GREMLIN Database
MREBH - Protein MreBH
UniProt: P39763 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (313)
Sequences: 11081 (6335)
Seq/√Len: 358.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_N127_K3.5141.00
155_V258_I3.3341.00
177_S257_H3.1541.00
224_A241_M3.1111.00
188_D253_E3.0271.00
196_K246_E3.0211.00
263_R301_E2.9941.00
214_G218_I2.9821.00
61_V183_D2.8441.00
311_N314_E2.7351.00
103_V121_V2.4281.00
296_E300_E2.3641.00
252_R256_L2.3641.00
166_I265_T2.3221.00
299_T305_P2.2951.00
189_I242_L2.2851.00
208_Q212_E2.2101.00
288_G291_L2.2091.00
115_R119_D2.1511.00
104_C320_T2.1271.00
243_Q246_E2.0971.00
259_L301_E2.0401.00
22_N25_I2.0301.00
87_K91_S2.0251.00
246_E249_D2.0191.00
151_A168_S2.0061.00
297_W300_E1.9941.00
19_Y321_G1.9831.00
185_L254_S1.9361.00
290_L313_L1.9321.00
295_K308_V1.8831.00
14_A159_G1.8501.00
192_F250_A1.8491.00
259_L297_W1.8431.00
251_M291_L1.8361.00
157_I162_T1.8341.00
192_F196_K1.8241.00
226_E239_T1.8191.00
226_E241_M1.7841.00
89_A93_G1.7731.00
13_T160_G1.7691.00
83_H86_K1.7681.00
16_I31_S1.7631.00
255_L293_G1.7581.00
166_I269_C1.7001.00
244_S248_Q1.6911.00
118_S122_K1.6871.00
314_E318_I1.6681.00
251_M255_L1.6671.00
19_Y317_A1.6551.00
185_L251_M1.6371.00
193_V213_I1.6281.00
100_N129_V1.6171.00
153_V166_I1.6111.00
247_I291_L1.6071.00
157_I185_L1.5961.00
193_V240_I1.5911.00
47_A51_N1.5791.00
264_A268_D1.5701.00
252_R297_W1.5631.00
7_I18_V1.5401.00
216_A227_I1.5361.00
188_D191_S1.5301.00
190_V210_K1.5191.00
259_L263_R1.5071.00
249_D252_R1.5061.00
110_T113_E1.5011.00
56_T59_K1.4851.00
119_D122_K1.4831.00
150_V279_D1.4831.00
17_L28_N1.4751.00
255_L297_W1.4621.00
265_T269_C1.4581.00
105_T131_L1.4551.00
260_E264_A1.4391.00
188_D254_S1.4351.00
251_M254_S1.4221.00
212_E215_H1.4161.00
65_P68_D1.4041.00
17_L317_A1.3901.00
248_Q296_E1.3681.00
176_H264_A1.3671.00
155_V162_T1.3671.00
18_V88_A1.3641.00
196_K199_L1.3621.00
133_E136_V1.3611.00
193_V227_I1.3571.00
262_I298_L1.3561.00
284_L298_L1.3511.00
153_V164_V1.3421.00
192_F246_E1.3361.00
71_I76_M1.3361.00
189_I213_I1.3351.00
85_M89_A1.3341.00
78_T123_N1.3281.00
272_E276_D1.3241.00
187_E191_S1.3161.00
164_V265_T1.3061.00
162_T258_I1.3031.00
311_N318_I1.3001.00
90_K94_M1.2951.00
195_K198_N1.2901.00
216_A225_M1.2851.00
215_H219_E1.2801.00
21_K325_E1.2771.00
150_V281_G1.2721.00
82_K86_K1.2691.00
260_E263_R1.2581.00
297_W301_E1.2571.00
8_G320_T1.2421.00
16_I88_A1.2361.00
6_E324_L1.2351.00
11_L117_I1.2331.00
114_R133_E1.2311.00
15_N313_L1.2261.00
