GREMLIN Database
PYRP - Uracil permease
UniProt: P39766 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 435 (396)
Sequences: 4316 (2264)
Seq/√Len: 113.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_V200_F5.5591.00
173_I196_G5.5231.00
147_A167_A4.7301.00
134_V408_A4.2521.00
174_T193_G4.0341.00
50_V328_G3.8391.00
199_L203_T3.7551.00
217_W332_K3.6051.00
210_Q214_D3.4261.00
386_I411_V3.2431.00
177_C192_I3.2391.00
209_F212_V3.1141.00
166_V201_A3.0691.00
107_I243_V3.0501.00
53_G325_L2.8981.00
383_I412_G2.8791.00
166_V206_I2.8331.00
169_V196_G2.7261.00
215_A332_K2.5391.00
171_L351_L2.5291.00
23_S319_G2.5231.00
27_L323_I2.5051.00
257_Q277_S2.4871.00
55_G284_A2.4801.00
375_R420_P2.4021.00
166_V204_Q2.3871.00
198_Y207_V2.3841.00
102_L289_S2.3711.00
227_F290_L2.3711.00
98_F289_S2.3401.00
169_V173_I2.3131.00
66_Q271_K2.2911.00
195_I199_L2.2871.00
102_L286_I2.2411.00
20_V323_I2.2251.00
165_S169_V2.2191.00
213_L216_K2.2051.00
19_W319_G2.2011.00
57_L321_A2.1861.00
51_T291_I2.1851.00
96_G233_S2.1541.00
173_I200_F2.1371.00
57_L318_G2.1081.00
162_K206_I2.0831.00
199_L202_L2.0741.00
212_V336_L2.0731.00
173_I177_C2.0621.00
122_I417_L2.0471.00
311_V316_V2.0251.00
60_L318_G1.9821.00
414_I418_I1.9681.00
174_T348_V1.9661.00
41_V81_I1.9481.00
211_P339_S1.9271.00
176_I180_F1.9041.00
50_V325_L1.9021.00
198_Y339_S1.8971.00
11_R266_Q1.8521.00
102_L106_L1.8241.00
161_L165_S1.7991.00
137_L357_A1.7881.00
200_F204_Q1.7661.00
91_G233_S1.7641.00
124_P416_N1.7491.00
177_C181_L1.7381.00
215_A335_A1.7361.00
210_Q213_L1.7351.00
322_V326_C1.7341.00
95_V234_V1.7221.00
146_M342_S1.7171.00
27_L320_A1.7121.00
171_L382_V1.6711.00
165_S168_G1.6681.00
184_F188_I1.6551.00
235_T238_I1.6381.00
106_L110_L1.6361.00
273_G276_R1.5991.00
212_V215_A1.5741.00
383_I411_V1.5611.00
52_S70_Y1.5581.00
181_L185_L1.5481.00
126_V380_T1.5461.00
168_G172_A1.5301.00
379_I415_L1.5251.00
13_V315_F1.5251.00
105_G279_M1.5211.00
197_G344_V1.5081.00
109_L286_I1.4861.00
162_K204_Q1.4571.00
386_I407_L1.4461.00
185_L192_I1.4441.00
157_L160_S1.4411.00
181_L186_S1.4321.00
266_Q273_G1.4171.00
410_I414_I1.4061.00
203_T206_I1.4041.00
172_A176_I1.3951.00
82_I85_K1.3871.00
202_L209_F1.3851.00
395_V398_G1.3851.00
394_Q401_Q1.3841.00
200_F203_T1.3801.00
196_G200_F1.3781.00
78_I82_I1.3721.00
56_T70_Y1.3701.00
57_L60_L1.3631.00
211_P214_D1.3591.00
26_H302_N1.3411.00
57_L325_L1.3411.00
148_M158_V1.3341.00
60_L317_I1.3231.00
61_L318_G1.3231.00
84_V238_I1.3201.00
88_G235_T1.3161.00
85_K97_A1.3131.00
