GREMLIN Database
CLPY - ATP-dependent protease ATPase subunit ClpY
UniProt: P39778 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 467 (445)
Sequences: 913 (506)
Seq/√Len: 24.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
399_K450_E6.7821.00
239_M247_V5.6181.00
102_V276_I5.4291.00
116_E269_R5.2651.00
42_L50_V5.1221.00
133_I195_V5.1131.00
101_M276_I4.8481.00
366_R370_E4.4371.00
360_T363_D4.1381.00
136_L195_V4.0191.00
191_E245_R4.0101.00
24_N357_N3.9291.00
361_V402_E3.9041.00
399_K402_E3.9031.00
117_K120_E3.7501.00
361_V398_H3.4821.00
309_V350_F3.4681.00
130_N186_A3.3971.00
183_H187_L3.3441.00
117_K265_E3.2891.00
365_V398_H3.2371.00
184_Q189_E3.1131.00
109_S270_A3.1111.00
391_E441_K3.0801.00
77_G116_E2.9591.00
106_V270_A2.9491.00
83_I278_I2.9281.00
10_Q13_D2.9261.00
365_V397_I2.9021.00
14_R17_Q2.8150.99
384_Q389_S2.7710.99
133_I245_R2.5840.99
53_K424_E2.5560.99
16_D23_Q2.5310.99
270_A326_V2.5250.99
389_S441_K2.4390.98
447_Q450_E2.3590.98
37_Y41_L2.3430.98
119_N122_K2.3060.98
410_D460_K2.1910.97
240_T243_E2.1830.97
381_A384_Q2.0900.95
313_T320_S2.0340.95
131_K182_A2.0320.95
106_V267_V2.0280.95
265_E268_Q2.0050.94
126_E249_T1.9960.94
133_I136_L1.9770.94
130_N182_A1.9670.94
129_A249_T1.9560.94
177_K180_R1.9480.93
396_A445_T1.9370.93
208_D211_Q1.9320.93
395_E446_P1.9090.93
403_V422_I1.8920.92
258_D261_E1.8550.92
424_E434_A1.8550.92
390_L444_I1.8100.91
106_V321_V1.7510.89
181_M184_Q1.7120.88
138_V181_M1.6830.87
122_K126_E1.6710.87
365_V394_D1.6650.86
388_I439_M1.6560.86
185_L191_E1.6390.86
138_V177_K1.6300.85
437_V440_E1.6280.85
185_L245_R1.6230.85
53_K434_A1.6040.84
132_R251_E1.6020.84
182_A186_A1.5830.83
259_M262_V1.5820.83
18_Y373_N1.5740.83
111_R305_I1.5700.83
106_V318_Y1.5690.83
133_I241_V1.5540.82
27_K425_R1.5380.82
270_A321_V1.5140.81
125_A129_A1.5020.80
179_K182_A1.4870.79
115_E119_N1.4820.79
460_K464_Q1.4650.78
28_A133_I1.4460.77
177_K181_M1.4420.77
129_A253_A1.4390.77
44_E47_K1.4280.76
245_R249_T1.4100.75
268_Q272_E1.4090.75
429_D452_K1.4070.75
132_R252_E1.4050.75
384_Q387_G1.4030.75
9_R436_D1.3950.75
430_L444_I1.3920.75
213_S221_N1.3910.74
47_K272_E1.3880.74
220_M223_Q1.3880.74
376_L396_A1.3880.74
199_V247_V1.3820.74
87_K96_R1.3680.73
37_Y305_I1.3610.73
424_E431_S1.3570.73
42_L45_K1.3560.73
107_E318_Y1.3530.72
122_K249_T1.3480.72
286_K294_A1.3400.72
258_D331_A1.3320.71
53_K431_S1.3300.71
81_I270_A1.3280.71
252_E255_K1.3270.71
242_R245_R1.3220.71
45_K372_D1.3150.70
445_T451_E1.3130.70
396_A430_L1.3110.70
126_E130_N1.3100.70
9_R27_K1.3080.70
208_D272_E1.3040.69
113_I269_R1.3020.69
130_N185_L1.2740.68
117_K261_E1.2660.67
407_V422_I1.2640.67
281_I284_I1.2580.67
45_K50_V1.2520.66
433_E440_E1.2500.66
407_V411_T1.2430.66
28_A428_E1.2390.65
86_T140_G1.2380.65
423_L426_L1.2350.65
53_K448_Y1.2170.64
239_M243_E1.2150.64
