MREBH - BACSU - GREMLIN Contacts

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MREBH - Protein MreBH

UniProt:	P39763	Sequences: MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLAIGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVVVCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGGTTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALIEHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGDIVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	335 (313)
Sequences:	11081 (6335)
Seq/√Len:	358.1

ECOLI - MREB HSCC DNAK HSCA YEGD FTSA EUTJ
BACSU - MREBH MREB MBL DNAK FTSA
HALSA - DNAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
100_N	127_K	3.514	1.00
155_V	258_I	3.334	1.00
177_S	257_H	3.154	1.00
224_A	241_M	3.111	1.00
188_D	253_E	3.027	1.00
196_K	246_E	3.021	1.00
263_R	301_E	2.994	1.00
214_G	218_I	2.982	1.00
61_V	183_D	2.844	1.00
311_N	314_E	2.735	1.00
103_V	121_V	2.428	1.00
296_E	300_E	2.364	1.00
252_R	256_L	2.364	1.00
166_I	265_T	2.322	1.00
299_T	305_P	2.295	1.00
189_I	242_L	2.285	1.00
208_Q	212_E	2.210	1.00
288_G	291_L	2.209	1.00
115_R	119_D	2.151	1.00
104_C	320_T	2.127	1.00
243_Q	246_E	2.097	1.00
259_L	301_E	2.040	1.00
22_N	25_I	2.030	1.00
87_K	91_S	2.025	1.00
246_E	249_D	2.019	1.00
151_A	168_S	2.006	1.00
297_W	300_E	1.994	1.00
19_Y	321_G	1.983	1.00
185_L	254_S	1.936	1.00
290_L	313_L	1.932	1.00
295_K	308_V	1.883	1.00
14_A	159_G	1.850	1.00
192_F	250_A	1.849	1.00
259_L	297_W	1.843	1.00
251_M	291_L	1.836	1.00
157_I	162_T	1.834	1.00
192_F	196_K	1.824	1.00
226_E	239_T	1.819	1.00
226_E	241_M	1.784	1.00
89_A	93_G	1.773	1.00
13_T	160_G	1.769	1.00
83_H	86_K	1.768	1.00
16_I	31_S	1.763	1.00
255_L	293_G	1.758	1.00
166_I	269_C	1.700	1.00
244_S	248_Q	1.691	1.00
118_S	122_K	1.687	1.00
314_E	318_I	1.668	1.00
251_M	255_L	1.667	1.00
19_Y	317_A	1.655	1.00
185_L	251_M	1.637	1.00
193_V	213_I	1.628	1.00
100_N	129_V	1.617	1.00
153_V	166_I	1.611	1.00
247_I	291_L	1.607	1.00
157_I	185_L	1.596	1.00
193_V	240_I	1.591	1.00
47_A	51_N	1.579	1.00
264_A	268_D	1.570	1.00
252_R	297_W	1.563	1.00
7_I	18_V	1.540	1.00
216_A	227_I	1.536	1.00
188_D	191_S	1.530	1.00
190_V	210_K	1.519	1.00
259_L	263_R	1.507	1.00
249_D	252_R	1.506	1.00
110_T	113_E	1.501	1.00
56_T	59_K	1.485	1.00
119_D	122_K	1.483	1.00
150_V	279_D	1.483	1.00
17_L	28_N	1.475	1.00
255_L	297_W	1.462	1.00
265_T	269_C	1.458	1.00
105_T	131_L	1.455	1.00
