KTRC - BACSU - GREMLIN Contacts

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KTRC - Ktr system potassium uptake protein C

UniProt:	P39760	Sequences: MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKIASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQNDYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAGNTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVLHTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	221 (207)
Sequences:	8721 (6197)
Seq/√Len:	430.7

ECOLI - TRKA KEFC
BACSU - KTRC KTRA YJBQ YUGO
HALSA - Q9HSL4 Q9HQ83 Q9HHY1 Q9HNV8 Q9HHS7 Q9HHU8 Q9HHU4 Q9HNK1 Q9HRN5
SULSO - Q97XI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_G	58_V	3.952	1.00
181_R	199_D	3.715	1.00
8_I	53_S	3.445	1.00
6_A	67_F	3.277	1.00
154_A	195_I	3.076	1.00
179_I	193_E	2.943	1.00
53_S	84_T	2.809	1.00
181_R	196_H	2.791	1.00
35_E	50_I	2.686	1.00
164_L	192_T	2.666	1.00
85_T	114_A	2.609	1.00
7_V	18_C	2.480	1.00
162_T	165_D	2.400	1.00
60_K	65_R	2.251	1.00
38_V	48_A	2.212	1.00
206_S	209_D	2.194	1.00
161_N	165_D	2.103	1.00
4_E	27_E	2.063	1.00
11_G	14_G	2.054	1.00
163_L	176_I	2.009	1.00
162_T	194_V	1.997	1.00
106_E	119_H	1.981	1.00
35_E	39_N	1.964	1.00
85_T	98_V	1.930	1.00
63_G	66_N	1.927	1.00
181_R	193_E	1.910	1.00
89_K	96_I	1.860	1.00
6_A	64_L	1.844	1.00
89_K	115_D	1.837	1.00
173_G	209_D	1.826	1.00
32_D	38_V	1.793	1.00
18_C	45_A	1.749	1.00
159_A	197_Q	1.729	1.00
160_G	196_H	1.727	1.00
90_E	111_K	1.680	1.00
8_I	71_I	1.673	1.00
10_L	30_A	1.647	1.00
71_I	84_T	1.611	1.00
62_L	67_F	1.582	1.00
85_T	96_I	1.579	1.00
71_I	88_L	1.578	1.00
32_D	48_A	1.575	1.00
149_L	154_A	1.537	1.00
37_K	40_E	1.535	1.00
158_L	166_L	1.527	1.00
15_G	41_Y	1.524	1.00
164_L	191_A	1.519	1.00
95_T	115_D	1.513	1.00
56_E	60_K	1.505	1.00
178_A	185_V	1.494	1.00
77_N	80_A	1.488	1.00
186_I	193_E	1.467	1.00
51_G	62_L	1.456	1.00
160_G	197_Q	1.454	1.00
49_V	62_L	1.452	1.00
30_A	45_A	1.423	1.00
60_K	91_L	1.423	1.00
181_R	186_I	1.408	1.00
156_S	197_Q	1.382	1.00
190_L	193_E	1.371	1.00
8_I	84_T	1.367	1.00
11_G	99_K	1.364	1.00
10_L	41_Y	1.343	1.00
57_S	60_K	1.320	1.00
176_I	203_V	1.309	1.00
195_I	201_L	1.288	1.00
34_D	37_K	1.267	1.00
151_E	200_I	1.239	1.00
19_K	44_I	1.222	1.00
29_M	67_F	1.218	1.00
78_I	81_S	1.214	1.00
205_G	210_I	1.196	1.00
14_G	74_I	1.181	1.00
125_A	129_A	1.179	1.00
169_R	175_N	1.172	1.00
40_E	44_I	1.169	1.00
58_V	62_L	1.152	1.00
10_L	38_V	1.144	1.00
98_V	114_A	1.127	1.00
17_I	72_V	1.120	1.00
179_I	199_D	1.093	1.00
209_D	212_R	1.090	1.00
174_I	205_G	1.089	1.00
17_I	125_A	1.080	1.00
153_V	198_E	1.075	1.00
196_H	199_D	1.067	1.00
150_V	154_A	1.065	1.00
41_Y	45_A	1.064	1.00
56_E	87_I	1.064	1.00
17_I	74_I	1.062	1.00
