GPMI - BACSU - GREMLIN Contacts

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GPMI - 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

UniProt:	P39773	Sequences: MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQTLTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAISNAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTAKTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALDVVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKDFRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAETEKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKHDAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADILITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSLIQK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	511 (499)
Sequences:	2438 (1489)
Seq/√Len:	66.7

ECOLI - GPMI
BACSU - GPMI
HALSA - GPMI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_E	203_R	5.087	1.00
27_L	411_V	3.572	1.00
381_D	427_E	3.568	1.00
356_E	392_H	3.482	1.00
315_N	502_E	3.473	1.00
32_N	426_G	3.069	1.00
221_D	225_A	3.051	1.00
198_V	267_Q	2.993	1.00
380_K	399_F	2.913	1.00
388_E	434_A	2.868	1.00
69_I	487_L	2.761	1.00
134_K	170_Q	2.705	1.00
493_D	507_S	2.684	1.00
30_K	34_D	2.651	1.00
50_E	87_R	2.610	1.00
215_S	218_D	2.583	1.00
35_R	39_Q	2.536	1.00
411_V	415_I	2.516	1.00
16_L	44_T	2.421	1.00
321_L	394_A	2.399	1.00
318_G	330_R	2.388	1.00
37_W	42_H	2.365	1.00
319_E	323_Q	2.351	1.00
223_S	228_I	2.339	1.00
51_A	483_I	2.326	1.00
200_K	234_I	2.317	1.00
186_Y	366_A	2.315	1.00
382_A	385_K	2.296	1.00
85_A	308_F	2.291	1.00
165_N	169_D	2.287	1.00
129_L	258_Y	2.277	1.00
213_Y	236_S	2.260	1.00
46_T	51_A	2.244	1.00
320_V	324_H	2.221	1.00
158_Q	229_Y	2.206	1.00
150_L	233_V	2.200	1.00
168_N	172_K	2.193	1.00
102_S	139_E	2.173	1.00
119_D	163_Y	2.168	1.00
110_A	145_Y	2.155	1.00
161_K	221_D	2.107	1.00
390_D	435_K	2.099	1.00
102_S	106_E	2.085	1.00
380_K	427_E	2.083	1.00
101_I	135_L	2.073	1.00
493_D	499_K	2.068	1.00
399_F	428_V	2.066	1.00
168_N	215_S	2.041	1.00
130_F	170_Q	2.023	1.00
98_L	139_E	2.006	1.00
134_K	138_K	1.992	1.00
486_D	505_G	1.966	1.00
110_A	143_K	1.928	1.00
130_F	166_Q	1.922	1.00
27_L	415_I	1.921	1.00
432_I	437_G	1.919	1.00
132_L	258_Y	1.911	1.00
146_I	171_I	1.894	1.00
183_S	204_A	1.872	1.00
110_A	250_Q	1.862	1.00
469_V	487_L	1.861	1.00
228_I	234_I	1.852	1.00