260_E	264_A	1.439	1.00
188_D	254_S	1.435	1.00
251_M	254_S	1.422	1.00
212_E	215_H	1.416	1.00
65_P	68_D	1.404	1.00
17_L	317_A	1.390	1.00
248_Q	296_E	1.368	1.00
176_H	264_A	1.367	1.00
155_V	162_T	1.367	1.00
18_V	88_A	1.364	1.00
196_K	199_L	1.362	1.00
133_E	136_V	1.361	1.00
193_V	227_I	1.357	1.00
262_I	298_L	1.356	1.00
284_L	298_L	1.351	1.00
153_V	164_V	1.342	1.00
192_F	246_E	1.336	1.00
71_I	76_M	1.336	1.00
189_I	213_I	1.335	1.00
85_M	89_A	1.334	1.00
78_T	123_N	1.328	1.00
272_E	276_D	1.324	1.00
187_E	191_S	1.316	1.00
164_V	265_T	1.306	1.00
162_T	258_I	1.303	1.00
311_N	318_I	1.300	1.00
90_K	94_M	1.295	1.00
195_K	198_N	1.290	1.00
216_A	225_M	1.285	1.00
215_H	219_E	1.280	1.00
21_K	325_E	1.277	1.00
150_V	281_G	1.272	1.00
82_K	86_K	1.269	1.00
260_E	263_R	1.258	1.00
297_W	301_E	1.257	1.00
8_G	320_T	1.242	1.00
16_I	88_A	1.236	1.00
6_E	324_L	1.235	1.00
11_L	117_I	1.233	1.00
114_R	133_E	1.231	1.00
15_N	313_L	1.226	1.00
100_N	128_N	1.222	1.00
296_E	299_T	1.221	1.00
252_R	293_G	1.219	1.00
228_R	239_T	1.218	1.00
153_V	262_I	1.212	1.00
79_D	82_K	1.206	1.00
272_E	277_I	1.206	1.00
38_T	42_V	1.204	1.00
295_K	299_T	1.200	1.00
188_D	251_M	1.192	1.00
293_G	296_E	1.186	1.00
132_I	323_S	1.184	1.00
185_L	291_L	1.182	1.00
164_V	261_A	1.170	1.00
256_L	260_E	1.167	1.00
6_E	129_V	1.160	1.00
166_I	278_V	1.160	1.00
80_L	84_I	1.158	1.00
157_I	294_I	1.149	1.00
107_S	135_P	1.143	1.00
187_E	210_K	1.143	1.00
63_V	134_E	1.142	1.00
81_L	85_M	1.141	1.00
282_V	302_I	1.141	1.00
35_V	83_H	1.140	1.00
185_L	288_G	1.131	1.00
134_E	163_E	1.126	1.00
219_E	222_P	1.126	1.00
284_L	289_A	1.123	1.00
298_L	306_V	1.116	1.00
185_L	247_I	1.110	1.00
281_G	307_H	1.108	1.00
88_A	91_S	1.106	1.00
293_G	297_W	1.087	1.00
90_K	93_G	1.084	1.00
82_K	123_N	1.077	1.00
16_I	84_I	1.074	1.00
62_A	81_L	1.070	1.00
122_K	127_K	1.070	1.00
62_A	80_L	1.068	1.00
79_D	83_H	1.067	1.00
8_G	317_A	1.061	1.00
187_E	190_V	1.057	1.00
111_A	115_R	1.052	1.00
264_A	267_E	1.052	1.00
6_E	100_N	1.051	1.00
33_V	80_L	1.050	1.00
87_K	90_K	1.047	1.00
88_A	92_I	1.023	1.00
247_I	288_G	1.022	1.00
151_A	271_P	1.022	1.00
78_T	119_D	1.021	1.00
323_S	326_V	1.013	1.00
34_A	44_A	1.010	1.00
190_V	213_I	1.009	1.00
118_S	131_L	1.002	1.00
216_A	242_L	0.999	1.00
36_D	39_T	0.995	1.00
35_V	79_D	0.994	1.00
196_K	240_I	0.993	1.00
132_I	137_A	0.990	1.00
196_K	200_L	0.988	1.00
182_G	288_G	0.981	1.00
245_N	248_Q	0.980	1.00