95_T	116_H	1.052	1.00
13_F	99_K	1.051	1.00
8_I	31_M	1.042	1.00
106_E	110_S	1.041	1.00
64_L	92_G	1.029	1.00
80_A	84_T	1.028	1.00
49_V	58_V	1.026	1.00
172_Y	209_D	1.024	1.00
18_C	30_A	1.021	1.00
181_R	184_E	1.020	1.00
31_M	51_G	1.018	1.00
57_S	61_N	1.009	1.00
159_A	196_H	1.006	1.00
45_A	48_A	1.005	1.00
41_Y	48_A	0.999	1.00
10_L	32_D	0.998	1.00
5_F	26_V	0.987	1.00
31_M	58_V	0.984	1.00
22_S	46_S	0.978	1.00
153_V	200_I	0.975	1.00
123_D	127_R	0.972	1.00
41_Y	44_I	0.966	1.00
96_I	115_D	0.966	1.00
151_E	154_A	0.959	1.00
31_M	62_L	0.946	1.00
7_V	14_G	0.935	1.00
14_G	32_D	0.930	1.00
148_S	207_V	0.929	1.00
36_D	39_N	0.926	1.00
78_I	105_H	0.922	1.00
205_G	209_D	0.915	1.00
11_G	32_D	0.910	1.00
75_G	80_A	0.899	1.00
189_P	193_E	0.896	1.00
203_V	213_F	0.891	1.00
89_K	113_G	0.891	1.00
180_K	200_I	0.891	1.00
29_M	62_L	0.891	1.00
6_A	62_L	0.890	1.00
151_E	202_I	0.889	1.00
4_E	67_F	0.880	1.00
73_A	81_S	0.872	1.00
10_L	15_G	0.867	1.00
103_D	122_R	0.863	1.00
152_I	203_V	0.862	1.00
16_S	19_K	0.859	1.00
164_L	190_L	0.858	1.00
168_I	174_I	0.854	1.00
175_N	191_A	0.851	1.00
26_V	68_D	0.845	1.00
179_I	186_I	0.843	1.00
182_G	196_H	0.833	1.00
14_G	18_C	0.829	1.00
154_A	159_A	0.829	1.00
14_G	99_K	0.824	1.00
59_L	91_L	0.820	1.00
166_L	195_I	0.819	1.00
32_D	37_K	0.815	1.00
64_L	91_L	0.810	1.00
178_A	202_I	0.804	1.00
72_V	88_L	0.798	1.00
39_N	43_K	0.798	1.00
158_L	213_F	0.796	1.00
160_G	194_V	0.792	1.00
162_T	192_T	0.781	1.00
161_N	166_L	0.780	1.00
56_E	91_L	0.778	1.00
100_A	109_L	0.776	1.00
106_E	122_R	0.776	1.00
186_I	199_D	0.772	1.00
7_V	28_V	0.770	1.00
15_G	19_K	0.769	1.00
26_V	133_V	0.761	1.00
7_V	30_A	0.756	1.00
88_L	92_G	0.754	1.00
165_D	194_V	0.754	1.00
174_I	213_F	0.753	1.00
11_G	53_S	0.753	1.00
155_N	158_L	0.749	1.00
36_D	40_E	0.747	1.00
79_Q	83_L	0.745	1.00
22_S	28_V	0.740	1.00
75_G	84_T	0.736	1.00
177_V	204_I	0.735	1.00
31_M	49_V	0.733	1.00
59_L	62_L	0.733	1.00
147_H	204_I	0.732	1.00
4_E	68_D	0.732	1.00
81_S	105_H	0.729	1.00
32_D	50_I	0.727	1.00
59_L	64_L	0.726	1.00
155_N	159_A	0.724	1.00
75_G	81_S	0.721	1.00
103_D	106_E	0.720	1.00
180_K	185_V	0.719	1.00
163_L	189_P	0.719	1.00
168_I	176_I	0.712	1.00
86_L	123_D	0.711	1.00
4_E	66_N	0.709	1.00
60_K	64_L	0.703	1.00
64_L	67_F	0.702	1.00
6_A	29_M	0.699	1.00
81_S	98_V	0.699	1.00
73_A	85_T	0.695	1.00
169_R	172_Y	0.689	1.00
21_L	28_V	0.688	1.00
96_I	114_A	0.684	1.00
18_C	28_V	0.683	1.00
114_A	117_I	0.682	1.00
210_I	214_E	0.678	1.00
127_R	131_N	0.678	1.00
211_S	214_E	0.673	1.00
110_S	116_H	0.673	1.00
16_S	20_A	0.671	1.00
212_R	215_K	0.669	1.00
29_M	49_V	0.668	1.00
16_S	125_A	0.655	0.99
162_T	166_L	0.653	0.99
86_L	90_E	0.653	0.99
20_A	23_E	0.651	0.99
163_L	191_A	0.648	0.99
