GREMLIN Database
NDHF - Probable NADH-quinone oxidoreductase subunit 5
UniProt: P39755 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 505 (444)
Sequences: 20234 (12575)
Seq/√Len: 596.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D255_R4.9661.00
118_M131_F4.5301.00
330_T368_G4.4901.00
185_Q188_L4.0241.00
78_T121_L3.7391.00
144_R156_A3.7231.00
158_I229_E3.2861.00
323_L378_D3.2641.00
289_D347_R3.1621.00
320_H382_L3.1051.00
85_G113_T3.1041.00
183_Q188_L3.0931.00
277_V414_T2.9741.00
288_V350_E2.6851.00
81_V120_W2.6641.00
294_L335_A2.6231.00
346_T351_R2.6131.00
273_A310_A2.6091.00
115_A134_A2.5871.00
173_A209_L2.5251.00
78_T117_S2.5111.00
366_V426_I2.4731.00
220_Q306_L2.4621.00
18_L114_G2.4111.00
452_V456_L2.3861.00
462_L466_V2.3801.00
348_T351_R2.3291.00
92_S105_Y2.2961.00
285_L420_A2.2301.00
69_H123_G2.2261.00
293_Q349_N2.1761.00
82_L117_S2.1421.00
451_I455_L2.0331.00
307_I411_A2.0181.00
246_V298_T1.9731.00
451_I454_C1.9551.00
308_Q386_L1.9441.00
359_A362_I1.9201.00
278_L414_T1.9071.00
14_F17_M1.8911.00
459_G463_G1.8821.00
188_L191_T1.8741.00
215_I220_Q1.8701.00
267_I271_L1.8651.00
297_S421_L1.8411.00
281_T300_G1.8181.00
71_D74_A1.7981.00
31_P34_P1.7961.00
460_S464_T1.7701.00
290_Y425_I1.7661.00
288_V348_T1.7591.00
447_S451_I1.7511.00
319_I382_L1.7361.00
270_L310_A1.7331.00
316_A389_G1.7211.00
48_P52_S1.7211.00
387_I411_A1.7091.00
465_W468_R1.7001.00
151_V232_V1.6951.00
219_A227_L1.6951.00
454_C458_F1.6881.00
80_F325_G1.6861.00
424_F428_H1.6811.00
464_T468_R1.6811.00
176_W206_I1.6791.00
128_M252_I1.6611.00
125_L189_V1.6591.00
211_V215_I1.6411.00
405_G409_R1.6351.00
287_Q292_R1.6271.00
125_L256_F1.6271.00
20_A42_I1.6161.00
274_S410_I1.6121.00
456_L459_G1.5921.00
41_H45_L1.5911.00
101_S104_K1.5701.00
123_G187_S1.5651.00
76_L322_I1.5551.00
254_T309_C1.5511.00
446_M449_V1.5481.00
180_A206_I1.5411.00
122_S127_L1.5341.00
74_A251_I1.5161.00
264_I267_I1.5131.00
456_L460_S1.5121.00
269_L310_A1.5051.00
108_L141_L1.4811.00
220_Q272_L1.4721.00
221_W275_I1.4701.00
188_L192_N1.4641.00
35_L39_R1.4631.00
365_L368_G1.4461.00
214_V252_I1.4451.00
459_G464_T1.4441.00
89_Q106_F1.4391.00
309_C317_A1.4311.00
281_T414_T1.4271.00
390_W408_G1.4181.00
311_L390_W1.4111.00
43_G47_L1.3991.00
69_H72_S1.3971.00
201_W205_G1.3871.00
89_Q109_F1.3801.00
270_L407_I1.3701.00
388_L392_L1.3701.00
211_V269_L1.3691.00
34_P37_F1.3631.00
124_D184_W1.3611.00
25_G28_F1.3611.00
253_L306_L1.3601.00
14_F114_G1.3581.00
305_M317_A1.3521.00
446_M451_I1.3501.00
460_S463_G1.3501.00
449_V453_V1.3401.00
128_M186_L1.3341.00