34_A	60_I	0.979	1.00
256_L	259_L	0.971	1.00
36_D	42_V	0.969	1.00
43_L	83_H	0.967	1.00
92_I	96_F	0.964	1.00
156_D	163_E	0.964	1.00
160_G	163_E	0.963	1.00
285_T	315_S	0.955	1.00
223_E	244_S	0.954	1.00
186_D	214_G	0.949	1.00
156_D	160_G	0.949	1.00
248_Q	293_G	0.945	1.00
119_D	123_N	0.944	1.00
192_F	242_L	0.935	1.00
34_A	52_M	0.931	1.00
224_A	243_Q	0.931	1.00
159_G	163_E	0.929	1.00
105_T	114_R	0.929	1.00
201_I	236_L	0.928	1.00
170_G	173_V	0.925	1.00
86_K	90_K	0.925	1.00
56_T	60_I	0.918	1.00
138_A	316_V	0.914	1.00
246_E	250_A	0.906	1.00
156_D	159_G	0.905	1.00
166_I	271_P	0.904	1.00
263_R	267_E	0.902	1.00
251_M	293_G	0.900	1.00
138_A	285_T	0.895	1.00
89_A	126_A	0.895	1.00
105_T	133_E	0.892	1.00
266_L	275_G	0.885	1.00
157_I	288_G	0.885	1.00
151_A	279_D	0.882	1.00
7_I	101_V	0.882	1.00
45_I	87_K	0.879	1.00
27_L	95_S	0.876	1.00
206_A	210_K	0.875	1.00
219_E	225_M	0.875	1.00
177_S	180_I	0.874	1.00
99_P	127_K	0.873	1.00
256_L	297_W	0.872	1.00
231_D	238_K	0.870	1.00
156_D	161_T	0.861	1.00
32_V	50_K	0.858	1.00
142_A	283_I	0.852	1.00
212_E	216_A	0.848	1.00
103_V	117_I	0.846	1.00
64_R	184_Q	0.839	1.00
318_I	322_R	0.839	1.00
114_R	118_S	0.833	1.00
261_A	265_T	0.828	1.00
11_L	62_A	0.827	1.00
91_S	94_M	0.826	1.00
93_G	97_R	0.826	1.00
220_H	292_N	0.825	1.00
248_Q	252_R	0.825	1.00
115_R	118_S	0.821	1.00
58_G	203_E	0.820	1.00
180_I	257_H	0.819	1.00
81_L	84_I	0.817	1.00
130_H	323_S	0.810	1.00
299_T	306_V	0.808	1.00
78_T	85_M	0.807	1.00
271_P	277_I	0.806	1.00
78_T	82_K	0.800	1.00
81_L	117_I	0.798	1.00
191_S	195_K	0.797	1.00
185_L	255_L	0.796	1.00
44_A	48_D	0.794	1.00
135_P	163_E	0.793	1.00
111_A	114_R	0.793	1.00
15_N	28_N	0.790	1.00
257_H	260_E	0.785	1.00
102_V	324_L	0.780	1.00
192_F	240_I	0.775	1.00
141_G	315_S	0.774	1.00
65_P	70_V	0.774	1.00
101_V	126_A	0.774	1.00
39_T	42_V	0.771	1.00
190_V	194_R	0.770	1.00
52_M	56_T	0.769	1.00
139_A	167_I	0.763	1.00
192_F	195_K	0.762	1.00
157_I	258_I	0.760	1.00
62_A	84_I	0.759	1.00
89_A	97_R	0.752	1.00
85_M	92_I	0.751	1.00
7_I	98_K	0.749	1.00
213_I	218_I	0.744	1.00
83_H	87_K	0.740	1.00
175_C	261_A	0.740	1.00
141_G	318_I	0.736	1.00
121_V	131_L	0.730	1.00
121_V	124_C	0.729	1.00
109_S	117_I	0.729	1.00
242_L	250_A	0.726	1.00
109_S	113_E	0.724	0.99
242_L	247_I	0.723	0.99
135_P	138_A	0.723	0.99
247_I	251_M	0.722	0.99
28_N	314_E	0.722	0.99
86_K	89_A	0.721	0.99
134_E	161_T	0.720	0.99
