ADEC - BACSU - GREMLIN Contacts

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ADEC - Adenine deaminase

UniProt:	P39761	Sequences: MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAITDGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVTDPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYEEEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVLNDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDDLLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDLENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSEQQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKGFGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLPIAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLFDVKSFQHISLQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	577 (559)
Sequences:	1524 (1131)
Seq/√Len:	47.9

ECOLI - ADEC
BACSU - ADEC YERA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
23_I	62_A	4.902	1.00
485_K	504_S	4.256	1.00
485_K	488_E	4.075	1.00
41_I	67_I	3.911	1.00
471_A	479_I	3.797	1.00
396_N	574_I	3.444	1.00
151_K	154_D	3.427	1.00
516_Q	520_Q	3.413	1.00
396_N	409_L	3.394	1.00
28_I	39_E	3.371	1.00
475_N	478_D	3.349	1.00
430_K	476_D	3.230	1.00
95_H	284_N	3.214	1.00
71_F	337_V	3.155	1.00
284_N	288_K	3.154	1.00
62_A	330_F	3.143	1.00
455_S	497_K	3.094	1.00
35_E	234_R	3.039	1.00
343_M	348_T	2.996	1.00
11_N	16_R	2.990	1.00
332_S	338_T	2.961	1.00
87_E	90_K	2.940	1.00
26_G	67_I	2.847	1.00
431_I	560_M	2.806	1.00
170_V	183_M	2.748	1.00
12_A	49_V	2.702	1.00
382_K	477_E	2.694	1.00
432_A	479_I	2.642	1.00
557_D	569_K	2.615	1.00
469_I	483_V	2.614	1.00
263_R	310_E	2.539	1.00
432_A	471_A	2.538	1.00
399_Q	449_K	2.535	1.00
459_A	482_A	2.529	1.00
516_Q	524_S	2.516	1.00
67_I	328_L	2.477	1.00
145_R	562_T	2.440	1.00
68_V	331_V	2.430	1.00
27_K	38_Y	2.419	1.00
489_I	504_S	2.408	1.00
399_Q	410_V	2.395	1.00
22_V	56_G	2.362	1.00
26_G	62_A	2.358	1.00
478_D	499_G	2.348	1.00
67_I	330_F	2.339	1.00
399_Q	408_R	2.279	1.00
172_D	175_S	2.256	1.00
448_V	550_L	2.246	1.00
332_S	340_T	2.229	1.00
23_I	330_F	2.220	1.00
30_D	33_N	2.212	1.00
124_R	163_E	2.203	1.00
267_F	290_A	2.150	1.00
117_E	161_E	2.130	1.00
385_F	483_V	2.122	1.00
408_R	557_D	2.071	1.00
291_I	337_V	2.041	1.00
279_S	526_L	2.041	1.00
29_M	68_V	2.018	0.99
412_V	449_K	2.014	0.99
495_I	531_K	1.984	0.99
65_Q	340_T	1.940	0.99
423_D	426_L	1.932	0.99
461_T	469_I	1.922	0.99
567_D	570_S	1.921	0.99
451_F	472_V	1.914	0.99
121_E	124_R	1.914	0.99
484_N	487_Q	1.910	0.99
471_A	483_V	1.904	0.99
287_V	329_L	1.897	0.99
29_M	36_W	1.896	0.99
333_D	336_N	1.896	0.99
32_Y	319_A	1.895	0.99
