GREMLIN Database
PYRR - Bifunctional protein PyrR
UniProt: P39765 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (170)
Sequences: 1969 (1219)
Seq/√Len: 93.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_E61_P3.8981.00
18_T53_R3.2791.00
100_K129_S3.1851.00
35_I94_V3.1311.00
108_L147_A3.1141.00
131_Q149_Y3.0661.00
9_D12_A3.0481.00
53_R56_Q2.5781.00
72_Y123_D2.4831.00
21_A50_L2.4101.00
51_A64_V2.2961.00
118_M130_I2.2611.00
140_H156_T2.1891.00
49_R173_D2.1841.00
165_Q172_N2.1531.00
13_I166_L2.1491.00
42_R170_D2.1391.00
7_I177_I2.1241.00
98_D128_S2.0641.00
165_Q174_L2.0521.00
36_L51_A2.0061.00
28_N131_Q1.9951.00
52_E56_Q1.9881.00
146_R153_N1.9251.00
6_V174_L1.9191.00
33_N99_Q1.8621.00
22_H57_I1.8081.00
35_I101_V1.7721.00
11_Q14_R1.7391.00
27_R131_Q1.7321.00
65_G92_I1.6911.00
49_R168_E1.6821.00
44_I66_E1.6751.00
10_E167_D1.6231.00
48_K52_E1.6171.00
66_E91_D1.6101.00
19_R26_E1.6041.00
17_L53_R1.5951.00
41_T45_Y1.5131.00
45_Y169_V1.4861.00
20_I133_A1.4731.00
109_Y158_K1.4651.00
65_G90_A1.4340.99
67_I118_M1.3960.99
13_I135_L1.3530.99
36_L54_I1.3490.99
8_L175_V1.3470.99
19_R23_E1.3140.99
96_I121_L1.3080.99
20_I149_Y1.2960.99
167_D173_D1.2940.99
35_I99_Q1.2670.99
20_I24_M1.2620.99
60_N63_T1.2520.99
165_Q176_A1.2490.99
40_K66_E1.2430.99
37_V121_L1.2380.98
41_T169_V1.2290.98
31_M34_C1.2240.98
100_K131_Q1.2240.98
41_T166_L1.2190.98
36_L104_V1.1910.98
92_I124_V1.1890.98
168_E171_Q1.1840.98
168_E173_D1.1560.98
172_N176_A1.1450.97
33_N128_S1.1410.97
100_K128_S1.1390.97
5_A177_I1.1270.97
108_L134_V1.1090.97
111_G141_R1.0990.97
71_L76_L1.0920.97
47_A64_V1.0880.97
154_I162_V1.0860.97
90_A124_V1.0740.96
52_E55_E1.0440.96
25_I31_M1.0430.96
48_K66_E1.0240.95
109_Y138_R1.0230.95
65_G94_V1.0140.95
34_C102_I1.0070.95
6_V176_A1.0000.94
7_I154_I0.9850.94
140_H155_P0.9740.94
23_E27_R0.9730.94
46_L166_L0.9710.94
90_A93_P0.9660.93
39_I114_V0.9660.93
78_K98_D0.9610.93
119_D123_D0.9610.93
39_I69_I0.9570.93
104_V133_A0.9540.93
51_A55_E0.9530.93
71_L87_V0.9460.93
103_L125_G0.9320.92
24_M133_A0.9310.92
150_I153_N0.9280.92
128_S142_E0.9280.92
17_L46_L0.9260.92
110_T122_V0.9210.92
116_A119_D0.9090.91
14_R53_R0.9090.91
30_G58_E0.9000.91
152_K155_P0.8980.91
52_E61_P0.8820.90
146_R157_S0.8780.90
28_N149_Y0.8750.89
27_R149_Y0.8650.89
96_I125_G0.8560.88
114_V132_L0.8520.88
65_G93_P0.8400.88
155_P160_E0.8240.86
162_V176_A0.8230.86
79_K163_M0.8220.86
8_L177_I0.8210.86
79_K82_N0.8140.86
45_Y168_E0.8090.85
136_V152_K0.8070.85
69_I79_K0.8040.85
70_T76_L0.8040.85
22_H26_E0.8030.85
108_L146_R0.8030.85
63_T99_Q0.7960.85
50_L104_V0.7930.84
44_I67_I0.7800.83
87_V90_A0.7780.83
110_T142_E0.7750.83
32_N60_N0.7740.83
54_I58_E0.7730.83
22_H54_I0.7700.83
22_H153_N0.7650.82
127_P130_I0.7570.81
8_L13_I0.7560.81
152_K157_S0.7540.81
96_I103_L0.7470.81
