FDHD - BACSU - GREMLIN Contacts

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FDHD - Protein FdhD homolog

UniProt:	P39756	Sequences: MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTLVCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRVIGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAALCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGVSIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	262 (248)
Sequences:	2278 (1575)
Seq/√Len:	100.0

ECOLI - FDHD
BACSU - FDHD
SULSO - FDHD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
26_M	232_I	4.044	1.00
36_L	59_L	3.888	1.00
53_E	189_L	3.847	1.00
214_A	240_I	3.403	1.00
53_E	171_R	3.399	1.00
222_I	246_V	3.326	1.00
163_D	166_K	3.284	1.00
56_I	71_I	3.260	1.00
199_I	213_A	2.965	1.00
184_Y	216_I	2.841	1.00
50_H	53_E	2.581	1.00
44_L	54_L	2.497	1.00
65_I	71_I	2.489	1.00
169_L	186_H	2.474	1.00
55_V	83_V	2.467	1.00
243_I	246_V	2.460	1.00
186_H	190_N	2.432	1.00
214_A	238_L	2.410	1.00
60_A	188_L	2.359	1.00
201_F	221_V	2.340	1.00
201_F	209_V	2.283	1.00
236_E	256_H	2.094	1.00
169_L	183_L	2.030	1.00
56_I	189_L	1.957	1.00
187_C	194_V	1.928	1.00
162_C	167_L	1.883	1.00
32_L	46_C	1.841	1.00
226_A	245_F	1.838	1.00
67_F	70_E	1.790	1.00
161_L	187_C	1.778	1.00
24_D	252_N	1.773	1.00
171_R	186_H	1.766	1.00
71_I	85_V	1.754	1.00
72_K	86_D	1.730	1.00
221_V	240_I	1.706	1.00
220_I	241_T	1.705	1.00
131_I	198_L	1.702	1.00
184_Y	218_V	1.672	1.00
139_L	198_L	1.670	1.00
138_A	142_D	1.664	1.00
243_I	253_V	1.628	1.00
72_K	88_V	1.626	1.00
24_D	245_F	1.604	1.00
180_L	199_I	1.596	1.00
193_S	196_D	1.584	1.00
161_L	197_K	1.583	1.00
34_V	55_V	1.581	1.00
74_F	85_V	1.569	1.00
229_E	233_Q	1.565	1.00
119_V	237_E	1.560	1.00
236_E	255_T	1.555	1.00
55_V	85_V	1.554	1.00
136_C	222_I	1.553	1.00
60_A	184_Y	1.546	1.00
52_E	189_L	1.513	1.00
27_V	156_V	1.499	1.00
198_L	220_I	1.480	1.00
91_E	94_D	1.476	1.00
199_I	218_V	1.465	1.00
66_R	70_E	1.453	1.00
154_G	254_Y	1.442	1.00
159_A	201_F	1.436	1.00
245_F	254_Y	1.434	1.00
35_I	82_F	1.430	1.00
50_H	171_R	1.430	1.00
131_I	220_I	1.383	0.99
52_E	74_F	1.383	0.99
209_V	221_V	1.363	0.99
162_C	198_L	1.358	0.99
32_L	51_I	1.342	0.99
14_Y	251_F	1.342	0.99
154_G	245_F	1.335	0.99
205_I	223_S	1.333	0.99
140_M	246_V	1.331	0.99
160_A	167_L	1.328	0.99
233_Q	237_E	1.310	0.99
132_S	135_A	1.306	0.99
14_Y	19_I	1.282	0.99
137_L	249_G	1.261	0.99
46_C	51_I	1.258	0.99
