AMPS - BACSU - GREMLIN Contacts

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AMPS - Aminopeptidase AmpS

UniProt:	P39762	Sequences: MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIVKHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVVSSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGKSEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTDLTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNIIENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFYNTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDGITADGKREPIFRNGNWAF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	410 (363)
Sequences:	1689 (1139)
Seq/√Len:	59.8

BACSU - AMPS
HALSA - Q9HMP2 Q9HSK5 Q9HMH0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
279_N	295_E	4.842	1.00
394_T	398_K	4.074	1.00
283_T	291_D	3.964	1.00
289_I	348_I	3.750	1.00
222_K	259_G	3.605	1.00
22_V	28_V	3.583	1.00
278_E	296_K	3.408	1.00
46_H	49_E	3.347	1.00
32_A	40_V	3.340	1.00
298_E	302_K	3.151	1.00
13_Q	46_H	3.069	1.00
267_T	385_S	2.998	1.00
261_D	286_N	2.839	1.00
306_E	312_H	2.833	1.00
15_A	145_V	2.717	1.00
70_E	112_I	2.707	1.00
13_Q	17_E	2.701	1.00
82_E	86_K	2.650	1.00
78_E	119_A	2.541	1.00
391_D	404_R	2.526	1.00
9_N	46_H	2.473	1.00
323_D	328_Q	2.465	1.00
209_A	220_T	2.452	1.00
16_V	43_I	2.393	1.00
16_V	50_K	2.340	1.00
284_F	314_L	2.337	1.00
263_V	283_T	2.284	1.00
22_V	97_A	2.282	1.00
20_V	99_I	2.243	1.00
401_P	404_R	2.200	1.00
17_E	50_K	2.174	1.00
323_D	407_N	2.147	1.00
154_H	165_A	2.127	1.00
281_T	293_K	2.081	1.00
205_R	400_E	2.062	1.00
292_I	302_K	2.046	1.00
305_V	312_H	2.036	1.00
293_K	298_E	2.027	1.00
389_N	405_N	2.024	1.00
211_H	218_D	1.988	1.00
288_R	312_H	1.951	1.00
15_A	99_I	1.943	1.00
196_H	200_D	1.906	1.00
141_S	236_N	1.894	1.00
107_D	155_K	1.876	1.00
66_K	111_G	1.865	1.00
391_D	399_R	1.855	1.00
58_N	87_G	1.851	1.00
30_V	43_I	1.848	1.00
254_L	372_L	1.825	1.00
74_F	116_R	1.824	1.00
28_V	99_I	1.805	0.99
221_I	346_L	1.800	0.99
263_V	281_T	1.785	0.99
394_T	400_E	1.781	0.99
215_E	387_D	1.770	0.99
175_K	180_N	1.767	0.99
389_N	404_R	1.758	0.99
99_I	143_T	1.725	0.99
226_K	357_E	1.725	0.99
302_K	306_E	1.709	0.99
27_Y	53_K	1.706	0.99
26_Q	97_A	1.703	0.99
29_V	96_A	1.697	0.99
257_K	313_Y	1.691	0.99
200_D	204_E	1.685	0.99
260_V	313_Y	1.682	0.99
225_R	395_A	1.681	0.99
288_R	313_Y	1.656	0.99
265_S	281_T	1.647	0.99
74_F	78_E	1.627	0.99
44_V	64_V	1.617	0.99
103_S	149_S	1.601	0.99
9_N	42_L	1.600	0.99
118_A	122_K	1.594	0.99
28_V	47_A	1.577	0.99
213_Q	389_N	1.576	0.99
47_A	52_A	1.575	0.99
289_I	305_V	1.570	0.99
292_I	298_E	1.561	0.99
100_S	144_V	1.532	0.98
9_N	45_K	1.524	0.98
305_V	311_S	1.517	0.98
222_K	256_Q	1.511	0.98
220_T	261_D	1.511	0.98
328_Q	407_N	1.505	0.98
39_F	43_I	1.505	0.98