190_V	206_A	0.720	0.99
140_I	323_S	0.719	0.99
66_M	117_I	0.715	0.99
259_L	262_I	0.715	0.99
245_N	249_D	0.715	0.99
262_I	301_E	0.715	0.99
153_V	278_V	0.711	0.99
141_G	144_L	0.711	0.99
71_I	77_T	0.710	0.99
8_G	321_G	0.707	0.99
180_I	184_Q	0.707	0.99
208_Q	230_R	0.706	0.99
78_T	120_A	0.706	0.99
42_V	45_I	0.705	0.99
179_R	184_Q	0.703	0.99
284_L	308_V	0.701	0.99
47_A	50_K	0.700	0.99
82_K	85_M	0.700	0.99
52_M	55_K	0.700	0.99
29_E	87_K	0.699	0.99
9_I	101_V	0.698	0.99
81_L	88_A	0.696	0.99
129_V	327_I	0.696	0.99
85_M	101_V	0.695	0.99
213_I	216_A	0.693	0.99
196_K	238_K	0.688	0.99
183_D	186_D	0.687	0.99
142_A	315_S	0.685	0.99
214_G	217_L	0.682	0.99
136_V	167_I	0.681	0.99
114_R	131_L	0.681	0.99
134_E	316_V	0.678	0.99
222_P	245_N	0.676	0.99
217_L	220_H	0.675	0.99
151_A	277_I	0.674	0.99
79_D	123_N	0.671	0.99
272_E	275_G	0.671	0.99
138_A	159_G	0.671	0.99
62_A	66_M	0.669	0.99
63_V	161_T	0.668	0.99
155_V	262_I	0.668	0.99
78_T	81_L	0.667	0.99
11_L	81_L	0.666	0.99
135_P	161_T	0.666	0.99
212_E	225_M	0.665	0.99
107_S	117_I	0.663	0.99
17_L	314_E	0.663	0.99
121_V	126_A	0.663	0.99
105_T	117_I	0.662	0.99
175_C	264_A	0.661	0.99
307_H	315_S	0.658	0.99
29_E	91_S	0.658	0.99
134_E	159_G	0.657	0.99
244_S	247_I	0.656	0.99
117_I	120_A	0.652	0.99
66_M	81_L	0.648	0.99
197_Y	201_I	0.647	0.99
93_G	98_K	0.647	0.99
10_D	13_T	0.646	0.99
46_G	49_A	0.645	0.99
158_G	287_G	0.645	0.99
9_I	81_L	0.645	0.99
120_A	124_C	0.639	0.99
164_V	175_C	0.638	0.99
159_G	287_G	0.638	0.99
13_T	161_T	0.637	0.99
34_A	56_T	0.637	0.99
215_H	218_I	0.637	0.99
198_N	201_I	0.635	0.99
227_I	230_R	0.632	0.99
204_R	237_P	0.625	0.99
48_D	51_N	0.623	0.98
208_Q	237_P	0.623	0.98
155_V	164_V	0.621	0.98
104_C	316_V	0.621	0.98
106_P	109_S	0.620	0.98
189_I	250_A	0.617	0.98
10_D	156_D	0.615	0.98
266_L	269_C	0.611	0.98
235_G	238_K	0.610	0.98
255_L	259_L	0.610	0.98
139_A	143_D	0.609	0.98
223_E	292_N	0.609	0.98
76_M	88_A	0.608	0.98
255_L	291_L	0.605	0.98
175_C	265_T	0.605	0.98
284_L	306_V	0.605	0.98
230_R	235_G	0.604	0.98
210_K	213_I	0.599	0.98
91_S	95_S	0.597	0.98
225_M	230_R	0.597	0.98
298_L	302_I	0.592	0.98
153_V	302_I	0.589	0.98
203_E	207_E	0.588	0.98
256_L	301_E	0.586	0.98
66_M	116_A	0.586	0.98
77_T	81_L	0.583	0.98
261_A	264_A	0.582	0.98
188_D	250_A	0.582	0.98
20_S	96_F	0.579	0.98
8_G	104_C	0.579	0.98
193_V	197_Y	0.578	0.98
62_A	65_P	0.578	0.98
44_A	52_M	0.578	0.98
282_V	298_L	0.577	0.98
