GREMLIN Database
KINC - Sporulation kinase C
UniProt: P39764 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (348)
Sequences: 40675 (34175)
Seq/√Len: 1832.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
282_H320_G3.2961.00
237_L254_I3.1301.00
407_K419_Q3.1171.00
362_K417_V3.0411.00
89_E186_S2.8401.00
356_H421_V2.7181.00
363_D367_G2.7121.00
360_S417_V2.6321.00
340_M364_E2.5911.00
349_S360_S2.5851.00
358_V419_Q2.5371.00
358_V421_V2.5231.00
360_S419_Q2.4821.00
241_K255_F2.4661.00
396_L400_K2.4641.00
373_L408_I2.4331.00
307_E345_V2.4101.00
369_P372_K2.3831.00
281_T319_N2.3441.00
411_E414_K2.3221.00
307_E347_T2.3181.00
309_N349_S2.3171.00
234_S258_I2.2371.00
92_F183_G2.1971.00
351_A358_V2.1961.00
347_T362_K2.1771.00
320_G402_H2.1761.00
241_K252_D2.1101.00
290_Q326_K2.0921.00
395_C406_L2.0771.00
349_S362_K1.9941.00
156_T160_T1.9911.00
280_K322_E1.9791.00
408_I418_F1.9621.00
351_A360_S1.9561.00
106_A109_S1.9341.00
84_M102_Y1.9151.00
309_N347_T1.8811.00
283_Q286_E1.8801.00
328_V399_L1.8781.00
151_T192_K1.8761.00
90_I110_I1.8521.00
399_L404_G1.8481.00
192_K195_E1.8361.00
370_Q373_L1.8191.00
90_I185_M1.8121.00
305_V345_V1.7911.00
409_E417_V1.7821.00
234_S259_K1.7811.00
405_E421_V1.7711.00
328_V395_C1.7631.00
345_V364_E1.7611.00
373_L410_S1.7531.00
368_M376_I1.7451.00
368_M372_K1.7411.00
409_E419_Q1.7361.00
281_T317_M1.7041.00
295_L330_I1.6941.00
375_Q381_Y1.6851.00
165_E186_S1.6781.00
236_F250_Y1.6731.00
377_G406_L1.6691.00
77_S81_N1.6691.00
399_L420_V1.6651.00
410_S416_S1.6261.00
95_N99_E1.6191.00
149_M165_E1.5651.00
191_R195_E1.5651.00
153_K161_I1.5601.00
372_K375_Q1.5581.00
241_K248_K1.5571.00
407_K421_V1.5501.00
76_L79_E1.5461.00
344_G364_E1.5451.00
153_K163_W1.5151.00
233_V258_I1.5141.00
262_D266_S1.5111.00
285_N350_T1.5071.00
279_F319_N1.5031.00
353_T358_V1.4981.00
121_T125_D1.4981.00
321_D324_Q1.4961.00
113_F157_K1.4941.00
92_F107_W1.4811.00
359_I420_V1.4691.00
166_V185_M1.4691.00
155_V161_I1.4631.00
165_E191_R1.4491.00
340_M346_V1.4411.00
328_V398_I1.4391.00
240_M251_F1.4381.00
156_T162_F1.4381.00
329_F359_I1.4281.00
103_L107_W1.4241.00
93_Q180_G1.4181.00
213_S217_E1.4171.00
398_I402_H1.4121.00
236_F253_I1.4111.00
243_Q247_R1.3841.00
81_N85_D1.3811.00
369_P412_A1.3801.00
105_Q109_S1.3771.00
108_A115_I1.3741.00
163_W192_K1.3731.00
255_F259_K1.3721.00
320_G325_L1.3511.00
296_D300_I1.3421.00
400_K405_E1.3341.00
378_K381_Y1.3331.00
237_L255_F1.3261.00
92_F100_I1.3201.00
372_K381_Y1.3111.00
238_Q255_F1.3061.00
85_D105_Q1.2951.00
152_A166_V1.2941.00
340_M344_G1.2861.00
299_A337_I1.2841.00
244_Y247_R1.2721.00
198_L201_I1.2631.00
138_N142_Q1.2571.00
352_K424_L1.2541.00
410_S414_K1.2481.00
283_Q317_M1.2441.00
290_Q322_E1.2371.00
375_Q378_K1.2341.00
339_A382_S1.2241.00
298_N301_L1.2191.00
324_Q327_Q1.2171.00