100_N128_N1.2221.00
296_E299_T1.2211.00
252_R293_G1.2191.00
228_R239_T1.2181.00
153_V262_I1.2121.00
79_D82_K1.2061.00
272_E277_I1.2061.00
38_T42_V1.2041.00
295_K299_T1.2001.00
188_D251_M1.1921.00
293_G296_E1.1861.00
132_I323_S1.1841.00
185_L291_L1.1821.00
164_V261_A1.1701.00
256_L260_E1.1671.00
6_E129_V1.1601.00
166_I278_V1.1601.00
80_L84_I1.1581.00
157_I294_I1.1491.00
107_S135_P1.1431.00
187_E210_K1.1431.00
63_V134_E1.1421.00
81_L85_M1.1411.00
282_V302_I1.1411.00
35_V83_H1.1401.00
185_L288_G1.1311.00
134_E163_E1.1261.00
219_E222_P1.1261.00
284_L289_A1.1231.00
298_L306_V1.1161.00
185_L247_I1.1101.00
281_G307_H1.1081.00
88_A91_S1.1061.00
293_G297_W1.0871.00
90_K93_G1.0841.00
82_K123_N1.0771.00
16_I84_I1.0741.00
62_A81_L1.0701.00
122_K127_K1.0701.00
62_A80_L1.0681.00
79_D83_H1.0671.00
8_G317_A1.0611.00
187_E190_V1.0571.00
111_A115_R1.0521.00
264_A267_E1.0521.00
6_E100_N1.0511.00
33_V80_L1.0501.00
87_K90_K1.0471.00
88_A92_I1.0231.00
247_I288_G1.0221.00
151_A271_P1.0221.00
78_T119_D1.0211.00
323_S326_V1.0131.00
34_A44_A1.0101.00
190_V213_I1.0091.00
118_S131_L1.0021.00
216_A242_L0.9991.00
36_D39_T0.9951.00
35_V79_D0.9941.00
196_K240_I0.9931.00
132_I137_A0.9901.00
196_K200_L0.9881.00
182_G288_G0.9811.00
245_N248_Q0.9801.00
34_A60_I0.9791.00
256_L259_L0.9711.00
36_D42_V0.9691.00
43_L83_H0.9671.00
92_I96_F0.9641.00
156_D163_E0.9641.00
160_G163_E0.9631.00
285_T315_S0.9551.00
223_E244_S0.9541.00
186_D214_G0.9491.00
156_D160_G0.9491.00
248_Q293_G0.9451.00
119_D123_N0.9441.00
192_F242_L0.9351.00
34_A52_M0.9311.00
224_A243_Q0.9311.00
159_G163_E0.9291.00
105_T114_R0.9291.00
201_I236_L0.9281.00
170_G173_V0.9251.00
86_K90_K0.9251.00
56_T60_I0.9181.00
138_A316_V0.9141.00
246_E250_A0.9061.00
156_D159_G0.9051.00
166_I271_P0.9041.00
263_R267_E0.9021.00
251_M293_G0.9001.00
138_A285_T0.8951.00
89_A126_A0.8951.00
105_T133_E0.8921.00
266_L275_G0.8851.00
157_I288_G0.8851.00
151_A279_D0.8821.00
7_I101_V0.8821.00
45_I87_K0.8791.00
27_L95_S0.8761.00
206_A210_K0.8751.00
219_E225_M0.8751.00
177_S180_I0.8741.00
99_P127_K0.8731.00
256_L297_W0.8721.00
231_D238_K0.8701.00
156_D161_T0.8611.00
32_V50_K0.8581.00
142_A283_I0.8521.00
212_E216_A0.8481.00
103_V117_I0.8461.00
64_R184_Q0.8391.00
318_I322_R0.8391.00
114_R118_S0.8331.00
261_A265_T0.8281.00
11_L62_A0.8271.00
91_S94_M0.8261.00
93_G97_R0.8261.00
220_H292_N0.8251.00
248_Q252_R0.8251.00
115_R118_S0.8211.00
58_G203_E0.8201.00
180_I257_H0.8191.00
81_L84_I0.8171.00
130_H323_S0.8101.00
299_T306_V0.8081.00