382_V411_V1.2980.99
99_L239_A1.2920.99
306_L312_F1.2910.99
105_G286_I1.2850.99
30_M34_T1.2820.99
17_F21_S1.2780.99
260_L306_L1.2760.99
256_H300_G1.2740.99
332_K335_A1.2710.99
262_K368_K1.2640.99
54_I325_L1.2510.99
228_K292_G1.2510.99
188_I192_I1.2450.99
112_R275_H1.2320.99
371_Y380_T1.2290.99
81_I97_A1.2270.99
219_A331_G1.2230.99
109_L282_S1.2070.99
234_V239_A1.1970.99
134_V387_G1.1970.99
69_A260_L1.1950.99
192_I196_G1.1710.99
50_V291_I1.1660.99
126_V130_P1.1630.99
330_I334_S1.1580.99
369_I376_N1.1540.99
398_G402_V1.1530.99
74_S249_T1.1490.99
227_F232_P1.1430.99
236_L239_A1.1420.99
109_L283_V1.1390.99
397_Q401_Q1.1330.99
326_C330_I1.1320.99
64_K276_R1.1180.98
89_G96_G1.1090.98
144_V389_G1.1090.98
76_A249_T1.1060.98
88_G91_G1.1050.98
71_L298_T1.1050.98
102_L105_G1.1000.98
72_G299_Y1.0960.98
261_S268_F1.0920.98
253_H257_Q1.0860.98
257_Q281_D1.0810.98
169_V204_Q1.0800.98
370_D373_N1.0720.98
109_L113_Q1.0670.98
104_Y246_A1.0650.98
103_V239_A1.0620.98
70_Y320_A1.0620.98
108_A279_M1.0590.98
16_P20_V1.0550.98
256_H303_I1.0540.98
54_I287_L1.0510.98
80_P245_V1.0510.98
202_L207_V1.0500.98
378_I382_V1.0470.98
39_K45_P1.0330.97
384_L388_V1.0280.97
288_A296_T1.0260.97
84_V242_M1.0250.97
102_L232_P1.0230.97
107_I250_M1.0210.97
14_P19_W1.0210.97
14_P313_S1.0180.97
145_N158_V1.0170.97
201_A205_G1.0140.97
182_R186_S1.0110.97
166_V200_F1.0050.97
269_I273_G1.0020.97
133_I384_L1.0020.97
171_L175_I1.0010.97
87_T90_P0.9990.97
173_I193_G0.9920.97
163_H343_A0.9850.97
252_E297_T0.9850.97
29_A305_V0.9840.97
101_G289_S0.9840.97
165_S204_Q0.9810.97
162_K166_V0.9810.97
160_S163_H0.9780.96
140_A385_V0.9750.96
287_L291_I0.9750.96
69_A298_T0.9690.96
162_K165_S0.9680.96
315_F318_G0.9560.96
198_Y209_F0.9540.96
10_V13_V0.9460.96
253_H277_S0.9440.96
14_P316_V0.9380.96
24_L323_I0.9340.95
83_L86_A0.9330.95
143_A167_A0.9200.95
83_L87_T0.9180.95
26_H30_M0.9160.95
163_H206_I0.9140.95
57_L322_V0.9120.95
138_G405_M0.9120.95
20_V319_G0.9100.95
264_V312_F0.9070.95
217_W330_I0.9050.95
201_A206_I0.9000.94
237_G241_A0.9000.94
26_H29_A0.8940.94
220_V329_F0.8920.94
94_M98_F0.8910.94
54_I58_A0.8830.94
178_A378_I0.8780.94
97_A100_A0.8760.94
58_A62_I0.8750.93
264_V267_D0.8730.93
103_V107_I0.8700.93
110_L114_L0.8680.93
53_G321_A0.8610.93
15_T18_S0.8580.93
51_T288_A0.8530.93
143_A170_T0.8520.93
59_Y67_I0.8510.93
117_G275_H0.8500.92
133_I361_L0.8480.92
13_V19_W0.8450.92
99_L234_V0.8420.92
74_S297_T0.8400.92
358_S377_L0.8390.92
20_V24_L0.8370.92
390_G394_Q0.8370.92