481_A	485_K	1.877	0.99
382_K	480_A	1.851	0.99
341_M	348_T	1.843	0.99
27_K	36_W	1.828	0.99
11_N	17_Q	1.814	0.99
480_A	484_N	1.803	0.99
301_Y	337_V	1.784	0.99
320_I	328_L	1.774	0.99
503_H	531_K	1.761	0.99
28_I	41_I	1.759	0.99
108_A	116_I	1.746	0.99
376_L	487_Q	1.726	0.98
134_L	155_L	1.700	0.98
387_M	447_V	1.693	0.98
233_I	265_F	1.690	0.98
251_L	293_A	1.679	0.98
350_A	353_S	1.673	0.98
65_Q	330_F	1.666	0.98
210_N	235_R	1.654	0.98
486_L	494_T	1.653	0.98
481_A	499_G	1.646	0.98
145_R	563_T	1.645	0.98
97_V	282_S	1.645	0.98
251_L	289_M	1.637	0.98
117_E	121_E	1.620	0.98
374_V	461_T	1.619	0.98
48_I	328_L	1.602	0.97
409_L	574_I	1.600	0.97
435_E	441_K	1.596	0.97
60_I	343_M	1.593	0.97
30_D	35_E	1.590	0.97
301_Y	305_S	1.589	0.97
8_N	44_T	1.589	0.97
83_V	521_V	1.587	0.97
25_N	61_D	1.582	0.97
380_L	480_A	1.581	0.97
330_F	343_M	1.561	0.97
489_I	494_T	1.554	0.97
20_D	44_T	1.540	0.97
485_K	489_I	1.540	0.97
187_L	197_I	1.537	0.97
78_I	130_I	1.536	0.97
14_A	208_L	1.534	0.97
12_A	44_T	1.528	0.96
143_F	566_F	1.525	0.96
34_Q	299_L	1.525	0.96
267_F	283_V	1.516	0.96
30_D	37_I	1.515	0.96
111_S	510_A	1.512	0.96
496_I	501_E	1.509	0.96
129_N	317_K	1.504	0.96
434_V	483_V	1.497	0.96
94_P	350_A	1.494	0.96
397_V	412_V	1.487	0.96
394_Q	413_P	1.478	0.96
341_M	351_E	1.467	0.96
34_Q	302_Q	1.465	0.96
325_D	345_K	1.458	0.95
160_E	193_A	1.452	0.95
243_E	251_L	1.451	0.95
74_G	268_C	1.450	0.95
289_M	293_A	1.434	0.95
508_P	515_D	1.431	0.95
219_N	311_C	1.424	0.95
49_V	214_T	1.407	0.94
238_Y	266_F	1.404	0.94
29_M	301_Y	1.395	0.94
428_L	447_V	1.394	0.94
21_I	43_I	1.392	0.94
129_N	345_K	1.392	0.94
23_I	43_I	1.361	0.93
91_A	518_A	1.358	0.93
392_E	413_P	1.351	0.93
302_Q	306_L	1.350	0.93
240_M	268_C	1.340	0.93
65_Q	332_S	1.339	0.93
230_L	234_R	1.334	0.93
172_D	180_E	1.334	0.93
553_P	561_T	1.334	0.93
395_I	447_V	1.334	0.93
8_N	45_D	1.332	0.93
129_N	344_V	1.328	0.92
374_V	490_G	1.326	0.92
387_M	445_L	1.326	0.92
396_N	411_Q	1.325	0.92
287_V	291_I	1.321	0.92
18_K	55_E	1.321	0.92
133_M	166_G	1.318	0.92
432_A	445_L	1.315	0.92
429_L	474_T	1.308	0.92
385_F	480_A	1.297	0.92
117_E	157_P	1.296	0.92
287_V	304_G	1.294	0.91
247_A	405_L	1.293	0.91
114_K	117_E	1.289	0.91
558_I	574_I	1.279	0.91
19_A	42_A	1.273	0.91
18_K	57_E	1.270	0.91
268_C	312_Y	1.267	0.91
434_V	461_T	1.264	0.90
486_L	489_I	1.262	0.90
29_M	298_F	1.249	0.90
156_K	192_V	1.247	0.90
295_L	303_L	1.243	0.90
145_R	442_E	1.239	0.90
395_I	414_A	1.239	0.90
222_E	242_R	1.235	0.89
414_A	447_V	1.233	0.89
566_F	573_H	1.232	0.89
124_R	161_E	1.229	0.89
434_V	443_T	1.224	0.89
34_Q	298_F	1.223	0.89
238_Y	264_R	1.221	0.89