218_D	222_D	1.850	1.00
22_G	452_I	1.850	1.00
150_L	160_A	1.848	1.00
429_V	439_A	1.830	1.00
170_Q	173_E	1.807	1.00
84_V	88_E	1.781	1.00
373_E	416_K	1.778	1.00
5_P	437_G	1.768	1.00
360_I	382_A	1.754	1.00
205_M	249_I	1.729	1.00
168_N	216_A	1.706	0.99
388_E	431_A	1.705	0.99
499_K	506_T	1.704	0.99
326_L	393_D	1.691	0.99
109_K	252_G	1.688	0.99
499_K	507_S	1.679	0.99
114_F	149_F	1.671	0.99
327_K	391_K	1.641	0.99
441_I	472_T	1.637	0.99
145_Y	180_A	1.628	0.99
168_N	217_L	1.626	0.99
204_A	237_V	1.623	0.99
103_N	254_S	1.618	0.99
178_E	240_K	1.591	0.99
394_A	491_L	1.589	0.99
158_Q	227_G	1.585	0.99
321_L	326_L	1.576	0.99
440_I	494_L	1.559	0.99
95_Q	99_D	1.553	0.99
317_V	394_A	1.551	0.99
33_F	425_L	1.549	0.99
384_V	431_A	1.547	0.99
249_I	255_V	1.535	0.99
249_I	272_F	1.527	0.99
32_N	35_R	1.519	0.99
432_I	439_A	1.517	0.99
100_A	254_S	1.513	0.99
68_N	75_V	1.513	0.99
146_I	167_L	1.509	0.99
104_A	254_S	1.496	0.99
203_R	209_E	1.478	0.99
366_A	370_L	1.470	0.98
126_I	130_F	1.465	0.98
133_L	171_I	1.463	0.98
382_A	386_E	1.462	0.98
7_A	432_I	1.461	0.98
377_Y	423_E	1.457	0.98
43_Q	481_G	1.440	0.98
9_I	439_A	1.434	0.98
94_N	307_A	1.426	0.98
331_I	379_V	1.420	0.98
252_G	289_N	1.410	0.98
277_F	280_F	1.408	0.98
20_T	26_A	1.407	0.98
430_D	434_A	1.402	0.98
320_V	497_V	1.389	0.98
270_N	274_N	1.388	0.98
387_I	431_A	1.383	0.98
377_Y	424_C	1.381	0.98
161_K	217_L	1.380	0.98
29_K	419_E	1.375	0.98
86_I	131_A	1.373	0.98
156_G	159_T	1.373	0.98
143_K	178_E	1.372	0.98
384_V	388_E	1.371	0.98
387_I	435_K	1.368	0.98
317_V	491_L	1.365	0.98
76_Y	84_V	1.364	0.98
214_R	218_D	1.363	0.97
386_E	389_A	1.362	0.97
92_E	138_K	1.359	0.97
257_F	265_A	1.353	0.97
86_I	91_F	1.351	0.97
161_K	165_N	1.347	0.97
31_P	419_E	1.344	0.97
43_Q	478_L	1.340	0.97
452_I	456_G	1.333	0.97
183_S	188_S	1.331	0.97
133_L	144_V	1.330	0.97
331_I	397_L	1.320	0.97
111_L	136_A	1.314	0.97
297_H	310_P	1.310	0.97
291_Y	305_Y	1.301	0.97
104_A	111_L	1.300	0.97
420_A	424_C	1.298	0.97
11_L	425_L	1.298	0.97
383_L	397_L	1.296	0.97
75_V	313_L	1.294	0.97
453_T	457_E	1.293	0.97
144_V	176_V	1.292	0.97
414_T	451_L	1.292	0.97
377_Y	420_A	1.291	0.97
426_G	430_D	1.291	0.97
11_L	33_F	1.288	0.96
113_L	258_Y	1.275	0.96
168_N	179_I	1.275	0.96
188_S	201_A	1.275	0.96
46_T	466_P	1.274	0.96
348_R	352_F	1.266	0.96
181_S	204_A	1.265	0.96
440_I	469_V	1.260	0.96