318_G321_A0.8350.92
70_Y317_I0.8340.92
261_S269_I0.8280.91
217_W221_P0.8280.91
27_L327_F0.8250.91
62_I283_V0.8220.91
177_C196_G0.8180.91
69_A257_Q0.8160.91
198_Y340_V0.8150.91
253_H281_D0.8140.91
33_S353_F0.8110.91
78_I247_F0.8090.91
109_L279_M0.8090.91
37_V75_F0.8070.90
132_I256_H0.8070.90
158_V161_L0.8070.90
20_V213_L0.8050.90
216_K219_A0.8050.90
373_N376_N0.7940.90
105_G112_R0.7920.90
177_C193_G0.7910.90
146_M353_F0.7860.89
375_R379_I0.7860.89
60_L314_V0.7800.89
33_S301_E0.7790.89
397_Q400_F0.7770.89
351_L378_I0.7770.89
193_G196_G0.7740.89
212_V339_S0.7740.89
327_F333_I0.7730.88
247_F251_S0.7720.88
249_T297_T0.7690.88
393_I397_Q0.7680.88
168_G204_Q0.7630.88
176_I418_I0.7610.88
191_L195_I0.7600.88
387_G408_A0.7580.87
50_V329_F0.7580.87
130_P383_I0.7570.87
145_N148_M0.7570.87
96_G235_T0.7570.87
73_S77_F0.7570.87
36_L146_M0.7560.87
178_A308_I0.7560.87
209_F339_S0.7550.87
123_L409_A0.7530.87
95_V233_S0.7520.87
32_G38_P0.7520.87
165_S200_F0.7510.87
76_A352_L0.7500.87
318_G322_V0.7500.87
48_A294_P0.7490.87
103_V234_V0.7480.87
22_F26_H0.7480.87
95_V99_L0.7480.87
382_V415_L0.7470.87
30_M70_Y0.7470.87
79_S82_I0.7460.87
267_D272_P0.7440.86
333_I336_L0.7440.86
99_L103_V0.7430.86
176_I181_L0.7430.86
207_V339_S0.7420.86
247_F259_V0.7420.86
254_I274_L0.7400.86
229_D232_P0.7400.86
323_I327_F0.7390.86
390_G393_I0.7390.86
379_I383_I0.7390.86
357_A384_L0.7360.86
68_P317_I0.7360.86
34_T52_S0.7330.86
283_V287_L0.7330.86
212_V332_K0.7320.86
74_S77_F0.7310.86
373_N422_A0.7300.85
105_G282_S0.7280.85
69_A305_V0.7280.85
381_S385_V0.7270.85
37_V73_S0.7260.85
199_L326_C0.7250.85
23_S320_A0.7250.85
30_M302_N0.7250.85
358_S380_T0.7240.85
208_N211_P0.7240.85
303_I306_L0.7240.85
10_V14_P0.7240.85
253_H297_T0.7230.85
146_M345_M0.7190.85
39_K345_M0.7170.84
286_I290_L0.7170.84
133_I364_L0.7170.84
51_T287_L0.7170.84
272_P276_R0.7120.84
177_C185_L0.7120.84
285_T296_T0.7100.84
122_I413_V0.7100.84
148_M159_Y0.7090.84
236_L240_A0.7080.84
47_V50_V0.7020.83
335_A338_S0.7020.83
148_M164_F0.7010.83
394_Q399_G0.6990.83
159_Y163_H0.6960.83
354_G358_S0.6910.82
106_L109_L0.6880.82
371_Y377_L0.6880.82
46_A334_S0.6860.82
264_V268_F0.6850.82
48_A52_S0.6840.82
220_V328_G0.6830.81
132_I135_I0.6830.81
201_A204_Q0.6820.81
88_G238_I0.6800.81
71_L253_H0.6790.81
187_L420_P0.6790.81
16_P323_I0.6780.81
265_G312_F0.6770.81
117_G121_K0.6760.81
108_A249_T0.6730.80
243_V246_A0.6730.80
181_L184_F0.6730.80
51_T293_G0.6720.80
195_I336_L0.6720.80
82_I86_A0.6710.80
190_V305_V0.6710.80
