GREMLIN Database
XTMA - PBSX phage terminase small subunit
UniProt: P39785 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (243)
Sequences: 170 (132)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_T109_E4.7050.99
104_R109_E3.9070.97
22_N37_G3.7030.96
38_I42_Q3.4200.94
107_K110_K3.3430.94
197_K204_A3.2370.92
99_H107_K3.0550.90
88_A93_Y3.0040.89
99_H110_K2.9090.87
103_S110_K2.7330.84
22_N34_K2.5840.80
114_E117_R2.5140.78
88_A95_P2.4810.77
146_T190_G2.4160.75
84_A102_G2.3830.74
25_I39_W2.3320.73
33_A37_G2.2690.70
135_Q139_K2.2300.69
26_A40_K2.1960.68
35_T38_I2.1070.64
12_I19_K2.0860.64
9_A12_I2.0210.61
23_R33_A1.9340.57
31_V36_I1.8950.56
100_V110_K1.8240.53
24_A27_D1.8130.52
105_L109_E1.8050.52
101_T104_R1.7670.50
12_I43_D1.7250.49
12_I16_H1.7240.49
25_I36_I1.7180.48
37_G42_Q1.6920.47
12_I20_I1.6730.46
29_I36_I1.6720.46
29_I32_S1.6460.45
9_A43_D1.6460.45
88_A101_T1.6450.45
22_N29_I1.6280.45
136_V139_K1.6140.44
215_E219_L1.5990.43
29_I39_W1.5830.43
155_E174_M1.5300.40
103_S107_K1.5270.40
154_K181_D1.5140.40
84_A106_L1.4740.38
97_S104_R1.4510.37
225_P228_F1.4370.37
32_S39_W1.4360.37
9_A38_I1.4320.37
36_I39_W1.4300.36
28_T37_G1.4040.35
29_I43_D1.3930.35
26_A45_W1.3860.35
22_N33_A1.3800.35
12_I38_I1.3760.34
134_L216_K1.3750.34
19_K43_D1.3620.34
13_Y17_Q1.3490.33
22_N38_I1.3440.33
102_G106_L1.3320.33
33_A38_I1.3200.32
10_L14_Q1.3050.32
101_T105_L1.3010.32
20_I36_I1.2960.31
39_W43_D1.2900.31
21_T42_Q1.2700.30
15_Q29_I1.2690.30
34_K37_G1.2550.30
16_H28_T1.2480.30
36_I53_S1.2450.30
234_N238_K1.2430.30
21_T38_I1.2350.29
29_I37_G1.2310.29
28_T31_V1.2310.29
9_A29_I1.2300.29
130_A134_L1.2270.29
29_I38_I1.2250.29
239_L248_D1.2220.29
77_Y90_K1.2170.29
195_E206_K1.2150.29
9_A16_H1.2070.28
229_K233_E1.2030.28
19_K38_I1.2020.28
28_T42_Q1.1990.28
95_P101_T1.1990.28
89_I95_P1.1940.28
89_I93_Y1.1920.28
13_Y16_H1.1860.28
16_H29_I1.1740.27
36_I40_K1.1710.27
68_N71_Q1.1630.27
20_I29_I1.1630.27
64_N93_Y1.1520.26
35_T42_Q1.1310.26
227_Q231_K1.1290.26
32_S36_I1.1270.26
21_T34_K1.1260.26
16_H43_D1.1260.26
97_S109_E1.1040.25
224_F235_E1.1030.25
199_G202_G1.0990.25
210_K219_L1.0990.25
36_I43_D1.0980.25
20_I34_K1.0930.25
22_N46_K1.0850.24
25_I29_I1.0840.24
9_A13_Y1.0830.24
77_Y81_S1.0810.24
26_A36_I1.0810.24
28_T33_A1.0770.24
28_T38_I1.0730.24
12_I29_I1.0730.24
160_G163_G1.0670.24
12_I39_W1.0610.24
86_Q89_I1.0600.24
86_Q139_K1.0600.24
29_I33_A1.0550.23
85_T102_G1.0410.23
119_K132_D1.0320.23
37_G46_K1.0270.23
22_N42_Q1.0270.23
137_Y211_M1.0120.22
33_A36_I1.0120.22
153_K176_E1.0080.22
