GREMLIN Database
XERC - Tyrosine recombinase XerC
UniProt: P39776 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (271)
Sequences: 37738 (30157)
Seq/√Len: 1831.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_A270_L5.0591.00
52_A55_D3.2471.00
158_I194_M3.2391.00
178_R271_G3.1681.00
147_G252_F2.7871.00
143_L245_P2.7451.00
244_H247_M2.7381.00
150_V246_H2.6781.00
252_F269_L2.5991.00
63_A76_K2.4661.00
46_N55_D2.2911.00
157_T211_L2.2261.00
169_L179_Y2.2021.00
143_L153_C2.1751.00
157_T220_P2.1691.00
272_H278_T2.1581.00
166_D187_R2.0991.00
250_H283_H2.0761.00
138_A193_Y2.0201.00
115_Y118_E2.0121.00
157_T210_D1.9651.00
32_S75_K1.9581.00
145_A183_G1.9181.00
262_D265_S1.9031.00
257_L266_V1.8891.00
187_R191_K1.8801.00
167_T179_Y1.8781.00
60_L77_I1.8431.00
152_E178_R1.8321.00
264_R267_Q1.7991.00
86_F90_E1.7471.00
30_V34_E1.7441.00
35_E76_K1.7431.00
162_D165_M1.7351.00
32_S79_A1.7151.00
12_V30_V1.6571.00
270_L278_T1.6491.00
181_P269_L1.6481.00
256_L261_A1.6211.00
176_K273_S1.6211.00
136_D229_I1.6091.00
56_T98_F1.5861.00
276_S279_Q1.5801.00
258_N288_M1.5781.00
8_V33_I1.5671.00
137_Q141_E1.5581.00
116_Q255_H1.5571.00
148_M153_C1.5551.00
8_V83_F1.5271.00
252_F256_L1.5061.00
257_L282_T1.4811.00
182_F187_R1.4631.00
51_A84_Y1.4591.00
47_G50_E1.4441.00
144_Y255_H1.4321.00
83_F87_L1.4301.00
114_L251_T1.4271.00
139_L226_I1.4151.00
157_T160_D1.4051.00
158_I212_L1.4041.00
256_L266_V1.4031.00
71_R75_K1.4021.00
163_L191_K1.4001.00
141_E189_A1.3991.00
267_Q275_L1.3841.00
25_T29_Y1.3831.00
150_V154_C1.3761.00
150_V223_A1.3741.00
24_Y27_V1.3651.00
145_A186_A1.3541.00
254_T283_H1.3491.00
119_L144_Y1.3441.00
277_S280_I1.3391.00
127_D137_Q1.3171.00
162_D167_T1.3131.00
126_S233_L1.3121.00
23_Q27_V1.3071.00
264_R268_E1.3061.00
118_E121_E1.2721.00
59_F76_K1.2721.00
151_S155_S1.2651.00
59_F63_A1.2541.00
114_L243_I1.2501.00
138_A192_V1.2481.00
211_L220_P1.2471.00
123_F141_E1.2381.00
267_Q278_T1.2221.00
7_F87_L1.2221.00
119_L255_H1.2131.00
139_L153_C1.2121.00
148_M170_V1.2041.00
251_T255_H1.2001.00
11_F82_S1.1911.00
64_Y73_I1.1911.00
16_Q26_I1.1891.00
60_L64_Y1.1891.00
74_S104_P1.1861.00
223_A227_R1.1851.00
77_I81_R1.1811.00
159_N210_D1.1731.00
258_N285_S1.1681.00
72_T76_K1.1661.00
27_V31_D1.1631.00
253_A266_V1.1561.00
222_T225_G1.1531.00
166_D184_S1.1531.00
138_A189_A1.1501.00
85_K99_Q1.1441.00
149_R246_H1.1341.00
120_E124_E1.1341.00
12_V26_I1.1331.00
234_V243_I1.1291.00
274_N277_S1.1281.00
224_R227_R1.1231.00
171_H177_Q1.1131.00
91_K95_E1.1081.00
144_Y248_L1.1081.00
156_I168_V1.1031.00
150_V227_R1.0941.00
7_F86_F1.0861.00
88_M93_I1.0841.00
69_S72_T1.0811.00
113_F251_T1.0801.00
227_R231_S1.0801.00
229_I232_G1.0741.00
139_L213_F1.0741.00
274_N279_Q1.0741.00
169_L177_Q1.0721.00
116_Q259_E1.0691.00
230_L234_V1.0681.00
57_R61_T1.0581.00
144_Y251_T1.0551.00
252_F270_L1.0451.00
40_L43_Q1.0431.00
253_A282_T1.0381.00
225_G228_H1.0381.00
