GREMLIN Database
PURT - Phosphoribosylglycinamide formyltransferase 2
UniProt: P39771 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (368)
Sequences: 24063 (13385)
Seq/√Len: 697.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_A163_E3.5231.00
123_G188_E3.4201.00
162_S165_D3.3521.00
134_I167_E3.1371.00
6_K29_Q3.0961.00
241_H245_T3.0871.00
129_T132_E2.9511.00
61_T65_K2.8671.00
263_A266_R2.8521.00
142_F163_E2.6571.00
84_L101_K2.6471.00
55_D58_Q2.5611.00
366_S369_T2.5161.00
244_K248_D2.4521.00
297_R302_F2.3621.00
84_L88_E2.2971.00
242_I245_T2.2851.00
114_A246_I2.2621.00
232_T235_Q2.2511.00
364_A369_T2.2481.00
125_E139_Q2.2401.00
22_E25_R2.2081.00
238_E266_R2.1931.00
116_T249_E2.1531.00
161_R165_D2.1401.00
237_E241_H2.1371.00
64_E89_E2.0831.00
233_E237_E2.0111.00
191_P264_K2.0091.00
163_E167_E1.9631.00
159_V189_F1.9541.00
108_G111_R1.9101.00
111_R116_T1.9031.00
288_N310_L1.8871.00
79_A104_M1.8831.00
136_A140_I1.8751.00
85_K89_E1.8621.00
288_N308_T1.8601.00
136_A139_Q1.8461.00
9_L20_V1.8211.00
345_V348_K1.8201.00
293_A297_R1.8111.00
235_Q238_E1.8081.00
365_D369_T1.7991.00
204_V253_Y1.7681.00
242_I267_V1.7611.00
60_R89_E1.7601.00
36_Y50_V1.7601.00
111_R115_E1.7331.00
56_P85_K1.7281.00
107_E111_R1.7181.00
238_E241_H1.7121.00
167_E171_E1.7031.00
24_Q46_H1.6961.00
107_E126_F1.6931.00
101_K108_G1.6741.00
134_I163_E1.6721.00
60_R64_E1.6691.00
71_I91_F1.6671.00
326_D329_V1.6521.00
294_L305_T1.6401.00
49_Y62_I1.6341.00
161_R191_P1.6331.00
130_Y134_I1.6231.00
237_E240_K1.6071.00
201_V294_L1.5941.00
316_R374_A1.5661.00
96_N99_A1.5631.00
344_R347_G1.5631.00
58_Q61_T1.5591.00
110_R187_E1.5501.00
25_R293_A1.5451.00
135_Q139_Q1.5411.00
102_L108_G1.5391.00
120_A266_R1.5381.00
23_A30_T1.5311.00
114_A269_F1.5291.00
130_Y167_E1.5241.00
144_C186_V1.5231.00
130_Y171_E1.5181.00
168_S172_T1.4971.00
87_E97_A1.4901.00
235_Q262_L1.4841.00
245_T248_D1.4761.00
42_M48_S1.4651.00
115_E123_G1.4651.00
137_A142_F1.4631.00
196_I262_L1.4601.00
109_I114_A1.4581.00
22_E293_A1.4521.00
117_L249_E1.4471.00
134_I138_A1.4191.00
342_Q345_V1.4081.00
8_L33_V1.4021.00
128_N132_E1.3961.00
238_E242_I1.3891.00
188_E268_Y1.3871.00
201_V255_L1.3761.00
174_M182_G1.3711.00
285_V361_L1.3661.00
105_D149_L1.3621.00
7_V94_I1.3621.00
61_T64_E1.3511.00
56_P60_R1.3491.00
240_K244_K1.3451.00
6_K31_V1.3391.00
149_L183_R1.3381.00
85_K88_E1.3291.00
57_E85_K1.3201.00
285_V363_A1.3111.00
128_N183_R1.3031.00
98_R102_L1.3021.00
190_I270_S1.2951.00
7_V23_A1.2941.00
111_R124_Y1.2911.00
327_Y330_E1.2871.00
115_E121_T1.2791.00
198_L239_A1.2731.00
201_V298_A1.2731.00
125_E136_A1.2721.00
236_I240_K1.2701.00
246_I249_E1.2691.00
87_E96_N1.2641.00
135_Q138_A1.2621.00
368_E372_E1.2611.00
347_G350_I1.2561.00
145_V159_V1.2501.00
62_I66_E1.2451.00
49_Y66_E1.2451.00
107_E149_L1.2401.00
369_T373_N1.2381.00
158_S172_T1.2381.00
137_A144_C1.2351.00
130_Y170_W1.2211.00
21_I25_R1.2121.00
86_L91_F1.2011.00
