GREMLIN Database
AMPS - Aminopeptidase AmpS
UniProt: P39762 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (363)
Sequences: 1689 (1139)
Seq/√Len: 59.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
279_N295_E4.8421.00
394_T398_K4.0741.00
283_T291_D3.9641.00
289_I348_I3.7501.00
222_K259_G3.6051.00
22_V28_V3.5831.00
278_E296_K3.4081.00
46_H49_E3.3471.00
32_A40_V3.3401.00
298_E302_K3.1511.00
13_Q46_H3.0691.00
267_T385_S2.9981.00
261_D286_N2.8391.00
306_E312_H2.8331.00
15_A145_V2.7171.00
70_E112_I2.7071.00
13_Q17_E2.7011.00
82_E86_K2.6501.00
78_E119_A2.5411.00
391_D404_R2.5261.00
9_N46_H2.4731.00
323_D328_Q2.4651.00
209_A220_T2.4521.00
16_V43_I2.3931.00
16_V50_K2.3401.00
284_F314_L2.3371.00
263_V283_T2.2841.00
22_V97_A2.2821.00
20_V99_I2.2431.00
401_P404_R2.2001.00
17_E50_K2.1741.00
323_D407_N2.1471.00
154_H165_A2.1271.00
281_T293_K2.0811.00
205_R400_E2.0621.00
292_I302_K2.0461.00
305_V312_H2.0361.00
293_K298_E2.0271.00
389_N405_N2.0241.00
211_H218_D1.9881.00
288_R312_H1.9511.00
15_A99_I1.9431.00
196_H200_D1.9061.00
141_S236_N1.8941.00
107_D155_K1.8761.00
66_K111_G1.8651.00
391_D399_R1.8551.00
58_N87_G1.8511.00
30_V43_I1.8481.00
254_L372_L1.8251.00
74_F116_R1.8241.00
28_V99_I1.8050.99
221_I346_L1.8000.99
263_V281_T1.7850.99
394_T400_E1.7810.99
215_E387_D1.7700.99
175_K180_N1.7670.99
389_N404_R1.7580.99
99_I143_T1.7250.99
226_K357_E1.7250.99
302_K306_E1.7090.99
27_Y53_K1.7060.99
26_Q97_A1.7030.99
29_V96_A1.6970.99
257_K313_Y1.6910.99
200_D204_E1.6850.99
260_V313_Y1.6820.99
225_R395_A1.6810.99
288_R313_Y1.6560.99
265_S281_T1.6470.99
74_F78_E1.6270.99
44_V64_V1.6170.99
103_S149_S1.6010.99
9_N42_L1.6000.99
118_A122_K1.5940.99
28_V47_A1.5770.99
213_Q389_N1.5760.99
47_A52_A1.5750.99
289_I305_V1.5700.99
292_I298_E1.5610.99
100_S144_V1.5320.98
9_N45_K1.5240.98
305_V311_S1.5170.98
222_K256_Q1.5110.98
220_T261_D1.5110.98
328_Q407_N1.5050.98
39_F43_I1.5050.98
68_K72_A1.5050.98
272_Y277_I1.5020.98
177_T246_M1.4900.98
390_I403_F1.4840.98
254_L351_A1.4540.98
226_K370_E1.4530.98
146_G338_F1.4520.98
209_A399_R1.4410.97
256_Q259_G1.4400.97
72_A77_F1.4320.97
18_V189_I1.3930.97
264_V346_L1.3810.97
346_L383_I1.3750.97
86_K89_E1.3730.97
69_Y77_F1.3710.97
201_H205_R1.3680.97
102_V146_G1.3670.97
208_A395_A1.3670.97
30_V40_V1.3580.96
86_K90_E1.3570.96
28_V143_T1.3530.96
292_I305_V1.3480.96
49_E71_L1.3410.96
150_A166_I1.3180.96
39_F147_A1.3140.96
351_A372_L1.3080.96
285_E290_V1.2940.95
208_A259_G1.2930.95
307_T376_I1.2780.95
344_N384_G1.2770.95
391_D401_P1.2700.95
136_Q350_S1.2690.95
299_D303_E1.2540.94
43_I99_I1.2400.94
350_S374_E1.2380.94
254_L352_Y1.2340.94
254_L355_N1.2330.94
10_T13_Q1.2250.94
42_L45_K1.2240.94
31_N58_N1.2150.93
22_V47_A1.2110.93
40_V99_I1.2110.93
23_Q26_Q1.2080.93
35_D149_S1.1870.93
66_K70_E1.1850.93
282_L305_V1.1820.92
42_L46_H1.1800.92
74_F119_A1.1800.92