41_I	320_I	1.221	0.89
455_S	474_T	1.221	0.89
461_T	483_V	1.214	0.89
123_A	163_E	1.213	0.89
43_I	328_L	1.208	0.88
29_M	66_M	1.195	0.88
213_R	237_M	1.194	0.88
509_I	515_D	1.192	0.88
170_V	175_S	1.190	0.88
32_Y	324_F	1.190	0.88
117_E	158_F	1.189	0.88
113_E	158_F	1.180	0.87
494_T	504_S	1.171	0.87
11_N	179_A	1.169	0.87
459_A	471_A	1.158	0.86
380_L	385_F	1.158	0.86
238_Y	310_E	1.156	0.86
506_P	524_S	1.156	0.86
514_S	521_V	1.153	0.86
264_R	310_E	1.153	0.86
123_A	126_T	1.153	0.86
289_M	292_Q	1.152	0.86
331_V	337_V	1.148	0.86
249_N	252_N	1.143	0.85
268_C	304_G	1.142	0.85
424_T	429_L	1.140	0.85
42_A	52_G	1.138	0.85
120_L	163_E	1.137	0.85
478_D	481_A	1.132	0.85
401_I	408_R	1.131	0.85
409_L	558_I	1.130	0.85
464_H	467_H	1.130	0.85
328_L	343_M	1.126	0.85
87_E	518_A	1.125	0.84
485_K	494_T	1.124	0.84
463_S	470_I	1.122	0.84
473_G	479_I	1.122	0.84
442_E	562_T	1.121	0.84
92_V	100_V	1.119	0.84
520_Q	523_Q	1.118	0.84
331_V	339_V	1.118	0.84
263_R	302_Q	1.112	0.84
133_M	165_L	1.109	0.84
287_V	305_S	1.109	0.84
143_F	573_H	1.109	0.84
486_L	490_G	1.109	0.84
238_Y	311_C	1.105	0.83
12_A	19_A	1.102	0.83
140_A	466_S	1.100	0.83
495_I	535_I	1.099	0.83
283_V	304_G	1.096	0.83
11_N	14_A	1.094	0.83
26_G	330_F	1.089	0.82
84_T	509_I	1.085	0.82
43_I	343_M	1.077	0.82
249_N	404_Q	1.077	0.82
56_G	59_I	1.074	0.82
470_I	551_A	1.074	0.82
102_T	132_F	1.067	0.81
8_N	17_Q	1.067	0.81
175_S	183_M	1.062	0.81
94_P	128_L	1.062	0.81
209_I	231_D	1.057	0.81
302_Q	307_N	1.054	0.80
71_F	329_L	1.051	0.80
517_S	520_Q	1.050	0.80
240_M	312_Y	1.049	0.80
144_E	562_T	1.044	0.80
266_F	311_C	1.044	0.80
219_N	312_Y	1.042	0.80
291_I	297_P	1.040	0.79
317_K	325_D	1.035	0.79
107_I	115_G	1.035	0.79
100_V	128_L	1.034	0.79
36_W	334_L	1.032	0.79
431_I	446_G	1.026	0.79
68_V	329_L	1.023	0.78
482_A	496_I	1.022	0.78
21_I	60_I	1.021	0.78
24_K	59_I	1.018	0.78
26_G	328_L	1.017	0.78
39_E	51_L	1.017	0.78
503_H	527_T	1.017	0.78
13_S	211_I	1.017	0.78
219_N	268_C	1.015	0.78
257_V	303_L	1.013	0.78
319_A	324_F	1.010	0.77
316_T	325_D	1.010	0.77
410_V	449_K	1.007	0.77
383_Q	386_H	1.006	0.77
333_D	338_T	1.004	0.77
37_I	234_R	1.004	0.77
472_V	547_L	1.004	0.77
297_P	300_A	1.000	0.77
33_N	234_R	0.999	0.77
226_K	256_A	0.996	0.76
434_V	469_I	0.995	0.76
22_V	54_Y	0.994	0.76
22_V	42_A	0.993	0.76
206_T	231_D	0.992	0.76
229_A	256_A	0.991	0.76
174_V	571_F	0.991	0.76
431_I	472_V	0.984	0.76
417_A	421_E	0.981	0.75
159_Y	195_K	0.980	0.75
76_V	269_T	0.978	0.75
134_L	158_F	0.977	0.75
254_L	295_L	0.975	0.75
76_V	88_F	0.974	0.75
28_I	51_L	0.971	0.75
348_T	351_E	0.971	0.75
448_V	451_F	0.970	0.74