29_Q47_N1.1991.00
132_E135_Q1.1981.00
28_V300_L1.1981.00
103_T272_V1.1881.00
233_E236_I1.1881.00
32_A47_N1.1841.00
247_T250_L1.1831.00
26_L297_R1.1801.00
246_I250_L1.1801.00
200_T247_T1.1771.00
127_A136_A1.1691.00
343_V347_G1.1681.00
92_H300_L1.1671.00
142_F162_S1.1651.00
200_T243_A1.1581.00
319_K355_R1.1561.00
47_N66_E1.1541.00
131_D135_Q1.1511.00
344_R348_K1.1381.00
341_T344_R1.1371.00
123_G139_Q1.1321.00
120_A242_I1.1281.00
19_V72_V1.1281.00
227_Q286_T1.1261.00
86_L93_V1.1261.00
316_R359_V1.1251.00
371_R375_K1.1231.00
171_E175_E1.1201.00
262_L267_V1.1111.00
126_F183_R1.1101.00
364_A373_N1.1071.00
123_G140_I1.1011.00
312_P365_D1.0891.00
200_T258_V1.0821.00
84_L98_R1.0801.00
362_S374_A1.0781.00
170_W174_M1.0771.00
247_T251_G1.0771.00
145_V189_F1.0631.00
158_S173_A1.0611.00
133_F166_L1.0581.00
373_N376_K1.0581.00
119_L269_F1.0541.00
71_I86_L1.0531.00
364_A370_A1.0501.00
234_Q238_E1.0501.00
142_F166_L1.0491.00
131_D134_I1.0481.00
360_A377_A1.0451.00
140_I144_C1.0431.00
115_E124_Y1.0411.00
200_T256_F1.0401.00
110_R121_T1.0381.00
8_L63_I1.0361.00
63_I91_F1.0311.00
231_M235_Q1.0221.00
345_V350_I1.0201.00
330_E333_E1.0171.00
165_D168_S1.0121.00
202_R207_T1.0081.00
168_S171_E1.0061.00
82_E86_L0.9991.00
81_D84_L0.9971.00
60_R85_K0.9961.00
84_L97_A0.9921.00
303_P306_E0.9921.00
243_A260_L0.9911.00
7_V28_V0.9891.00
203_A207_T0.9881.00
205_N303_P0.9871.00
96_N253_Y0.9861.00
6_K69_D0.9861.00
79_A82_E0.9851.00
328_T331_G0.9841.00
192_F264_K0.9801.00
98_R101_K0.9701.00
319_K378_L0.9671.00
289_L294_L0.9651.00
310_L363_A0.9611.00
284_L361_L0.9611.00
164_A168_S0.9591.00
194_S214_G0.9561.00
158_S169_C0.9531.00
276_P291_E0.9531.00
246_I251_G0.9491.00
326_D330_E0.9461.00
202_R248_D0.9381.00
8_L68_P0.9371.00
57_E61_T0.9371.00
103_T250_L0.9371.00
226_W286_T0.9371.00
34_D39_A0.9361.00
105_D150_M0.9341.00
127_A133_F0.9331.00
372_E376_K0.9311.00
81_D85_K0.9291.00
160_C169_C0.9281.00
245_T249_E0.9271.00
20_V30_T0.9241.00
294_L297_R0.9221.00
137_A166_L0.9211.00
202_R208_A0.9191.00
211_E236_I0.9191.00
144_C160_C0.9161.00
26_L293_A0.9131.00
62_I68_P0.9121.00
343_V346_F0.9071.00
209_F306_E0.9061.00
198_L243_A0.9051.00
107_E183_R0.8971.00
208_A244_K0.8941.00
7_V296_V0.8931.00
258_V272_V0.8911.00
334_N337_A0.8901.00
206_G248_D0.8891.00
329_V333_E0.8851.00
138_A167_E0.8851.00
241_H244_K0.8831.00
84_L87_E0.8821.00
296_V300_L0.8791.00
191_P263_A0.8781.00
145_V157_Q0.8761.00
342_Q346_F0.8751.00
198_L240_K0.8751.00
26_L290_S0.8671.00
346_F349_P0.8661.00
23_A296_V0.8661.00
72_V295_H0.8611.00
34_D48_S0.8601.00
247_T256_F0.8561.00
351_T354_G0.8551.00
261_F270_S0.8541.00
23_A72_V0.8531.00
243_A258_V0.8521.00
239_A267_V0.8511.00
170_W184_V0.8451.00
211_E214_G0.8401.00
146_V169_C0.8401.00
190_I268_Y0.8371.00
146_V184_V0.8331.00
341_T362_S0.8311.00
326_D331_G0.8241.00
238_E267_V0.8221.00
234_Q237_E0.8221.00
341_T377_A0.8201.00
214_G217_Q0.8201.00
207_T248_D0.8191.00