147_A350_F0.6690.80
118_W122_I0.6660.80
47_V51_T0.6660.80
335_A339_S0.6650.80
260_L298_T0.6630.79
177_C189_P0.6620.79
309_T323_I0.6590.79
96_G100_A0.6580.79
164_F168_G0.6580.79
34_T37_V0.6540.79
34_T48_A0.6520.78
62_I280_G0.6510.78
48_A73_S0.6510.78
179_I358_S0.6490.78
194_I251_S0.6480.78
212_V335_A0.6450.78
108_A250_M0.6440.77
138_G403_S0.6430.77
79_S83_L0.6410.77
371_Y376_N0.6410.77
26_H305_V0.6400.77
140_A388_V0.6400.77
252_E281_D0.6390.77
85_K93_A0.6390.77
396_S399_G0.6390.77
241_A400_F0.6380.77
113_Q279_M0.6380.77
41_V194_I0.6370.77
260_L303_I0.6330.76
283_V286_I0.6310.76
58_A280_G0.6310.76
194_I348_V0.6290.76
232_P289_S0.6280.76
124_P129_G0.6280.76
179_I356_I0.6270.76
30_M362_R0.6260.75
36_L39_K0.6240.75
185_L189_P0.6240.75
174_T177_C0.6240.75
192_I195_I0.6230.75
65_G273_G0.6210.75
125_P377_L0.6210.75
126_V376_N0.6200.75
300_G359_S0.6200.75
68_P264_V0.6190.75
174_T351_L0.6180.75
76_A135_I0.6170.74
22_F300_G0.6150.74
204_Q333_I0.6150.74
307_A362_R0.6140.74
386_I391_A0.6140.74
160_S165_S0.6130.74
55_G280_G0.6130.74
11_R393_I0.6130.74
301_E353_F0.6120.74
146_M349_S0.6120.74
394_Q398_G0.6110.74
90_P93_A0.6110.74
131_V171_L0.6110.74
172_A175_I0.6110.74
166_V194_I0.6090.73
13_V16_P0.6090.73
142_T146_M0.6080.73
51_T284_A0.6080.73
166_V343_A0.6070.73
54_I291_I0.6070.73
170_T197_G0.6060.73
368_K372_E0.6060.73
249_T252_E0.6030.73
263_V307_A0.6030.73
140_A381_S0.6010.73
277_S281_D0.5990.72
67_I277_S0.5980.72
128_V331_G0.5970.72
52_S69_A0.5960.72
40_L82_I0.5950.72
129_G360_G0.5940.72
12_D313_S0.5930.72
391_A397_Q0.5930.72
196_G199_L0.5910.71
124_P304_G0.5910.71
354_G377_L0.5910.71
202_L205_G0.5910.71
10_V313_S0.5900.71
246_A285_T0.5890.71
43_M294_P0.5890.71
413_V417_L0.5870.71
123_L183_G0.5870.71
176_I414_I0.5860.71
242_M343_A0.5840.70
53_G57_L0.5830.70
380_T384_L0.5820.70
215_A331_G0.5820.70
326_C400_F0.5820.70
364_L369_I0.5800.70
379_I420_P0.5790.70
81_I85_K0.5790.70
81_I242_M0.5780.70
32_G301_E0.5770.69
227_F230_Y0.5770.69
71_L285_T0.5750.69
28_F379_I0.5740.69
199_L213_L0.5740.69
56_T297_T0.5740.69
283_V318_G0.5730.69
404_G408_A0.5730.69
382_V388_V0.5730.69
256_H359_S0.5730.69
249_T257_Q0.5710.69
197_G205_G0.5700.69
108_A246_A0.5700.69
16_P19_W0.5700.69
261_S265_G0.5700.69
59_Y314_V0.5690.68
254_I258_M0.5680.68
35_I45_P0.5670.68
23_S132_I0.5670.68
281_D381_S0.5670.68
205_G344_V0.5670.68
311_V345_M0.5660.68
173_I192_I0.5660.68
202_L418_I0.5640.68
126_V379_I0.5630.68
194_I345_M0.5590.67
390_G397_Q0.5590.67
64_K105_G0.5590.67