394_Q	411_Q	0.963	0.74
36_W	66_M	0.963	0.74
385_F	479_I	0.958	0.74
432_A	483_V	0.958	0.74
523_Q	527_T	0.954	0.73
99_T	131_H	0.953	0.73
129_N	325_D	0.945	0.73
185_Q	189_D	0.945	0.73
372_D	490_G	0.945	0.73
25_N	63_E	0.944	0.72
226_K	230_L	0.941	0.72
470_I	560_M	0.940	0.72
179_A	184_V	0.939	0.72
89_A	127_P	0.938	0.72
23_I	343_M	0.937	0.72
176_V	187_L	0.937	0.72
156_K	189_D	0.937	0.72
202_A	232_R	0.936	0.72
15_K	207_D	0.934	0.72
228_E	231_D	0.933	0.72
113_E	157_P	0.932	0.71
435_E	440_L	0.932	0.71
41_I	51_L	0.931	0.71
48_I	51_L	0.928	0.71
389_I	416_V	0.926	0.71
262_A	299_L	0.924	0.71
67_I	320_I	0.923	0.71
31_V	319_A	0.918	0.70
431_I	550_L	0.918	0.70
172_D	183_M	0.915	0.70
81_S	88_F	0.915	0.70
29_M	334_L	0.911	0.70
105_H	171_M	0.911	0.70
385_F	432_A	0.909	0.70
205_S	231_D	0.909	0.70
171_M	554_V	0.906	0.69
295_L	300_A	0.904	0.69
105_H	467_H	0.897	0.69
131_H	165_L	0.896	0.68
423_D	427_D	0.896	0.68
105_H	464_H	0.894	0.68
74_G	308_A	0.893	0.68
119_M	513_L	0.893	0.68
159_Y	189_D	0.890	0.68
566_F	571_F	0.890	0.68
93_L	128_L	0.889	0.68
459_A	483_V	0.887	0.68
291_I	301_Y	0.887	0.68
106_E	464_H	0.885	0.68
22_V	59_I	0.880	0.67
70_G	98_T	0.880	0.67
287_V	301_Y	0.877	0.67
460_T	548_S	0.876	0.67
24_K	40_D	0.875	0.67
524_S	527_T	0.875	0.67
240_M	266_F	0.874	0.67
340_T	352_D	0.872	0.66
12_A	17_Q	0.872	0.66
100_V	130_I	0.868	0.66
159_Y	245_S	0.866	0.66
481_A	501_E	0.864	0.66
21_I	343_M	0.862	0.65
351_E	354_K	0.861	0.65
306_L	310_E	0.859	0.65
42_A	50_G	0.858	0.65
458_I	532_L	0.858	0.65
251_L	292_Q	0.857	0.65
405_L	555_I	0.854	0.65
74_G	312_Y	0.853	0.65
107_I	119_M	0.851	0.64
80_S	467_H	0.851	0.64
455_S	498_N	0.850	0.64
97_V	545_L	0.850	0.64
22_V	40_D	0.848	0.64
137_S	175_S	0.848	0.64
241_M	267_F	0.847	0.64
106_E	467_H	0.846	0.64
114_K	369_A	0.846	0.64
485_K	501_E	0.846	0.64
58_N	348_T	0.845	0.64
283_V	286_Q	0.845	0.64
86_I	122_Q	0.845	0.64
123_A	130_I	0.844	0.64
137_S	171_M	0.841	0.64
111_S	370_L	0.840	0.63
448_V	472_V	0.840	0.63
116_I	134_L	0.837	0.63
188_L	192_V	0.836	0.63
116_I	158_F	0.834	0.63
10_L	179_A	0.833	0.63
235_R	322_P	0.832	0.63
184_V	187_L	0.832	0.63
475_N	479_I	0.832	0.63
560_M	565_L	0.831	0.63
481_A	496_I	0.828	0.62
88_F	100_V	0.825	0.62
224_T	406_E	0.825	0.62
247_A	549_F	0.821	0.62
118_F	122_Q	0.821	0.62
58_N	347_Q	0.820	0.62
30_D	319_A	0.820	0.62
530_D	534_L	0.818	0.61
92_V	128_L	0.818	0.61
497_K	502_L	0.817	0.61
462_I	512_L	0.817	0.61
80_S	271_D	0.814	0.61
80_S	105_H	0.812	0.61
66_M	334_L	0.811	0.61
464_H	552_L	0.809	0.60
456_G	478_D	0.808	0.60
62_A	67_I	0.807	0.60
532_L	535_I	0.805	0.60
101_V	312_Y	0.802	0.60