68_K	72_A	1.505	0.98
272_Y	277_I	1.502	0.98
177_T	246_M	1.490	0.98
390_I	403_F	1.484	0.98
254_L	351_A	1.454	0.98
226_K	370_E	1.453	0.98
146_G	338_F	1.452	0.98
209_A	399_R	1.441	0.97
256_Q	259_G	1.440	0.97
72_A	77_F	1.432	0.97
18_V	189_I	1.393	0.97
264_V	346_L	1.381	0.97
346_L	383_I	1.375	0.97
86_K	89_E	1.373	0.97
69_Y	77_F	1.371	0.97
201_H	205_R	1.368	0.97
102_V	146_G	1.367	0.97
208_A	395_A	1.367	0.97
30_V	40_V	1.358	0.96
86_K	90_E	1.357	0.96
28_V	143_T	1.353	0.96
292_I	305_V	1.348	0.96
49_E	71_L	1.341	0.96
150_A	166_I	1.318	0.96
39_F	147_A	1.314	0.96
351_A	372_L	1.308	0.96
285_E	290_V	1.294	0.95
208_A	259_G	1.293	0.95
307_T	376_I	1.278	0.95
344_N	384_G	1.277	0.95
391_D	401_P	1.270	0.95
136_Q	350_S	1.269	0.95
299_D	303_E	1.254	0.94
43_I	99_I	1.240	0.94
350_S	374_E	1.238	0.94
254_L	352_Y	1.234	0.94
254_L	355_N	1.233	0.94
10_T	13_Q	1.225	0.94
42_L	45_K	1.224	0.94
31_N	58_N	1.215	0.93
22_V	47_A	1.211	0.93
40_V	99_I	1.211	0.93
23_Q	26_Q	1.208	0.93
35_D	149_S	1.187	0.93
66_K	70_E	1.185	0.93
282_L	305_V	1.182	0.92
42_L	46_H	1.180	0.92
74_F	119_A	1.180	0.92
219_L	346_L	1.176	0.92
211_H	220_T	1.172	0.92
344_N	388_M	1.169	0.92
16_V	47_A	1.161	0.92
101_V	145_V	1.159	0.92
165_A	168_L	1.157	0.92
305_V	348_I	1.144	0.91
45_K	49_E	1.143	0.91
210_L	317_V	1.139	0.91
33_S	103_S	1.133	0.91
70_E	111_G	1.131	0.91
144_V	352_Y	1.126	0.90
256_Q	313_Y	1.123	0.90
311_S	377_T	1.121	0.90
289_I	312_H	1.114	0.90
89_E	130_T	1.106	0.90
40_V	57_V	1.096	0.89
26_Q	141_S	1.096	0.89
15_A	143_T	1.084	0.89
303_E	306_E	1.083	0.89
105_N	151_G	1.080	0.89
271_S	276_I	1.056	0.87
201_H	400_E	1.052	0.87
211_H	399_R	1.045	0.87
28_V	97_A	1.044	0.87
121_Q	273_G	1.036	0.86
252_F	354_F	1.035	0.86
282_L	289_I	1.034	0.86
209_A	393_I	1.034	0.86
223_L	253_T	1.030	0.86
146_G	149_S	1.028	0.86
291_D	302_K	1.027	0.86
21_N	240_H	1.022	0.86
22_V	50_K	1.013	0.85
72_A	76_A	1.012	0.85
155_K	334_Y	1.003	0.85
292_I	306_E	1.001	0.84
41_R	61_D	0.998	0.84
264_V	383_I	0.995	0.84
275_N	300_I	0.994	0.84
46_H	50_K	0.993	0.84
208_A	212_Y	0.991	0.84
37_R	59_W	0.982	0.83
103_S	146_G	0.979	0.83
6_Q	9_N	0.975	0.83
98_F	140_V	0.973	0.83
73_P	77_F	0.972	0.83
302_K	312_H	0.969	0.82
192_D	238_S	0.967	0.82
45_K	67_L	0.964	0.82
16_V	28_V	0.962	0.82
255_P	314_L	0.952	0.81
393_I	399_R	0.951	0.81
280_F	336_T	0.951	0.81
221_I	260_V	0.942	0.81
301_L	304_L	0.942	0.81
307_T	377_T	0.942	0.81
7_K	10_T	0.936	0.80
16_V	22_V	0.936	0.80
44_V	57_V	0.935	0.80
27_Y	96_A	0.935	0.80
148_A	170_W	0.932	0.80
348_I	377_T	0.931	0.80
147_A	170_W	0.931	0.80
138_D	354_F	0.930	0.80
80_Y	124_A	0.928	0.80
193_Q	197_E	0.925	0.79
281_T	291_D	0.922	0.79
82_E	90_E	0.919	0.79
387_D	405_N	0.918	0.79
270_L	379_V	0.917	0.79
213_Q	391_D	0.907	0.78
