_F326_E0.7630.87
347_P405_W0.7590.86
357_V408_L0.7580.86
199_A229_K0.7580.86
117_S141_H0.7570.86
285_P289_Y0.7540.86
14_V17_W0.7530.86
19_Q22_Q0.7530.86
152_T232_F0.7500.86
218_E221_P0.7490.86
353_Y409_D0.7460.85
294_W317_Q0.7450.85
270_G276_N0.7440.85
365_C369_C0.7430.85
271_F331_Q0.7420.85
23_F165_F0.7390.85
26_G29_G0.7390.85
390_I393_E0.7390.85
370_E374_Y0.7390.85
311_R338_F0.7380.85
394_F397_D0.7380.85
153_N227_A0.7360.85
108_A126_E0.7360.85
26_G197_S0.7360.85
295_E371_N0.7340.84
282_A291_Y0.7330.84
111_K126_E0.7330.84
63_D102_K0.7310.84
401_L405_W0.7290.84
250_Q291_Y0.7260.84
133_K223_L0.7250.84
36_T149_I0.7250.84
73_I84_S0.7240.84
261_P282_A0.7230.84
254_C366_S0.7110.83
324_S327_P0.7090.82
111_K155_V0.7080.82
269_F330_I0.7080.82
267_M276_N0.7070.82
49_R97_S0.7060.82
39_K147_H0.7040.82
324_S340_M0.7030.82
271_F328_K0.7000.82
62_R73_I0.7000.82
104_M127_V0.6980.81
66_F101_F0.6980.81
226_I233_G0.6960.81
245_V367_D0.6960.81
271_F329_S0.6910.81
292_I363_I0.6890.81
23_F150_C0.6880.80
281_L404_I0.6860.80
351_L355_K0.6850.80
63_D100_M0.6850.80
191_D215_G0.6820.80
336_Q339_R0.6790.80
398_P402_S0.6780.79
92_R98_R0.6760.79
21_Y150_C0.6760.79
131_G134_E0.6760.79
58_F62_R0.6740.79
51_A99_I0.6730.79
43_K47_E0.6730.79
12_D16_N0.6730.79
107_P130_E0.6710.79
307_A311_R0.6680.78
40_I51_A0.6660.78
244_E362_K0.6640.78
158_S374_Y0.6610.78
156_G226_I0.6580.77
267_M306_T0.6560.77
163_R167_R0.6550.77
22_Q39_K0.6550.77
33_S112_S0.6550.77
296_Y316_T0.6550.77
390_I398_P0.6540.77
202_N230_G0.6530.77
379_L405_W0.6500.77
74_E79_T0.6490.76
103_G153_N0.6470.76
150_C160_W0.6460.76
245_V373_I0.6450.76
347_P355_K0.6440.76
34_Y72_V0.6440.76
26_G202_N0.6430.76
111_K122_E0.6400.75
345_K350_R0.6390.75
330_I340_M0.6380.75
141_H144_L0.6370.75
350_R354_T0.6370.75
272_E329_S0.6370.75
50_T100_M0.6360.75
277_A403_A0.6340.75
154_P232_F0.6320.75
351_L354_T0.6310.74
280_R314_I0.6310.74
56_E105_D0.6270.74
379_L398_P0.6270.74
397_D400_T0.6250.74
254_C368_R0.6250.74
100_M113_V0.6230.74
242_Q248_H0.6220.73
392_D397_D0.6220.73
42_L46_K0.6210.73
126_E152_T0.6170.73
54_I119_I0.6150.73
322_A326_E0.6150.73
162_Y166_F0.6140.72
29_G33_S0.6140.72
43_K147_H0.6130.72
41_V99_I0.6130.72
323_D326_E0.6120.72
269_F273_E0.6120.72
314_I317_Q0.6120.72
22_Q195_H0.6110.72
53_V120_W0.6110.72
399_H402_S0.6090.72
399_H403_A0.6090.72
302_T335_Q0.6090.72
28_Y125_S0.6070.72
271_F322_A0.6070.72
270_G325_A0.6060.71
124_C127_V0.6030.71
27_G230_G0.6030.71
47_E97_S0.6030.71
32_K230_G0.6030.71
369_C406_Y0.6010.71
189_K215_G0.6010.71
226_I232_F0.6000.71
15_F35_H0.5990.71
248_H361_K0.5990.71
380_T394_F0.5980.70
109_K126_E0.5980.70
301_M306_T0.5980.70
330_I342_G0.5980.70
277_A295_E0.5960.70
307_A314_I0.5940.70
205_L209_Y0.5940.70