119_D	126_I	1.259	0.96
313_L	316_T	1.258	0.96
99_D	305_Y	1.254	0.96
162_T	165_N	1.253	0.96
387_I	395_I	1.251	0.96
25_V	448_A	1.251	0.96
17_R	20_T	1.250	0.96
207_Y	283_G	1.248	0.96
203_R	207_Y	1.239	0.96
83_N	127_N	1.239	0.96
85_A	90_E	1.238	0.96
105_K	139_E	1.237	0.96
431_A	434_A	1.237	0.96
133_L	174_I	1.237	0.96
360_I	386_E	1.228	0.95
377_Y	381_D	1.228	0.95
141_L	144_V	1.225	0.95
14_F	33_F	1.209	0.95
187_Y	234_I	1.207	0.95
223_S	234_I	1.206	0.95
219_V	236_S	1.198	0.95
101_I	136_A	1.195	0.95
113_L	129_L	1.193	0.95
193_K	270_N	1.192	0.95
415_I	419_E	1.190	0.94
402_P	418_I	1.189	0.94
164_I	220_V	1.188	0.94
100_A	104_A	1.187	0.94
376_A	420_A	1.182	0.94
104_A	109_K	1.177	0.94
81_R	311_I	1.173	0.94
380_K	384_V	1.172	0.94
442_T	487_L	1.171	0.94
418_I	448_A	1.171	0.94
68_N	483_I	1.159	0.94
14_F	25_V	1.155	0.94
223_S	226_N	1.153	0.94
331_I	383_L	1.150	0.93
6_A	495_L	1.147	0.93
358_I	382_A	1.144	0.93
219_V	238_I	1.142	0.93
425_L	441_I	1.141	0.93
356_E	391_K	1.141	0.93
32_N	36_Y	1.135	0.93
321_L	324_H	1.133	0.93
493_D	509_I	1.126	0.93
17_R	26_A	1.118	0.92
431_A	435_K	1.114	0.92
273_T	302_V	1.107	0.92
332_A	400_A	1.098	0.92
89_G	92_E	1.096	0.92
317_V	321_L	1.095	0.92
217_L	221_D	1.093	0.92
113_L	132_L	1.088	0.91
9_I	425_L	1.088	0.91
483_I	506_T	1.082	0.91
270_N	302_V	1.081	0.91
257_F	268_I	1.081	0.91
315_N	323_Q	1.079	0.91
384_V	427_E	1.078	0.91
450_I	459_H	1.074	0.91
251_D	289_N	1.072	0.91
345_S	348_R	1.072	0.91
402_P	448_A	1.070	0.91
211_P	226_N	1.065	0.90
251_D	288_K	1.064	0.90
111_L	141_L	1.062	0.90
103_N	107_N	1.059	0.90
324_H	497_V	1.059	0.90
430_D	433_L	1.057	0.90
208_G	248_K	1.056	0.90
117_L	167_L	1.056	0.90
103_N	291_Y	1.054	0.90
241_E	248_K	1.051	0.90
130_F	167_L	1.049	0.90
213_Y	219_V	1.048	0.90
479_R	506_T	1.044	0.90
97_F	295_L	1.043	0.90
317_V	488_A	1.040	0.89
96_T	305_Y	1.034	0.89
69_I	344_M	1.034	0.89
326_L	495_L	1.028	0.89
43_Q	469_V	1.027	0.89
165_N	217_L	1.024	0.89
30_K	419_E	1.024	0.89
388_E	435_K	1.023	0.89
183_S	235_P	1.022	0.89
269_S	292_F	1.021	0.89
459_H	463_T	1.019	0.88
40_Y	433_L	1.018	0.88
33_F	37_W	1.017	0.88
6_A	491_L	1.010	0.88
68_N	71_A	1.010	0.88
50_E	56_E	1.009	0.88
98_L	105_K	1.006	0.88
220_V	233_V	1.001	0.88
258_Y	295_L	1.000	0.87
164_I	179_I	0.999	0.87
205_M	268_I	0.997	0.87
257_F	292_F	0.995	0.87
98_L	102_S	0.994	0.87