219_L346_L1.1760.92
211_H220_T1.1720.92
344_N388_M1.1690.92
16_V47_A1.1610.92
101_V145_V1.1590.92
165_A168_L1.1570.92
305_V348_I1.1440.91
45_K49_E1.1430.91
210_L317_V1.1390.91
33_S103_S1.1330.91
70_E111_G1.1310.91
144_V352_Y1.1260.90
256_Q313_Y1.1230.90
311_S377_T1.1210.90
289_I312_H1.1140.90
89_E130_T1.1060.90
40_V57_V1.0960.89
26_Q141_S1.0960.89
15_A143_T1.0840.89
303_E306_E1.0830.89
105_N151_G1.0800.89
271_S276_I1.0560.87
201_H400_E1.0520.87
211_H399_R1.0450.87
28_V97_A1.0440.87
121_Q273_G1.0360.86
252_F354_F1.0350.86
282_L289_I1.0340.86
209_A393_I1.0340.86
223_L253_T1.0300.86
146_G149_S1.0280.86
291_D302_K1.0270.86
21_N240_H1.0220.86
22_V50_K1.0130.85
72_A76_A1.0120.85
155_K334_Y1.0030.85
292_I306_E1.0010.84
41_R61_D0.9980.84
264_V383_I0.9950.84
275_N300_I0.9940.84
46_H50_K0.9930.84
208_A212_Y0.9910.84
37_R59_W0.9820.83
103_S146_G0.9790.83
6_Q9_N0.9750.83
98_F140_V0.9730.83
73_P77_F0.9720.83
302_K312_H0.9690.82
192_D238_S0.9670.82
45_K67_L0.9640.82
16_V28_V0.9620.82
255_P314_L0.9520.81
393_I399_R0.9510.81
280_F336_T0.9510.81
221_I260_V0.9420.81
301_L304_L0.9420.81
307_T377_T0.9420.81
7_K10_T0.9360.80
16_V22_V0.9360.80
44_V57_V0.9350.80
27_Y96_A0.9350.80
148_A170_W0.9320.80
348_I377_T0.9310.80
147_A170_W0.9310.80
138_D354_F0.9300.80
80_Y124_A0.9280.80
193_Q197_E0.9250.79
281_T291_D0.9220.79
82_E90_E0.9190.79
387_D405_N0.9180.79
270_L379_V0.9170.79
213_Q391_D0.9070.78
192_D199_V0.9060.78
100_S352_Y0.9000.77
270_L336_T0.8980.77
192_D196_H0.8960.77
205_R392_G0.8950.77
311_S348_I0.8900.77
67_L70_E0.8840.76
261_D285_E0.8780.76
85_A89_E0.8780.76
198_K402_I0.8700.75
33_S36_V0.8690.75
208_A222_K0.8690.75
289_I311_S0.8690.75
15_A144_V0.8680.75
129_H132_R0.8660.75
119_A123_A0.8650.75
385_S388_M0.8630.74
178_R191_H0.8630.74
176_A332_L0.8620.74
212_Y390_I0.8620.74
214_A387_D0.8600.74
84_E87_G0.8600.74
45_K71_L0.8570.74
216_G281_T0.8570.74
214_A385_S0.8550.74
135_I140_V0.8550.74
7_K180_N0.8530.74
20_V97_A0.8520.73
39_F42_L0.8510.73
195_L251_V0.8350.72
189_I192_D0.8340.72
289_I292_I0.8320.72
73_P76_A0.8310.72
219_L260_V0.8290.71
172_E176_A0.8280.71
237_E248_T0.8270.71
150_A154_H0.8270.71
113_D116_R0.8250.71
115_K303_E0.8240.71
31_N60_Q0.8240.71
43_I101_V0.8240.71
344_N390_I0.8220.71
277_I301_L0.8210.71
36_V103_S0.8180.70
288_R309_E0.8180.70
208_A224_P0.8150.70
197_E201_H0.8120.70
37_R41_R0.8090.70
65_A109_L0.8010.69
83_W90_E0.8000.69
219_L314_L0.7990.69
120_F124_A0.7990.69
260_V346_L0.7980.69
118_A303_E0.7950.68
20_V143_T0.7880.68
210_L223_L0.7880.68
57_V64_V0.7820.67
72_A116_R0.7820.67
31_N98_F0.7820.67
280_F381_F0.7800.67
225_R256_Q0.7800.67
171_E180_N0.7740.66
291_D298_E0.7740.66
327_S387_D0.7730.66
112_I117_I0.7670.65
7_K174_F0.7670.65
122_K126_K0.7640.65
114_S303_E0.7610.65
209_A222_K0.7610.65
318_A321_P0.7600.65
279_N296_K0.7570.64
83_W97_A0.7570.64
214_A344_N0.7550.64
277_I304_L0.7540.64
