GREMLIN Database
FDHD - Protein FdhD homolog
UniProt: P39756 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (248)
Sequences: 2278 (1575)
Seq/√Len: 100.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_M232_I4.0441.00
36_L59_L3.8881.00
53_E189_L3.8471.00
214_A240_I3.4031.00
53_E171_R3.3991.00
222_I246_V3.3261.00
163_D166_K3.2841.00
56_I71_I3.2601.00
199_I213_A2.9651.00
184_Y216_I2.8411.00
50_H53_E2.5811.00
44_L54_L2.4971.00
65_I71_I2.4891.00
169_L186_H2.4741.00
55_V83_V2.4671.00
243_I246_V2.4601.00
186_H190_N2.4321.00
214_A238_L2.4101.00
60_A188_L2.3591.00
201_F221_V2.3401.00
201_F209_V2.2831.00
236_E256_H2.0941.00
169_L183_L2.0301.00
56_I189_L1.9571.00
187_C194_V1.9281.00
162_C167_L1.8831.00
32_L46_C1.8411.00
226_A245_F1.8381.00
67_F70_E1.7901.00
161_L187_C1.7781.00
24_D252_N1.7731.00
171_R186_H1.7661.00
71_I85_V1.7541.00
72_K86_D1.7301.00
221_V240_I1.7061.00
220_I241_T1.7051.00
131_I198_L1.7021.00
184_Y218_V1.6721.00
139_L198_L1.6701.00
138_A142_D1.6641.00
243_I253_V1.6281.00
72_K88_V1.6261.00
24_D245_F1.6041.00
180_L199_I1.5961.00
193_S196_D1.5841.00
161_L197_K1.5831.00
34_V55_V1.5811.00
74_F85_V1.5691.00
229_E233_Q1.5651.00
119_V237_E1.5601.00
236_E255_T1.5551.00
55_V85_V1.5541.00
136_C222_I1.5531.00
60_A184_Y1.5461.00
52_E189_L1.5131.00
27_V156_V1.4991.00
198_L220_I1.4801.00
91_E94_D1.4761.00
199_I218_V1.4651.00
66_R70_E1.4531.00
154_G254_Y1.4421.00
159_A201_F1.4361.00
245_F254_Y1.4341.00
35_I82_F1.4301.00
50_H171_R1.4301.00
131_I220_I1.3830.99
52_E74_F1.3830.99
209_V221_V1.3630.99
162_C198_L1.3580.99
32_L51_I1.3420.99
14_Y251_F1.3420.99
154_G245_F1.3350.99
205_I223_S1.3330.99
140_M246_V1.3310.99
160_A167_L1.3280.99
233_Q237_E1.3100.99
132_S135_A1.3060.99
14_Y19_I1.2820.99
137_L249_G1.2610.99
46_C51_I1.2580.99
24_D254_Y1.2490.99
136_C246_V1.2420.99
59_L85_V1.2410.99
146_G167_L1.2340.99
240_I256_H1.2310.99
53_E186_H1.2270.99
135_A138_A1.2240.99
38_G84_Y1.2200.99
28_T229_E1.2080.99
232_I242_A1.2060.99
24_D154_G1.2030.99
70_E91_E1.1960.98
103_I106_C1.1880.98
159_A179_A1.1830.98
163_D168_L1.1740.98
73_R86_D1.1610.98
79_S82_F1.1450.98
210_L221_V1.1450.98
71_I74_F1.1410.98
25_R152_D1.1320.98
207_S211_L1.1150.98
70_E88_V1.0990.97
159_A180_L1.0920.97
133_P251_F1.0750.97
148_G170_M1.0720.97
72_K89_H1.0710.97
42_V58_F1.0680.97
150_F245_F1.0600.97
16_Q249_G1.0510.97
56_I68_Q1.0380.96
245_F252_N1.0350.96
253_V260_I1.0330.96
243_I260_I1.0280.96
142_D166_K1.0260.96
201_F223_S1.0250.96
77_D80_L1.0240.96
223_S244_G1.0230.96
244_G254_Y1.0200.96
76_I83_V1.0140.96
167_L170_M1.0130.96
235_A242_A1.0060.96
142_D145_Q1.0040.96
180_L201_F1.0010.95
241_T259_R0.9910.95
31_P43_T0.9760.95
37_N87_L0.9740.95