24_D	254_Y	1.249	0.99
136_C	246_V	1.242	0.99
59_L	85_V	1.241	0.99
146_G	167_L	1.234	0.99
240_I	256_H	1.231	0.99
53_E	186_H	1.227	0.99
135_A	138_A	1.224	0.99
38_G	84_Y	1.220	0.99
28_T	229_E	1.208	0.99
232_I	242_A	1.206	0.99
24_D	154_G	1.203	0.99
70_E	91_E	1.196	0.98
103_I	106_C	1.188	0.98
159_A	179_A	1.183	0.98
163_D	168_L	1.174	0.98
73_R	86_D	1.161	0.98
79_S	82_F	1.145	0.98
210_L	221_V	1.145	0.98
71_I	74_F	1.141	0.98
25_R	152_D	1.132	0.98
207_S	211_L	1.115	0.98
70_E	88_V	1.099	0.97
159_A	180_L	1.092	0.97
133_P	251_F	1.075	0.97
148_G	170_M	1.072	0.97
72_K	89_H	1.071	0.97
42_V	58_F	1.068	0.97
150_F	245_F	1.060	0.97
16_Q	249_G	1.051	0.97
56_I	68_Q	1.038	0.96
245_F	252_N	1.035	0.96
253_V	260_I	1.033	0.96
243_I	260_I	1.028	0.96
142_D	166_K	1.026	0.96
201_F	223_S	1.025	0.96
77_D	80_L	1.024	0.96
223_S	244_G	1.023	0.96
244_G	254_Y	1.020	0.96
76_I	83_V	1.014	0.96
167_L	170_M	1.013	0.96
235_A	242_A	1.006	0.96
142_D	145_Q	1.004	0.96
180_L	201_F	1.001	0.95
241_T	259_R	0.991	0.95
31_P	43_T	0.976	0.95
37_N	87_L	0.974	0.95
147_S	158_N	0.962	0.94
210_L	240_I	0.961	0.94
15_E	250_S	0.959	0.94
65_I	74_F	0.957	0.94
27_V	149_T	0.950	0.94
52_E	83_V	0.949	0.94
160_A	200_V	0.948	0.94
136_C	243_I	0.946	0.94
52_E	76_I	0.945	0.94
143_M	202_S	0.932	0.93
32_L	55_V	0.928	0.93
65_I	188_L	0.925	0.93
36_L	85_V	0.924	0.93
146_G	170_M	0.918	0.93
198_L	222_I	0.917	0.93
58_F	102_V	0.905	0.92
68_Q	188_L	0.903	0.92
24_D	153_T	0.897	0.92
201_F	240_I	0.896	0.92
33_T	40_E	0.896	0.92
153_T	245_F	0.891	0.92
168_L	197_K	0.882	0.91
60_A	65_I	0.881	0.91
187_C	197_K	0.881	0.91
99_T	103_I	0.877	0.91
148_G	152_D	0.875	0.91
36_L	87_L	0.874	0.91
56_I	65_I	0.874	0.91
106_C	201_F	0.871	0.91
175_G	178_N	0.871	0.91
66_R	94_D	0.867	0.91
154_G	226_A	0.863	0.90
56_I	74_F	0.862	0.90
24_D	244_G	0.861	0.90
205_I	245_F	0.858	0.90
115_F	119_V	0.858	0.90
50_H	186_H	0.852	0.90
24_D	150_F	0.849	0.90
157_H	204_R	0.846	0.90
181_D	212_K	0.844	0.89
209_V	228_T	0.844	0.89
200_V	222_I	0.841	0.89
45_V	111_R	0.837	0.89
183_L	199_I	0.836	0.89
45_V	109_K	0.830	0.89
24_D	202_S	0.829	0.89
106_C	111_R	0.829	0.89
239_N	256_H	0.828	0.89
46_C	54_L	0.826	0.88
13_R	20_S	0.824	0.88
136_C	251_F	0.822	0.88
158_N	202_S	0.822	0.88
142_D	146_G	0.822	0.88
77_D	82_F	0.816	0.88
35_I	84_Y	0.815	0.88
13_R	22_V	0.811	0.88
135_A	139_L	0.806	0.87
34_V	85_V	0.804	0.87
161_L	183_L	0.801	0.87