192_D	199_V	0.906	0.78
100_S	352_Y	0.900	0.77
270_L	336_T	0.898	0.77
192_D	196_H	0.896	0.77
205_R	392_G	0.895	0.77
311_S	348_I	0.890	0.77
67_L	70_E	0.884	0.76
261_D	285_E	0.878	0.76
85_A	89_E	0.878	0.76
198_K	402_I	0.870	0.75
33_S	36_V	0.869	0.75
208_A	222_K	0.869	0.75
289_I	311_S	0.869	0.75
15_A	144_V	0.868	0.75
129_H	132_R	0.866	0.75
119_A	123_A	0.865	0.75
385_S	388_M	0.863	0.74
178_R	191_H	0.863	0.74
176_A	332_L	0.862	0.74
212_Y	390_I	0.862	0.74
214_A	387_D	0.860	0.74
84_E	87_G	0.860	0.74
45_K	71_L	0.857	0.74
216_G	281_T	0.857	0.74
214_A	385_S	0.855	0.74
135_I	140_V	0.855	0.74
7_K	180_N	0.853	0.74
20_V	97_A	0.852	0.73
39_F	42_L	0.851	0.73
195_L	251_V	0.835	0.72
189_I	192_D	0.834	0.72
289_I	292_I	0.832	0.72
73_P	76_A	0.831	0.72
219_L	260_V	0.829	0.71
172_E	176_A	0.828	0.71
237_E	248_T	0.827	0.71
150_A	154_H	0.827	0.71
113_D	116_R	0.825	0.71
115_K	303_E	0.824	0.71
31_N	60_Q	0.824	0.71
43_I	101_V	0.824	0.71
344_N	390_I	0.822	0.71
277_I	301_L	0.821	0.71
36_V	103_S	0.818	0.70
288_R	309_E	0.818	0.70
208_A	224_P	0.815	0.70
197_E	201_H	0.812	0.70
37_R	41_R	0.809	0.70
65_A	109_L	0.801	0.69
83_W	90_E	0.800	0.69
219_L	314_L	0.799	0.69
120_F	124_A	0.799	0.69
260_V	346_L	0.798	0.69
118_A	303_E	0.795	0.68
20_V	143_T	0.788	0.68
210_L	223_L	0.788	0.68
57_V	64_V	0.782	0.67
72_A	116_R	0.782	0.67
31_N	98_F	0.782	0.67
280_F	381_F	0.780	0.67
225_R	256_Q	0.780	0.67
171_E	180_N	0.774	0.66
291_D	298_E	0.774	0.66
327_S	387_D	0.773	0.66
112_I	117_I	0.767	0.65
7_K	174_F	0.767	0.65
122_K	126_K	0.764	0.65
114_S	303_E	0.761	0.65
209_A	222_K	0.761	0.65
318_A	321_P	0.760	0.65
279_N	296_K	0.757	0.64
83_W	97_A	0.757	0.64
214_A	344_N	0.755	0.64
277_I	304_L	0.754	0.64
36_V	147_A	0.754	0.64
212_Y	317_V	0.752	0.64
205_R	394_T	0.750	0.64
399_R	404_R	0.749	0.64
105_N	154_H	0.746	0.63
6_Q	151_G	0.745	0.63
158_P	165_A	0.745	0.63
384_G	388_M	0.744	0.63
82_E	85_A	0.741	0.63
14_L	178_R	0.738	0.62
128_L	131_Y	0.735	0.62
168_L	171_E	0.733	0.62
7_K	171_E	0.731	0.62
312_H	348_I	0.731	0.62
395_A	398_K	0.726	0.61
202_L	251_V	0.722	0.61
265_S	279_N	0.719	0.60
213_Q	218_D	0.718	0.60
214_A	265_S	0.716	0.60
280_F	301_L	0.715	0.60
216_G	265_S	0.715	0.60
129_H	133_Q	0.715	0.60
17_E	46_H	0.715	0.60
198_K	409_A	0.712	0.60
356_I	370_E	0.711	0.60
31_N	100_S	0.704	0.59
177_T	338_F	0.701	0.58
58_N	84_E	0.698	0.58
350_S	353_A	0.695	0.58
97_A	141_S	0.695	0.58
115_K	119_A	0.694	0.58
67_L	71_L	0.690	0.57
205_R	402_I	0.689	0.57
74_F	115_K	0.688	0.57
292_I	312_H	0.688	0.57
347_A	378_H	0.687	0.57
38_D	63_E	0.686	0.57
20_V	28_V	0.685	0.57
136_Q	353_A	0.684	0.57
212_Y	388_M	0.683	0.57
40_V	59_W	0.682	0.56
310_G	375_S	0.681	0.56
189_I	193_Q	0.679	0.56
180_N	246_M	0.676	0.56
45_K	70_E	0.675	0.56
272_Y	304_L	0.674	0.56