180_R184_Q1.1900.62
102_V123_E1.1850.62
56_L86_T1.1810.62
395_E445_T1.1740.61
308_I312_S1.1730.61
134_V181_M1.1720.61
112_L281_I1.1710.61
409_Q412_D1.1680.61
112_L312_S1.1670.61
48_D74_K1.1630.60
217_Q284_I1.1450.59
386_E434_A1.1410.59
58_M407_V1.1410.59
299_E374_A1.1400.59
88_F254_S1.1390.59
121_V253_A1.1330.58
424_E448_Y1.1280.58
266_A325_H1.1270.58
224_D227_S1.1260.58
312_S343_I1.1150.57
177_K193_Y1.1080.57
109_S267_V1.1070.57
269_R273_S1.1050.56
113_I116_E1.1000.56
189_E396_A1.0990.56
50_V123_E1.0930.56
78_A81_I1.0900.55
130_N245_R1.0900.55
102_V270_A1.0870.55
46_L373_N1.0870.55
255_K426_L1.0840.55
425_R456_I1.0810.55
107_E291_S1.0780.55
17_Q374_A1.0760.54
447_Q451_E1.0750.54
431_S434_A1.0730.54
42_L53_K1.0630.53
13_D123_E1.0620.53
131_K432_F1.0600.53
28_A226_L1.0590.53
198_E236_R1.0560.53
429_D433_E1.0500.53
50_V390_L1.0490.52
352_I401_A1.0490.52
130_N134_V1.0480.52
134_V182_A1.0480.52
439_M445_T1.0450.52
406_H410_D1.0450.52
106_V109_S1.0420.52
312_S420_H1.0330.51
196_T236_R1.0310.51
212_G221_N1.0290.51
200_E234_K1.0230.51
180_R193_Y1.0220.51
262_V374_A1.0220.51
17_Q210_L1.0210.50
96_R335_H1.0210.50
238_K377_K1.0160.50
205_S210_L1.0150.50
400_I426_L1.0120.50
139_P364_F1.0090.50
285_A336_M1.0080.50
110_V318_Y1.0050.49
377_K380_Q1.0030.49
49_E385_T1.0030.49
42_L86_T1.0030.49
299_E436_D1.0000.49
93_Y178_R0.9930.49
291_S294_A0.9890.48
17_Q250_N0.9850.48
138_V278_I0.9810.48
138_V180_R0.9780.47
308_I373_N0.9760.47
46_L459_N0.9750.47
134_V177_K0.9730.47
124_Q128_N0.9720.47
136_L197_V0.9700.47
267_V352_I0.9650.47
391_E443_T0.9580.46
72_I325_H0.9570.46
312_S371_P0.9530.46
42_L424_E0.9500.45
125_A256_L0.9490.45
96_R99_E0.9490.45
135_R177_K0.9480.45
47_K374_A0.9470.45
23_Q27_K0.9470.45
295_D331_A0.9450.45
121_V125_A0.9420.45
331_A397_I0.9410.45
374_A435_P0.9400.45
390_L427_L0.9370.45
198_E234_K0.9360.44
214_G218_M0.9220.44
313_T322_K0.9200.43
369_V394_D0.9180.43
129_A241_V0.9110.43
315_V376_L0.9100.43
135_R182_A0.9080.43
201_E235_K0.9060.42
28_A374_A0.9030.42
240_T245_R0.9020.42
58_M463_S0.9010.42
46_L381_A0.9010.42
198_E322_K0.8990.42
336_M465_F0.8970.42
226_L375_L0.8970.42
299_E312_S0.8940.42
436_D440_E0.8940.42
350_F373_N0.8930.41
278_I429_D0.8930.41
27_K428_E0.8910.41
93_Y298_R0.8880.41
205_S209_M0.8880.41
384_Q391_E0.8880.41
53_K86_T0.8870.41
109_S450_E0.8860.41
97_D335_H0.8850.41
134_V193_Y0.8830.41
19_I29_V0.8820.41
195_V241_V0.8810.41
195_V248_L0.8800.41
53_K385_T0.8800.41
86_T424_E0.8770.40
231_P256_L0.8760.40
118_M254_S0.8740.40
14_R364_F0.8740.40
136_L331_A0.8720.40
433_E452_K0.8710.40
456_I463_S0.8700.40
388_I438_T0.8690.40
195_V263_G0.8680.40
45_K445_T0.8680.40
31_V256_L0.8660.40
403_V457_A0.8610.39
431_S448_Y0.8560.39
88_F138_V0.8560.39
213_S305_I0.8530.39
148_K151_F0.8470.38
196_T293_S0.8420.38
13_D17_Q0.8380.38