111_K125_S0.5940.70
81_A93_F0.5930.70
402_S406_Y0.5930.70
354_T358_K0.5890.69
324_S343_A0.5890.69
242_Q247_P0.5890.69
112_S124_C0.5880.69
302_T305_R0.5860.69
327_P330_I0.5840.69
274_S302_T0.5820.68
30_S153_N0.5790.68
125_S226_I0.5790.68
278_V306_T0.5780.68
273_E276_N0.5780.68
239_V266_G0.5760.68
274_S347_P0.5750.67
27_G111_K0.5740.67
310_L313_F0.5730.67
258_I262_I0.5720.67
125_S137_G0.5720.67
358_K365_C0.5720.67
41_V44_L0.5700.67
82_V93_F0.5700.67
322_A358_K0.5680.67
358_K376_L0.5670.66
397_D401_L0.5670.66
278_V310_L0.5660.66
333_F355_K0.5650.66
274_S328_K0.5640.66
37_A69_F0.5630.66
315_E319_L0.5630.66
37_A68_L0.5620.66
315_E318_E0.5620.66
283_V289_Y0.5620.66
21_Y148_M0.5620.66
25_V153_N0.5590.65
129_Y136_I0.5570.65
114_H228_R0.5570.65
9_H201_D0.5560.65
239_V375_E0.5560.65
253_K257_A0.5560.65
266_G406_Y0.5550.65
280_R372_V0.5540.65
136_I213_L0.5540.65
118_L149_I0.5530.64
261_P285_P0.5530.64
214_D219_Y0.5530.64
43_K149_I0.5520.64
24_L36_T0.5510.64
134_E227_A0.5500.64
208_S211_K0.5480.64
269_F327_P0.5470.64
33_S40_I0.5460.64
191_D211_K0.5460.64
56_E60_T0.5450.63
324_S330_I0.5450.63
334_R342_G0.5430.63
14_V149_I0.5420.63
357_V360_F0.5420.63
20_T148_M0.5400.63
322_A327_P0.5380.62
97_S117_S0.5380.62
56_E128_K0.5380.62
404_I407_A0.5360.62
235_N238_R0.5360.62
55_R104_M0.5350.62
68_L71_E0.5350.62
43_K49_R0.5340.62
288_K362_K0.5330.62
263_F282_A0.5320.62
349_S352_Q0.5310.61
153_N230_G0.5310.61
135_L139_L0.5300.61
54_I107_P0.5280.61
283_V411_Y0.5270.61
300_K303_D0.5270.61
370_E373_I0.5250.61
400_T405_W0.5250.61
392_D399_H0.5250.61
137_G228_R0.5230.60
243_F247_P0.5220.60
54_I121_I0.5210.60
262_I283_V0.5200.60
100_M106_N0.5170.59
321_K410_D0.5170.59
55_R122_E0.5160.59
85_L89_L0.5150.59
300_K305_R0.5150.59
163_R374_Y0.5150.59
81_A86_S0.5150.59
9_H12_D0.5130.59
29_G32_K0.5130.59
257_A366_S0.5110.58
133_K137_G0.5100.58
52_L110_L0.5090.58
24_L151_T0.5090.58
240_L270_G0.5080.58
42_L45_L0.5080.58
261_P284_D0.5080.58
45_L78_L0.5080.58
280_R294_W0.5070.58
20_T132_F0.5060.58
125_S227_A0.5050.58
214_D218_E0.5040.57
142_P206_P0.5030.57
385_K390_I0.5020.57
166_F232_F0.5020.57
86_S89_L0.5020.57
266_G321_K0.5010.57
375_E379_L0.5010.57
73_I91_L0.5010.57
373_I377_E0.5000.57
136_I212_Q0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4idhA 1 0.8938 100 0.424 Contact Map
3cpeA 1 0.8891 100 0.5 Contact Map
4znkA 1 0.5289 100 0.61 Contact Map
2wbnA 1 0.3972 100 0.671 Contact Map
4bijA 3 0.8176 99.9 0.694 Contact Map
2o0jA 1 0.4896 99.9 0.704 Contact Map
4dkwA 1 0.4157 99.9 0.707 Contact Map
3c6aA 1 0.3949 99.6 0.799 Contact Map
1rifA 1 0.388 98.8 0.866 Contact Map
3berA 1 0.3949 98.5 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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