87_L91_V1.2161.00
128_I131_K1.2161.00
232_S257_E1.2151.00
310_F350_T1.2051.00
103_L108_A1.1861.00
198_L202_N1.1811.00
114_S117_E1.1761.00
240_M247_R1.1681.00
94_T183_G1.1601.00
237_L258_I1.1571.00
334_K338_E1.1451.00
173_D177_Q1.1381.00
376_I408_I1.1361.00
322_E326_K1.1341.00
324_Q401_E1.1341.00
372_K383_T1.1321.00
285_N289_K1.1251.00
139_T143_N1.1241.00
101_T180_G1.1231.00
195_E199_I1.1161.00
194_A197_E1.1111.00
193_E197_E1.1051.00
356_H405_E1.1021.00
368_M408_I1.0941.00
253_I257_E1.0881.00
283_Q315_G1.0801.00
212_L215_T1.0791.00
289_K308_K1.0761.00
99_E122_M1.0751.00
93_Q182_L1.0741.00
282_H287_I1.0701.00
199_I202_N1.0661.00
295_L333_I1.0571.00
197_E201_I1.0571.00
108_A114_S1.0511.00
233_V254_I1.0441.00
93_Q102_Y1.0431.00
294_L330_I1.0411.00
122_M125_D1.0381.00
80_K84_M1.0381.00
252_D256_S1.0381.00
248_K252_D1.0361.00
368_M373_L1.0321.00
285_N310_F1.0251.00
284_L359_I1.0231.00
105_Q108_A1.0201.00
263_L323_N1.0191.00
292_T296_D1.0181.00
279_F402_H1.0161.00
328_V420_V1.0091.00
347_T364_E1.0081.00
134_A138_N1.0031.00
107_W111_T1.0021.00
196_D199_I1.0011.00
232_S236_F0.9941.00
357_A424_L0.9931.00
292_T308_K0.9921.00
324_Q398_I0.9911.00
237_L241_K0.9881.00
316_C352_K0.9861.00
368_M416_S0.9861.00
234_S262_D0.9861.00
234_S255_F0.9841.00
196_D200_E0.9771.00
291_V326_K0.9751.00
192_K196_D0.9681.00
170_L178_F0.9681.00
70_E74_K0.9671.00
172_Y178_F0.9641.00
79_E93_Q0.9581.00
227_R262_D0.9561.00
199_I203_E0.9541.00
338_E384_K0.9541.00
410_S413_G0.9511.00
326_K330_I0.9491.00
190_E193_E0.9481.00
311_K351_A0.9451.00
257_E260_R0.9431.00
151_T165_E0.9401.00
249_D253_I0.9391.00
327_Q398_I0.9301.00
95_N101_T0.9251.00
162_F187_D0.9241.00
237_L251_F0.9211.00
226_V261_I0.9201.00
168_Y181_S0.9141.00
78_E82_R0.9131.00
215_T219_A0.9121.00
69_N73_Y0.9001.00
287_I291_V0.8941.00
399_L406_L0.8931.00
277_I324_Q0.8931.00
103_L118_C0.8921.00
102_Y115_I0.8871.00
283_Q316_C0.8871.00
363_D415_G0.8831.00
288_L350_T0.8831.00
377_G408_I0.8811.00
73_Y77_S0.8791.00
286_E290_Q0.8781.00
212_L216_S0.8651.00
379_P397_R0.8621.00
333_I346_V0.8561.00
325_L402_H0.8551.00
149_M167_H0.8501.00
340_M343_G0.8471.00
329_F333_I0.8471.00
358_V407_K0.8441.00
277_I321_D0.8421.00
279_F320_G0.8411.00
113_F117_E0.8401.00
79_E102_Y0.8391.00
404_G422_L0.8371.00
333_I348_I0.8361.00
115_I119_M0.8361.00
316_C357_A0.8341.00
94_T100_I0.8321.00
293_T296_D0.8301.00
294_L326_K0.8281.00
74_K77_S0.8221.00
341_P344_G0.8211.00
304_I337_I0.8191.00
74_K78_E0.8191.00
353_T421_V0.8191.00
73_Y76_L0.8121.00
169_K182_L0.8101.00
168_Y183_G0.8101.00
69_N72_K0.8091.00
92_F185_M0.8061.00
286_E322_E0.8041.00
224_H228_N0.8031.00
332_I395_C0.8021.00
94_T168_Y0.8011.00
368_M374_K0.8001.00
395_C399_L0.8001.00
291_V295_L0.8001.00
332_I406_L0.7971.00
235_G239_I0.7971.00
292_T306_I0.7961.00
191_R194_A0.7961.00