26_I30_V1.0371.00
121_E125_V1.0361.00
7_F48_F1.0331.00
32_S76_K1.0321.00
68_L76_K1.0291.00
114_L122_L1.0281.00
159_N209_H1.0171.00
28_N31_D1.0171.00
125_V236_K1.0141.00
193_Y197_G1.0121.00
183_G186_A1.0081.00
125_V237_A1.0071.00
254_T282_T1.0061.00
42_V62_E1.0001.00
28_N32_S0.9991.00
145_A185_Y0.9991.00
184_S188_E0.9931.00
116_Q258_N0.9741.00
137_Q189_A0.9701.00
84_Y93_I0.9691.00
22_S25_T0.9631.00
29_Y79_A0.9591.00
290_R294_M0.9571.00
57_R90_E0.9541.00
10_L14_Y0.9531.00
141_E185_Y0.9531.00
24_Y28_N0.9521.00
31_D35_E0.9431.00
162_D169_L0.9431.00
171_H175_K0.9401.00
288_M291_N0.9401.00
21_Y26_I0.9371.00
116_Q120_E0.9351.00
142_L213_F0.9351.00
126_S140_L0.9331.00
64_Y70_R0.9291.00
142_L168_V0.9271.00
15_L21_Y0.9221.00
85_K96_N0.9211.00
68_L72_T0.9141.00
255_H258_N0.9131.00
53_Y57_R0.9091.00
158_I197_G0.9091.00
154_C223_A0.9051.00
63_A68_L0.9011.00
114_L118_E0.8951.00
231_S242_H0.8911.00
232_G236_K0.8891.00
87_L92_L0.8861.00
265_S292_T0.8751.00
253_A257_L0.8731.00
268_E289_L0.8711.00
81_R85_K0.8681.00
134_M196_S0.8671.00
53_Y89_R0.8651.00
134_M192_V0.8641.00
9_K40_L0.8641.00
46_N50_E0.8631.00
89_R102_H0.8631.00
185_Y188_E0.8631.00
267_Q279_Q0.8581.00
43_Q59_F0.8571.00
261_A265_S0.8571.00
28_N75_K0.8551.00
156_I161_V0.8541.00
211_L214_V0.8531.00
84_Y97_P0.8531.00
113_F283_H0.8521.00
138_A213_F0.8501.00
75_K78_S0.8471.00
233_L236_K0.8471.00
250_H280_I0.8461.00
263_L279_Q0.8451.00
10_L92_L0.8451.00
231_S235_Q0.8411.00
21_Y29_Y0.8401.00
215_N219_G0.8371.00
227_R245_P0.8371.00
23_Q26_I0.8351.00
142_L186_A0.8331.00
9_K13_E0.8291.00
163_L187_R0.8291.00
150_V226_I0.8251.00
88_M96_N0.8251.00
58_I62_E0.8191.00
160_D171_H0.8171.00
68_L73_I0.8141.00
63_A73_I0.8131.00
130_Q133_G0.8091.00
36_F84_Y0.8091.00
146_T180_I0.8051.00
118_E241_L0.8051.00
12_V16_Q0.8051.00
37_E41_R0.7941.00
287_E291_N0.7931.00
192_V196_S0.7921.00
182_F186_A0.7921.00
147_G270_L0.7921.00
154_C226_I0.7851.00
91_K100_L0.7831.00
89_R100_L0.7831.00
112_K247_M0.7821.00
87_L93_I0.7791.00
112_K241_L0.7781.00
55_D58_I0.7771.00
59_F62_E0.7771.00
84_Y98_F0.7751.00
9_K30_V0.7731.00
134_M138_A0.7681.00
274_N278_T0.7681.00
186_A189_A0.7651.00
253_A278_T0.7641.00
149_R171_H0.7581.00
230_L245_P0.7571.00
96_N99_Q0.7541.00
77_I98_F0.7501.00
269_L289_L0.7481.00
11_F15_L0.7481.00
253_A272_H0.7471.00
150_V245_P0.7421.00
142_L153_C0.7391.00
134_M137_Q0.7361.00
228_H232_G0.7321.00
57_R60_L0.7251.00
31_D34_E0.7231.00
224_R231_S0.7171.00
156_I212_L0.7171.00
125_V233_L0.7161.00
191_K194_M0.7161.00
122_L234_V0.7131.00
88_M95_E0.7111.00
275_L278_T0.7101.00
126_S137_Q0.7101.00
162_D166_D0.7081.00
143_L150_V0.7051.00
263_L275_L0.7031.00
88_M99_Q0.7021.00
258_N287_E0.7021.00
275_L279_Q0.7011.00
191_K195_N0.6941.00
142_L148_M0.6941.00
225_G229_I0.6931.00
229_I233_L0.6891.00
83_F86_F0.6881.00
257_L285_S0.6871.00
61_T64_Y0.6871.00
230_L248_L0.6861.00
291_N294_M0.6841.00
