GREMLIN Database
KTRC - Ktr system potassium uptake protein C
UniProt: P39760 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (207)
Sequences: 8721 (6197)
Seq/√Len: 430.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_G58_V3.9521.00
181_R199_D3.7151.00
8_I53_S3.4451.00
6_A67_F3.2771.00
154_A195_I3.0761.00
179_I193_E2.9431.00
53_S84_T2.8091.00
181_R196_H2.7911.00
35_E50_I2.6861.00
164_L192_T2.6661.00
85_T114_A2.6091.00
7_V18_C2.4801.00
162_T165_D2.4001.00
60_K65_R2.2511.00
38_V48_A2.2121.00
206_S209_D2.1941.00
161_N165_D2.1031.00
4_E27_E2.0631.00
11_G14_G2.0541.00
163_L176_I2.0091.00
162_T194_V1.9971.00
106_E119_H1.9811.00
35_E39_N1.9641.00
85_T98_V1.9301.00
63_G66_N1.9271.00
181_R193_E1.9101.00
89_K96_I1.8601.00
6_A64_L1.8441.00
89_K115_D1.8371.00
173_G209_D1.8261.00
32_D38_V1.7931.00
18_C45_A1.7491.00
159_A197_Q1.7291.00
160_G196_H1.7271.00
90_E111_K1.6801.00
8_I71_I1.6731.00
10_L30_A1.6471.00
71_I84_T1.6111.00
62_L67_F1.5821.00
85_T96_I1.5791.00
71_I88_L1.5781.00
32_D48_A1.5751.00
149_L154_A1.5371.00
37_K40_E1.5351.00
158_L166_L1.5271.00
15_G41_Y1.5241.00
164_L191_A1.5191.00
95_T115_D1.5131.00
56_E60_K1.5051.00
178_A185_V1.4941.00
77_N80_A1.4881.00
186_I193_E1.4671.00
51_G62_L1.4561.00
160_G197_Q1.4541.00
49_V62_L1.4521.00
30_A45_A1.4231.00
60_K91_L1.4231.00
181_R186_I1.4081.00
156_S197_Q1.3821.00
190_L193_E1.3711.00
8_I84_T1.3671.00
11_G99_K1.3641.00
10_L41_Y1.3431.00
57_S60_K1.3201.00
176_I203_V1.3091.00
195_I201_L1.2881.00
34_D37_K1.2671.00
151_E200_I1.2391.00
19_K44_I1.2221.00
29_M67_F1.2181.00
78_I81_S1.2141.00
205_G210_I1.1961.00
14_G74_I1.1811.00
125_A129_A1.1791.00
169_R175_N1.1721.00
40_E44_I1.1691.00
58_V62_L1.1521.00
10_L38_V1.1441.00
98_V114_A1.1271.00
17_I72_V1.1201.00
179_I199_D1.0931.00
209_D212_R1.0901.00
174_I205_G1.0891.00
17_I125_A1.0801.00
153_V198_E1.0751.00
196_H199_D1.0671.00
150_V154_A1.0651.00
41_Y45_A1.0641.00
56_E87_I1.0641.00
17_I74_I1.0621.00
95_T116_H1.0521.00
13_F99_K1.0511.00
8_I31_M1.0421.00
106_E110_S1.0411.00
64_L92_G1.0291.00
80_A84_T1.0281.00
49_V58_V1.0261.00
172_Y209_D1.0241.00
18_C30_A1.0211.00
181_R184_E1.0201.00
31_M51_G1.0181.00
57_S61_N1.0091.00
159_A196_H1.0061.00
45_A48_A1.0051.00
41_Y48_A0.9991.00
10_L32_D0.9981.00
5_F26_V0.9871.00
31_M58_V0.9841.00
22_S46_S0.9781.00
153_V200_I0.9751.00
123_D127_R0.9721.00
41_Y44_I0.9661.00
96_I115_D0.9661.00
151_E154_A0.9591.00
31_M62_L0.9461.00
7_V14_G0.9351.00
14_G32_D0.9301.00
148_S207_V0.9291.00
36_D39_N0.9261.00
78_I105_H0.9221.00
205_G209_D0.9151.00
11_G32_D0.9101.00
75_G80_A0.8991.00
189_P193_E0.8961.00
203_V213_F0.8911.00
89_K113_G0.8911.00
180_K200_I0.8911.00
29_M62_L0.8911.00
6_A62_L0.8901.00
151_E202_I0.8891.00
4_E67_F0.8801.00
73_A81_S0.8721.00
10_L15_G0.8671.00
103_D122_R0.8631.00
152_I203_V0.8621.00
16_S19_K0.8591.00
164_L190_L0.8581.00
168_I174_I0.8541.00
175_N191_A0.8511.00
26_V68_D0.8451.00
179_I186_I0.8431.00
182_G196_H0.8331.00
14_G18_C0.8291.00
154_A159_A0.8291.00
14_G99_K0.8241.00
59_L91_L0.8201.00
166_L195_I0.8191.00
32_D37_K0.8151.00
64_L91_L0.8101.00
178_A202_I0.8041.00
72_V88_L0.7981.00
39_N43_K0.7981.00
158_L213_F0.7961.00
160_G194_V0.7921.00
162_T192_T0.7811.00
161_N166_L0.7801.00
56_E91_L0.7781.00
100_A109_L0.7761.00
106_E122_R0.7761.00
186_I199_D0.7721.00
7_V28_V0.7701.00
15_G19_K0.7691.00