78_T85_M0.8071.00
271_P277_I0.8061.00
78_T82_K0.8001.00
81_L117_I0.7981.00
191_S195_K0.7971.00
185_L255_L0.7961.00
44_A48_D0.7941.00
135_P163_E0.7931.00
111_A114_R0.7931.00
15_N28_N0.7901.00
257_H260_E0.7851.00
102_V324_L0.7801.00
192_F240_I0.7751.00
141_G315_S0.7741.00
65_P70_V0.7741.00
101_V126_A0.7741.00
39_T42_V0.7711.00
190_V194_R0.7701.00
52_M56_T0.7691.00
139_A167_I0.7631.00
192_F195_K0.7621.00
157_I258_I0.7601.00
62_A84_I0.7591.00
89_A97_R0.7521.00
85_M92_I0.7511.00
7_I98_K0.7491.00
213_I218_I0.7441.00
83_H87_K0.7401.00
175_C261_A0.7401.00
141_G318_I0.7361.00
121_V131_L0.7301.00
121_V124_C0.7291.00
109_S117_I0.7291.00
242_L250_A0.7261.00
109_S113_E0.7240.99
242_L247_I0.7230.99
135_P138_A0.7230.99
247_I251_M0.7220.99
28_N314_E0.7220.99
86_K89_A0.7210.99
134_E161_T0.7200.99
190_V206_A0.7200.99
140_I323_S0.7190.99
66_M117_I0.7150.99
259_L262_I0.7150.99
245_N249_D0.7150.99
262_I301_E0.7150.99
153_V278_V0.7110.99
141_G144_L0.7110.99
71_I77_T0.7100.99
8_G321_G0.7070.99
180_I184_Q0.7070.99
208_Q230_R0.7060.99
78_T120_A0.7060.99
42_V45_I0.7050.99
179_R184_Q0.7030.99
284_L308_V0.7010.99
47_A50_K0.7000.99
82_K85_M0.7000.99
52_M55_K0.7000.99
29_E87_K0.6990.99
9_I101_V0.6980.99
81_L88_A0.6960.99
129_V327_I0.6960.99
85_M101_V0.6950.99
213_I216_A0.6930.99
196_K238_K0.6880.99
183_D186_D0.6870.99
142_A315_S0.6850.99
214_G217_L0.6820.99
136_V167_I0.6810.99
114_R131_L0.6810.99
134_E316_V0.6780.99
222_P245_N0.6760.99
217_L220_H0.6750.99
151_A277_I0.6740.99
79_D123_N0.6710.99
272_E275_G0.6710.99
138_A159_G0.6710.99
62_A66_M0.6690.99
63_V161_T0.6680.99
155_V262_I0.6680.99
78_T81_L0.6670.99
11_L81_L0.6660.99
135_P161_T0.6660.99
212_E225_M0.6650.99
107_S117_I0.6630.99
17_L314_E0.6630.99
121_V126_A0.6630.99
105_T117_I0.6620.99
175_C264_A0.6610.99
307_H315_S0.6580.99
29_E91_S0.6580.99
134_E159_G0.6570.99
244_S247_I0.6560.99
117_I120_A0.6520.99
66_M81_L0.6480.99
197_Y201_I0.6470.99
93_G98_K0.6470.99
10_D13_T0.6460.99
46_G49_A0.6450.99
158_G287_G0.6450.99
9_I81_L0.6450.99
120_A124_C0.6390.99
164_V175_C0.6380.99
159_G287_G0.6380.99
13_T161_T0.6370.99
34_A56_T0.6370.99
215_H218_I0.6370.99
198_N201_I0.6350.99
227_I230_R0.6320.99
204_R237_P0.6250.99
48_D51_N0.6230.98
208_Q237_P0.6230.98
155_V164_V0.6210.98
104_C316_V0.6210.98
106_P109_S0.6200.98
189_I250_A0.6170.98
10_D156_D0.6150.98
266_L269_C0.6110.98
235_G238_K0.6100.98
255_L259_L0.6100.98
139_A143_D0.6090.98
223_E292_N0.6090.98
76_M88_A0.6080.98
255_L291_L0.6050.98
175_C265_T0.6050.98