178_F184_W1.3301.00
173_A213_A1.3281.00
142_L237_V1.3261.00
449_V452_V1.3181.00
455_L459_G1.3101.00
46_A49_L1.3091.00
441_S444_P1.3081.00
124_D185_Q1.3061.00
457_L461_A1.3051.00
76_L318_I1.2981.00
365_L425_I1.2971.00
242_H246_V1.2941.00
91_F333_L1.2941.00
254_T317_A1.2911.00
448_A451_I1.2881.00
175_M179_H1.2871.00
38_V42_I1.2771.00
229_E292_R1.2771.00
149_W152_A1.2771.00
162_L225_R1.2731.00
47_L51_V1.2701.00
155_A232_V1.2671.00
308_Q313_A1.2641.00
459_G462_L1.2621.00
462_L465_W1.2621.00
266_S270_L1.2591.00
327_F370_A1.2551.00
67_P123_G1.2541.00
84_I325_G1.2491.00
459_G466_V1.2491.00
446_M450_M1.2411.00
173_A210_I1.2401.00
448_A452_V1.2311.00
173_A206_I1.2311.00
308_Q317_A1.2241.00
313_A389_G1.2141.00
84_I329_A1.2141.00
44_I48_P1.2091.00
363_L366_V1.2031.00
307_I390_W1.1991.00
70_L121_L1.1991.00
170_L213_A1.1971.00
463_G466_V1.1911.00
174_M210_I1.1801.00
391_S408_G1.1701.00
44_I86_F1.1661.00
50_L82_L1.1631.00
458_F462_L1.1611.00
119_T248_A1.1601.00
126_R184_W1.1551.00
176_W202_E1.1531.00
215_I272_L1.1511.00
331_L368_G1.1471.00
273_A303_G1.1451.00
129_V171_F1.1411.00
258_P261_H1.1381.00
36_S40_I1.1351.00
112_T116_A1.1321.00
154_E158_I1.1311.00
12_T16_I1.1311.00
339_V347_R1.1281.00
149_W232_V1.1241.00
316_A385_A1.1141.00
243_A247_N1.1081.00
349_N429_L1.1071.00
271_L275_I1.1031.00
35_L38_V1.0981.00
77_M321_L1.0971.00
279_I283_I1.0941.00
300_G418_G1.0941.00
451_I459_G1.0881.00
247_N251_I1.0871.00
15_F18_L1.0801.00
324_H328_K1.0781.00
123_G185_Q1.0771.00
11_L14_F1.0761.00
366_V430_F1.0721.00
29_L32_R1.0711.00
82_L86_F1.0681.00
28_F31_P1.0651.00
74_A255_R1.0581.00
42_I46_A1.0571.00
406_R409_R1.0551.00
125_L174_M1.0531.00
47_L83_A1.0521.00
34_P39_R1.0511.00
166_S216_I1.0451.00
323_L382_L1.0451.00
371_F422_V1.0451.00
73_L254_T1.0391.00
16_I20_A1.0351.00
451_I456_L1.0351.00
187_S191_T1.0291.00
180_A202_E1.0251.00
33_V36_S1.0251.00
81_V113_T1.0251.00
32_R36_S1.0181.00
451_I464_T1.0121.00
211_V253_L1.0091.00
445_P448_A1.0091.00
418_G421_L1.0041.00
170_L174_M1.0041.00
231_I242_H1.0011.00
216_I223_F1.0011.00
228_V296_G0.9961.00
453_V457_L0.9961.00
456_L464_T0.9931.00
369_V374_T0.9891.00
21_S25_G0.9881.00
385_A388_L0.9841.00
273_A307_I0.9831.00
362_I444_P0.9811.00
280_G303_G0.9781.00
326_L458_F0.9771.00
91_F336_G0.9751.00
84_I243_A0.9711.00
146_N149_W0.9681.00
110_T114_G0.9671.00
43_G46_A0.9671.00
178_F181_T0.9671.00
70_L75_C0.9661.00
83_A87_I0.9661.00
231_I246_V0.9661.00
181_T189_V0.9651.00
334_Q365_L0.9631.00
221_W279_I0.9621.00
206_I210_I0.9561.00
17_M20_A0.9551.00
452_V459_G0.9541.00
445_P451_I0.9521.00
