GREMLIN Database
SYN - Asparagine--tRNA ligase
UniProt: P39772 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (406)
Sequences: 9351 (4739)
Seq/√Len: 235.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_E240_N4.5311.00
72_K91_D3.8981.00
45_G89_V3.7951.00
11_H14_E3.7091.00
145_N199_F3.6501.00
17_T72_K3.5341.00
15_E72_K3.5131.00
138_R142_E3.4831.00
143_F240_N3.4151.00
15_E90_T3.2641.00
138_R145_N3.2131.00
142_E146_N3.1891.00
70_Y93_E2.9121.00
139_A248_S2.8601.00
188_M198_V2.8041.00
139_A244_F2.7581.00
229_V233_E2.7231.00
359_E396_S2.6781.00
269_Q282_A2.6581.00
132_I410_S2.4231.00
156_I205_F2.4181.00
45_G71_I2.3471.00
192_A395_H2.2851.00
140_T222_I2.2751.00
19_G70_Y2.2321.00
136_I406_V2.2071.00
99_T389_K2.1911.00
137_I402_L2.1251.00
141_Y151_K2.0951.00
43_I87_L2.0791.00
247_Q253_C2.0761.00
156_I202_G2.0671.00
170_A177_D2.0581.00
142_E145_N2.0341.00
368_E372_K2.0111.00
15_E74_I1.9951.00
74_I90_T1.9941.00
372_K378_S1.9861.00
134_N145_N1.9861.00
347_A354_I1.9851.00
244_F248_S1.9671.00
226_M229_V1.9491.00
129_I412_A1.9301.00
320_R332_P1.9201.00
16_V87_L1.9081.00
142_E248_S1.8801.00
13_G74_I1.8761.00
143_F244_F1.8761.00
231_F341_L1.8751.00
143_F147_E1.8611.00
140_T241_Y1.8581.00
224_P398_F1.8321.00
18_I43_I1.8251.00
143_F241_Y1.8071.00
236_Q240_N1.8061.00
234_N396_S1.7841.00
277_I314_K1.7811.00
76_K88_A1.7681.00
127_H131_K1.7601.00
236_Q276_R1.7511.00
146_N244_F1.7481.00
317_F345_L1.7411.00
364_M368_E1.7361.00
139_A245_I1.7221.00
369_S373_E1.7191.00
242_V345_L1.7061.00
152_V191_A1.6791.00
230_E233_E1.6541.00
131_K150_V1.6481.00
333_A341_L1.6221.00
239_E276_R1.5861.00
278_T320_R1.5841.00
332_P341_L1.5721.00
368_E385_A1.5641.00
172_K175_D1.5621.00
149_F226_M1.5581.00
284_E288_E1.5421.00
368_E378_S1.5341.00
17_T70_Y1.5261.00
297_G300_F1.5251.00
364_M389_K1.5241.00
128_A132_I1.5241.00
309_A312_Y1.5211.00
301_G305_E1.5201.00
369_S372_K1.5141.00
22_V69_L1.5051.00
296_W300_F1.5011.00
74_I88_A1.4801.00
275_P285_F1.4741.00
226_M237_V1.4701.00
243_S272_A1.4641.00
148_G197_K1.4631.00
22_V34_L1.4541.00
281_E284_E1.4531.00
135_E138_R1.4501.00
295_E298_D1.4501.00
113_L120_W1.4461.00
124_K128_A1.4211.00
22_V63_V1.4121.00
335_D338_D1.4091.00
331_Q362_H1.4091.00
246_V409_I1.4061.00
211_K214_R1.4001.00
172_K177_D1.4001.00
278_T281_E1.3951.00
331_Q363_D1.3941.00
277_I282_A1.3931.00
377_D380_A1.3891.00
12_V77_E1.3861.00
125_R412_A1.3741.00
281_E285_F1.3691.00
204_T221_M1.3661.00
130_M195_L1.3661.00
32_A57_F1.3591.00
229_V396_S1.3521.00
232_E236_Q1.3491.00
359_E362_H1.3471.00
139_A142_E1.3451.00