384_V	428_V	0.991	0.87
212_S	239_T	0.991	0.87
181_S	237_V	0.990	0.87
275_K	286_Y	0.989	0.87
164_I	168_N	0.987	0.87
361_N	364_K	0.984	0.87
193_K	267_Q	0.983	0.87
17_R	23_N	0.983	0.87
410_M	413_P	0.982	0.87
50_E	84_V	0.981	0.86
294_C	304_G	0.980	0.86
31_P	34_D	0.980	0.86
96_T	99_D	0.978	0.86
210_G	237_V	0.976	0.86
48_S	464_T	0.973	0.86
386_E	392_H	0.972	0.86
410_M	414_T	0.972	0.86
126_I	163_Y	0.970	0.86
412_E	415_I	0.966	0.86
327_K	354_G	0.961	0.85
91_F	307_A	0.960	0.85
47_A	466_P	0.958	0.85
114_F	255_V	0.957	0.85
423_E	427_E	0.949	0.85
108_N	142_T	0.949	0.85
199_E	209_E	0.948	0.85
211_P	234_I	0.947	0.84
213_Y	238_I	0.947	0.84
164_I	216_A	0.944	0.84
74_I	483_I	0.943	0.84
14_F	418_I	0.940	0.84
135_L	307_A	0.937	0.84
9_I	428_V	0.935	0.84
394_A	495_L	0.935	0.84
452_I	455_S	0.934	0.84
90_E	93_R	0.931	0.83
277_F	282_R	0.931	0.83
34_D	419_E	0.927	0.83
272_F	292_F	0.923	0.83
297_H	300_E	0.923	0.83
134_K	173_E	0.922	0.83
179_I	216_A	0.921	0.83
329_L	358_I	0.919	0.83
222_D	226_N	0.919	0.83
478_L	481_G	0.916	0.82
358_I	386_E	0.916	0.82
9_I	397_L	0.915	0.82
91_F	131_A	0.913	0.82
187_Y	200_K	0.910	0.82
335_E	368_Y	0.910	0.82
6_A	438_H	0.907	0.82
440_I	471_V	0.907	0.82
16_L	37_W	0.906	0.82
6_A	394_A	0.905	0.82
24_A	414_T	0.903	0.82
273_T	304_G	0.901	0.81
377_Y	427_E	0.900	0.81
109_K	250_Q	0.897	0.81
322_S	353_P	0.894	0.81
293_V	307_A	0.894	0.81
155_V	163_Y	0.893	0.81
5_P	435_K	0.892	0.81
414_T	448_A	0.888	0.80
5_P	432_I	0.885	0.80
420_A	423_E	0.884	0.80
97_F	307_A	0.882	0.80
39_Q	474_E	0.882	0.80
371_K	378_E	0.882	0.80
345_S	355_E	0.881	0.80
82_V	295_L	0.881	0.80
99_D	102_S	0.880	0.80
107_N	252_G	0.880	0.80
84_V	90_E	0.877	0.80
380_K	424_C	0.876	0.80
170_Q	174_I	0.868	0.79
129_L	146_I	0.867	0.79
199_E	281_D	0.862	0.78
93_R	98_L	0.861	0.78
85_A	88_E	0.860	0.78
326_L	497_V	0.859	0.78
47_A	465_N	0.856	0.78
14_F	30_K	0.855	0.78
108_N	143_K	0.854	0.78
165_N	221_D	0.854	0.78
100_A	293_V	0.853	0.78
324_H	498_E	0.852	0.78
78_S	81_R	0.849	0.77
100_A	256_I	0.846	0.77
218_D	221_D	0.844	0.77
271_T	280_F	0.844	0.77
99_D	291_Y	0.843	0.77
28_A	419_E	0.842	0.77
408_S	413_P	0.842	0.77
162_T	166_Q	0.840	0.77
320_V	323_Q	0.839	0.77
25_V	449_D	0.838	0.76
161_K	220_V	0.837	0.76
156_G	160_A	0.833	0.76
17_R	22_G	0.833	0.76
327_K	393_D	0.832	0.76
429_V	441_I	0.831	0.76
130_F	134_K	0.828	0.76