10_L43_D1.0070.22
81_S86_Q1.0040.22
10_L36_I0.9960.22
21_T25_I0.9930.22
208_A211_M0.9880.21
13_Y43_D0.9870.21
16_H20_I0.9860.21
19_K22_N0.9830.21
20_I28_T0.9800.21
10_L16_H0.9750.21
100_V109_E0.9720.21
224_F232_I0.9700.21
25_I33_A0.9700.21
13_Y18_G0.9690.21
212_K215_E0.9620.21
23_R36_I0.9550.20
75_C90_K0.9500.20
152_G178_S0.9500.20
21_T43_D0.9480.20
10_L29_I0.9450.20
28_T36_I0.9330.20
20_I25_I0.9310.20
25_I40_K0.9250.20
16_H32_S0.9240.20
243_K247_T0.9160.19
7_E43_D0.9150.19
100_V103_S0.9120.19
38_I43_D0.9100.19
111_V187_L0.9070.19
133_V221_F0.9070.19
23_R37_G0.9060.19
12_I21_T0.9050.19
15_Q33_A0.9040.19
142_F214_L0.9020.19
49_L52_A0.9010.19
15_Q28_T0.8930.19
18_G22_N0.8890.19
23_R38_I0.8820.19
225_P230_Q0.8810.19
25_I43_D0.8730.18
12_I42_Q0.8700.18
23_R42_Q0.8660.18
16_H31_V0.8650.18
239_L244_A0.8570.18
93_Y101_T0.8560.18
233_E240_A0.8530.18
143_A149_V0.8450.18
21_T37_G0.8420.18
20_I33_A0.8380.17
10_L38_I0.8360.17
16_H22_N0.8350.17
9_A15_Q0.8350.17
13_Y29_I0.8350.17
26_A39_W0.8280.17
10_L15_Q0.8240.17
58_K200_K0.8210.17
194_T206_K0.8200.17
16_H19_K0.8200.17
133_V235_E0.8200.17
9_A39_W0.8190.17
40_K45_W0.8170.17
8_Q25_I0.8140.17
17_Q20_I0.8140.17
15_Q20_I0.8120.17
32_S38_I0.8100.17
12_I17_Q0.7990.17
35_T40_K0.7930.16
226_D229_K0.7910.16
19_K25_I0.7890.16
134_L225_P0.7870.16
25_I28_T0.7860.16
8_Q11_A0.7840.16
22_N45_W0.7830.16
14_Q18_G0.7820.16
26_A31_V0.7810.16
210_K232_I0.7800.16
101_T108_N0.7720.16
23_R50_F0.7700.16
31_V47_E0.7650.16
22_N28_T0.7620.16
12_I15_Q0.7600.16
241_K245_E0.7600.16
33_A42_Q0.7590.16
20_I26_A0.7590.16
140_I211_M0.7520.15
159_V163_G0.7520.15
94_S101_T0.7500.15
115_I140_I0.7460.15
240_A244_A0.7400.15
22_N40_K0.7380.15
159_V173_I0.7370.15
88_A104_R0.7370.15
23_R34_K0.7370.15
22_N39_W0.7370.15
27_D32_S0.7360.15
242_Q245_E0.7350.15
82_F137_Y0.7350.15
22_N25_I0.7340.15
10_L39_W0.7330.15
160_G166_F0.7320.15
15_Q26_A0.7270.15
7_E38_I0.7270.15
210_K224_F0.7260.15
230_Q235_E0.7250.15
159_V162_S0.7220.15
43_D49_L0.7210.15
143_A220_Y0.7200.15
28_T32_S0.7200.15
26_A29_I0.7180.15
11_A18_G0.7170.15
106_L109_E0.7150.15
134_L224_F0.7130.15
81_S90_K0.7120.15
10_L22_N0.7120.15
124_N128_I0.7060.14
159_V166_F0.7060.14
10_L31_V0.6980.14
125_E131_M0.6960.14
75_C78_Y0.6950.14
28_T47_E0.6930.14
167_D170_D0.6920.14
61_P65_D0.6890.14
12_I25_I0.6810.14
235_E238_K0.6800.14
192_I219_L0.6770.14
15_Q22_N0.6770.14
22_N47_E0.6720.14
216_K228_F0.6700.14
45_W56_E0.6690.14
32_S43_D0.6690.14
9_A36_I0.6680.14
22_N26_A0.6670.14
12_I36_I0.6640.14
102_G109_E0.6630.14