284_L306_V0.6050.98
230_R235_G0.6040.98
210_K213_I0.5990.98
91_S95_S0.5970.98
225_M230_R0.5970.98
298_L302_I0.5920.98
153_V302_I0.5890.98
203_E207_E0.5880.98
256_L301_E0.5860.98
66_M116_A0.5860.98
77_T81_L0.5830.98
261_A264_A0.5820.98
188_D250_A0.5820.98
20_S96_F0.5790.98
8_G104_C0.5790.98
193_V197_Y0.5780.98
62_A65_P0.5780.98
44_A52_M0.5780.98
282_V298_L0.5770.98
202_G205_T0.5760.98
157_I289_A0.5760.98
233_V236_L0.5750.97
76_M81_L0.5730.97
275_G301_E0.5730.97
154_V285_T0.5710.97
197_Y246_E0.5700.97
211_M215_H0.5690.97
35_V43_L0.5660.97
186_D217_L0.5650.97
197_Y238_K0.5640.97
85_M88_A0.5640.97
250_A253_E0.5640.97
154_V283_I0.5620.97
244_S292_N0.5610.97
248_Q291_L0.5590.97
254_S257_H0.5540.97
151_A166_I0.5530.97
57_P60_I0.5530.97
275_G303_V0.5510.97
50_K214_G0.5510.97
122_K128_N0.5490.97
20_S95_S0.5480.97
78_T116_A0.5480.97
26_I318_I0.5470.97
89_A92_I0.5460.97
159_G182_G0.5460.97
261_A266_L0.5460.97
101_V124_C0.5450.97
217_L288_G0.5450.97
257_H261_A0.5430.96
175_C178_I0.5430.96
65_P71_I0.5400.96
89_A101_V0.5400.96
81_L92_I0.5380.96
262_I302_I0.5380.96
266_L270_P0.5370.96
63_V160_G0.5350.96
108_G163_E0.5340.96
176_H268_D0.5320.96
189_I247_I0.5310.96
21_K321_G0.5310.96
53_I60_I0.5310.96
299_T307_H0.5310.96
193_V209_V0.5300.96
251_M288_G0.5290.96
158_G161_T0.5290.96
186_D210_K0.5280.96
62_A68_D0.5280.96
17_L26_I0.5270.96
11_L85_M0.5270.96
154_V159_G0.5270.96
31_S80_L0.5260.96
54_G207_E0.5240.96
35_V71_I0.5240.96
19_Y318_I0.5230.96
32_V49_A0.5220.96
263_R302_I0.5200.95
189_I192_F0.5190.95
9_I103_V0.5190.95
100_N327_I0.5180.95
50_K53_I0.5180.95
85_M126_A0.5170.95
249_D267_E0.5170.95
295_K309_A0.5160.95
161_T181_G0.5160.95
117_I131_L0.5150.95
194_R197_Y0.5110.95
181_G184_Q0.5110.95
134_E160_G0.5100.95
184_Q187_E0.5100.95
108_G177_S0.5100.95
205_T208_Q0.5070.95
247_I250_A0.5060.95
18_V84_I0.5060.95
116_A119_D0.5050.95
92_I98_K0.5040.95
177_S181_G0.5040.95
80_L85_M0.5030.95
258_I294_I0.5030.95
175_C268_D0.5000.94
225_M229_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fl9A 1 0.9463 100 0.212 Contact Map
3d2fA 1 0.9731 100 0.215 Contact Map
4jneA 2 0.9672 100 0.22 Contact Map
2v7yA 1 0.9642 100 0.234 Contact Map
4rtfD 1 0.9403 100 0.252 Contact Map
3i33A 1 0.9493 100 0.259 Contact Map
4kboA 1 0.9463 100 0.268 Contact Map
4j8fA 2 0.9821 100 0.29 Contact Map
4gniA 2 0.9433 100 0.31 Contact Map
1jceA 1 0.9582 100 0.34 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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