239_A333_L0.9461.00
143_I230_S0.9461.00
204_T265_A0.9451.00
86_F90_R0.9441.00
139_L245_L0.9431.00
301_Q320_H0.9431.00
409_R413_L0.9371.00
45_L49_L0.9361.00
109_F240_I0.9321.00
450_M454_C0.9291.00
422_V425_I0.9251.00
55_I58_N0.9251.00
462_L469_H0.9221.00
35_L50_L0.9181.00
73_L318_I0.9151.00
282_G417_G0.9131.00
47_L50_L0.9131.00
301_Q421_L0.9121.00
452_V460_S0.9101.00
353_S435_H0.9101.00
153_S156_A0.9091.00
308_Q316_A0.9091.00
301_Q418_G0.9071.00
177_L206_I0.9041.00
290_Y335_A0.9031.00
36_S43_G0.9021.00
36_S39_R0.9021.00
246_V251_I0.9011.00
199_G203_R0.9001.00
281_T421_L0.8991.00
319_I323_L0.8971.00
361_R364_S0.8961.00
26_L29_L0.8941.00
111_F138_G0.8941.00
456_L463_G0.8941.00
183_Q186_L0.8931.00
298_T324_H0.8931.00
68_W121_L0.8921.00
267_I270_L0.8901.00
38_V49_L0.8881.00
36_S48_P0.8871.00
201_W204_T0.8771.00
150_Q154_E0.8761.00
235_T291_K0.8761.00
169_S212_L0.8751.00
394_V404_E0.8751.00
19_M23_I0.8731.00
274_S407_I0.8701.00
289_D348_T0.8681.00
238_S242_H0.8681.00
338_A355_L0.8671.00
363_L367_I0.8671.00
461_A464_T0.8641.00
183_Q189_V0.8641.00
218_A250_G0.8631.00
39_R46_A0.8591.00
364_S368_G0.8571.00
242_H298_T0.8561.00
250_G305_M0.8561.00
129_V133_G0.8551.00
85_G109_F0.8541.00
204_T264_I0.8531.00
270_L273_A0.8531.00
42_I45_L0.8521.00
281_T417_G0.8521.00
305_M321_L0.8521.00
164_L167_W0.8511.00
320_H327_F0.8501.00
365_L430_F0.8491.00
284_S421_L0.8481.00
74_A78_T0.8471.00
49_L52_S0.8471.00
152_A232_V0.8461.00
384_S388_L0.8431.00
115_A138_G0.8401.00
36_S50_L0.8391.00
41_H48_P0.8381.00
353_S428_H0.8381.00
112_T139_L0.8381.00
39_R50_L0.8381.00
176_W180_A0.8381.00
447_S462_L0.8371.00
34_P42_I0.8321.00
197_G200_E0.8321.00
414_T417_G0.8311.00
208_L212_L0.8311.00
387_I408_G0.8311.00
337_S362_I0.8301.00
14_F29_L0.8241.00
94_R97_M0.8201.00
304_F386_L0.8191.00
115_A131_F0.8171.00
186_L190_V0.8151.00
14_F26_L0.8131.00
22_G25_G0.8121.00
64_N126_R0.8121.00
234_P242_H0.8101.00
34_P38_V0.8041.00
129_V174_M0.8031.00
290_Y352_T0.8011.00
353_S432_K0.8011.00
46_A50_L0.8001.00
39_R42_I0.8001.00
117_S121_L0.7991.00
349_N428_H0.7981.00
246_V250_G0.7971.00
277_V303_G0.7951.00
79_F83_A0.7941.00
204_T208_L0.7931.00
28_F103_R0.7931.00
30_H33_V0.7931.00
169_S209_L0.7921.00
45_L48_P0.7921.00
55_I65_V0.7891.00
426_I431_Y0.7871.00
205_G209_L0.7861.00
275_I279_I0.7831.00
253_L309_C0.7831.00
461_A465_W0.7831.00
281_T297_S0.7801.00
32_R37_F0.7801.00
132_W170_L0.7781.00
36_S41_H0.7771.00
293_Q425_I0.7761.00
370_A377_G0.7761.00
373_L383_I0.7761.00
238_S246_V0.7741.00
140_T156_A0.7721.00
280_G283_I0.7721.00
363_L430_F0.7711.00
