GREMLIN Database
MOAA - Cyclic pyranopterin monophosphate synthase
UniProt: P39757 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (280)
Sequences: 10539 (7913)
Seq/√Len: 472.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_F110_S4.2201.00
157_E191_K3.6141.00
59_E93_K3.4931.00
135_E150_S2.9811.00
63_T93_K2.7591.00
54_S57_E2.6961.00
117_K162_A2.5261.00
278_E290_D2.5151.00
57_E295_V2.5121.00
88_P118_R2.4621.00
28_N108_N2.4241.00
88_P115_Y2.4041.00
63_T97_I2.3551.00
114_V158_A2.3291.00
138_R180_D2.3021.00
117_K121_E2.2771.00
158_A161_Q2.2361.00
95_A125_K2.2191.00
60_R64_L2.1751.00
170_M184_M2.0831.00
278_E293_A2.0721.00
19_L65_F2.0391.00
132_D143_N2.0341.00
62_A94_L2.0071.00
115_Y118_R1.9701.00
264_F282_C1.9581.00
180_D183_P1.9341.00
113_P154_E1.9301.00
168_I188_F1.9141.00
134_L180_D1.8551.00
149_V187_Y1.8061.00
26_R52_L1.7981.00
55_F89_E1.7811.00
76_L94_L1.7661.00
149_V153_L1.7621.00
118_R121_E1.7571.00
300_S303_E1.7441.00
157_E160_K1.7411.00
150_S154_E1.6891.00
93_K96_R1.6851.00
33_Y132_D1.6701.00
134_L138_R1.6661.00
86_D89_E1.6641.00
186_R190_E1.6551.00
28_N111_L1.6501.00
158_A162_A1.6461.00
58_L90_L1.6351.00
154_E157_E1.6161.00
290_D293_A1.6111.00
274_S280_F1.5991.00
92_K96_R1.5771.00
89_E92_K1.5741.00
294_P307_M1.5591.00
151_K154_E1.5351.00
55_F59_E1.5351.00
55_F86_D1.5271.00
57_E60_R1.5271.00
157_E161_Q1.5251.00
82_L105_M1.5211.00
133_S138_R1.5211.00
183_P186_R1.5111.00
109_G129_I1.5031.00
186_R227_H1.4851.00
92_K118_R1.4811.00
68_R305_S1.4791.00
274_S278_E1.4711.00
59_E63_T1.4411.00
135_E180_D1.4401.00
187_Y191_K1.4251.00
66_V97_I1.4201.00
140_K146_G1.4141.00
129_I156_I1.4121.00
32_T141_K1.4121.00
127_V159_A1.4101.00
182_L226_K1.4051.00
114_V161_Q1.4031.00
175_G178_E1.3981.00
93_K97_I1.3961.00
160_K192_G1.3901.00
129_I155_G1.3811.00
95_A103_I1.3641.00
23_V76_L1.3541.00
293_A296_R1.3211.00
174_K219_E1.3201.00
136_D146_G1.3161.00
17_R72_E1.3151.00
32_T144_G1.3141.00
74_I94_L1.3041.00
136_D150_S1.3031.00
59_E89_E1.3011.00
139_F152_V1.3001.00
66_V100_I1.2941.00
138_R179_K1.2921.00
221_I225_N1.2841.00
152_V155_G1.2501.00
160_K191_K1.2481.00
118_R122_A1.2431.00
106_T128_T1.2301.00
153_L157_E1.2261.00
116_A120_K1.2181.00
297_Q301_D1.1991.00
84_R90_L1.1911.00
170_M195_L1.1831.00
264_F268_C1.1771.00
82_L111_L1.1761.00
91_I124_L1.1741.00
218_A222_D1.1731.00
222_D226_K1.1721.00
299_L303_E1.1681.00
52_L84_R1.1661.00
298_E301_D1.1641.00
160_K193_H1.1631.00
305_S309_G1.1611.00
94_L103_I1.1551.00
139_F148_S1.1531.00
153_L187_Y1.1471.00
21_I58_L1.1441.00
306_E309_G1.1341.00
306_E310_T1.1321.00
138_R141_K1.1311.00
222_D225_N1.1111.00
120_K162_A1.1071.00
168_I193_H1.1021.00
76_L103_I1.1011.00
140_K148_S1.0961.00
135_E140_K1.0961.00
60_R301_D1.0881.00
23_V87_M1.0881.00
279_L302_D1.0851.00
117_K158_A1.0841.00
186_R189_K1.0741.00
114_V162_A1.0731.00
64_L298_E1.0591.00
134_L187_Y1.0581.00
76_L91_I1.0511.00
141_K175_G1.0491.00
62_A74_I1.0461.00
116_A158_A1.0441.00
127_V164_L1.0391.00
89_E93_K1.0341.00
154_E158_A1.0311.00