376_I418_F0.7921.00
90_I107_W0.7921.00
258_I262_D0.7901.00
324_Q402_H0.7891.00
311_K314_D0.7871.00
367_G416_S0.7831.00
133_V136_H0.7831.00
135_D139_T0.7821.00
70_E73_Y0.7801.00
332_I418_F0.7791.00
289_K292_T0.7781.00
271_L393_P0.7781.00
263_L267_E0.7771.00
399_L422_L0.7761.00
227_R269_L0.7721.00
222_I268_L0.7721.00
128_I161_I0.7711.00
253_I256_S0.7701.00
282_H322_E0.7691.00
228_N235_G0.7681.00
140_Q143_N0.7651.00
87_L184_T0.7651.00
136_H139_T0.7641.00
111_T154_Y0.7611.00
336_G346_V0.7561.00
236_F254_I0.7551.00
164_G185_M0.7531.00
259_K262_D0.7501.00
363_D416_S0.7481.00
256_S290_Q0.7471.00
329_F361_V0.7451.00
75_Q79_E0.7451.00
137_I141_I0.7421.00
193_E196_D0.7421.00
133_V140_Q0.7421.00
298_N334_K0.7401.00
311_K350_T0.7381.00
129_K132_H0.7381.00
96_A178_F0.7371.00
287_I320_G0.7371.00
227_R266_S0.7331.00
210_Q213_S0.7331.00
225_E228_N0.7321.00
136_H140_Q0.7311.00
291_V330_I0.7301.00
94_T123_Y0.7291.00
163_W189_T0.7291.00
239_I250_Y0.7271.00
197_E200_E0.7231.00
210_Q214_I0.7221.00
105_Q115_I0.7181.00
245_P248_K0.7181.00
124_N132_H0.7171.00
131_K153_K0.7171.00
117_E157_K0.7141.00
154_Y164_G0.7121.00
211_K215_T0.7121.00
94_T137_I0.7101.00
353_T356_H0.7091.00
377_G418_F0.7081.00
225_E331_N0.7071.00
93_Q101_T0.7041.00
370_Q411_E0.7031.00
171_Y182_L0.7011.00
236_F257_E0.7011.00
267_E324_Q0.7001.00
302_S337_I0.6991.00
167_H186_S0.6991.00
232_S235_G0.6981.00
285_N315_G0.6951.00
189_T193_E0.6941.00
72_K76_L0.6931.00
291_V333_I0.6921.00
217_E221_G0.6911.00
288_L348_I0.6901.00
304_I340_M0.6891.00
171_Y180_G0.6881.00
80_K83_I0.6881.00
266_S270_L0.6871.00
404_G420_V0.6871.00
249_D252_D0.6851.00
279_F403_D0.6841.00
269_L273_K0.6841.00
173_D179_T0.6811.00
238_Q241_K0.6781.00
397_R400_K0.6771.00
259_K263_L0.6761.00
277_I401_E0.6761.00
89_E184_T0.6751.00
231_T235_G0.6731.00
336_G361_V0.6731.00
108_A118_C0.6711.00
338_E382_S0.6711.00
332_I420_V0.6711.00
252_D255_F0.6701.00
345_V362_K0.6691.00
76_L80_K0.6691.00
397_R401_E0.6681.00
89_E106_A0.6681.00
254_I258_I0.6671.00
200_E203_E0.6671.00
285_N316_C0.6631.00
133_V138_N0.6621.00
247_R250_Y0.6611.00
356_H423_P0.6611.00
90_I106_A0.6581.00
304_I308_K0.6581.00
163_W188_I0.6561.00
77_S80_K0.6561.00
71_W75_Q0.6551.00
91_V104_N0.6521.00
335_N391_G0.6521.00
84_M91_V0.6501.00
94_T181_S0.6491.00
408_I416_S0.6491.00
221_G379_P0.6471.00
90_I104_N0.6431.00
190_E194_A0.6381.00
127_F132_H0.6371.00
173_D180_G0.6361.00
295_L334_K0.6351.00
299_A304_I0.6321.00
234_S238_Q0.6311.00
348_I361_V0.6271.00
288_L329_F0.6261.00
111_T185_M0.6261.00
241_K251_F0.6241.00
339_A366_N0.6231.00
260_R326_K0.6231.00
289_K293_T0.6221.00
93_Q171_Y0.6211.00
225_E327_Q0.6211.00
287_I325_L0.6211.00
228_N232_S0.6201.00
106_A110_I0.6181.00
127_F131_K0.6181.00
224_H331_N0.6171.00
194_A198_L0.6161.00
243_Q250_Y0.6141.00