147_S158_N0.9620.94
210_L240_I0.9610.94
15_E250_S0.9590.94
65_I74_F0.9570.94
27_V149_T0.9500.94
52_E83_V0.9490.94
160_A200_V0.9480.94
136_C243_I0.9460.94
52_E76_I0.9450.94
143_M202_S0.9320.93
32_L55_V0.9280.93
65_I188_L0.9250.93
36_L85_V0.9240.93
146_G170_M0.9180.93
198_L222_I0.9170.93
58_F102_V0.9050.92
68_Q188_L0.9030.92
24_D153_T0.8970.92
201_F240_I0.8960.92
33_T40_E0.8960.92
153_T245_F0.8910.92
168_L197_K0.8820.91
60_A65_I0.8810.91
187_C197_K0.8810.91
99_T103_I0.8770.91
148_G152_D0.8750.91
36_L87_L0.8740.91
56_I65_I0.8740.91
106_C201_F0.8710.91
175_G178_N0.8710.91
66_R94_D0.8670.91
154_G226_A0.8630.90
56_I74_F0.8620.90
24_D244_G0.8610.90
205_I245_F0.8580.90
115_F119_V0.8580.90
50_H186_H0.8520.90
24_D150_F0.8490.90
157_H204_R0.8460.90
181_D212_K0.8440.89
209_V228_T0.8440.89
200_V222_I0.8410.89
45_V111_R0.8370.89
183_L199_I0.8360.89
45_V109_K0.8300.89
24_D202_S0.8290.89
106_C111_R0.8290.89
239_N256_H0.8280.89
46_C54_L0.8260.88
13_R20_S0.8240.88
136_C251_F0.8220.88
158_N202_S0.8220.88
142_D146_G0.8220.88
77_D82_F0.8160.88
35_I84_Y0.8150.88
13_R22_V0.8110.88
135_A139_L0.8060.87
34_V85_V0.8040.87
161_L183_L0.8010.87
127_S196_D0.7990.87
129_I220_I0.7970.87
68_Q191_G0.7950.86
41_F102_V0.7910.86
205_I244_G0.7880.86
65_I87_L0.7830.86
144_Q151_Q0.7800.85
157_H176_R0.7740.85
56_I188_L0.7740.85
68_Q189_L0.7730.85
150_F252_N0.7720.85
37_N92_T0.7710.85
39_S99_T0.7680.85
200_V246_V0.7670.84
76_I80_L0.7650.84
205_I231_A0.7640.84
154_G250_S0.7590.84
14_Y253_V0.7590.84
174_I228_T0.7560.84
69_K191_G0.7530.83
135_A165_E0.7520.83
180_L209_V0.7510.83
176_R204_R0.7490.83
233_Q236_E0.7440.83
155_G245_F0.7420.82
131_I222_I0.7420.82
205_I210_L0.7420.82
61_S103_I0.7410.82
111_R147_S0.7400.82
31_P108_G0.7350.82
220_I259_R0.7330.82
125_A128_Q0.7300.81
40_E101_R0.7300.81
244_G252_N0.7300.81
48_P182_K0.7280.81
39_S95_Q0.7240.81
36_L41_F0.7230.81
180_L206_S0.7200.81
150_F155_G0.7200.81
102_V106_C0.7180.80
120_K215_K0.7160.80
93_L96_K0.7080.79
149_T156_V0.7030.79
15_E18_E0.7010.79
79_S255_T0.6990.79
110_G147_S0.6990.79
161_L218_V0.6980.78
30_F81_G0.6920.78
159_A199_I0.6910.78
154_G202_S0.6830.77
152_D168_L0.6810.77
153_T156_V0.6770.76
201_F205_I0.6770.76
135_A162_C0.6720.76
199_I216_I0.6690.75
187_C192_M0.6690.75
150_F154_G0.6690.75
154_G244_G0.6680.75
125_A240_I0.6630.75
33_T43_T0.6620.75
145_Q151_Q0.6590.74
174_I210_L0.6570.74
171_R223_S0.6570.74
180_L183_L0.6550.74
19_I251_F0.6510.73
211_L234_M0.6500.73
32_L83_V0.6480.73
141_K144_Q0.6480.73
202_S252_N0.6470.73
243_I251_F0.6450.73
45_V106_C0.6440.73
109_K118_D0.6440.73
213_A218_V0.6380.72
88_V91_E0.6370.72
219_S239_N0.6350.72
153_T226_A0.6330.71
61_S215_K0.6310.71