9_R433_E0.8360.38
463_S466_I0.8340.37
366_R371_P0.8340.37
181_M193_Y0.8300.37
275_I329_I0.8280.37
230_M331_A0.8190.37
53_K425_R0.8160.36
358_K366_R0.8140.36
197_V239_M0.8130.36
339_P355_E0.8120.36
337_A429_D0.8100.36
260_D376_L0.8050.36
221_N224_D0.8040.36
265_E381_A0.8030.35
20_V270_A0.8000.35
223_Q453_L0.7970.35
299_E400_I0.7950.35
122_K173_N0.7930.35
386_E440_E0.7910.35
402_E406_H0.7890.35
184_Q193_Y0.7880.34
20_V40_S0.7840.34
56_L197_V0.7830.34
42_L390_L0.7830.34
27_K109_S0.7820.34
364_F374_A0.7820.34
376_L397_I0.7810.34
117_K259_M0.7780.34
53_K411_T0.7770.34
177_K305_I0.7750.34
330_A461_D0.7700.33
106_V120_E0.7680.33
86_T242_R0.7670.33
426_L453_L0.7670.33
201_E233_K0.7670.33
212_G331_A0.7670.33
138_V270_A0.7660.33
234_K321_V0.7620.33
446_P450_E0.7620.33
24_N31_V0.7600.33
97_D103_R0.7590.33
106_V110_V0.7580.33
178_R296_V0.7580.33
118_M261_E0.7570.33
200_E251_E0.7560.32
86_T180_R0.7510.32
284_I315_V0.7480.32
186_A217_Q0.7460.32
114_K259_M0.7460.32
101_M308_I0.7450.32
358_K413_N0.7450.32
399_K446_P0.7420.32
371_P466_I0.7410.32
376_L380_Q0.7410.32
374_A377_K0.7410.32
246_K261_E0.7390.31
44_E109_S0.7390.31
117_K331_A0.7380.31
208_D217_Q0.7370.31
41_L117_K0.7370.31
88_F219_G0.7360.31
210_L213_S0.7350.31
199_V272_E0.7350.31
385_T424_E0.7340.31
298_R364_F0.7330.31
140_G305_I0.7310.31
231_P308_I0.7310.31
285_A335_H0.7270.31
129_A245_R0.7250.31
374_A466_I0.7250.31
60_P86_T0.7220.30
414_I421_T0.7220.30
86_T142_K0.7210.30
106_V352_I0.7210.30
278_I362_D0.7200.30
225_A358_K0.7200.30
17_Q288_G0.7190.30
276_I308_I0.7180.30
93_Y296_V0.7180.30
407_V463_S0.7140.30
438_T447_Q0.7130.30
136_L241_V0.7130.30
191_E200_E0.7090.30
56_L135_R0.7080.30
413_N462_L0.7080.30
207_F211_Q0.7050.29
329_I400_I0.7050.29
204_P240_T0.7040.29
77_G295_D0.7000.29
27_K450_E0.6990.29
74_K271_E0.6990.29
214_G226_L0.6990.29
51_V261_E0.6980.29
129_A318_Y0.6970.29
388_I437_V0.6950.29
56_L253_A0.6920.29
50_V385_T0.6920.29
101_M231_P0.6890.28
20_V106_V0.6870.28
134_V179_K0.6860.28
350_F366_R0.6860.28
185_L426_L0.6850.28
20_V358_K0.6830.28
10_Q119_N0.6810.28
294_A336_M0.6810.28
45_K371_P0.6810.28
102_V106_V0.6800.28
49_E101_M0.6800.28
220_M284_I0.6800.28
191_E305_I0.6800.28
257_I262_V0.6780.28
330_A452_K0.6770.28
371_P463_S0.6770.28
215_M222_M0.6760.28
136_L222_M0.6760.28
259_M263_G0.6750.28
81_I312_S0.6730.28
81_I108_T0.6730.28
390_L430_L0.6730.28
74_K315_V0.6730.28
48_D269_R0.6730.28
28_A352_I0.6720.27
309_V384_Q0.6720.27
185_L403_V0.6710.27
380_Q391_E0.6700.27
50_V429_D0.6690.27
10_Q186_A0.6660.27
285_A305_I0.6660.27
339_P353_R0.6650.27
189_E245_R0.6640.27
194_Y238_K0.6640.27
177_K325_H0.6630.27
411_T424_E0.6630.27
86_T108_T0.6630.27
112_L371_P0.6620.27
211_Q299_E0.6620.27
185_L190_L0.6620.27
371_P436_D0.6610.27
270_A325_H0.6600.27
81_I465_F0.6600.27
48_D278_I0.6590.27