327_F379_G0.7711.00
177_L189_V0.7711.00
36_S46_A0.7701.00
67_P185_Q0.7691.00
80_F322_I0.7671.00
47_L82_L0.7671.00
88_I333_L0.7671.00
39_R43_G0.7661.00
58_N63_G0.7661.00
13_L25_G0.7661.00
274_S307_I0.7621.00
29_L33_V0.7601.00
423_Y427_H0.7571.00
452_V463_G0.7561.00
37_F41_H0.7551.00
184_W188_L0.7551.00
280_G300_G0.7551.00
135_T245_L0.7541.00
273_A306_L0.7541.00
43_G49_L0.7531.00
452_V455_L0.7531.00
140_T163_F0.7531.00
437_T440_Q0.7521.00
357_V360_G0.7521.00
367_I456_L0.7511.00
294_L331_L0.7501.00
311_L393_S0.7491.00
455_L464_T0.7491.00
49_L53_L0.7491.00
419_A423_Y0.7461.00
116_A135_T0.7451.00
42_I49_L0.7401.00
81_V116_A0.7381.00
200_E204_T0.7351.00
27_L30_H0.7351.00
277_V307_I0.7341.00
452_V464_T0.7341.00
32_R35_L0.7331.00
287_Q296_G0.7321.00
17_M21_S0.7311.00
270_L274_S0.7291.00
251_I255_R0.7281.00
297_S324_H0.7281.00
346_T352_T0.7271.00
36_S47_L0.7271.00
304_F414_T0.7271.00
20_A24_S0.7261.00
358_M434_L0.7231.00
435_H438_I0.7211.00
46_A53_L0.7211.00
455_L458_F0.7201.00
416_L420_A0.7201.00
301_Q328_K0.7191.00
377_G381_H0.7161.00
36_S53_L0.7151.00
105_Y236_P0.7131.00
445_P452_V0.7131.00
35_L49_L0.7121.00
250_G306_L0.7121.00
238_S241_M0.7111.00
207_Q265_A0.7091.00
370_A379_G0.7091.00
270_L307_I0.7071.00
235_T336_G0.7071.00
394_V405_G0.7061.00
116_A245_L0.7061.00
393_S404_E0.7061.00
12_T15_F0.7041.00
250_G321_L0.7021.00
199_G202_E0.7001.00
254_T314_Y0.7001.00
451_I460_S0.6981.00
447_S455_L0.6971.00
124_D127_L0.6961.00
466_V469_H0.6941.00
30_H34_P0.6931.00
57_A60_G0.6931.00
40_I44_I0.6911.00
190_V258_P0.6891.00
200_E203_R0.6891.00
18_L22_G0.6871.00
103_R107_T0.6871.00
13_L17_M0.6851.00
34_P41_H0.6801.00
67_P124_D0.6751.00
123_G127_L0.6731.00
135_T248_A0.6731.00
69_H187_S0.6721.00
373_L377_G0.6701.00
268_I271_L0.6681.00
116_A244_G0.6671.00
18_L21_S0.6671.00
242_H324_H0.6671.00
70_L74_A0.6651.00
364_S456_L0.6651.00
231_I238_S0.6641.00
256_F259_L0.6631.00
40_I43_G0.6631.00
344_V352_T0.6601.00
33_V37_F0.6601.00
21_S111_F0.6601.00
12_T26_L0.6591.00
43_G50_L0.6581.00
372_W419_A0.6571.00
244_G247_N0.6551.00
448_A462_L0.6551.00
35_L42_I0.6551.00
73_L77_M0.6531.00
38_V46_A0.6521.00
387_I415_V0.6491.00
120_W251_I0.6491.00
36_S45_L0.6491.00
13_L16_I0.6481.00
37_F48_P0.6481.00
37_F45_L0.6441.00
278_L282_G0.6421.00
297_S301_Q0.6421.00
283_I296_G0.6391.00
14_F68_W0.6381.00
22_G26_L0.6381.00
273_A277_V0.6371.00
87_I454_C0.6351.00
84_I240_I0.6351.00
57_A65_V0.6311.00
102_Y106_F0.6301.00
35_L46_A0.6291.00
30_H35_L0.6271.00
15_F29_L0.6271.00
14_F121_L0.6261.00
177_L210_I0.6261.00
14_F22_G0.6261.00
11_L54_L0.6241.00