111_S	115_G	0.802	0.60
126_T	130_I	0.801	0.60
80_S	464_H	0.800	0.60
196_R	311_C	0.799	0.60
156_K	193_A	0.798	0.59
16_R	231_D	0.795	0.59
423_D	447_V	0.794	0.59
282_S	545_L	0.792	0.59
429_L	472_V	0.790	0.59
134_L	164_V	0.790	0.59
379_P	488_E	0.787	0.58
508_P	514_S	0.785	0.58
155_L	159_Y	0.782	0.58
531_K	534_L	0.781	0.58
27_K	66_M	0.781	0.58
379_P	487_Q	0.778	0.57
239_V	256_A	0.777	0.57
459_A	486_L	0.776	0.57
505_V	521_V	0.776	0.57
99_T	316_T	0.775	0.57
150_L	155_L	0.773	0.57
263_R	307_N	0.768	0.57
9_R	49_V	0.768	0.57
74_G	240_M	0.768	0.57
458_I	495_I	0.767	0.56
36_W	298_F	0.764	0.56
245_S	312_Y	0.762	0.56
427_D	452_G	0.762	0.56
229_A	239_V	0.762	0.56
206_T	209_I	0.761	0.56
106_E	552_L	0.758	0.56
145_R	440_L	0.754	0.55
241_M	254_L	0.754	0.55
267_F	304_G	0.751	0.55
412_V	428_L	0.750	0.55
291_I	333_D	0.749	0.55
532_L	542_N	0.748	0.55
467_H	552_L	0.745	0.54
159_Y	190_A	0.742	0.54
76_V	81_S	0.740	0.54
375_K	438_K	0.739	0.54
146_S	466_S	0.739	0.54
405_L	559_K	0.738	0.54
243_E	289_M	0.738	0.54
88_F	282_S	0.737	0.53
466_S	553_P	0.737	0.53
131_H	317_K	0.735	0.53
536_G	543_P	0.734	0.53
205_S	241_M	0.733	0.53
89_A	126_T	0.724	0.52
28_I	328_L	0.723	0.52
203_G	406_E	0.723	0.52
401_I	404_Q	0.723	0.52
108_A	220_D	0.722	0.52
502_L	535_I	0.722	0.52
520_Q	524_S	0.722	0.52
59_I	63_E	0.722	0.52
40_D	56_G	0.720	0.52
78_I	85_P	0.719	0.52
153_A	185_Q	0.716	0.51
72_I	101_V	0.715	0.51
95_H	339_V	0.713	0.51
347_Q	354_K	0.712	0.51
72_I	309_A	0.708	0.51
157_P	160_E	0.707	0.50
209_I	235_R	0.706	0.50
109_N	147_G	0.706	0.50
314_L	317_K	0.706	0.50
445_L	476_D	0.705	0.50
106_E	110_V	0.703	0.50
498_N	501_E	0.702	0.50
60_I	348_T	0.702	0.50
102_T	168_A	0.697	0.49
269_T	495_I	0.695	0.49
136_S	464_H	0.694	0.49
105_H	552_L	0.694	0.49
274_V	545_L	0.693	0.49
182_D	186_K	0.693	0.49
120_L	132_F	0.692	0.49
136_S	467_H	0.692	0.49
272_K	286_Q	0.691	0.49
414_A	423_D	0.690	0.49
88_F	92_V	0.689	0.49
54_Y	59_I	0.689	0.49
280_E	285_H	0.688	0.49
479_I	483_V	0.688	0.49
255_P	293_A	0.688	0.49
155_L	189_D	0.687	0.48
209_I	213_R	0.687	0.48
72_I	308_A	0.687	0.48
17_Q	44_T	0.686	0.48
267_F	286_Q	0.686	0.48
171_M	467_H	0.685	0.48
80_S	106_E	0.685	0.48
266_F	308_A	0.684	0.48
81_S	92_V	0.683	0.48
136_S	167_L	0.683	0.48
321_A	324_F	0.682	0.48
505_V	524_S	0.682	0.48
416_V	419_E	0.682	0.48
412_V	426_L	0.681	0.48
136_S	171_M	0.680	0.48
478_D	498_N	0.680	0.48
424_T	474_T	0.678	0.48
154_D	157_P	0.677	0.47
291_I	332_S	0.676	0.47
16_R	179_A	0.675	0.47
71_F	305_S	0.672	0.47
9_R	12_A	0.670	0.47
181_K	185_Q	0.669	0.47
109_N	467_H	0.665	0.46
389_I	420_F	0.664	0.46
271_D	467_H	0.664	0.46
