GREMLIN Database
ABH - Putative transition state regulator Abh
UniProt: P39758 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 92 (79)
Sequences: 825 (463)
Seq/√Len: 52.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_T75_S4.5781.00
20_I24_R3.6851.00
57_T78_G3.6311.00
75_S78_G3.5931.00
28_I34_I2.2711.00
12_E31_K1.9941.00
54_C57_T1.9881.00
9_K12_E1.9230.99
24_R29_A1.8930.99
37_F46_K1.8190.99
39_D42_K1.7910.99
54_C78_G1.7880.99
29_A32_D1.5590.98
69_N81_L1.5490.98
59_E77_E1.5290.97
30_I36_F1.4710.97
24_R32_D1.4410.96
56_M74_L1.3940.95
67_Y70_G1.3920.95
55_L74_L1.3830.95
64_N76_P1.3630.95
42_K46_K1.3200.94
3_S50_P1.3180.94
80_Q84_E1.3090.93
4_I25_A1.2670.92
56_M68_G1.2240.91
31_K36_F1.2100.90
69_N82_L1.1280.87
56_M60_I1.0980.86
18_M22_L1.0650.84
46_K68_G1.0520.83
56_M67_Y1.0460.83
7_V43_I1.0260.81
27_D82_L1.0230.81
12_E20_I1.0180.81
54_C75_S0.9830.79
56_M71_K0.9680.78
29_A42_K0.9620.77
79_A83_L0.9410.76
6_V21_E0.9400.75
43_I64_N0.9330.75
55_L68_G0.9040.73
65_K75_S0.8960.72
6_V25_A0.8700.70
53_V57_T0.8690.70
10_V17_V0.8560.68
78_G83_L0.8530.68
74_L78_G0.8530.68
4_I38_V0.8500.68
72_I77_E0.8490.68
36_F45_L0.8450.67
56_M78_G0.8180.65
25_A30_I0.8150.65
3_S43_I0.8150.65
40_G80_Q0.8090.64
54_C68_G0.8080.64
13_L22_L0.8070.64
33_S48_Y0.7920.62
64_N70_G0.7910.62
7_V24_R0.7900.62
2_K40_G0.7890.62
72_I75_S0.7860.62
41_D59_E0.7540.58
9_K29_A0.7520.58
18_M31_K0.7500.58
69_N79_A0.7430.57
42_K61_T0.7410.57
18_M55_L0.7310.56
59_E69_N0.7200.55
10_V20_I0.7170.55
3_S12_E0.7140.54
37_F84_E0.7140.54
27_D32_D0.7130.54
7_V12_E0.7030.53
16_I64_N0.6880.52
30_I44_I0.6830.51
28_I47_K0.6700.50
17_V23_R0.6620.49
54_C58_G0.6550.48
77_E80_Q0.6550.48
77_E82_L0.6470.47
11_D15_R0.6460.47
39_D45_L0.6440.47
41_D69_N0.6440.47
49_K53_V0.6390.47
68_G74_L0.6350.46
45_L58_G0.6350.46
61_T67_Y0.6310.46
65_K70_G0.6280.45
20_I40_G0.6270.45
61_T76_P0.6250.45
20_I33_S0.6050.43
78_G82_L0.5930.42
49_K66_E0.5890.41
65_K72_I0.5860.41
3_S36_F0.5780.40
39_D44_I0.5750.40
34_I50_P0.5740.40
57_T83_L0.5730.40
29_A49_K0.5690.39
14_G23_R0.5660.39
58_G75_S0.5650.39
20_I82_L0.5640.39
5_G21_E0.5620.39
30_I84_E0.5570.38
48_Y55_L0.5530.38
22_L38_V0.5470.37
55_L61_T0.5420.37
13_L81_L0.5380.36
18_M21_E0.5380.36
28_I32_D0.5320.36
16_I20_I0.5310.36
53_V60_I0.5270.35
64_N82_L0.5270.35
31_K43_I0.5110.34
54_C74_L0.5010.33
19_P35_E0.5010.33
77_E81_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w1tA 2 0.9565 99.6 0.554 Contact Map
1yfbA 2 0.5543 99.3 0.622 Contact Map
2mrnA 2 0.5543 98.7 0.71 Contact Map
2l66A 2 0.5543 98.6 0.719 Contact Map
3o27A 2 0.5217 97.9 0.763 Contact Map
2glwA 1 0.5 97.5 0.784 Contact Map
1mvfD 1 0.4783 97.5 0.784 Contact Map
2mjgA 2 0.4783 97.3 0.793 Contact Map
1n0eA 5 0.7609 67.2 0.889 Contact Map
2ds5A 2 0.4674 60.6 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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