55_F93_K1.0271.00
142_I173_Q1.0251.00
223_L226_K1.0241.00
302_D305_S1.0241.00
133_S149_V1.0171.00
53_L57_E1.0141.00
21_I273_L1.0121.00
216_T219_E1.0031.00
153_L191_K0.9991.00
139_F143_N0.9981.00
116_A155_G0.9971.00
51_E276_R0.9861.00
156_I193_H0.9861.00
225_N229_P0.9801.00
62_A97_I0.9801.00
160_K166_V0.9721.00
82_L87_M0.9701.00
28_N80_E0.9651.00
105_M124_L0.9641.00
116_A162_A0.9631.00
128_T169_N0.9601.00
120_K164_L0.9591.00
61_L273_L0.9541.00
219_E223_L0.9531.00
135_E138_R0.9521.00
148_S151_K0.9521.00
300_S304_L0.9471.00
65_F71_V0.9471.00
87_M91_I0.9471.00
88_P122_A0.9451.00
59_E96_R0.9441.00
172_V181_I0.9431.00
135_E183_P0.9411.00
182_L186_R0.9381.00
113_P158_A0.9321.00
25_D275_A0.9301.00
219_E222_D0.9261.00
280_F290_D0.9251.00
88_P92_K0.9241.00
65_F74_I0.9221.00
230_V234_A0.9221.00
297_Q302_D0.9221.00
159_A166_V0.9191.00
156_I168_I0.9161.00
265_C268_C0.9021.00
24_T52_L0.9011.00
90_L94_L0.8971.00
73_K102_D0.8921.00
91_I122_A0.8881.00
155_G158_A0.8841.00
145_R148_S0.8831.00
65_F308_I0.8731.00
19_L271_A0.8671.00
73_K104_A0.8641.00
145_R151_K0.8581.00
86_D90_L0.8551.00
188_F195_L0.8541.00
87_M105_M0.8541.00
216_T220_I0.8501.00
102_D126_R0.8471.00
156_I166_V0.8471.00
19_L273_L0.8471.00
55_F90_L0.8411.00
129_I159_A0.8401.00
265_C282_C0.8401.00
33_Y142_I0.8391.00
186_R230_V0.8391.00
188_F193_H0.8391.00
35_M77_T0.8371.00
182_L227_H0.8351.00
194_I253_E0.8341.00
60_R63_T0.8341.00
53_L292_R0.8321.00
303_E307_M0.8311.00
140_K145_R0.8271.00
151_K155_G0.8241.00
133_S180_D0.8231.00
112_L129_I0.8181.00
134_L183_P0.8131.00
230_V233_I0.8131.00
302_D306_E0.8051.00
130_S171_V0.8041.00
307_M310_T0.8031.00
112_L155_G0.7951.00
23_V90_L0.7931.00
59_E97_I0.7901.00
102_D125_K0.7901.00
303_E306_E0.7871.00
29_F148_S0.7831.00
92_K121_E0.7771.00
150_S153_L0.7761.00
295_V298_E0.7741.00
60_R295_V0.7721.00
95_A123_G0.7701.00
120_K125_K0.7681.00
301_D305_S0.7671.00
140_K143_N0.7651.00
62_A100_I0.7621.00
22_S77_T0.7621.00
133_S143_N0.7601.00
224_I227_H0.7561.00
28_N110_S0.7561.00
165_G194_I0.7521.00
159_A164_L0.7471.00
88_P91_I0.7441.00
53_L58_L0.7431.00
221_I256_V0.7401.00
17_R269_N0.7401.00
184_M195_L0.7401.00
160_K194_I0.7381.00
80_E108_N0.7371.00
21_I62_A0.7371.00
75_R104_A0.7341.00
82_L155_G0.7331.00
182_L223_L0.7281.00
107_T129_I0.7281.00
231_E234_A0.7251.00
140_K149_V0.7231.00
115_Y120_K0.7221.00
22_S272_R0.7201.00
247_Y250_G0.7191.00
76_L90_L0.7171.00
92_K122_A0.7151.00
53_L61_L0.7131.00
120_K123_G0.7121.00
271_A299_L0.7121.00
139_F149_V0.7101.00
217_K220_I0.7031.00
283_L286_S0.7031.00
113_P155_G0.6971.00
56_E59_E0.6971.00
298_E303_E0.6951.00
112_L159_A0.6941.00
217_K258_S0.6861.00
24_T84_R0.6851.00
84_R87_M0.6831.00
244_R248_L0.6791.00
246_R249_D0.6721.00
55_F84_R0.6681.00
105_M127_V0.6621.00
117_K120_K0.6581.00
22_S275_A0.6571.00
23_V84_R0.6571.00
187_Y190_E0.6551.00
177_N180_D0.6551.00
91_I103_I0.6541.00
168_I195_L0.6531.00
20_R77_T0.6501.00
131_L168_I0.6491.00
136_D140_K0.6481.00
115_Y119_L0.6471.00
56_E93_K0.6451.00
74_I100_I0.6451.00