37_V65_G0.7420.80
12_A16_A0.7330.79
21_A54_I0.7330.79
131_Q148_D0.7320.79
37_V110_T0.7270.79
22_H146_R0.7250.79
21_A53_R0.7190.78
13_I16_A0.7190.78
24_M102_I0.7160.78
8_L16_A0.7140.78
56_Q59_G0.7090.77
10_E14_R0.7080.77
40_K68_D0.7010.76
115_R119_D0.6960.76
26_E160_E0.6950.76
140_H160_E0.6940.76
23_E29_K0.6930.75
14_R173_D0.6920.75
41_T44_I0.6900.75
167_D172_N0.6860.75
77_S80_T0.6790.74
146_R155_P0.6780.74
65_G127_P0.6760.74
77_S87_V0.6750.74
24_M34_C0.6750.74
91_D94_V0.6730.73
18_T57_I0.6690.73
6_V10_E0.6690.73
29_K58_E0.6670.73
166_L169_V0.6600.72
40_K70_T0.6590.72
59_G168_E0.6560.71
51_A62_V0.6550.71
45_Y76_L0.6540.71
24_M36_L0.6530.71
167_D171_Q0.6530.71
8_L154_I0.6530.71
36_L50_L0.6520.71
76_L79_K0.6510.71
37_V92_I0.6500.71
61_P128_S0.6490.71
122_V130_I0.6480.70
48_K64_V0.6460.70
65_G124_V0.6430.70
96_I101_V0.6420.70
139_G155_P0.6390.69
6_V9_D0.6300.68
30_G33_N0.6250.68
11_Q56_Q0.6200.67
37_V122_V0.6190.67
136_V175_V0.6140.66
103_L121_L0.6110.66
156_T160_E0.6100.66
26_E152_K0.6090.66
42_R166_L0.6050.65
15_R26_E0.5960.64
71_L90_A0.5950.64
88_K91_D0.5940.64
28_N102_I0.5910.63
5_A154_I0.5890.63
46_L165_Q0.5880.63
5_A87_V0.5760.61
63_T94_V0.5760.61
16_A30_G0.5740.61
57_I113_T0.5730.61
157_S160_E0.5730.61
116_A132_L0.5720.61
134_V150_I0.5700.61
71_L123_D0.5690.61
7_I13_I0.5690.61
153_N157_S0.5680.60
40_K88_K0.5650.60
73_R132_L0.5600.59
137_D153_N0.5570.59
72_Y122_V0.5560.59
42_R169_V0.5560.59
37_V72_Y0.5560.59
137_D162_V0.5540.58
78_K81_S0.5540.58
40_K82_N0.5530.58
40_K119_D0.5530.58
16_A20_I0.5520.58
33_N100_K0.5520.58
121_L130_I0.5490.58
90_A94_V0.5480.58
15_R155_P0.5460.57
112_R132_L0.5450.57
31_M60_N0.5450.57
71_L80_T0.5420.57
139_G153_N0.5370.56
73_R116_A0.5360.56
48_K91_D0.5350.56
68_D73_R0.5350.56
112_R115_R0.5330.56
103_L117_G0.5320.55
112_R141_R0.5300.55
147_A150_I0.5290.55
36_L64_V0.5290.55
32_N168_E0.5270.55
132_L147_A0.5260.55
23_E155_P0.5260.55
15_R19_R0.5230.54
142_E158_K0.5220.54
23_E28_N0.5220.54
128_S143_L0.5180.54
26_E155_P0.5170.53
103_L130_I0.5170.53
60_N174_L0.5150.53
140_H153_N0.5120.53
122_V154_I0.5100.52
23_E153_N0.5090.52
8_L12_A0.5090.52
73_R115_R0.5080.52
35_I96_I0.5080.52
11_Q171_Q0.5060.52
18_T113_T0.5050.52
24_M149_Y0.5040.52
125_G141_R0.5020.51
6_V172_N0.5010.51
81_S97_T0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w30A 3 0.9337 100 0.54 Contact Map
1ufrA 2 0.9227 100 0.546 Contact Map
4p82A 2 0.9945 100 0.552 Contact Map
4lyyA 3 0.895 99.9 0.67 Contact Map
1pzmA 2 0.884 99.9 0.681 Contact Map
2xbuA 2 0.895 99.8 0.681 Contact Map
2jbhA 4 0.9392 99.8 0.682 Contact Map
4rhxA 3 0.9171 99.8 0.685 Contact Map
4raoA 4 0.9116 99.8 0.686 Contact Map
1tc1A 2 0.9503 99.8 0.686 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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