135_E248_S1.3441.00
136_I245_I1.3411.00
302_A306_T1.3211.00
89_V92_I1.3181.00
40_T43_I1.3151.00
368_E382_K1.3141.00
63_V69_L1.3091.00
139_A249_V1.3041.00
386_E389_K1.2951.00
54_E58_Q1.2921.00
247_Q251_K1.2911.00
30_K49_K1.2801.00
345_L355_I1.2791.00
261_G265_S1.2781.00
300_F304_H1.2761.00
144_F222_I1.2741.00
116_H386_E1.2561.00
222_I402_L1.2561.00
273_P276_R1.2501.00
130_M420_P1.2481.00
70_Y95_I1.2401.00
142_E244_F1.2331.00
197_K226_M1.2321.00
144_F224_P1.2301.00
363_D366_L1.2251.00
366_L369_S1.2181.00
373_E376_L1.2121.00
18_I36_L1.2001.00
31_I46_V1.1941.00
131_K135_E1.1901.00
300_F303_P1.1861.00
135_E253_C1.1801.00
275_P314_K1.1781.00
75_V85_Y1.1781.00
323_T370_R1.1771.00
332_P339_V1.1761.00
184_G204_T1.1721.00
71_I89_V1.1711.00
128_A131_K1.1681.00
75_V87_L1.1571.00
63_V92_I1.1421.00
58_Q61_K1.1391.00
270_I273_P1.1371.00
152_V195_L1.1311.00
24_N35_Q1.1291.00
140_T402_L1.1281.00
35_Q42_F1.1201.00
370_R373_E1.1071.00
186_L383_W1.1061.00
303_P307_A1.1061.00
184_G221_M1.0931.00
193_M392_S1.0921.00
277_I316_V1.0911.00
331_Q366_L1.0881.00
140_T245_I1.0881.00
151_K199_F1.0881.00
315_P347_A1.0841.00
127_H195_L1.0831.00
242_V405_T1.0821.00
37_R66_E1.0811.00
144_F241_Y1.0791.00
132_I249_V1.0731.00
23_A37_R1.0701.00
238_Q400_L1.0701.00
47_V89_V1.0651.00
34_L45_G1.0621.00
153_D203_P1.0601.00
136_I409_I1.0601.00
243_S255_I1.0591.00
18_I87_L1.0581.00
38_D41_G1.0541.00
37_R42_F1.0521.00
209_K425_L1.0501.00
64_T67_T1.0481.00
329_Y358_S1.0431.00
297_G303_P1.0431.00
245_I249_V1.0421.00
136_I402_L1.0371.00
170_A179_Y1.0311.00
239_E243_S1.0301.00
240_N243_S1.0291.00
135_E145_N1.0271.00
147_E237_V1.0231.00
370_R374_H1.0231.00
256_E259_T1.0131.00
62_S97_E1.0091.00
40_T196_G1.0081.00
141_Y199_F1.0081.00
36_L69_L1.0041.00
243_S253_C1.0021.00
287_K295_E0.9991.00
48_V88_A0.9891.00
298_D301_G0.9871.00
412_A418_T0.9851.00
132_I136_I0.9821.00
296_W299_D0.9771.00
63_V94_V0.9731.00
105_P108_H0.9701.00
412_A417_E0.9701.00
258_N314_K0.9681.00
158_T187_Y0.9671.00
270_I282_A0.9641.00
109_G112_F0.9631.00
301_G304_H0.9621.00
320_R339_V0.9541.00
297_G305_E0.9531.00
229_V234_N0.9501.00
282_A318_I0.9481.00
243_S271_K0.9471.00
286_L311_H0.9441.00
137_I151_K0.9361.00
184_G187_Y0.9351.00
78_D82_P0.9271.00
248_S252_N0.9231.00
240_N244_F0.9231.00
16_V75_V0.9221.00
297_G304_H0.9211.00
18_I71_I0.9171.00
299_D303_P0.9141.00
392_S395_H0.9121.00
157_L178_A0.9111.00
233_E236_Q0.9071.00
68_S96_H0.9051.00
191_A420_P0.9041.00
224_P238_Q0.9041.00
323_T331_Q0.9041.00
96_H392_S0.9031.00
241_Y245_I0.9031.00
132_I135_E0.9031.00
184_G202_G0.8970.99