206_A	272_F	0.827	0.75
92_E	135_L	0.827	0.75
433_L	472_T	0.826	0.75
438_H	494_L	0.825	0.75
76_Y	80_T	0.823	0.75
25_V	33_F	0.822	0.75
323_Q	353_P	0.822	0.75
270_N	299_S	0.821	0.75
429_V	433_L	0.821	0.75
376_A	424_C	0.819	0.75
159_T	163_Y	0.816	0.74
345_S	351_E	0.816	0.74
239_T	247_A	0.816	0.74
33_F	470_I	0.813	0.74
200_K	235_P	0.812	0.74
320_V	495_L	0.810	0.74
104_A	141_L	0.808	0.74
317_V	344_M	0.807	0.74
160_A	163_Y	0.805	0.73
91_F	135_L	0.804	0.73
130_F	133_L	0.802	0.73
27_L	412_E	0.801	0.73
44_T	466_P	0.800	0.73
322_S	325_G	0.800	0.73
7_A	439_A	0.800	0.73
105_K	142_T	0.798	0.73
101_I	139_E	0.798	0.73
42_H	470_I	0.797	0.73
36_Y	470_I	0.796	0.73
169_D	173_E	0.795	0.73
14_F	402_P	0.794	0.72
117_L	258_Y	0.794	0.72
171_I	177_G	0.792	0.72
486_D	504_T	0.791	0.72
270_N	301_T	0.791	0.72
351_E	356_E	0.789	0.72
71_A	75_V	0.788	0.72
127_N	166_Q	0.788	0.72
213_Y	222_D	0.788	0.72
37_W	470_I	0.785	0.72
356_E	386_E	0.779	0.71
273_T	303_D	0.777	0.71
429_V	472_T	0.777	0.71
160_A	220_V	0.774	0.71
371_K	377_Y	0.772	0.70
196_D	200_K	0.771	0.70
48_S	51_A	0.770	0.70
271_T	277_F	0.770	0.70
7_A	397_L	0.769	0.70
150_L	220_V	0.767	0.70
216_A	238_I	0.765	0.70
383_L	395_I	0.765	0.70
449_D	464_T	0.764	0.70
442_T	469_V	0.763	0.69
32_N	425_L	0.763	0.69
84_V	87_R	0.763	0.69
256_I	307_A	0.762	0.69
134_K	174_I	0.760	0.69
102_S	105_K	0.760	0.69
416_K	419_E	0.760	0.69
133_L	146_I	0.759	0.69
33_F	402_P	0.757	0.69
226_N	234_I	0.756	0.69
104_A	107_N	0.756	0.69
119_D	162_T	0.756	0.69
450_I	465_N	0.755	0.69
117_L	126_I	0.750	0.68
182_I	220_V	0.749	0.68
402_P	421_V	0.747	0.68
98_L	135_L	0.747	0.68
14_F	421_V	0.745	0.68
376_A	400_A	0.744	0.68
29_K	415_I	0.743	0.67
81_R	296_T	0.743	0.67
196_D	364_K	0.743	0.67
133_L	170_Q	0.742	0.67
376_A	399_F	0.739	0.67
294_C	306_V	0.739	0.67
316_T	352_F	0.737	0.67
265_A	292_F	0.734	0.66
384_V	387_I	0.733	0.66
319_E	348_R	0.732	0.66
105_K	141_L	0.732	0.66
166_Q	169_D	0.731	0.66
216_A	219_V	0.731	0.66
56_E	87_R	0.730	0.66
267_Q	292_F	0.729	0.66
155_V	160_A	0.728	0.66
448_A	461_A	0.727	0.66
148_G	179_I	0.725	0.66
40_Y	472_T	0.722	0.65
299_S	302_V	0.722	0.65
126_I	174_I	0.722	0.65
7_A	383_L	0.721	0.65
148_G	182_I	0.721	0.65
294_C	299_S	0.721	0.65
424_C	427_E	0.721	0.65
16_L	45_L	0.721	0.65
232_F	367_T	0.720	0.65
17_R	450_I	0.719	0.65
432_I	435_K	0.719	0.65