177_Q	211_I	0.663	0.46
427_D	474_T	0.663	0.46
201_L	232_R	0.662	0.46
31_V	302_Q	0.662	0.46
79_E	271_D	0.661	0.46
427_D	450_G	0.660	0.46
80_S	171_M	0.660	0.46
219_N	240_M	0.660	0.46
444_G	560_M	0.659	0.46
106_E	465_D	0.657	0.45
239_V	265_F	0.654	0.45
339_V	342_T	0.654	0.45
98_T	269_T	0.654	0.45
120_L	161_E	0.652	0.45
301_Y	331_V	0.652	0.45
223_V	228_E	0.651	0.45
446_G	560_M	0.650	0.45
213_R	235_R	0.649	0.45
144_E	553_P	0.649	0.45
423_D	428_L	0.648	0.45
70_G	305_S	0.648	0.45
109_N	139_P	0.647	0.44
463_S	551_A	0.647	0.44
109_N	464_H	0.647	0.44
189_D	193_A	0.647	0.44
85_P	365_A	0.647	0.44
396_N	558_I	0.646	0.44
232_R	239_V	0.646	0.44
296_N	299_L	0.646	0.44
291_I	339_V	0.646	0.44
315_D	324_F	0.646	0.44
23_I	67_I	0.643	0.44
451_F	460_T	0.642	0.44
42_A	56_G	0.642	0.44
330_F	340_T	0.642	0.44
20_D	57_E	0.641	0.44
29_M	331_V	0.640	0.44
398_I	407_T	0.639	0.44
299_L	302_Q	0.638	0.44
76_V	282_S	0.638	0.44
99_T	129_N	0.636	0.43
462_I	493_L	0.634	0.43
461_T	489_I	0.634	0.43
195_K	509_I	0.633	0.43
74_G	463_S	0.631	0.43
141_A	466_S	0.631	0.43
182_D	185_Q	0.630	0.43
105_H	109_N	0.630	0.43
171_M	464_H	0.629	0.43
70_G	327_D	0.628	0.43
268_C	283_V	0.627	0.42
23_I	142_S	0.626	0.42
80_S	552_L	0.624	0.42
137_S	554_V	0.624	0.42
48_I	320_I	0.624	0.42
88_F	559_K	0.624	0.42
79_E	105_H	0.624	0.42
271_D	464_H	0.623	0.42
488_E	504_S	0.623	0.42
31_V	298_F	0.622	0.42
429_L	448_V	0.620	0.42
527_T	531_K	0.619	0.42
107_I	510_A	0.618	0.42
44_T	49_V	0.616	0.41
83_V	518_A	0.616	0.41
409_L	567_D	0.613	0.41
79_E	552_L	0.612	0.41
301_Y	334_L	0.612	0.41
249_N	253_V	0.612	0.41
275_D	542_N	0.610	0.41
82_M	273_H	0.610	0.41
183_M	186_K	0.610	0.41
210_N	322_P	0.610	0.41
105_H	554_V	0.608	0.41
233_I	239_V	0.608	0.41
227_E	231_D	0.607	0.41
530_D	533_S	0.606	0.40
89_A	123_A	0.605	0.40
433_V	562_T	0.604	0.40
138_V	171_M	0.604	0.40
113_E	154_D	0.603	0.40
105_H	139_P	0.603	0.40
28_I	36_W	0.602	0.40
514_S	524_S	0.602	0.40
140_A	171_M	0.600	0.40
243_E	248_K	0.600	0.40
272_K	283_V	0.599	0.40
80_S	136_S	0.598	0.40
414_A	428_L	0.598	0.40
82_M	462_I	0.598	0.40
350_A	355_A	0.598	0.40
168_A	404_Q	0.596	0.39
197_I	217_V	0.596	0.39
508_P	516_Q	0.595	0.39
50_G	56_G	0.595	0.39
297_P	301_Y	0.594	0.39
371_L	515_D	0.593	0.39
305_S	309_A	0.591	0.39
106_E	271_D	0.591	0.39
397_V	410_V	0.591	0.39
450_G	561_T	0.589	0.39
71_F	339_V	0.589	0.39
277_L	282_S	0.589	0.39
30_D	324_F	0.588	0.39
233_I	295_L	0.587	0.39
427_D	449_K	0.587	0.39
380_L	483_V	0.587	0.39
105_H	136_S	0.586	0.38
381_N	384_D	0.586	0.38
186_K	549_F	0.586	0.38
422_P	476_D	0.584	0.38
83_V	274_V	0.584	0.38