26_V133_V0.7611.00
7_V30_A0.7561.00
88_L92_G0.7541.00
165_D194_V0.7541.00
174_I213_F0.7531.00
11_G53_S0.7531.00
155_N158_L0.7491.00
36_D40_E0.7471.00
79_Q83_L0.7451.00
22_S28_V0.7401.00
75_G84_T0.7361.00
177_V204_I0.7351.00
31_M49_V0.7331.00
59_L62_L0.7331.00
147_H204_I0.7321.00
4_E68_D0.7321.00
81_S105_H0.7291.00
32_D50_I0.7271.00
59_L64_L0.7261.00
155_N159_A0.7241.00
75_G81_S0.7211.00
103_D106_E0.7201.00
180_K185_V0.7191.00
163_L189_P0.7191.00
168_I176_I0.7121.00
86_L123_D0.7111.00
4_E66_N0.7091.00
60_K64_L0.7031.00
64_L67_F0.7021.00
6_A29_M0.6991.00
81_S98_V0.6991.00
73_A85_T0.6951.00
169_R172_Y0.6891.00
21_L28_V0.6881.00
96_I114_A0.6841.00
18_C28_V0.6831.00
114_A117_I0.6821.00
210_I214_E0.6781.00
127_R131_N0.6781.00
211_S214_E0.6731.00
110_S116_H0.6731.00
16_S20_A0.6711.00
212_R215_K0.6691.00
29_M49_V0.6681.00
16_S125_A0.6550.99
162_T166_L0.6530.99
86_L90_E0.6530.99
20_A23_E0.6510.99
163_L191_A0.6480.99
122_R126_K0.6410.99
123_D126_K0.6410.99
142_E148_S0.6380.99
14_G53_S0.6360.99
87_I91_L0.6360.99
4_E29_M0.6330.99
22_S45_A0.6310.99
30_A41_Y0.6300.99
54_T80_A0.6280.99
165_D168_I0.6270.99
15_G45_A0.6260.99
79_Q82_I0.6260.99
55_D58_V0.6220.99
19_K23_E0.6220.99
10_L14_G0.6200.99
20_A24_E0.6140.99
149_L177_V0.6110.99
84_T88_L0.6100.99
143_L146_E0.6080.99
20_A125_A0.6070.99
15_G44_I0.6060.99
6_A51_G0.6050.99
8_I88_L0.6010.99
186_I189_P0.6000.99
175_N187_V0.5980.99
7_V17_I0.5970.99
173_G206_S0.5960.99
179_I195_I0.5940.99
78_I102_N0.5940.99
15_G40_E0.5920.99
193_E196_H0.5920.99
19_K22_S0.5910.99
159_A195_I0.5850.99
180_K202_I0.5850.99
11_G15_G0.5850.99
116_H131_N0.5830.99
42_A46_S0.5820.99
6_A71_I0.5810.99
90_E107_K0.5810.99
5_F21_L0.5770.99
78_I101_Q0.5770.99
79_Q105_H0.5760.99
144_S147_H0.5750.99
33_I52_D0.5750.99
76_E101_Q0.5710.99
42_A48_A0.5700.99
64_L88_L0.5690.99
38_V42_A0.5660.98
22_S44_I0.5640.98
79_Q102_N0.5630.98
168_I213_F0.5610.98
86_L109_L0.5600.98
86_L92_G0.5570.98
38_V50_I0.5550.98
163_L168_I0.5530.98
74_I84_T0.5530.98
74_I99_K0.5520.98
101_Q121_E0.5510.98
39_N42_A0.5470.98
102_N105_H0.5450.98
60_K63_G0.5430.98
156_S159_A0.5430.98
47_H50_I0.5420.98
158_L195_I0.5410.98
13_F105_H0.5400.98
109_L117_I0.5400.98
29_M47_H0.5380.98
58_V61_N0.5360.98
82_I109_L0.5350.98
9_G14_G0.5330.98
146_E154_A0.5330.98
108_V112_I0.5290.98
63_G67_F0.5240.98
71_I93_V0.5220.97
11_G75_G0.5210.97
73_A132_I0.5200.97
109_L112_I0.5160.97
129_A132_I0.5150.97
99_K124_M0.5140.97
64_L93_V0.5130.97
31_M53_S0.5120.97
5_F68_D0.5120.97
61_N66_N0.5110.97
118_V121_E0.5110.97
134_S137_V0.5100.97
32_D53_S0.5100.97
42_A49_V0.5080.97
32_D120_P0.5080.97
22_S41_Y0.5070.97
100_A119_H0.5070.97
59_L88_L0.5050.97
86_L112_I0.5050.97
59_L87_I0.5050.97
17_I83_L0.5040.97
110_S117_I0.5030.97
13_F121_E0.5020.97
5_F17_I0.5010.97
30_A38_V0.5000.97
183_K200_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gx0A 3 0.9593 100 0.22 Contact Map
4g65A 2 0.9774 100 0.237 Contact Map
2aefA 2 0.9729 100 0.247 Contact Map
1lnqA 6 0.9638 100 0.258 Contact Map
3mt5A 5 0.9548 100 0.275 Contact Map
3nafA 3 0.9864 100 0.293 Contact Map
4hpfA 3 0.9276 100 0.331 Contact Map
4j91A 3 0.9683 100 0.338 Contact Map
3l4bC 2 0.9593 100 0.34 Contact Map
3l9wA 2 0.7964 99.9 0.53 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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