230_M234_K0.6540.26
257_I312_S0.6530.26
128_N131_K0.6520.26
144_Q241_V0.6520.26
337_A409_Q0.6500.26
407_V456_I0.6490.26
299_E371_P0.6480.26
78_A223_Q0.6480.26
220_M227_S0.6480.26
23_Q384_Q0.6480.26
28_A278_I0.6480.26
232_K270_A0.6470.26
339_P407_V0.6470.26
172_A176_E0.6460.26
226_L284_I0.6450.26
312_S350_F0.6430.26
425_R428_E0.6420.26
86_T111_R0.6420.26
18_Y374_A0.6410.26
383_L403_V0.6410.26
362_D398_H0.6410.26
51_V285_A0.6400.26
184_Q195_V0.6390.26
358_K412_D0.6370.26
284_I326_V0.6370.26
180_R189_E0.6370.26
58_M339_P0.6360.25
106_V465_F0.6350.25
403_V426_L0.6350.25
147_V150_P0.6330.25
427_L465_F0.6320.25
357_N452_K0.6320.25
114_K221_N0.6310.25
87_K104_D0.6310.25
242_R442_I0.6300.25
330_A350_F0.6290.25
291_S413_N0.6290.25
194_Y258_D0.6280.25
210_L221_N0.6270.25
218_M284_I0.6240.25
284_I289_G0.6220.25
215_M233_K0.6220.25
281_I369_V0.6220.25
371_P374_A0.6220.25
200_E444_I0.6220.25
96_R427_L0.6210.25
23_Q43_D0.6210.25
44_E262_V0.6210.25
129_A375_L0.6190.25
400_I405_Y0.6180.25
393_S443_T0.6160.24
254_S271_E0.6160.24
44_E397_I0.6160.24
131_K440_E0.6150.24
120_E444_I0.6140.24
132_R255_K0.6140.24
173_N176_E0.6130.24
362_D365_V0.6130.24
386_E436_D0.6130.24
179_K187_L0.6130.24
241_V246_K0.6110.24
229_L237_R0.6110.24
134_V138_V0.6100.24
17_Q196_T0.6100.24
20_V437_V0.6090.24
23_Q248_L0.6090.24
48_D99_E0.6090.24
355_E407_V0.6090.24
209_M216_E0.6080.24
184_Q374_A0.6070.24
111_R177_K0.6070.24
112_L295_D0.6070.24
335_H427_L0.6070.24
276_I321_V0.6040.24
383_L427_L0.6040.24
19_I453_L0.6030.24
386_E439_M0.6030.24
20_V406_H0.6020.24
312_S466_I0.6000.24
37_Y40_S0.5990.24
254_S263_G0.5990.24
99_E136_L0.5980.23
78_A273_S0.5980.23
431_S437_V0.5980.23
138_V376_L0.5970.23
202_Q357_N0.5970.23
24_N284_I0.5960.23
48_D396_A0.5960.23
270_A320_S0.5940.23
40_S56_L0.5930.23
29_V68_I0.5930.23
63_V379_Y0.5920.23
238_K292_S0.5920.23
68_I356_L0.5910.23
285_A308_I0.5910.23
375_L423_L0.5900.23
380_Q389_S0.5900.23
129_A191_E0.5900.23
45_K466_I0.5880.23
77_G432_F0.5860.23
108_T420_H0.5860.23
398_H446_P0.5860.23
37_Y134_V0.5850.23
453_L467_L0.5850.23
211_Q217_Q0.5850.23
7_T109_S0.5840.23
146_G215_M0.5820.23
196_T382_L0.5820.23
220_M396_A0.5810.23
136_L269_R0.5810.23
398_H445_T0.5800.23
18_Y233_K0.5800.23
259_M308_I0.5790.23
178_R298_R0.5790.23
130_N179_K0.5780.22
229_L412_D0.5780.22
271_E407_V0.5780.22
321_V326_V0.5770.22
88_F313_T0.5770.22
86_T224_D0.5770.22
403_V454_G0.5760.22
37_Y57_M0.5750.22
195_V242_R0.5750.22
57_M130_N0.5750.22
56_L264_Q0.5750.22
56_L136_L0.5740.22
111_R308_I0.5740.22
370_E436_D0.5720.22
397_I445_T0.5710.22
383_L434_A0.5710.22
101_M111_R0.5690.22
94_V412_D0.5690.22
27_K399_K0.5690.22
433_E437_V0.5680.22
107_E262_V0.5680.22
86_T431_S0.5680.22
60_P296_V0.5680.22
37_Y76_S0.5680.22
134_V185_L0.5670.22
41_L272_E0.5670.22
46_L137_L0.5660.22