9_I	376_A	0.718	0.65
30_K	33_F	0.717	0.65
149_F	205_M	0.712	0.64
114_F	205_M	0.710	0.64
194_R	335_E	0.710	0.64
46_T	483_I	0.709	0.64
18_N	26_A	0.708	0.64
449_D	463_T	0.706	0.63
78_S	262_P	0.705	0.63
438_H	471_V	0.705	0.63
135_L	139_E	0.705	0.63
384_V	435_K	0.702	0.63
127_N	130_F	0.701	0.63
87_R	127_N	0.699	0.63
36_Y	472_T	0.698	0.63
36_Y	439_A	0.698	0.63
114_F	292_F	0.698	0.63
255_V	272_F	0.696	0.62
473_K	476_I	0.696	0.62
324_H	495_L	0.695	0.62
441_I	470_I	0.695	0.62
316_T	319_E	0.694	0.62
211_P	222_D	0.694	0.62
36_Y	429_V	0.694	0.62
143_K	250_Q	0.694	0.62
92_E	131_A	0.693	0.62
222_D	225_A	0.692	0.62
149_F	188_S	0.692	0.62
40_Y	470_I	0.690	0.62
389_A	392_H	0.689	0.62
30_K	418_I	0.686	0.61
321_L	495_L	0.686	0.61
126_I	166_Q	0.686	0.61
183_S	201_A	0.686	0.61
272_F	290_L	0.685	0.61
383_L	428_V	0.684	0.61
19_E	23_N	0.681	0.61
319_E	352_F	0.681	0.61
322_S	345_S	0.680	0.61
262_P	302_V	0.680	0.61
45_L	469_V	0.678	0.60
167_L	171_I	0.678	0.60
275_K	303_D	0.676	0.60
137_K	177_G	0.676	0.60
7_A	395_I	0.675	0.60
114_F	265_A	0.674	0.60
345_S	356_E	0.674	0.60
21_V	452_I	0.673	0.60
91_F	132_L	0.672	0.60
381_D	384_V	0.672	0.60
452_I	463_T	0.670	0.59
399_F	427_E	0.670	0.59
86_I	92_E	0.668	0.59
219_V	223_S	0.667	0.59
85_A	91_F	0.667	0.59
103_N	109_K	0.666	0.59
89_G	93_R	0.664	0.59
251_D	287_P	0.659	0.58
35_R	433_L	0.659	0.58
329_L	392_H	0.658	0.58
223_S	236_S	0.658	0.58
408_S	414_T	0.658	0.58
321_L	325_G	0.656	0.58
99_D	103_N	0.655	0.58
168_N	171_I	0.654	0.58
51_A	485_G	0.654	0.58
97_F	256_I	0.653	0.57
416_K	420_A	0.648	0.57
338_P	359_L	0.648	0.57
116_L	124_S	0.647	0.57
440_I	487_L	0.647	0.57
268_I	292_F	0.645	0.57
45_L	508_L	0.644	0.56
178_E	239_T	0.642	0.56
193_K	198_V	0.642	0.56
59_M	75_V	0.641	0.56
49_G	56_E	0.640	0.56
132_L	256_I	0.640	0.56
498_E	501_K	0.640	0.56
98_L	141_L	0.640	0.56
17_R	21_V	0.640	0.56
269_S	304_G	0.639	0.56
97_F	135_L	0.639	0.56
380_K	428_V	0.637	0.56
124_S	258_Y	0.636	0.55
96_T	293_V	0.636	0.55
161_K	225_A	0.636	0.55
14_F	37_W	0.636	0.55
344_M	396_I	0.634	0.55
202_Y	206_A	0.633	0.55
4_K	393_D	0.633	0.55
50_E	83_N	0.633	0.55
194_R	368_Y	0.633	0.55
436_G	439_A	0.632	0.55
416_K	423_E	0.632	0.55
214_R	239_T	0.631	0.55
331_I	360_I	0.627	0.54
274_N	302_V	0.626	0.54
163_Y	166_Q	0.625	0.54
278_R	281_D	0.625	0.54
6_A	494_L	0.625	0.54