36_V147_A0.7540.64
212_Y317_V0.7520.64
205_R394_T0.7500.64
399_R404_R0.7490.64
105_N154_H0.7460.63
6_Q151_G0.7450.63
158_P165_A0.7450.63
384_G388_M0.7440.63
82_E85_A0.7410.63
14_L178_R0.7380.62
128_L131_Y0.7350.62
168_L171_E0.7330.62
7_K171_E0.7310.62
312_H348_I0.7310.62
395_A398_K0.7260.61
202_L251_V0.7220.61
265_S279_N0.7190.60
213_Q218_D0.7180.60
214_A265_S0.7160.60
280_F301_L0.7150.60
216_G265_S0.7150.60
129_H133_Q0.7150.60
17_E46_H0.7150.60
198_K409_A0.7120.60
356_I370_E0.7110.60
31_N100_S0.7040.59
177_T338_F0.7010.58
58_N84_E0.6980.58
350_S353_A0.6950.58
97_A141_S0.6950.58
115_K119_A0.6940.58
67_L71_L0.6900.57
205_R402_I0.6890.57
74_F115_K0.6880.57
292_I312_H0.6880.57
347_A378_H0.6870.57
38_D63_E0.6860.57
20_V28_V0.6850.57
136_Q353_A0.6840.57
212_Y388_M0.6830.57
40_V59_W0.6820.56
310_G375_S0.6810.56
189_I193_Q0.6790.56
180_N246_M0.6760.56
45_K70_E0.6750.56
272_Y304_L0.6740.56
180_N307_T0.6740.56
8_L42_L0.6730.55
344_N403_F0.6710.55
342_A382_M0.6700.55
213_Q290_V0.6690.55
223_L402_I0.6660.55
212_Y221_I0.6640.54
136_Q351_A0.6630.54
176_A338_F0.6620.54
226_K356_I0.6570.54
272_Y377_T0.6540.53
54_N68_K0.6530.53
102_V144_V0.6510.53
45_K63_E0.6510.53
249_E320_V0.6500.53
270_L381_F0.6500.53
48_Y54_N0.6500.53
80_Y123_A0.6500.53
11_Y145_V0.6490.53
227_H253_T0.6470.53
358_G371_G0.6470.53
199_V203_N0.6460.52
170_W174_F0.6450.52
222_K261_D0.6450.52
249_E341_N0.6450.52
104_S271_S0.6450.52
351_A374_E0.6440.52
382_M385_S0.6420.52
200_D203_N0.6420.52
304_L307_T0.6410.52
226_K355_N0.6400.52
71_L74_F0.6390.52
24_K51_G0.6380.51
38_D42_L0.6380.51
345_H378_H0.6360.51
53_K79_E0.6350.51
146_G152_W0.6330.51
5_S38_D0.6330.51
111_G168_L0.6330.51
320_V341_N0.6310.51
23_Q240_H0.6290.50
22_V52_A0.6290.50
332_L339_D0.6280.50
224_P236_N0.6270.50
288_R311_S0.6270.50
339_D342_A0.6250.50
30_V190_N0.6250.50
205_R208_A0.6240.50
333_F339_D0.6200.49
15_A39_F0.6200.49
215_E265_S0.6200.49
5_S46_H0.6190.49
283_T286_N0.6190.49
134_Y148_A0.6190.49
175_K286_N0.6190.49
148_A174_F0.6180.49
87_G91_L0.6170.49
125_G376_I0.6160.49
221_I317_V0.6150.49
65_A120_F0.6140.49
29_V98_F0.6100.48
273_G377_T0.6090.48
166_I170_W0.6080.48
140_V143_T0.6040.48
284_F348_I0.6040.48
272_Y379_V0.6020.47
112_I154_H0.6020.47
132_R136_Q0.6010.47
8_L11_Y0.6010.47
81_P122_K0.5980.47
201_H204_E0.5980.47
152_W169_L0.5980.47
304_L377_T0.5980.47
258_D313_Y0.5970.47
69_Y109_L0.5960.47
131_Y135_I0.5950.47
118_A300_I0.5950.47
33_S83_W0.5910.46
32_A36_V0.5910.46
279_N302_K0.5900.46
318_A344_N0.5880.46
117_I273_G0.5850.46
336_T381_F0.5840.45
196_H236_N0.5840.45
351_A356_I0.5830.45
14_L246_M0.5820.45
208_A256_Q0.5810.45
14_L46_H0.5800.45
245_N337_L0.5800.45
316_E378_H0.5790.45
278_E295_E0.5780.45
128_L132_R0.5780.45
403_F407_N0.5770.45
171_E175_K0.5770.45
70_E74_F0.5760.45
190_N194_N0.5760.45
369_K395_A0.5750.44
114_S118_A0.5750.44