127_S	196_D	0.799	0.87
129_I	220_I	0.797	0.87
68_Q	191_G	0.795	0.86
41_F	102_V	0.791	0.86
205_I	244_G	0.788	0.86
65_I	87_L	0.783	0.86
144_Q	151_Q	0.780	0.85
157_H	176_R	0.774	0.85
56_I	188_L	0.774	0.85
68_Q	189_L	0.773	0.85
150_F	252_N	0.772	0.85
37_N	92_T	0.771	0.85
39_S	99_T	0.768	0.85
200_V	246_V	0.767	0.84
76_I	80_L	0.765	0.84
205_I	231_A	0.764	0.84
154_G	250_S	0.759	0.84
14_Y	253_V	0.759	0.84
174_I	228_T	0.756	0.84
69_K	191_G	0.753	0.83
135_A	165_E	0.752	0.83
180_L	209_V	0.751	0.83
176_R	204_R	0.749	0.83
233_Q	236_E	0.744	0.83
155_G	245_F	0.742	0.82
131_I	222_I	0.742	0.82
205_I	210_L	0.742	0.82
61_S	103_I	0.741	0.82
111_R	147_S	0.740	0.82
31_P	108_G	0.735	0.82
220_I	259_R	0.733	0.82
125_A	128_Q	0.730	0.81
40_E	101_R	0.730	0.81
244_G	252_N	0.730	0.81
48_P	182_K	0.728	0.81
39_S	95_Q	0.724	0.81
36_L	41_F	0.723	0.81
180_L	206_S	0.720	0.81
150_F	155_G	0.720	0.81
102_V	106_C	0.718	0.80
120_K	215_K	0.716	0.80
93_L	96_K	0.708	0.79
149_T	156_V	0.703	0.79
15_E	18_E	0.701	0.79
79_S	255_T	0.699	0.79
110_G	147_S	0.699	0.79
161_L	218_V	0.698	0.78
30_F	81_G	0.692	0.78
159_A	199_I	0.691	0.78
154_G	202_S	0.683	0.77
152_D	168_L	0.681	0.77
153_T	156_V	0.677	0.76
201_F	205_I	0.677	0.76
135_A	162_C	0.672	0.76
199_I	216_I	0.669	0.75
187_C	192_M	0.669	0.75
150_F	154_G	0.669	0.75
154_G	244_G	0.668	0.75
125_A	240_I	0.663	0.75
33_T	43_T	0.662	0.75
145_Q	151_Q	0.659	0.74
174_I	210_L	0.657	0.74
171_R	223_S	0.657	0.74
180_L	183_L	0.655	0.74
19_I	251_F	0.651	0.73
211_L	234_M	0.650	0.73
32_L	83_V	0.648	0.73
141_K	144_Q	0.648	0.73
202_S	252_N	0.647	0.73
243_I	251_F	0.645	0.73
45_V	106_C	0.644	0.73
109_K	118_D	0.644	0.73
213_A	218_V	0.638	0.72
88_V	91_E	0.637	0.72
219_S	239_N	0.635	0.72
153_T	226_A	0.633	0.71
61_S	215_K	0.631	0.71
21_K	134_E	0.629	0.71
41_F	64_V	0.628	0.71
53_E	169_L	0.626	0.71
234_M	237_E	0.624	0.70
157_H	177_H	0.621	0.70
63_G	215_K	0.616	0.69
101_R	112_H	0.615	0.69
143_M	155_G	0.611	0.69
45_V	147_S	0.610	0.69
158_N	172_T	0.607	0.68
58_F	61_S	0.607	0.68
180_L	213_A	0.606	0.68
129_I	196_D	0.606	0.68
45_V	107_C	0.604	0.68
148_G	151_Q	0.603	0.68
157_H	175_G	0.601	0.67
140_M	222_I	0.601	0.67
177_H	204_R	0.599	0.67
199_I	221_V	0.598	0.67
124_T	127_S	0.595	0.67
129_I	164_T	0.594	0.67
127_S	219_S	0.593	0.66
42_V	61_S	0.588	0.66
56_I	85_V	0.588	0.66
150_F	226_A	0.585	0.65
149_T	155_G	0.585	0.65
39_S	96_K	0.585	0.65
155_G	187_C	0.584	0.65