385_K	389_A	0.625	0.54
438_H	474_E	0.625	0.54
199_E	283_G	0.625	0.54
117_L	150_L	0.624	0.54
7_A	437_G	0.623	0.54
209_E	212_S	0.623	0.54
148_G	164_I	0.623	0.54
232_F	460_T	0.622	0.54
78_S	296_T	0.621	0.54
22_G	411_V	0.620	0.54
79_L	83_N	0.620	0.54
385_K	388_E	0.619	0.53
334_T	359_L	0.619	0.53
391_K	395_I	0.617	0.53
69_I	442_T	0.617	0.53
93_R	138_K	0.617	0.53
458_P	463_T	0.611	0.53
239_T	248_K	0.609	0.52
330_R	394_A	0.609	0.52
136_A	141_L	0.607	0.52
183_S	234_I	0.606	0.52
471_V	476_I	0.605	0.52
282_R	286_Y	0.605	0.52
133_L	176_V	0.605	0.52
101_I	141_L	0.604	0.52
137_K	174_I	0.604	0.52
59_M	461_A	0.604	0.52
199_E	280_F	0.604	0.52
17_R	449_D	0.602	0.51
164_I	182_I	0.602	0.51
271_T	282_R	0.599	0.51
452_I	457_E	0.597	0.51
379_V	400_A	0.597	0.51
11_L	418_I	0.596	0.51
186_Y	267_Q	0.596	0.51
327_K	353_P	0.596	0.51
473_K	477_T	0.595	0.51
402_P	425_L	0.594	0.51
51_A	56_E	0.593	0.50
27_L	448_A	0.592	0.50
9_I	432_I	0.592	0.50
469_V	508_L	0.591	0.50
188_S	268_I	0.591	0.50
322_S	354_G	0.588	0.50
212_S	240_K	0.587	0.50
45_L	442_T	0.587	0.50
215_S	238_I	0.586	0.50
479_R	509_I	0.583	0.49
114_F	249_I	0.582	0.49
409_G	451_L	0.581	0.49
266_I	349_E	0.579	0.49
137_K	176_V	0.579	0.49
171_I	179_I	0.576	0.48
450_I	463_T	0.576	0.48
363_P	371_K	0.574	0.48
461_A	465_N	0.573	0.48
223_S	233_V	0.573	0.48
314_D	319_E	0.573	0.48
361_N	378_E	0.573	0.48
367_T	370_L	0.572	0.48
423_E	426_G	0.572	0.48
50_E	80_T	0.570	0.48
86_I	135_L	0.570	0.48
425_L	429_V	0.568	0.47
332_A	376_A	0.567	0.47
439_A	472_T	0.567	0.47
327_K	392_H	0.565	0.47
115_G	258_Y	0.565	0.47
118_S	124_S	0.565	0.47
364_K	371_K	0.564	0.47
388_E	427_E	0.564	0.47
47_A	402_P	0.563	0.47
23_N	26_A	0.562	0.47
35_R	426_G	0.562	0.47
76_Y	342_F	0.560	0.47
133_L	177_G	0.560	0.47
376_A	397_L	0.559	0.46
480_E	506_T	0.559	0.46
38_N	42_H	0.557	0.46
17_R	465_N	0.557	0.46
94_N	97_F	0.557	0.46
271_T	279_D	0.555	0.46
100_A	291_Y	0.555	0.46
67_L	346_G	0.553	0.46
360_I	378_E	0.553	0.46
117_L	148_G	0.553	0.46
126_I	170_Q	0.552	0.46
209_E	283_G	0.551	0.45
25_V	418_I	0.551	0.45
101_I	109_K	0.549	0.45
117_L	129_L	0.549	0.45
182_I	216_A	0.549	0.45
47_A	449_D	0.549	0.45
491_L	494_L	0.549	0.45
287_P	290_L	0.548	0.45
119_D	166_Q	0.548	0.45
17_R	44_T	0.545	0.45
26_A	448_A	0.545	0.45
89_G	134_K	0.545	0.45
255_V	268_I	0.543	0.45
331_I	358_I	0.543	0.45