264_F267_S0.6411.00
217_K221_I0.6411.00
133_S139_F0.6401.00
185_A247_Y0.6401.00
184_M188_F0.6401.00
169_N198_I0.6391.00
210_E213_D0.6381.00
74_I103_I0.6381.00
226_K230_V0.6371.00
114_V117_K0.6361.00
155_G159_A0.6341.00
106_T169_N0.6341.00
220_I224_I0.6341.00
231_E246_R0.6331.00
32_T142_I0.6311.00
133_S136_D0.6291.00
231_E235_P0.6270.99
110_S145_R0.6270.99
69_F305_S0.6260.99
128_T167_K0.6240.99
100_I103_I0.6240.99
241_V244_R0.6240.99
213_D216_T0.6180.99
62_A76_L0.6170.99
58_L84_R0.6160.99
111_L114_V0.6130.99
227_H230_V0.6120.99
136_D149_V0.6110.99
224_I228_M0.6110.99
18_D73_K0.6110.99
27_C31_C0.6080.99
20_R270_R0.6080.99
95_A122_A0.6070.99
80_E83_M0.6060.99
194_I244_R0.6050.99
229_P232_P0.6000.99
294_P297_Q0.5990.99
64_L301_D0.5980.99
182_L185_A0.5970.99
305_S308_I0.5970.99
231_E248_L0.5960.99
170_M188_F0.5950.99
97_I100_I0.5940.99
31_C34_C0.5940.99
77_T283_L0.5930.99
64_L300_S0.5930.99
61_L65_F0.5930.99
94_L97_I0.5920.99
227_H231_E0.5920.99
273_L279_L0.5910.99
29_F139_F0.5900.99
104_A126_R0.5880.99
60_R298_E0.5880.99
220_I227_H0.5870.99
113_P151_K0.5860.99
182_L230_V0.5860.99
144_G148_S0.5840.99
129_I152_V0.5820.99
64_L69_F0.5820.99
258_S262_D0.5810.99
82_L115_Y0.5800.99
27_C34_C0.5800.99
218_A221_I0.5780.99
181_I197_F0.5780.99
58_L62_A0.5770.99
64_L68_R0.5760.99
297_Q305_S0.5740.99
281_T289_F0.5740.99
279_L299_L0.5740.99
228_M232_P0.5720.99
185_A195_L0.5710.99
110_S151_K0.5700.99
126_R167_K0.5660.99
292_R302_D0.5650.99
75_R106_T0.5640.99
121_E162_A0.5640.99
131_L149_V0.5620.99
131_L153_L0.5620.99
94_L100_I0.5610.99
298_E302_D0.5600.99
64_L305_S0.5600.99
77_T169_N0.5590.99
242_A245_F0.5580.99
301_D304_L0.5580.99
21_I61_L0.5520.99
36_P77_T0.5520.99
135_E149_V0.5490.99
69_F309_G0.5490.99
215_M220_I0.5460.99
131_L152_V0.5440.99
108_N111_L0.5420.99
252_G255_G0.5400.98
22_S36_P0.5390.98
77_T106_T0.5390.98
110_S155_G0.5380.98
171_V198_I0.5360.98
272_R283_L0.5360.98
246_R251_S0.5350.98
58_L61_L0.5350.98
19_L71_V0.5340.98
33_Y143_N0.5310.98
23_V58_L0.5300.98
33_Y36_P0.5280.98
135_E179_K0.5250.98
132_D171_V0.5250.98
56_E60_R0.5240.98
84_R89_E0.5220.98
233_I236_N0.5200.98
242_A246_R0.5200.98
20_R272_R0.5190.98
57_E61_L0.5160.98
278_E292_R0.5140.98
281_T285_A0.5130.98
112_L119_L0.5120.98
82_L112_L0.5110.98
61_L64_L0.5090.98
64_L304_L0.5090.98
254_I257_I0.5070.98
166_V193_H0.5070.98
243_S248_L0.5050.98
241_V245_F0.5050.98
220_I223_L0.5050.98
29_F145_R0.5040.98
278_E288_G0.5020.98
179_K223_L0.5010.98
38_E205_N0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tv8A 2 0.9501 100 0.339 Contact Map
4k36A 1 0.9179 100 0.436 Contact Map
4m7tA 1 0.6833 100 0.526 Contact Map
3c8fA 1 0.6598 100 0.604 Contact Map
4rtbA 2 0.8622 100 0.618 Contact Map
2a5hA 4 0.8534 99.9 0.624 Contact Map
2yx0A 1 0.7419 99.9 0.63 Contact Map
2z2uA 1 0.6422 99.9 0.634 Contact Map
2qgqA 1 0.739 99.9 0.641 Contact Map
3rfaA 1 0.7361 99.9 0.641 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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