21_K134_E0.6290.71
41_F64_V0.6280.71
53_E169_L0.6260.71
234_M237_E0.6240.70
157_H177_H0.6210.70
63_G215_K0.6160.69
101_R112_H0.6150.69
143_M155_G0.6110.69
45_V147_S0.6100.69
158_N172_T0.6070.68
58_F61_S0.6070.68
180_L213_A0.6060.68
129_I196_D0.6060.68
45_V107_C0.6040.68
148_G151_Q0.6030.68
157_H175_G0.6010.67
140_M222_I0.6010.67
177_H204_R0.5990.67
199_I221_V0.5980.67
124_T127_S0.5950.67
129_I164_T0.5940.67
127_S219_S0.5930.66
42_V61_S0.5880.66
56_I85_V0.5880.66
150_F226_A0.5850.65
149_T155_G0.5850.65
39_S96_K0.5850.65
155_G187_C0.5840.65
39_S92_T0.5780.64
111_R231_A0.5770.64
161_L202_S0.5750.64
31_P45_V0.5740.64
58_F159_A0.5730.64
160_A163_D0.5730.64
98_Y232_I0.5730.64
107_C110_G0.5720.64
17_G20_S0.5720.64
202_S245_F0.5710.64
56_I190_N0.5700.63
89_H93_L0.5700.63
246_V251_F0.5690.63
99_T113_F0.5690.63
100_K110_G0.5670.63
16_Q23_E0.5660.63
68_Q71_I0.5650.63
107_C177_H0.5650.63
141_K248_N0.5640.63
187_C202_S0.5640.63
226_A230_L0.5630.62
169_L187_C0.5630.62
45_V108_G0.5630.62
150_F224_K0.5620.62
207_S231_A0.5610.62
149_T153_T0.5590.62
33_T113_F0.5590.62
239_N255_T0.5580.62
128_Q195_R0.5570.62
63_G213_A0.5560.61
125_A195_R0.5560.61
58_F109_K0.5560.61
142_D165_E0.5550.61
201_F232_I0.5540.61
29_E175_G0.5520.61
14_Y221_V0.5520.61
202_S224_K0.5500.61
112_H120_K0.5490.61
44_L51_I0.5480.60
150_F178_N0.5470.60
67_F191_G0.5460.60
178_N219_S0.5450.60
163_D192_M0.5440.60
34_V44_L0.5440.60
24_D205_I0.5390.59
59_L65_I0.5370.59
102_V112_H0.5370.59
21_K74_F0.5330.58
118_D207_S0.5330.58
125_A260_I0.5320.58
103_I112_H0.5320.58
61_S184_Y0.5290.58
172_T242_A0.5270.57
59_L203_G0.5270.57
143_M200_V0.5270.57
63_G232_I0.5270.57
15_E249_G0.5260.57
230_L234_M0.5230.57
48_P230_L0.5230.57
106_C112_H0.5220.57
107_C175_G0.5210.57
62_E107_C0.5170.56
72_K161_L0.5160.56
187_C191_G0.5150.56
194_V197_K0.5130.55
110_G158_N0.5130.55
109_K147_S0.5110.55
205_I221_V0.5090.55
126_V129_I0.5080.55
148_G240_I0.5070.55
45_V229_E0.5070.55
169_L192_M0.5060.54
162_C200_V0.5050.54
111_R175_G0.5050.54
40_E113_F0.5040.54
43_T207_S0.5030.54
16_Q151_Q0.5030.54
141_K249_G0.5020.54
48_P159_A0.5020.54
80_L83_V0.5020.54
44_L104_G0.5010.54
48_P227_P0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pdeA 2 0.9122 100 0.089 Contact Map
2pw9A 2 0.8931 100 0.121 Contact Map
2yv2A 1 0.5 31.6 0.961 Contact Map
1oi7A 1 0.5038 31.2 0.961 Contact Map
1assA 2 0.313 29.9 0.962 Contact Map
2fp4A 1 0.5344 28.7 0.962 Contact Map
3mtjA 3 0.5344 27.8 0.962 Contact Map
3i23A 2 0.5076 26.8 0.963 Contact Map
3ec7A 6 0.4924 24.8 0.963 Contact Map
2duwA 1 0.4733 24.3 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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