180_N	307_T	0.674	0.56
8_L	42_L	0.673	0.55
344_N	403_F	0.671	0.55
342_A	382_M	0.670	0.55
213_Q	290_V	0.669	0.55
223_L	402_I	0.666	0.55
212_Y	221_I	0.664	0.54
136_Q	351_A	0.663	0.54
176_A	338_F	0.662	0.54
226_K	356_I	0.657	0.54
272_Y	377_T	0.654	0.53
54_N	68_K	0.653	0.53
102_V	144_V	0.651	0.53
45_K	63_E	0.651	0.53
249_E	320_V	0.650	0.53
270_L	381_F	0.650	0.53
48_Y	54_N	0.650	0.53
80_Y	123_A	0.650	0.53
11_Y	145_V	0.649	0.53
227_H	253_T	0.647	0.53
358_G	371_G	0.647	0.53
199_V	203_N	0.646	0.52
170_W	174_F	0.645	0.52
222_K	261_D	0.645	0.52
249_E	341_N	0.645	0.52
104_S	271_S	0.645	0.52
351_A	374_E	0.644	0.52
382_M	385_S	0.642	0.52
200_D	203_N	0.642	0.52
304_L	307_T	0.641	0.52
226_K	355_N	0.640	0.52
71_L	74_F	0.639	0.52
24_K	51_G	0.638	0.51
38_D	42_L	0.638	0.51
345_H	378_H	0.636	0.51
53_K	79_E	0.635	0.51
146_G	152_W	0.633	0.51
5_S	38_D	0.633	0.51
111_G	168_L	0.633	0.51
320_V	341_N	0.631	0.51
23_Q	240_H	0.629	0.50
22_V	52_A	0.629	0.50
332_L	339_D	0.628	0.50
224_P	236_N	0.627	0.50
288_R	311_S	0.627	0.50
339_D	342_A	0.625	0.50
30_V	190_N	0.625	0.50
205_R	208_A	0.624	0.50
333_F	339_D	0.620	0.49
15_A	39_F	0.620	0.49
215_E	265_S	0.620	0.49
5_S	46_H	0.619	0.49
283_T	286_N	0.619	0.49
134_Y	148_A	0.619	0.49
175_K	286_N	0.619	0.49
148_A	174_F	0.618	0.49
87_G	91_L	0.617	0.49
125_G	376_I	0.616	0.49
221_I	317_V	0.615	0.49
65_A	120_F	0.614	0.49
29_V	98_F	0.610	0.48
273_G	377_T	0.609	0.48
166_I	170_W	0.608	0.48
140_V	143_T	0.604	0.48
284_F	348_I	0.604	0.48
272_Y	379_V	0.602	0.47
112_I	154_H	0.602	0.47
132_R	136_Q	0.601	0.47
8_L	11_Y	0.601	0.47
81_P	122_K	0.598	0.47
201_H	204_E	0.598	0.47
152_W	169_L	0.598	0.47
304_L	377_T	0.598	0.47
258_D	313_Y	0.597	0.47
69_Y	109_L	0.596	0.47
131_Y	135_I	0.595	0.47
118_A	300_I	0.595	0.47
33_S	83_W	0.591	0.46
32_A	36_V	0.591	0.46
279_N	302_K	0.590	0.46
318_A	344_N	0.588	0.46
117_I	273_G	0.585	0.46
336_T	381_F	0.584	0.45
196_H	236_N	0.584	0.45
351_A	356_I	0.583	0.45
14_L	246_M	0.582	0.45
208_A	256_Q	0.581	0.45
14_L	46_H	0.580	0.45
245_N	337_L	0.580	0.45
316_E	378_H	0.579	0.45
278_E	295_E	0.578	0.45
128_L	132_R	0.578	0.45
403_F	407_N	0.577	0.45
171_E	175_K	0.577	0.45
70_E	74_F	0.576	0.45
190_N	194_N	0.576	0.45
369_K	395_A	0.575	0.44
114_S	118_A	0.575	0.44
212_Y	383_I	0.573	0.44
267_T	343_S	0.573	0.44
177_T	254_L	0.573	0.44
208_A	393_I	0.572	0.44
333_F	342_A	0.572	0.44
136_Q	352_Y	0.571	0.44
70_E	76_A	0.571	0.44
125_G	129_H	0.570	0.44
213_Q	220_T	0.570	0.44
347_A	380_D	0.569	0.44
109_L	112_I	0.568	0.44
265_S	278_E	0.568	0.44
25_G	75_E	0.567	0.44
305_V	314_L	0.566	0.43
266_S	311_S	0.565	0.43
139_K	237_E	0.565	0.43
32_A	101_V	0.564	0.43
143_T	148_A	0.564	0.43
283_T	293_K	0.562	0.43
263_V	291_D	0.562	0.43
120_F	123_A	0.561	0.43