263_D268_E0.8960.99
121_L130_M0.8930.99
43_I75_V0.8900.99
283_I300_F0.8890.99
73_G87_L0.8870.99
143_F237_V0.8860.99
284_E287_K0.8860.99
231_F235_L0.8830.99
234_N398_F0.8810.99
34_L69_L0.8800.99
232_E276_R0.8760.99
294_I297_G0.8730.99
238_Q398_F0.8680.99
277_I318_I0.8670.99
278_T319_T0.8630.99
190_A421_F0.8610.99
57_F61_K0.8600.99
382_K386_E0.8590.99
294_I302_A0.8580.99
364_M385_A0.8530.99
56_I59_T0.8500.99
235_L276_R0.8480.99
258_N262_R0.8480.99
289_K311_H0.8470.99
67_T97_E0.8470.99
294_I298_D0.8470.99
368_E389_K0.8470.99
259_T262_R0.8430.99
118_H386_E0.8420.99
71_I87_L0.8420.99
332_P335_D0.8390.99
125_R129_I0.8380.99
134_N138_R0.8340.99
301_G325_L0.8320.99
214_R352_G0.8290.99
132_I250_L0.8240.99
376_L381_Y0.8220.99
299_D305_E0.8210.99
27_S30_K0.8200.99
371_L381_Y0.8170.99
232_E259_T0.8150.99
27_S32_A0.8140.99
149_F197_K0.8130.99
192_A227_A0.8130.99
361_I366_L0.8130.99
47_V60_A0.8110.99
137_I222_I0.8090.99
39_G131_K0.8080.99
256_E411_G0.8030.99
238_Q355_I0.8020.99
282_A308_I0.8020.99
147_E197_K0.8010.99
268_E285_F0.7990.99
268_E271_K0.7940.99
64_T97_E0.7920.99
28_S31_I0.7890.99
139_A143_F0.7880.99
332_P366_L0.7860.99
34_L47_V0.7860.99
354_I405_T0.7850.99
280_D296_W0.7830.99
21_W228_F0.7800.99
245_I248_S0.7800.99
129_I410_S0.7790.99
59_T62_S0.7740.99
303_P306_T0.7690.98
277_I285_F0.7690.98
55_S58_Q0.7680.98
23_A42_F0.7680.98
193_M388_R0.7680.98
254_K258_N0.7660.98
271_K276_R0.7660.98
224_P234_N0.7620.98
294_I300_F0.7610.98
104_T107_E0.7610.98
304_H307_A0.7610.98
265_S269_Q0.7570.98
68_S393_V0.7540.98
57_F60_A0.7540.98
295_E324_S0.7530.98
248_S251_K0.7520.98
282_A286_L0.7520.98
224_P237_V0.7520.98
24_N65_Q0.7510.98
192_A392_S0.7500.98
263_D339_V0.7500.98
37_R124_K0.7490.98
259_T411_G0.7480.98
229_V237_V0.7480.98
258_N411_G0.7470.98
239_E273_P0.7450.98
134_N199_F0.7440.98
297_G301_G0.7430.98
296_W303_P0.7400.98
249_V409_I0.7390.98
25_K32_A0.7390.98
330_M333_A0.7390.98
190_A387_L0.7380.98
407_A415_V0.7310.98
118_H390_Y0.7310.98
365_E368_E0.7310.98
246_V313_D0.7310.98
320_R333_A0.7300.98
298_D302_A0.7300.98
156_I184_G0.7280.98
173_Y178_A0.7260.98
342_C356_G0.7260.98
323_T340_V0.7260.98
376_L380_A0.7220.98
277_I312_Y0.7220.98
136_I249_V0.7210.98
56_I60_A0.7200.98
18_I45_G0.7180.98
382_K385_A0.7170.98
330_M362_H0.7160.98
326_K342_C0.7150.98
324_S338_D0.7150.98
336_R339_V0.7140.97
60_A92_I0.7120.97
229_V359_E0.7110.97
103_I108_H0.7110.97
343_A357_G0.7100.97
361_I370_R0.7090.97
400_L405_T0.7080.97
123_S126_Q0.7040.97
156_I203_P0.7010.97
231_F320_R0.7000.97
330_M341_L0.6990.97
94_V97_E0.6960.97