202_G	205_T	0.576	0.98
157_I	289_A	0.576	0.98
233_V	236_L	0.575	0.97
76_M	81_L	0.573	0.97
275_G	301_E	0.573	0.97
154_V	285_T	0.571	0.97
197_Y	246_E	0.570	0.97
211_M	215_H	0.569	0.97
35_V	43_L	0.566	0.97
186_D	217_L	0.565	0.97
197_Y	238_K	0.564	0.97
85_M	88_A	0.564	0.97
250_A	253_E	0.564	0.97
154_V	283_I	0.562	0.97
244_S	292_N	0.561	0.97
248_Q	291_L	0.559	0.97
254_S	257_H	0.554	0.97
151_A	166_I	0.553	0.97
57_P	60_I	0.553	0.97
275_G	303_V	0.551	0.97
50_K	214_G	0.551	0.97
122_K	128_N	0.549	0.97
20_S	95_S	0.548	0.97
78_T	116_A	0.548	0.97
26_I	318_I	0.547	0.97
89_A	92_I	0.546	0.97
159_G	182_G	0.546	0.97
261_A	266_L	0.546	0.97
101_V	124_C	0.545	0.97
217_L	288_G	0.545	0.97
257_H	261_A	0.543	0.96
175_C	178_I	0.543	0.96
65_P	71_I	0.540	0.96
89_A	101_V	0.540	0.96
81_L	92_I	0.538	0.96
262_I	302_I	0.538	0.96
266_L	270_P	0.537	0.96
63_V	160_G	0.535	0.96
108_G	163_E	0.534	0.96
176_H	268_D	0.532	0.96
189_I	247_I	0.531	0.96
21_K	321_G	0.531	0.96
53_I	60_I	0.531	0.96
299_T	307_H	0.531	0.96
193_V	209_V	0.530	0.96
251_M	288_G	0.529	0.96
158_G	161_T	0.529	0.96
186_D	210_K	0.528	0.96
62_A	68_D	0.528	0.96
17_L	26_I	0.527	0.96
11_L	85_M	0.527	0.96
154_V	159_G	0.527	0.96
31_S	80_L	0.526	0.96
54_G	207_E	0.524	0.96
35_V	71_I	0.524	0.96
19_Y	318_I	0.523	0.96
32_V	49_A	0.522	0.96
263_R	302_I	0.520	0.95
189_I	192_F	0.519	0.95
9_I	103_V	0.519	0.95
100_N	327_I	0.518	0.95
50_K	53_I	0.518	0.95
85_M	126_A	0.517	0.95
249_D	267_E	0.517	0.95
295_K	309_A	0.516	0.95
161_T	181_G	0.516	0.95
117_I	131_L	0.515	0.95
194_R	197_Y	0.511	0.95
181_G	184_Q	0.511	0.95
134_E	160_G	0.510	0.95
184_Q	187_E	0.510	0.95
108_G	177_S	0.510	0.95
205_T	208_Q	0.507	0.95
247_I	250_A	0.506	0.95
18_V	84_I	0.506	0.95
116_A	119_D	0.505	0.95
92_I	98_K	0.504	0.95
177_S	181_G	0.504	0.95
80_L	85_M	0.503	0.95
258_I	294_I	0.503	0.95
175_C	268_D	0.500	0.94
225_M	229_G	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fl9A	1	0.9463	100	0.212	Contact Map
3d2fA	1	0.9731	100	0.215	Contact Map
4jneA	2	0.9672	100	0.22	Contact Map
2v7yA	1	0.9642	100	0.234	Contact Map
4rtfD	1	0.9403	100	0.252	Contact Map
3i33A	1	0.9493	100	0.259	Contact Map
4kboA	1	0.9463	100	0.268	Contact Map
4j8fA	2	0.9821	100	0.29	Contact Map
4gniA	2	0.9433	100	0.31	Contact Map
1jceA	1	0.9582	100	0.34	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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