375_S	378_E	0.542	0.44
18_N	37_W	0.542	0.44
96_T	309_K	0.541	0.44
216_A	236_S	0.541	0.44
59_M	64_V	0.539	0.44
269_S	294_C	0.538	0.44
33_F	397_L	0.537	0.44
167_L	179_I	0.537	0.44
241_E	249_I	0.537	0.44
325_G	353_P	0.536	0.44
317_V	492_L	0.536	0.44
33_F	441_I	0.536	0.44
316_T	320_V	0.535	0.44
145_Y	247_A	0.534	0.43
473_K	478_L	0.533	0.43
208_G	237_V	0.533	0.43
173_E	177_G	0.533	0.43
365_V	368_Y	0.533	0.43
256_I	293_V	0.533	0.43
35_R	429_V	0.532	0.43
194_R	296_T	0.532	0.43
83_N	262_P	0.532	0.43
251_D	286_Y	0.532	0.43
192_D	232_F	0.532	0.43
279_D	282_R	0.532	0.43
276_D	282_R	0.531	0.43
192_D	367_T	0.531	0.43
68_N	485_G	0.531	0.43
182_I	236_S	0.528	0.43
357_R	362_S	0.527	0.43
32_N	429_V	0.527	0.43
180_A	247_A	0.527	0.43
273_T	300_E	0.526	0.43
158_Q	164_I	0.526	0.43
9_I	383_L	0.524	0.42
100_A	292_F	0.524	0.42
266_I	269_S	0.523	0.42
249_I	289_N	0.522	0.42
21_V	26_A	0.521	0.42
332_A	379_V	0.521	0.42
111_L	133_L	0.520	0.42
113_L	133_L	0.520	0.42
103_N	289_N	0.519	0.42
11_L	468_P	0.519	0.42
237_V	247_A	0.519	0.42
24_A	451_L	0.519	0.42
22_G	26_A	0.518	0.42
58_Q	79_L	0.518	0.42
425_L	432_I	0.517	0.41
169_D	172_K	0.517	0.41
321_L	491_L	0.515	0.41
296_T	355_E	0.515	0.41
58_Q	120_G	0.513	0.41
179_I	238_I	0.512	0.41
331_I	382_A	0.511	0.41
79_L	364_K	0.511	0.41
202_Y	272_F	0.511	0.41
78_S	310_P	0.510	0.41
370_L	410_M	0.509	0.41
214_R	222_D	0.509	0.41
255_V	292_F	0.509	0.41
453_T	459_H	0.508	0.40
156_G	453_T	0.508	0.40
207_Y	281_D	0.506	0.40
73_R	330_R	0.505	0.40
64_V	343_F	0.505	0.40
183_S	205_M	0.505	0.40
213_Y	216_A	0.505	0.40
305_Y	309_K	0.505	0.40
226_N	236_S	0.504	0.40
387_I	432_I	0.503	0.40
394_A	437_G	0.503	0.40
397_L	428_V	0.501	0.40
414_T	463_T	0.501	0.40
85_A	94_N	0.501	0.40
358_I	361_N	0.500	0.40
240_K	248_K	0.500	0.40
17_R	155_V	0.500	0.40
135_L	138_K	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1o98A	1	0.9941	100	0.189	Contact Map
4my4A	1	0.9843	100	0.227	Contact Map
3igzB	1	0.9883	100	0.23	Contact Map
2zktA	3	0.6556	100	0.83	Contact Map
3kd8A	1	0.6497	100	0.836	Contact Map
1zedA	2	0.6986	100	0.878	Contact Map
3m7vA	1	0.7182	99.9	0.897	Contact Map
3ot9A	1	0.6869	99.9	0.898	Contact Map
3q3qA	2	0.5969	99.9	0.901	Contact Map
3nkqA	1	0.499	99.9	0.903	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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