274_G	339_D	0.560	0.43
213_Q	404_R	0.559	0.43
105_N	155_K	0.559	0.43
209_A	299_D	0.558	0.43
202_L	390_I	0.558	0.43
319_L	344_N	0.555	0.42
144_V	254_L	0.555	0.42
173_I	338_F	0.555	0.42
389_N	408_W	0.554	0.42
60_Q	127_A	0.553	0.42
69_Y	114_S	0.552	0.42
109_L	116_R	0.551	0.42
316_E	345_H	0.550	0.42
134_Y	237_E	0.550	0.42
215_E	389_N	0.548	0.41
36_V	40_V	0.547	0.41
22_V	67_L	0.546	0.41
258_D	286_N	0.546	0.41
393_I	397_G	0.546	0.41
254_L	357_E	0.545	0.41
43_I	282_L	0.545	0.41
115_K	193_Q	0.543	0.41
99_I	144_V	0.542	0.41
33_S	101_V	0.542	0.41
179_V	325_P	0.542	0.41
74_F	77_F	0.542	0.41
154_H	168_L	0.542	0.41
175_K	193_Q	0.541	0.41
258_D	369_K	0.541	0.41
289_I	313_Y	0.540	0.41
83_W	87_G	0.540	0.41
71_L	119_A	0.538	0.40
394_T	399_R	0.538	0.40
121_Q	244_A	0.536	0.40
76_A	179_V	0.536	0.40
177_T	180_N	0.535	0.40
157_F	172_E	0.535	0.40
16_V	46_H	0.534	0.40
401_P	405_N	0.533	0.40
271_S	336_T	0.533	0.40
285_E	291_D	0.533	0.40
250_E	378_H	0.532	0.40
31_N	88_R	0.532	0.40
212_Y	219_L	0.531	0.40
123_A	127_A	0.530	0.40
172_E	175_K	0.530	0.40
19_G	246_M	0.529	0.39
10_T	179_V	0.528	0.39
138_D	199_V	0.528	0.39
314_L	333_F	0.528	0.39
189_I	286_N	0.526	0.39
250_E	255_P	0.525	0.39
402_I	409_A	0.525	0.39
17_E	203_N	0.524	0.39
264_V	314_L	0.524	0.39
179_V	246_M	0.523	0.39
250_E	345_H	0.522	0.39
118_A	126_K	0.522	0.39
212_Y	215_E	0.522	0.39
214_A	384_G	0.521	0.39
248_T	339_D	0.521	0.39
174_F	179_V	0.521	0.39
47_A	97_A	0.520	0.38
356_I	374_E	0.520	0.38
111_G	369_K	0.520	0.38
287_G	349_G	0.519	0.38
54_N	76_A	0.519	0.38
174_F	177_T	0.518	0.38
6_Q	10_T	0.517	0.38
264_V	344_N	0.517	0.38
63_E	105_N	0.517	0.38
260_V	271_S	0.516	0.38
64_V	67_L	0.515	0.38
126_K	129_H	0.515	0.38
203_N	228_V	0.515	0.38
177_T	317_V	0.514	0.38
48_Y	53_K	0.514	0.38
158_P	321_P	0.513	0.38
99_I	124_A	0.513	0.38
200_D	213_Q	0.513	0.38
52_A	291_D	0.510	0.37
69_Y	120_F	0.510	0.37
78_E	85_A	0.509	0.37
314_L	346_L	0.508	0.37
219_L	261_D	0.508	0.37
195_L	236_N	0.508	0.37
156_V	169_L	0.506	0.37
73_P	78_E	0.504	0.37
34_T	59_W	0.503	0.37
7_K	179_V	0.503	0.37
35_D	40_V	0.503	0.37
293_K	302_K	0.503	0.37
77_F	294_A	0.502	0.37
336_T	382_M	0.501	0.36
282_L	381_F	0.501	0.36
30_V	47_A	0.500	0.36
15_A	43_I	0.500	0.36
106_P	155_K	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4icsA	2	1	100	0.162	Contact Map
2ayiA	2	0.9683	100	0.175	Contact Map
1zjcA	2	0.9951	100	0.175	Contact Map
4n6dA	1	0.439	23.4	0.978	Contact Map
4xpmB	1	0.1634	18.1	0.979	Contact Map
3lygA	2	0.2805	17.6	0.979	Contact Map
3ebtA	2	0.2829	17.5	0.979	Contact Map
3riyA	1	0.1659	17.2	0.979	Contact Map
2eb4A	5	0.1463	17	0.979	Contact Map
3kkgA	2	0.3146	15.1	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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