225_P235_E0.6620.14
18_G36_I0.6620.14
136_V191_T0.6610.14
134_L138_I0.6610.14
21_T33_A0.6600.14
9_A31_V0.6580.13
37_G47_E0.6570.13
221_F225_P0.6550.13
227_Q234_N0.6550.13
17_Q21_T0.6520.13
134_L235_E0.6500.13
148_Y190_G0.6480.13
34_K50_F0.6390.13
7_E10_L0.6310.13
20_I38_I0.6300.13
79_V115_I0.6290.13
11_A22_N0.6270.13
239_L243_K0.6270.13
230_Q237_L0.6220.13
10_L21_T0.6200.13
19_K36_I0.6200.13
16_H35_T0.6190.13
31_V38_I0.6190.13
15_Q32_S0.6130.13
19_K24_A0.6120.13
97_S106_L0.6120.13
227_Q230_Q0.6090.13
71_Q91_A0.6060.12
10_L18_G0.5960.12
39_W45_W0.5940.12
22_N36_I0.5930.12
12_I28_T0.5910.12
12_I22_N0.5900.12
20_I39_W0.5860.12
13_Y49_L0.5860.12
137_Y209_D0.5860.12
17_Q25_I0.5860.12
134_L227_Q0.5840.12
23_R52_A0.5830.12
29_I45_W0.5790.12
145_I151_F0.5780.12
29_I40_K0.5740.12
18_G49_L0.5720.12
180_V203_I0.5720.12
134_L228_F0.5720.12
143_A213_A0.5700.12
178_S188_V0.5690.12
12_I37_G0.5660.12
14_Q38_I0.5660.12
11_A29_I0.5650.12
32_S41_K0.5630.12
232_I236_K0.5610.12
178_S182_V0.5600.12
103_S109_E0.5580.12
12_I31_V0.5570.12
153_K184_D0.5570.12
235_E243_K0.5570.12
216_K219_L0.5560.12
81_S132_D0.5550.12
48_A55_N0.5530.12
24_A35_T0.5530.12
64_N75_C0.5520.12
11_A34_K0.5520.12
139_K220_Y0.5510.12
7_E12_I0.5490.11
126_M227_Q0.5480.11
133_V225_P0.5480.11
9_A33_A0.5450.11
46_K49_L0.5450.11
42_Q46_K0.5440.11
242_Q246_K0.5420.11
119_K127_F0.5400.11
196_A201_E0.5370.11
11_A43_D0.5350.11
182_V187_L0.5350.11
140_I213_A0.5350.11
9_A26_A0.5350.11
17_Q43_D0.5340.11
13_Y32_S0.5290.11
13_Y19_K0.5250.11
26_A32_S0.5250.11
228_F232_I0.5220.11
15_Q38_I0.5220.11
19_K35_T0.5200.11
161_K165_L0.5180.11
122_M130_A0.5180.11
100_V106_L0.5170.11
18_G38_I0.5160.11
20_I31_V0.5130.11
11_A51_S0.5130.11
12_I32_S0.5120.11
136_V214_L0.5120.11
130_A139_K0.5120.11
18_G37_G0.5100.11
9_A25_I0.5100.11
171_N200_K0.5100.11
125_E139_K0.5090.11
238_K242_Q0.5040.11
88_A99_H0.5020.11
228_F237_L0.5020.11
9_A22_N0.5010.11
179_F183_K0.5010.11
178_S183_K0.5010.11
16_H38_I0.5010.11
15_Q31_V0.5000.11
209_D217_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zqpA 3 0.2906 100 0.685 Contact Map
2cmpA 1 0.2075 99.8 0.794 Contact Map
2ao9A 7 0.3774 96.7 0.928 Contact Map
2x48A 1 0.1585 96.2 0.932 Contact Map
2elhA 1 0.2566 96 0.933 Contact Map
1k78A 1 0.3925 95.7 0.935 Contact Map
2m8eA 1 0.1962 95.7 0.935 Contact Map
1tc3C 1 0.1849 95.4 0.936 Contact Map
3zqoA 5 0.2189 95.2 0.937 Contact Map
2jn6A 1 0.3509 95 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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