82_M	507_L	0.583	0.38
105_H	137_S	0.582	0.38
254_L	257_V	0.582	0.38
109_N	552_L	0.580	0.38
532_L	537_F	0.580	0.38
240_M	311_C	0.579	0.38
138_V	467_H	0.579	0.38
155_L	187_L	0.578	0.38
395_I	422_P	0.578	0.38
348_T	390_D	0.578	0.38
141_A	553_P	0.578	0.38
38_Y	63_E	0.578	0.38
329_L	339_V	0.577	0.38
108_A	150_L	0.577	0.38
247_A	273_H	0.576	0.38
380_L	434_V	0.576	0.38
417_A	524_S	0.576	0.38
210_N	284_N	0.576	0.38
165_L	176_V	0.576	0.38
477_E	499_G	0.575	0.37
262_A	303_L	0.575	0.37
201_L	204_L	0.574	0.37
305_S	308_A	0.571	0.37
172_D	447_V	0.571	0.37
244_G	430_K	0.571	0.37
79_E	464_H	0.570	0.37
201_L	206_T	0.570	0.37
201_L	228_E	0.570	0.37
246_V	249_N	0.568	0.37
226_K	229_A	0.568	0.37
271_D	468_N	0.568	0.37
153_A	530_D	0.568	0.37
68_V	71_F	0.568	0.37
138_V	552_L	0.567	0.37
73_D	282_S	0.567	0.37
229_A	305_S	0.566	0.37
84_T	374_V	0.565	0.37
71_F	331_V	0.565	0.37
302_Q	305_S	0.565	0.37
110_V	437_H	0.565	0.37
405_L	549_F	0.565	0.37
79_E	467_H	0.565	0.37
416_V	420_F	0.564	0.36
249_N	551_A	0.564	0.36
50_G	54_Y	0.563	0.36
14_A	211_I	0.563	0.36
434_V	471_A	0.563	0.36
291_I	306_L	0.563	0.36
158_F	161_E	0.562	0.36
9_R	45_D	0.562	0.36
137_S	172_D	0.561	0.36
81_S	219_N	0.561	0.36
108_A	158_F	0.561	0.36
202_A	545_L	0.561	0.36
60_I	341_M	0.561	0.36
141_A	202_A	0.559	0.36
97_V	202_A	0.559	0.36
228_E	433_V	0.559	0.36
385_F	471_A	0.559	0.36
65_Q	331_V	0.559	0.36
288_K	339_V	0.558	0.36
225_S	228_E	0.558	0.36
529_H	542_N	0.558	0.36
232_R	420_F	0.557	0.36
241_M	289_M	0.557	0.36
269_T	286_Q	0.557	0.36
43_I	330_F	0.556	0.36
364_A	367_D	0.554	0.36
271_D	465_D	0.554	0.36
79_E	106_E	0.553	0.35
109_N	171_M	0.553	0.35
291_I	335_E	0.553	0.35
287_V	337_V	0.552	0.35
219_N	566_F	0.551	0.35
137_S	466_S	0.551	0.35
198_D	219_N	0.551	0.35
533_S	572_Q	0.550	0.35
71_F	295_L	0.549	0.35
202_A	206_T	0.548	0.35
258_N	261_N	0.548	0.35
105_H	465_D	0.548	0.35
19_A	22_V	0.548	0.35
81_S	271_D	0.547	0.35
68_V	320_I	0.547	0.35
219_N	239_V	0.546	0.35
89_A	514_S	0.546	0.35
355_A	359_D	0.546	0.35
68_V	301_Y	0.545	0.35
495_I	528_L	0.545	0.35
374_V	486_L	0.545	0.35
106_E	171_M	0.544	0.35
105_H	138_V	0.544	0.35
134_L	159_Y	0.544	0.35
355_A	358_Q	0.543	0.34
262_A	302_Q	0.543	0.34
42_A	54_Y	0.542	0.34
122_Q	125_H	0.542	0.34
331_V	340_T	0.541	0.34
106_E	136_S	0.541	0.34
171_M	552_L	0.541	0.34
122_Q	211_I	0.541	0.34
223_V	249_N	0.541	0.34
146_S	155_L	0.540	0.34
233_I	264_R	0.540	0.34
175_S	180_E	0.539	0.34
222_E	244_G	0.539	0.34
500_E	523_Q	0.539	0.34
227_E	413_P	0.538	0.34
133_M	198_D	0.538	0.34
58_N	351_E	0.537	0.34
50_G	210_N	0.536	0.34
265_F	303_L	0.535	0.34