78_A86_T0.5650.22
5_P436_D0.5650.22
10_Q464_Q0.5640.22
340_S370_E0.5640.22
289_G294_A0.5640.22
51_V263_G0.5630.22
339_P352_I0.5630.22
288_G451_E0.5620.22
337_A369_V0.5620.22
81_I276_I0.5610.22
221_N426_L0.5610.22
305_I396_A0.5610.22
114_K140_G0.5590.22
353_R463_S0.5580.22
254_S261_E0.5580.22
208_D248_L0.5570.21
402_E450_E0.5560.21
128_N255_K0.5560.21
216_E426_L0.5550.21
50_V361_V0.5550.21
262_V291_S0.5540.21
364_F413_N0.5540.21
360_T366_R0.5540.21
175_E459_N0.5540.21
14_R47_K0.5530.21
313_T324_D0.5530.21
191_E458_K0.5530.21
339_P411_T0.5520.21
379_Y453_L0.5510.21
411_T464_Q0.5500.21
99_E312_S0.5500.21
33_L76_S0.5480.21
388_I440_E0.5480.21
41_L411_T0.5470.21
142_K314_V0.5470.21
57_M239_M0.5460.21
400_I429_D0.5460.21
176_E180_R0.5450.21
14_R252_E0.5420.21
74_K130_N0.5410.21
124_Q246_K0.5390.21
343_I457_A0.5390.21
318_Y322_K0.5380.21
31_V352_I0.5380.21
37_Y127_E0.5370.21
46_L72_I0.5370.21
78_A108_T0.5370.21
177_K184_Q0.5360.20
118_M121_V0.5360.20
20_V183_H0.5360.20
411_T422_I0.5350.20
86_T428_E0.5350.20
77_G149_N0.5350.20
179_K361_V0.5340.20
285_A427_L0.5340.20
288_G292_S0.5330.20
88_F101_M0.5320.20
238_K246_K0.5310.20
305_I448_Y0.5300.20
49_E60_P0.5290.20
173_N251_E0.5290.20
293_S422_I0.5270.20
231_P435_P0.5270.20
388_I399_K0.5260.20
97_D465_F0.5250.20
75_L214_G0.5240.20
201_E380_Q0.5240.20
56_L219_G0.5220.20
263_G267_V0.5220.20
20_V360_T0.5210.20
109_S194_Y0.5200.20
106_V243_E0.5190.20
369_V374_A0.5190.20
42_L88_F0.5190.20
362_D402_E0.5180.20
219_G360_T0.5180.20
122_K278_I0.5180.20
31_V236_R0.5180.20
324_D401_A0.5170.20
241_V245_R0.5170.20
185_L352_I0.5170.20
27_K373_N0.5160.20
143_K147_V0.5150.20
192_D200_E0.5150.20
308_I350_F0.5140.19
58_M466_I0.5140.19
42_L371_P0.5130.19
194_Y263_G0.5120.19
383_L395_E0.5110.19
211_Q219_G0.5110.19
41_L305_I0.5110.19
440_E445_T0.5100.19
48_D116_E0.5090.19
135_R423_L0.5090.19
126_E321_V0.5080.19
357_N451_E0.5080.19
289_G441_K0.5080.19
170_E400_I0.5080.19
23_Q432_F0.5080.19
330_A453_L0.5080.19
96_R104_D0.5080.19
331_A344_P0.5070.19
278_I366_R0.5070.19
173_N428_E0.5070.19
305_I343_I0.5060.19
184_Q393_S0.5060.19
325_H339_P0.5050.19
213_S321_V0.5050.19
228_G444_I0.5050.19
19_I49_E0.5050.19
41_L47_K0.5050.19
386_E396_A0.5040.19
44_E264_Q0.5040.19
19_I344_P0.5010.19
181_M305_I0.5000.19
340_S388_I0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g41A 3 0.7152 100 0.657 Contact Map
1ofhA 3 0.6617 100 0.783 Contact Map
1um8A 1 0.5867 100 0.844 Contact Map
3hwsA 3 0.636 100 0.859 Contact Map
1r6bX 1 0.5931 100 0.878 Contact Map
3pxiA 3 0.5439 99.9 0.891 Contact Map
4ww4B 2 0.8051 99.9 0.895 Contact Map
1qvrA 3 0.561 99.9 0.902 Contact Map
4ciuA 1 0.5739 99.9 0.903 Contact Map
4d2uA 3 0.5739 99.9 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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