71_W74_K0.6121.00
277_I402_H0.6061.00
240_M254_I0.6061.00
284_L357_A0.6051.00
331_N395_C0.6051.00
270_L324_Q0.6041.00
90_I164_G0.6041.00
382_S387_G0.6021.00
103_L115_I0.6011.00
104_N107_W0.6011.00
82_R86_N0.5981.00
404_G423_P0.5981.00
360_S409_E0.5971.00
83_I182_L0.5951.00
240_M250_Y0.5941.00
137_I168_Y0.5941.00
341_P366_N0.5941.00
299_A306_I0.5931.00
121_T126_Y0.5921.00
295_L337_I0.5921.00
96_A179_T0.5901.00
332_I361_V0.5881.00
382_S386_K0.5851.00
368_M410_S0.5851.00
305_V308_K0.5851.00
373_L409_E0.5831.00
154_Y162_F0.5831.00
250_Y253_I0.5831.00
338_E386_K0.5821.00
282_H319_N0.5821.00
96_A177_Q0.5811.00
127_F152_A0.5801.00
239_I243_Q0.5791.00
373_L377_G0.5761.00
143_N146_S0.5751.00
257_E261_I0.5751.00
288_L308_K0.5741.00
152_A155_V0.5731.00
299_A346_V0.5721.00
128_I153_K0.5711.00
188_I192_K0.5711.00
134_A137_I0.5691.00
297_T301_L0.5681.00
303_N342_K0.5681.00
225_E229_P0.5661.00
124_N134_A0.5651.00
309_N351_A0.5641.00
225_E264_V0.5631.00
390_L394_I0.5611.00
230_L261_I0.5601.00
216_S275_Q0.5571.00
379_P393_P0.5571.00
325_L329_F0.5561.00
238_Q242_T0.5561.00
134_A141_I0.5551.00
246_D250_Y0.5551.00
250_Y254_I0.5551.00
217_E379_P0.5541.00
232_S253_I0.5541.00
373_L418_F0.5521.00
230_L265_L0.5521.00
323_N326_K0.5511.00
214_I217_E0.5501.00
407_K420_V0.5471.00
163_W196_D0.5441.00
297_T300_I0.5441.00
91_V182_L0.5431.00
72_K75_Q0.5411.00
286_E289_K0.5411.00
98_G123_Y0.5371.00
253_I293_T0.5361.00
289_K310_F0.5341.00
151_T191_R0.5341.00
170_L181_S0.5341.00
370_Q374_K0.5301.00
287_I326_K0.5301.00
140_Q144_K0.5291.00
84_M104_N0.5291.00
141_I144_K0.5281.00
113_F156_T0.5281.00
94_T98_G0.5271.00
113_F118_C0.5261.00
350_T359_I0.5241.00
328_V402_H0.5231.00
355_S424_L0.5231.00
346_V350_T0.5221.00
172_Y179_T0.5211.00
90_I111_T0.5191.00
223_A227_R0.5191.00
88_Q106_A0.5191.00
339_A384_K0.5191.00
316_C424_L0.5181.00
234_S237_L0.5161.00
95_N180_G0.5161.00
331_N334_K0.5131.00
188_I191_R0.5111.00
138_N141_I0.5101.00
304_I344_G0.5101.00
166_V183_G0.5091.00
271_L397_R0.5081.00
83_I86_N0.5081.00
226_V229_P0.5081.00
327_Q330_I0.5071.00
376_I393_P0.5071.00
123_Y127_F0.5061.00
273_K388_T0.5061.00
92_F166_V0.5051.00
215_T223_A0.5051.00
82_R182_L0.5051.00
348_I359_I0.5031.00
91_V184_T0.5031.00
300_I303_N0.5021.00
394_I398_I0.5021.00
127_F130_E0.5001.00
302_S340_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.8972 100 0.226 Contact Map
4gczA 2 0.8364 100 0.278 Contact Map
3a0rA 2 0.764 100 0.316 Contact Map
4r3aA 1 0.722 100 0.419 Contact Map
4bixA 2 0.528 100 0.476 Contact Map
4q20A 2 0.5257 100 0.48 Contact Map
2c2aA 2 0.5327 100 0.494 Contact Map
3d36A 2 0.507 100 0.5 Contact Map
3jz3A 2 0.3621 100 0.501 Contact Map
4mpcA 2 0.6939 100 0.511 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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