139_P	467_H	0.534	0.34
198_D	549_F	0.534	0.34
48_I	348_T	0.534	0.34
30_D	268_C	0.533	0.34
298_F	301_Y	0.532	0.34
502_L	531_K	0.532	0.34
47_V	315_D	0.532	0.34
461_T	482_A	0.532	0.34
271_D	552_L	0.531	0.33
256_A	265_F	0.530	0.33
475_N	498_N	0.529	0.33
246_V	266_F	0.529	0.33
495_I	544_F	0.527	0.33
528_L	539_G	0.527	0.33
477_E	481_A	0.527	0.33
109_N	271_D	0.527	0.33
275_D	526_L	0.526	0.33
432_A	480_A	0.526	0.33
139_P	464_H	0.526	0.33
12_A	214_T	0.525	0.33
106_E	109_N	0.525	0.33
480_A	487_Q	0.525	0.33
285_H	288_K	0.525	0.33
42_A	210_N	0.525	0.33
118_F	121_E	0.524	0.33
255_P	258_N	0.523	0.33
292_Q	425_E	0.522	0.33
97_V	461_T	0.522	0.33
187_L	190_A	0.521	0.33
92_V	137_S	0.521	0.33
115_G	510_A	0.521	0.33
233_I	256_A	0.521	0.33
252_N	255_P	0.520	0.32
100_V	495_I	0.520	0.32
514_S	517_S	0.519	0.32
16_R	177_Q	0.519	0.32
437_H	552_L	0.519	0.32
29_M	337_V	0.518	0.32
185_Q	535_I	0.518	0.32
105_H	271_D	0.517	0.32
105_H	110_V	0.517	0.32
90_K	126_T	0.517	0.32
322_P	558_I	0.516	0.32
171_M	175_S	0.516	0.32
43_I	225_S	0.516	0.32
167_L	554_V	0.516	0.32
93_L	350_A	0.515	0.32
227_E	498_N	0.515	0.32
18_K	59_I	0.514	0.32
414_A	420_F	0.514	0.32
71_F	308_A	0.514	0.32
43_I	287_V	0.514	0.32
23_I	328_L	0.514	0.32
550_L	559_K	0.514	0.32
241_M	253_V	0.514	0.32
81_S	468_N	0.513	0.32
41_I	345_K	0.513	0.32
379_P	484_N	0.513	0.32
147_G	467_H	0.512	0.32
231_D	235_R	0.512	0.32
93_L	344_V	0.512	0.32
177_Q	239_V	0.511	0.32
351_E	358_Q	0.510	0.32
19_A	49_V	0.510	0.32
196_R	308_A	0.510	0.32
468_N	552_L	0.509	0.31
467_H	554_V	0.508	0.31
30_D	235_R	0.508	0.31
23_I	143_F	0.506	0.31
429_L	537_F	0.505	0.31
278_L	519_E	0.505	0.31
171_M	465_D	0.505	0.31
109_N	468_N	0.504	0.31
97_V	127_P	0.504	0.31
71_F	269_T	0.504	0.31
292_Q	336_N	0.504	0.31
424_T	449_K	0.503	0.31
203_G	225_S	0.503	0.31
231_D	276_D	0.503	0.31
292_Q	530_D	0.503	0.31
104_P	171_M	0.502	0.31
83_V	273_H	0.502	0.31
51_L	298_F	0.502	0.31
258_N	295_L	0.501	0.31
356_V	359_D	0.501	0.31
213_R	322_P	0.501	0.31
248_K	533_S	0.501	0.31
278_L	522_N	0.500	0.31
140_A	554_V	0.500	0.31
151_K	182_D	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3nqbA	2	0.9827	100	0.312	Contact Map
2vunA	3	0.5789	100	0.797	Contact Map
2icsA	1	0.5581	100	0.797	Contact Map
2ogjA	4	0.5737	100	0.804	Contact Map
3be7A	5	0.5633	100	0.807	Contact Map
3mtwA	5	0.5615	100	0.808	Contact Map
4whbE	3	0.5893	100	0.809	Contact Map
3lnpA	2	0.5962	100	0.811	Contact Map
4c65A	6	0.5823	100	0.813	Contact Map
4cqbA	2	0.5685	100	0.813	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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