300_G406_A0.5580.67
98_F104_Y0.5580.67
14_P315_F0.5570.67
394_Q397_Q0.5570.67
118_W123_L0.5570.67
95_V239_A0.5550.67
183_G186_S0.5540.66
73_S297_T0.5540.66
80_P404_G0.5540.66
255_G387_G0.5530.66
159_Y388_V0.5520.66
385_V388_V0.5520.66
328_G334_S0.5520.66
268_F273_G0.5510.66
110_L216_K0.5510.66
135_I299_Y0.5500.66
85_K90_P0.5490.66
161_L397_Q0.5480.66
37_V96_G0.5480.66
345_M348_V0.5470.65
133_I174_T0.5460.65
111_I278_I0.5460.65
102_L235_T0.5450.65
45_P338_S0.5450.65
50_V229_D0.5440.65
256_H298_T0.5440.65
259_V359_S0.5440.65
56_T321_A0.5440.65
20_V326_C0.5420.65
285_T288_A0.5420.65
387_G404_G0.5410.65
253_H298_T0.5410.65
140_A350_F0.5390.64
60_L321_A0.5380.64
281_D297_T0.5370.64
14_P23_S0.5360.64
269_I272_P0.5360.64
76_A297_T0.5360.64
375_R421_Q0.5340.64
71_L257_Q0.5340.64
34_T324_A0.5340.64
130_P412_G0.5330.63
357_A361_L0.5320.63
106_L218_F0.5320.63
57_L61_L0.5320.63
176_I237_G0.5320.63
105_G109_L0.5290.63
358_S381_S0.5280.63
47_V292_G0.5280.63
37_V48_A0.5270.63
198_Y202_L0.5260.62
358_S361_L0.5260.62
302_N305_V0.5250.62
392_F396_S0.5240.62
103_V340_V0.5220.62
362_R368_K0.5210.62
98_F286_I0.5200.62
108_A112_R0.5200.62
80_P83_L0.5190.61
121_K417_L0.5190.61
314_V318_G0.5180.61
37_V129_G0.5180.61
258_M310_R0.5180.61
76_A245_V0.5170.61
84_V93_A0.5170.61
136_G143_A0.5160.61
249_T256_H0.5160.61
180_F418_I0.5160.61
220_V247_F0.5150.61
116_T254_I0.5150.61
196_G203_T0.5150.61
77_F285_T0.5150.61
235_T242_M0.5150.61
400_F410_I0.5130.60
138_G404_G0.5130.60
48_A295_P0.5120.60
24_L148_M0.5120.60
183_G193_G0.5120.60
11_R193_G0.5120.60
73_S256_H0.5110.60
36_L40_L0.5110.60
334_S339_S0.5100.60
300_G303_I0.5090.60
50_V402_V0.5080.60
286_I289_S0.5080.60
182_R322_V0.5080.60
85_K88_G0.5070.60
163_H167_A0.5060.59
14_P420_P0.5050.59
96_G101_G0.5050.59
19_W315_F0.5050.59
106_L199_L0.5050.59
186_S371_Y0.5040.59
88_G96_G0.5030.59
419_L422_A0.5020.59
195_I418_I0.5010.59
256_H281_D0.5010.59
10_V67_I0.5010.59
47_V98_F0.5010.59
10_V38_P0.5000.59
103_V243_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.9264 100 0.37 Contact Map
2jlnA 1 0.8736 81.7 0.959 Contact Map
3o7qA 1 0.4322 52.2 0.967 Contact Map
2gfpA 2 0.4161 46.5 0.968 Contact Map
4wgvA 2 0.7655 35.3 0.97 Contact Map
1pw4A 1 0.4575 33.4 0.97 Contact Map
4pypA 1 0.4276 22.9 0.973 Contact Map
4ltoA 3 0.2138 22.2 0.973 Contact Map
2nwlA 3 0.3862 19.1 0.974 Contact Map
3mktA 1 0.9563 18.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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