68_S228_F0.6960.97
49_K57_F0.6950.97
255_I258_N0.6910.97
260_L316_V0.6910.97
258_N261_G0.6900.97
34_L89_V0.6850.97
365_E369_S0.6850.97
289_K307_A0.6850.97
376_L379_D0.6830.97
58_Q62_S0.6820.97
271_K274_F0.6800.97
254_K261_G0.6800.97
159_G187_Y0.6800.97
251_K254_K0.6780.97
48_V76_K0.6770.97
295_E299_D0.6750.96
132_I406_V0.6720.96
320_R341_L0.6710.96
244_F247_Q0.6710.96
263_D269_Q0.6700.96
253_C271_K0.6670.96
366_L370_R0.6670.96
134_N150_V0.6650.96
59_T92_I0.6650.96
212_T414_H0.6630.96
157_L171_T0.6630.96
72_K90_T0.6620.96
298_D306_T0.6610.96
119_L386_E0.6610.96
318_I346_I0.6610.96
235_L319_T0.6600.96
406_V410_S0.6600.96
104_T108_H0.6590.96
12_V85_Y0.6560.96
299_D304_H0.6550.96
162_P183_S0.6490.96
101_Y104_T0.6480.96
126_Q417_E0.6470.96
114_M417_E0.6450.95
77_E80_R0.6440.95
238_Q343_A0.6440.95
112_F116_H0.6440.95
22_V25_K0.6430.95
36_L45_G0.6420.95
201_F402_L0.6390.95
67_T94_V0.6370.95
279_Y283_I0.6370.95
154_P200_S0.6360.95
56_I92_I0.6360.95
410_S418_T0.6350.95
299_D302_A0.6340.95
120_W123_S0.6330.95
39_G196_G0.6300.95
311_H411_G0.6290.95
242_V400_L0.6290.95
287_K308_I0.6290.95
144_F237_V0.6250.95
45_G69_L0.6250.95
326_K358_S0.6240.95
298_D305_E0.6230.95
302_A307_A0.6230.95
302_A305_E0.6220.95
277_I281_E0.6220.95
237_V240_N0.6220.95
108_H125_R0.6220.95
132_I260_L0.6210.94
13_G77_E0.6200.94
235_L317_F0.6190.94
321_Y346_I0.6190.94
243_S247_Q0.6180.94
341_L359_E0.6180.94
47_V92_I0.6170.94
137_I153_D0.6160.94
257_L315_P0.6140.94
345_L400_L0.6130.94
153_D220_W0.6130.94
25_K65_Q0.6110.94
126_Q129_I0.6110.94
289_K303_P0.6100.94
308_I312_Y0.6090.94
260_L266_K0.6090.94
231_F332_P0.6090.94
159_G176_E0.6080.94
344_D356_G0.6080.94
266_K272_A0.6070.94
133_R153_D0.6060.94
298_D303_P0.6050.94
14_E75_V0.6040.94
34_L60_A0.6030.94
270_I274_F0.6030.94
260_L318_I0.6020.94
294_I305_E0.6010.93
125_R417_E0.6000.93
250_L253_C0.6000.93
294_I299_D0.6000.93
234_N238_Q0.5990.93
230_E359_E0.5960.93
352_G408_W0.5940.93
124_K127_H0.5920.93
210_S424_L0.5900.93
362_H392_S0.5890.93
247_Q250_L0.5870.93
193_M393_V0.5870.93
135_E252_N0.5860.93
330_M366_L0.5860.93
277_I280_D0.5860.93
117_R121_L0.5850.93
388_R392_S0.5840.92
144_F199_F0.5840.92
384_Y388_R0.5820.92
232_E235_L0.5820.92
40_T131_K0.5810.92
246_V270_I0.5800.92
160_S179_Y0.5790.92
355_I400_L0.5790.92
294_I303_P0.5790.92
55_S59_T0.5790.92
234_N237_V0.5780.92
97_E363_D0.5780.92
97_E365_E0.5760.92
25_K34_L0.5740.92
14_E74_I0.5730.92
150_V195_L0.5730.92
50_A88_A0.5730.92
280_D283_I0.5730.92
204_T222_I0.5720.92
265_S268_E0.5720.92
32_A60_A0.5710.92
226_M233_E0.5700.92