150_M181_N0.8171.00
314_A370_A0.8151.00
130_Y174_M0.8131.00
146_V160_C0.8111.00
369_T372_E0.8111.00
172_T176_G0.8061.00
212_P215_H0.8061.00
362_S377_A0.8041.00
164_A167_E0.8031.00
133_F170_W0.8011.00
20_V45_A0.7991.00
83_L93_V0.7971.00
326_D333_E0.7971.00
194_S262_L0.7961.00
332_L347_G0.7961.00
341_T348_K0.7901.00
115_E125_E0.7871.00
132_E136_A0.7861.00
336_L370_A0.7861.00
198_L212_P0.7851.00
32_A45_A0.7841.00
63_I71_I0.7771.00
105_D183_R0.7761.00
79_A83_L0.7731.00
120_A268_Y0.7731.00
312_P363_A0.7721.00
87_E253_Y0.7701.00
60_R88_E0.7631.00
210_C240_K0.7631.00
222_Y225_S0.7601.00
340_K373_N0.7561.00
346_F350_I0.7551.00
28_V296_V0.7541.00
23_A28_V0.7531.00
331_G334_N0.7521.00
341_T345_V0.7511.00
329_V332_L0.7501.00
344_R350_I0.7491.00
77_A80_T0.7481.00
173_A184_V0.7471.00
253_Y298_A0.7471.00
172_T175_E0.7471.00
190_I263_A0.7461.00
86_L89_E0.7421.00
341_T346_F0.7421.00
6_K32_A0.7411.00
137_A141_G0.7411.00
9_L23_A0.7411.00
218_K223_I0.7401.00
10_L82_E0.7381.00
188_E263_A0.7361.00
6_K47_N0.7351.00
82_E85_K0.7331.00
32_A43_Q0.7331.00
149_L185_I0.7311.00
242_I246_I0.7301.00
290_S293_A0.7301.00
202_R247_T0.7301.00
99_A251_G0.7251.00
36_Y39_A0.7241.00
177_G182_G0.7141.00
206_G209_F0.7121.00
56_P82_E0.7081.00
51_V58_Q0.7061.00
214_G225_S0.7041.00
7_V30_T0.7031.00
362_S370_A0.7021.00
201_V210_C0.7001.00
194_S230_D0.6991.00
137_A163_E0.6951.00
332_L336_L0.6911.00
125_E132_E0.6911.00
205_N301_G0.6911.00
203_A206_G0.6901.00
224_E316_R0.6901.00
214_G230_D0.6881.00
45_A48_S0.6861.00
243_A247_T0.6851.00
317_P320_A0.6851.00
174_M184_V0.6851.00
199_L255_L0.6841.00
230_D262_L0.6831.00
231_M236_I0.6801.00
368_E371_R0.6801.00
327_Y331_G0.6791.00
205_N251_G0.6791.00
134_I171_E0.6781.00
29_Q293_A0.6771.00
140_I188_E0.6741.00
202_R253_Y0.6691.00
314_A371_R0.6691.00
343_V348_K0.6661.00
239_A242_I0.6651.00
96_N251_G0.6641.00
374_A378_L0.6621.00
206_G210_C0.6611.00
6_K66_E0.6611.00
216_V224_E0.6611.00
133_F186_V0.6601.00
80_T101_K0.6581.00
329_V334_N0.6581.00
173_A177_G0.6571.00
87_E93_V0.6571.00
242_I260_L0.6561.00
51_V62_I0.6551.00
262_L265_D0.6541.00
35_S46_H0.6531.00
146_V170_W0.6521.00
252_G256_F0.6521.00
342_Q350_I0.6511.00
24_Q30_T0.6511.00
332_L335_A0.6511.00
29_Q46_H0.6491.00
83_L87_E0.6461.00
315_S320_A0.6461.00
297_R300_L0.6451.00
17_K43_Q0.6441.00
107_E185_I0.6421.00
282_V285_V0.6411.00
297_R305_T0.6411.00
188_E266_R0.6411.00
322_E325_A0.6361.00
160_C166_L0.6341.00
83_L86_L0.6321.00
87_E98_R0.6321.00
22_E26_L0.6311.00
92_H204_V0.6301.00
203_A304_I0.6301.00
295_H299_I0.6301.00
263_A268_Y0.6291.00
146_V186_V0.6281.00
199_L257_G0.6271.00
169_C173_A0.6271.00
29_Q296_V0.6251.00
33_V51_V0.6221.00
105_D108_G0.6211.00
39_A42_M0.6201.00
342_Q348_K0.6201.00
240_K245_T0.6191.00
342_Q347_G0.6181.00
255_L275_R0.6181.00
63_I68_P0.6171.00
246_I272_V0.6151.00
125_E128_N0.6141.00
207_T210_C0.6131.00
211_E215_H0.6131.00
294_L306_E0.6131.00
58_Q62_I0.6121.00