39_S	92_T	0.578	0.64
111_R	231_A	0.577	0.64
161_L	202_S	0.575	0.64
31_P	45_V	0.574	0.64
58_F	159_A	0.573	0.64
160_A	163_D	0.573	0.64
98_Y	232_I	0.573	0.64
107_C	110_G	0.572	0.64
17_G	20_S	0.572	0.64
202_S	245_F	0.571	0.64
56_I	190_N	0.570	0.63
89_H	93_L	0.570	0.63
246_V	251_F	0.569	0.63
99_T	113_F	0.569	0.63
100_K	110_G	0.567	0.63
16_Q	23_E	0.566	0.63
68_Q	71_I	0.565	0.63
107_C	177_H	0.565	0.63
141_K	248_N	0.564	0.63
187_C	202_S	0.564	0.63
226_A	230_L	0.563	0.62
169_L	187_C	0.563	0.62
45_V	108_G	0.563	0.62
150_F	224_K	0.562	0.62
207_S	231_A	0.561	0.62
149_T	153_T	0.559	0.62
33_T	113_F	0.559	0.62
239_N	255_T	0.558	0.62
128_Q	195_R	0.557	0.62
63_G	213_A	0.556	0.61
125_A	195_R	0.556	0.61
58_F	109_K	0.556	0.61
142_D	165_E	0.555	0.61
201_F	232_I	0.554	0.61
29_E	175_G	0.552	0.61
14_Y	221_V	0.552	0.61
202_S	224_K	0.550	0.61
112_H	120_K	0.549	0.61
44_L	51_I	0.548	0.60
150_F	178_N	0.547	0.60
67_F	191_G	0.546	0.60
178_N	219_S	0.545	0.60
163_D	192_M	0.544	0.60
34_V	44_L	0.544	0.60
24_D	205_I	0.539	0.59
59_L	65_I	0.537	0.59
102_V	112_H	0.537	0.59
21_K	74_F	0.533	0.58
118_D	207_S	0.533	0.58
125_A	260_I	0.532	0.58
103_I	112_H	0.532	0.58
61_S	184_Y	0.529	0.58
172_T	242_A	0.527	0.57
59_L	203_G	0.527	0.57
143_M	200_V	0.527	0.57
63_G	232_I	0.527	0.57
15_E	249_G	0.526	0.57
230_L	234_M	0.523	0.57
48_P	230_L	0.523	0.57
106_C	112_H	0.522	0.57
107_C	175_G	0.521	0.57
62_E	107_C	0.517	0.56
72_K	161_L	0.516	0.56
187_C	191_G	0.515	0.56
194_V	197_K	0.513	0.55
110_G	158_N	0.513	0.55
109_K	147_S	0.511	0.55
205_I	221_V	0.509	0.55
126_V	129_I	0.508	0.55
148_G	240_I	0.507	0.55
45_V	229_E	0.507	0.55
169_L	192_M	0.506	0.54
162_C	200_V	0.505	0.54
111_R	175_G	0.505	0.54
40_E	113_F	0.504	0.54
43_T	207_S	0.503	0.54
16_Q	151_Q	0.503	0.54
141_K	249_G	0.502	0.54
48_P	159_A	0.502	0.54
80_L	83_V	0.502	0.54
44_L	104_G	0.501	0.54
48_P	227_P	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pdeA	2	0.9122	100	0.089	Contact Map
2pw9A	2	0.8931	100	0.121	Contact Map
2yv2A	1	0.5	31.6	0.961	Contact Map
1oi7A	1	0.5038	31.2	0.961	Contact Map
1assA	2	0.313	29.9	0.962	Contact Map
2fp4A	1	0.5344	28.7	0.962	Contact Map
3mtjA	3	0.5344	27.8	0.962	Contact Map
3i23A	2	0.5076	26.8	0.963	Contact Map
3ec7A	6	0.4924	24.8	0.963	Contact Map
2duwA	1	0.4733	24.3	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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