235_L238_Q0.5700.92
276_R279_Y0.5700.92
20_A45_G0.5680.91
317_F343_A0.5680.91
333_A339_V0.5670.91
144_F398_F0.5660.91
159_G423_R0.5640.91
250_L409_I0.5640.91
231_F319_T0.5640.91
280_D284_E0.5630.91
31_I76_K0.5630.91
161_A179_Y0.5620.91
282_A285_F0.5610.91
154_P184_G0.5610.91
235_L259_T0.5590.91
275_P278_T0.5590.91
295_E301_G0.5590.91
296_W302_A0.5590.91
186_L384_Y0.5570.91
257_L262_R0.5570.91
293_D300_F0.5560.91
379_D382_K0.5550.90
295_E300_F0.5550.90
104_T109_G0.5550.90
326_K329_Y0.5550.90
133_R403_E0.5540.90
147_E244_F0.5540.90
28_S32_A0.5540.90
188_M192_A0.5530.90
98_A390_Y0.5530.90
103_I106_K0.5520.90
102_P390_Y0.5490.90
270_I283_I0.5490.90
386_E390_Y0.5490.90
273_P286_L0.5480.90
167_E181_S0.5480.90
319_T332_P0.5470.90
226_M234_N0.5470.90
154_P188_M0.5460.90
278_T282_A0.5460.90
142_E252_N0.5450.90
49_K54_E0.5440.90
26_R35_Q0.5440.90
234_N343_A0.5420.89
149_F184_G0.5420.89
412_A415_V0.5410.89
305_E308_I0.5410.89
298_D304_H0.5400.89
103_I112_F0.5390.89
304_H308_I0.5370.89
269_Q283_I0.5370.89
184_G201_F0.5370.89
121_L195_L0.5360.89
168_L174_F0.5340.89
143_F245_I0.5330.89
99_T103_I0.5320.89
367_L388_R0.5310.88
203_P220_W0.5290.88
302_A308_I0.5290.88
23_A106_K0.5290.88
110_T114_M0.5280.88
11_H43_I0.5280.88
176_E423_R0.5270.88
293_D297_G0.5270.88
287_K292_D0.5260.88
54_E57_F0.5250.88
76_K79_E0.5240.88
217_I425_L0.5230.88
137_I201_F0.5220.88
67_T98_A0.5220.88
295_E304_H0.5220.88
355_I398_F0.5220.88
56_I91_D0.5210.88
239_E274_F0.5200.87
272_A276_R0.5190.87
135_E139_A0.5160.87
125_R128_A0.5160.87
190_A383_W0.5160.87
316_V345_L0.5150.87
301_G307_A0.5150.87
269_Q272_A0.5140.87
304_H318_I0.5140.87
19_G95_I0.5130.87
149_F234_N0.5100.86
65_Q104_T0.5100.86
43_I85_Y0.5100.86
257_L260_L0.5090.86
260_L263_D0.5080.86
300_F305_E0.5080.86
75_V86_E0.5060.86
28_S79_E0.5060.86
296_W304_H0.5060.86
27_S31_I0.5050.86
231_F359_E0.5040.86
256_E261_G0.5040.86
285_F312_Y0.5030.86
130_M191_A0.5030.86
187_Y204_T0.5020.86
136_I405_T0.5020.86
234_N357_G0.5010.85
68_S95_I0.5010.85
259_T263_D0.5000.85
287_K291_F0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i7fA 2 0.9442 100 0.156 Contact Map
1eovA 2 0.9907 100 0.17 Contact Map
2xgtA 2 0.9767 100 0.177 Contact Map
4j15A 2 0.8977 100 0.189 Contact Map
4up7A 2 0.9581 100 0.205 Contact Map
4ycuA 3 0.9791 100 0.206 Contact Map
4pg3A 2 0.9558 100 0.208 Contact Map
4ex5A 2 0.9535 100 0.208 Contact Map
1x54A 2 0.993 100 0.209 Contact Map
4wj4A 2 0.9791 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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