343_V350_I0.6121.00
315_S318_L0.6081.00
31_V47_N0.6081.00
161_R189_F0.6061.00
81_D101_K0.6051.00
271_E275_R0.6041.00
134_I137_A0.6041.00
255_L276_P0.6041.00
335_A377_A0.6031.00
98_R251_G0.6011.00
212_P228_P0.6001.00
314_A318_L0.5981.00
358_A361_L0.5981.00
221_D224_E0.5971.00
59_I86_L0.5971.00
160_C165_D0.5961.00
111_R126_F0.5961.00
92_H253_Y0.5951.00
344_R349_P0.5931.00
281_L284_L0.5931.00
141_G163_E0.5931.00
130_Y133_F0.5931.00
196_I239_A0.5921.00
130_Y166_L0.5901.00
314_A317_P0.5901.00
218_K222_Y0.5891.00
345_V349_P0.5881.00
315_S371_R0.5881.00
341_T350_I0.5841.00
333_E336_L0.5841.00
296_V299_I0.5831.00
245_T250_L0.5831.00
31_V49_Y0.5831.00
302_F306_E0.5821.00
338_V341_T0.5821.00
98_R108_G0.5811.00
287_Q309_Q0.5811.00
34_D62_I0.5761.00
62_I65_K0.5761.00
124_Y187_E0.5751.00
17_K42_M0.5731.00
158_S176_G0.5711.00
26_L296_V0.5711.00
122_A190_I0.5701.00
300_L303_P0.5701.00
146_V166_L0.5681.00
22_E290_S0.5661.00
219_D222_Y0.5661.00
232_T262_L0.5651.00
213_I225_S0.5641.00
239_A260_L0.5641.00
110_R122_A0.5631.00
97_A101_K0.5611.00
106_R147_K0.5601.00
7_V70_L0.5601.00
196_I260_L0.5601.00
328_T334_N0.5591.00
291_E295_H0.5591.00
235_Q267_V0.5581.00
57_E60_R0.5581.00
258_V269_F0.5571.00
83_L97_A0.5561.00
213_I217_Q0.5551.00
213_I216_V0.5551.00
199_L213_I0.5541.00
317_P321_P0.5531.00
24_Q45_A0.5511.00
120_A238_E0.5511.00
143_P189_F0.5511.00
238_E245_T0.5501.00
226_W367_V0.5501.00
367_V371_R0.5491.00
204_V207_T0.5481.00
362_S373_N0.5471.00
198_L260_L0.5441.00
136_A186_V0.5401.00
81_D86_L0.5391.00
99_A253_Y0.5361.00
240_K243_A0.5351.00
211_E309_Q0.5351.00
155_K176_G0.5321.00
370_A374_A0.5311.00
60_R91_F0.5301.00
212_P217_Q0.5301.00
243_A246_I0.5291.00
169_C172_T0.5271.00
6_K67_N0.5271.00
221_D225_S0.5261.00
333_E337_A0.5251.00
351_T355_R0.5251.00
223_I319_K0.5241.00
341_T347_G0.5241.00
114_A117_L0.5231.00
196_I231_M0.5221.00
205_N253_Y0.5201.00
207_T247_T0.5191.00
281_L315_S0.5181.00
227_Q282_V0.5171.00
33_V59_I0.5171.00
311_S363_A0.5171.00
343_V358_A0.5171.00
203_A301_G0.5161.00
284_L290_S0.5150.99
137_A170_W0.5140.99
64_E88_E0.5120.99
239_A245_T0.5100.99
30_T292_F0.5100.99
59_I71_I0.5100.99
109_I269_F0.5080.99
189_F261_F0.5070.99
137_A140_I0.5070.99
213_I227_Q0.5070.99
69_D92_H0.5060.99
331_G335_A0.5060.99
102_L116_T0.5060.99
294_L307_I0.5040.99
318_L321_P0.5030.99
191_P265_D0.5020.99
89_E92_H0.5010.99
142_F161_R0.5000.99
330_E334_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kjqA 2 0.9844 100 0.234 Contact Map
2dwcA 4 0.9635 100 0.236 Contact Map
4dimA 1 0.9635 100 0.263 Contact Map
4rcnA 6 0.9036 100 0.275 Contact Map
4mamA 2 0.9297 100 0.279 Contact Map
4qshA 4 0.8464 100 0.284 Contact Map
3aw8A 2 0.9245 100 0.288 Contact Map
4e4tA 2 0.9714 100 0.289 Contact Map
3va7A 1 0.8203 100 0.29 Contact Map
3hblA 4 0.9922 100 0.291 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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