122_R	126_K	0.641	0.99
123_D	126_K	0.641	0.99
142_E	148_S	0.638	0.99
14_G	53_S	0.636	0.99
87_I	91_L	0.636	0.99
4_E	29_M	0.633	0.99
22_S	45_A	0.631	0.99
30_A	41_Y	0.630	0.99
54_T	80_A	0.628	0.99
165_D	168_I	0.627	0.99
15_G	45_A	0.626	0.99
79_Q	82_I	0.626	0.99
55_D	58_V	0.622	0.99
19_K	23_E	0.622	0.99
10_L	14_G	0.620	0.99
20_A	24_E	0.614	0.99
149_L	177_V	0.611	0.99
84_T	88_L	0.610	0.99
143_L	146_E	0.608	0.99
20_A	125_A	0.607	0.99
15_G	44_I	0.606	0.99
6_A	51_G	0.605	0.99
8_I	88_L	0.601	0.99
186_I	189_P	0.600	0.99
175_N	187_V	0.598	0.99
7_V	17_I	0.597	0.99
173_G	206_S	0.596	0.99
179_I	195_I	0.594	0.99
78_I	102_N	0.594	0.99
15_G	40_E	0.592	0.99
193_E	196_H	0.592	0.99
19_K	22_S	0.591	0.99
159_A	195_I	0.585	0.99
180_K	202_I	0.585	0.99
11_G	15_G	0.585	0.99
116_H	131_N	0.583	0.99
42_A	46_S	0.582	0.99
6_A	71_I	0.581	0.99
90_E	107_K	0.581	0.99
5_F	21_L	0.577	0.99
78_I	101_Q	0.577	0.99
79_Q	105_H	0.576	0.99
144_S	147_H	0.575	0.99
33_I	52_D	0.575	0.99
76_E	101_Q	0.571	0.99
42_A	48_A	0.570	0.99
64_L	88_L	0.569	0.99
38_V	42_A	0.566	0.98
22_S	44_I	0.564	0.98
79_Q	102_N	0.563	0.98
168_I	213_F	0.561	0.98
86_L	109_L	0.560	0.98
86_L	92_G	0.557	0.98
38_V	50_I	0.555	0.98
163_L	168_I	0.553	0.98
74_I	84_T	0.553	0.98
74_I	99_K	0.552	0.98
101_Q	121_E	0.551	0.98
39_N	42_A	0.547	0.98
102_N	105_H	0.545	0.98
60_K	63_G	0.543	0.98
156_S	159_A	0.543	0.98
47_H	50_I	0.542	0.98
158_L	195_I	0.541	0.98
13_F	105_H	0.540	0.98
109_L	117_I	0.540	0.98
29_M	47_H	0.538	0.98
58_V	61_N	0.536	0.98
82_I	109_L	0.535	0.98
9_G	14_G	0.533	0.98
146_E	154_A	0.533	0.98
108_V	112_I	0.529	0.98
63_G	67_F	0.524	0.98
71_I	93_V	0.522	0.97
11_G	75_G	0.521	0.97
73_A	132_I	0.520	0.97
109_L	112_I	0.516	0.97
129_A	132_I	0.515	0.97
99_K	124_M	0.514	0.97
64_L	93_V	0.513	0.97
31_M	53_S	0.512	0.97
5_F	68_D	0.512	0.97
61_N	66_N	0.511	0.97
118_V	121_E	0.511	0.97
134_S	137_V	0.510	0.97
32_D	53_S	0.510	0.97
42_A	49_V	0.508	0.97
32_D	120_P	0.508	0.97
22_S	41_Y	0.507	0.97
100_A	119_H	0.507	0.97
59_L	88_L	0.505	0.97
86_L	112_I	0.505	0.97
59_L	87_I	0.505	0.97
17_I	83_L	0.504	0.97
110_S	117_I	0.503	0.97
13_F	121_E	0.502	0.97
5_F	17_I	0.501	0.97
30_A	38_V	0.500	0.97
183_K	200_I	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4gx0A	3	0.9593	100	0.22	Contact Map
4g65A	2	0.9774	100	0.237	Contact Map
2aefA	2	0.9729	100	0.247	Contact Map
1lnqA	6	0.9638	100	0.258	Contact Map
3mt5A	5	0.9548	100	0.275	Contact Map
3nafA	3	0.9864	100	0.293	Contact Map
4hpfA	3	0.9276	100	0.331	Contact Map
4j91A	3	0.9683	100	0.338	Contact Map
3l4bC	2	0.9593	100	0.34	Contact Map
3l9wA	2	0.7964	99.9	0.53	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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