7_F83_F0.6841.00
261_A292_T0.6831.00
54_Q58_I0.6801.00
15_L29_Y0.6791.00
246_H250_H0.6791.00
71_R74_S0.6781.00
53_Y91_K0.6741.00
114_L247_M0.6711.00
122_L140_L0.6701.00
197_G214_V0.6681.00
231_S234_V0.6661.00
136_D233_L0.6631.00
74_S78_S0.6631.00
127_D141_E0.6621.00
8_V12_V0.6611.00
36_F80_L0.6601.00
35_E59_F0.6581.00
194_M197_G0.6561.00
135_R193_Y0.6561.00
265_S269_L0.6531.00
15_L19_K0.6531.00
141_E186_A0.6511.00
119_L123_F0.6511.00
43_Q58_I0.6511.00
243_I247_M0.6491.00
60_L73_I0.6471.00
261_A266_V0.6461.00
188_E192_V0.6451.00
16_Q30_V0.6431.00
33_I83_F0.6411.00
15_L82_S0.6381.00
62_E66_K0.6381.00
113_F254_T0.6351.00
189_A192_V0.6351.00
121_E124_E0.6351.00
56_T80_L0.6311.00
172_G178_R0.6301.00
226_I245_P0.6301.00
10_L13_E0.6301.00
146_T183_G0.6291.00
287_E290_R0.6291.00
54_Q90_E0.6281.00
257_L264_R0.6261.00
184_S294_M0.6211.00
148_M152_E0.6211.00
188_E191_K0.6211.00
33_I40_L0.6211.00
264_R279_Q0.6201.00
116_Q251_T0.6191.00
13_E16_Q0.6181.00
84_Y88_M0.6161.00
117_K121_E0.6151.00
36_F59_F0.6151.00
148_M168_V0.6111.00
247_M250_H0.6091.00
70_R74_S0.6081.00
257_L262_D0.6081.00
285_S288_M0.6071.00
51_A56_T0.6071.00
138_A142_L0.6001.00
257_L263_L0.5991.00
233_L237_A0.5981.00
86_F92_L0.5981.00
190_L212_L0.5981.00
10_L86_F0.5961.00
141_E145_A0.5951.00
140_L248_L0.5951.00
138_A186_A0.5941.00
81_R98_F0.5911.00
123_F137_Q0.5881.00
81_R103_L0.5881.00
155_S220_P0.5871.00
119_L251_T0.5861.00
117_K120_E0.5851.00
193_Y196_S0.5821.00
85_K88_M0.5821.00
286_K289_L0.5781.00
111_P244_H0.5781.00
59_F80_L0.5741.00
33_I79_A0.5731.00
267_Q277_S0.5711.00
98_F101_V0.5691.00
48_F87_L0.5661.00
266_V282_T0.5631.00
161_V190_L0.5601.00
77_I101_V0.5531.00
88_M100_L0.5501.00
114_L119_L0.5491.00
273_S277_S0.5471.00
152_E271_G0.5461.00
148_M156_I0.5461.00
135_R138_A0.5441.00
74_S103_L0.5411.00
263_L278_T0.5391.00
267_Q270_L0.5371.00
163_L166_D0.5341.00
80_L98_F0.5291.00
143_L248_L0.5281.00
181_P290_R0.5251.00
138_A190_L0.5221.00
225_G232_G0.5221.00
15_L20_N0.5221.00
82_S85_K0.5191.00
82_S86_F0.5191.00
224_R228_H0.5191.00
53_Y100_L0.5181.00
267_Q274_N0.5151.00
135_R229_I0.5151.00
255_H259_E0.5151.00
29_Y32_S0.5131.00
192_V195_N0.5121.00
257_L284_V0.5111.00
142_L190_L0.5101.00
108_K280_I0.5091.00
140_L230_L0.5081.00
157_T209_H0.5041.00
158_I190_L0.5031.00
207_E210_D0.5031.00
33_I37_E0.5031.00
75_K79_A0.5021.00
111_P250_H0.5021.00
7_F90_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.8882 100 0.165 Contact Map
1z19A 3 0.9178 100 0.221 Contact Map
2a3vA 3 0.9309 100 0.222 Contact Map
1z1bA 3 0.9112 100 0.226 Contact Map
1xo0A 3 0.9408 100 0.239 Contact Map
4a8eA 2 0.8618 100 0.258 Contact Map
3nkhA 2 0.6414 100 0.413 Contact Map
1ae9A 4 0.5428 100 0.477 Contact Map
1aihA 2 0.5526 99.9 0.521 Contact Map
4e0gA 2 0.8849 99.9 0.556 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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