212_Y383_I0.5730.44
267_T343_S0.5730.44
177_T254_L0.5730.44
208_A393_I0.5720.44
333_F342_A0.5720.44
136_Q352_Y0.5710.44
70_E76_A0.5710.44
125_G129_H0.5700.44
213_Q220_T0.5700.44
347_A380_D0.5690.44
109_L112_I0.5680.44
265_S278_E0.5680.44
25_G75_E0.5670.44
305_V314_L0.5660.43
266_S311_S0.5650.43
139_K237_E0.5650.43
32_A101_V0.5640.43
143_T148_A0.5640.43
283_T293_K0.5620.43
263_V291_D0.5620.43
120_F123_A0.5610.43
274_G339_D0.5600.43
213_Q404_R0.5590.43
105_N155_K0.5590.43
209_A299_D0.5580.43
202_L390_I0.5580.43
319_L344_N0.5550.42
144_V254_L0.5550.42
173_I338_F0.5550.42
389_N408_W0.5540.42
60_Q127_A0.5530.42
69_Y114_S0.5520.42
109_L116_R0.5510.42
316_E345_H0.5500.42
134_Y237_E0.5500.42
215_E389_N0.5480.41
36_V40_V0.5470.41
22_V67_L0.5460.41
258_D286_N0.5460.41
393_I397_G0.5460.41
254_L357_E0.5450.41
43_I282_L0.5450.41
115_K193_Q0.5430.41
99_I144_V0.5420.41
33_S101_V0.5420.41
179_V325_P0.5420.41
74_F77_F0.5420.41
154_H168_L0.5420.41
175_K193_Q0.5410.41
258_D369_K0.5410.41
289_I313_Y0.5400.41
83_W87_G0.5400.41
71_L119_A0.5380.40
394_T399_R0.5380.40
121_Q244_A0.5360.40
76_A179_V0.5360.40
177_T180_N0.5350.40
157_F172_E0.5350.40
16_V46_H0.5340.40
401_P405_N0.5330.40
271_S336_T0.5330.40
285_E291_D0.5330.40
250_E378_H0.5320.40
31_N88_R0.5320.40
212_Y219_L0.5310.40
123_A127_A0.5300.40
172_E175_K0.5300.40
19_G246_M0.5290.39
10_T179_V0.5280.39
138_D199_V0.5280.39
314_L333_F0.5280.39
189_I286_N0.5260.39
250_E255_P0.5250.39
402_I409_A0.5250.39
17_E203_N0.5240.39
264_V314_L0.5240.39
179_V246_M0.5230.39
250_E345_H0.5220.39
118_A126_K0.5220.39
212_Y215_E0.5220.39
214_A384_G0.5210.39
248_T339_D0.5210.39
174_F179_V0.5210.39
47_A97_A0.5200.38
356_I374_E0.5200.38
111_G369_K0.5200.38
287_G349_G0.5190.38
54_N76_A0.5190.38
174_F177_T0.5180.38
6_Q10_T0.5170.38
264_V344_N0.5170.38
63_E105_N0.5170.38
260_V271_S0.5160.38
64_V67_L0.5150.38
126_K129_H0.5150.38
203_N228_V0.5150.38
177_T317_V0.5140.38
48_Y53_K0.5140.38
158_P321_P0.5130.38
99_I124_A0.5130.38
200_D213_Q0.5130.38
52_A291_D0.5100.37
69_Y120_F0.5100.37
78_E85_A0.5090.37
314_L346_L0.5080.37
219_L261_D0.5080.37
195_L236_N0.5080.37
156_V169_L0.5060.37
73_P78_E0.5040.37
34_T59_W0.5030.37
7_K179_V0.5030.37
35_D40_V0.5030.37
293_K302_K0.5030.37
77_F294_A0.5020.37
336_T382_M0.5010.36
282_L381_F0.5010.36
30_V47_A0.5000.36
15_A43_I0.5000.36
106_P155_K0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4icsA 2 1 100 0.162 Contact Map
2ayiA 2 0.9683 100 0.175 Contact Map
1zjcA 2 0.9951 100 0.175 Contact Map
4n6dA 1 0.439 23.4 0.978 Contact Map
4xpmB 1 0.1634 18.1 0.979 Contact Map
3lygA 2 0.2805 17.6 0.979 Contact Map
3ebtA 2 0.2829 17.5 0.979 Contact Map
3riyA 1 0.1659 17.2 0.979 Contact Map
2eb4A 5 0.1463 17 0.979 Contact Map
3kkgA 2 0.3146 15.1 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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