77_M251_I0.6231.00
42_I48_P0.6231.00
37_F46_A0.6221.00
11_L66_G0.6201.00
26_L30_H0.6201.00
41_H44_I0.6181.00
410_I414_T0.6171.00
313_A317_A0.6171.00
14_F28_F0.6171.00
75_C79_F0.6161.00
426_I430_F0.6161.00
125_L177_L0.6131.00
451_I462_L0.6121.00
334_Q364_S0.6111.00
297_S328_K0.6111.00
228_V299_I0.6101.00
231_I298_T0.6101.00
20_A25_G0.6081.00
38_V48_P0.6081.00
189_V192_N0.6081.00
157_K161_R0.6071.00
171_F175_M0.6061.00
281_T418_G0.6041.00
151_V154_E0.6021.00
451_I463_G0.6021.00
205_G208_L0.6011.00
20_A23_I0.6011.00
82_L113_T0.6001.00
79_F82_L0.6001.00
225_R228_V0.5991.00
35_L45_L0.5971.00
445_P449_V0.5961.00
112_T240_I0.5961.00
129_V167_W0.5961.00
367_I370_A0.5951.00
457_L460_S0.5951.00
235_T238_S0.5941.00
132_W248_A0.5921.00
232_V289_D0.5911.00
60_G63_G0.5901.00
278_L410_I0.5901.00
203_R206_I0.5881.00
37_F40_I0.5881.00
207_Q211_V0.5881.00
35_L52_S0.5871.00
461_A468_R0.5861.00
250_G302_M0.5861.00
363_L368_G0.5861.00
235_T242_H0.5851.00
373_L379_G0.5851.00
54_L57_A0.5841.00
81_V117_S0.5831.00
24_S28_F0.5821.00
88_I109_F0.5821.00
367_I460_S0.5781.00
112_T245_L0.5771.00
242_H328_K0.5761.00
50_L53_L0.5761.00
387_I412_G0.5751.00
287_Q293_Q0.5751.00
238_S324_H0.5751.00
456_L462_L0.5721.00
413_L417_G0.5721.00
17_M25_G0.5721.00
88_I239_A0.5701.00
234_P291_K0.5701.00
232_V292_R0.5701.00
21_S107_T0.5681.00
274_S278_L0.5671.00
334_Q452_V0.5641.00
207_Q260_F0.5631.00
209_L213_A0.5631.00
464_T467_A0.5621.00
301_Q304_F0.5621.00
25_G107_T0.5621.00
227_L246_V0.5611.00
133_G217_P0.5591.00
38_V50_L0.5591.00
277_V304_F0.5580.99
375_A380_Y0.5580.99
349_N425_I0.5570.99
14_F21_S0.5560.99
34_P48_P0.5550.99
88_I236_P0.5530.99
37_F49_L0.5510.99
327_F371_F0.5480.99
40_I46_A0.5480.99
105_Y237_V0.5470.99
343_E359_A0.5460.99
108_L138_G0.5450.99
166_S213_A0.5450.99
128_M170_L0.5450.99
15_F26_L0.5450.99
13_L30_H0.5450.99
13_L28_F0.5440.99
87_I329_A0.5440.99
25_G30_H0.5430.99
38_V41_H0.5430.99
15_F30_H0.5430.99
227_L230_S0.5420.99
143_I241_M0.5400.99
125_L186_L0.5390.99
356_W430_F0.5390.99
455_L462_L0.5390.99
58_N61_V0.5370.99
436_T439_F0.5370.99
38_V45_L0.5370.99
383_I415_V0.5360.99
463_G468_R0.5330.99
85_G240_I0.5330.99
290_Y429_L0.5320.99
111_F115_A0.5320.99
36_S42_I0.5320.99
95_Y236_P0.5320.99
234_P237_V0.5320.99
324_H332_F0.5320.99
237_V242_H0.5290.99
237_V240_I0.5290.99
282_G286_V0.5290.99
243_A246_V0.5280.99
39_R45_L0.5270.99
454_C457_L0.5270.99
308_Q389_G0.5270.99
29_L34_P0.5260.99
320_H323_L0.5260.99
176_W205_G0.5260.99
242_H251_I0.5250.99
139_L143_I0.5240.99
15_F19_M0.5240.99
247_N302_M0.5220.99
162_L216_I0.5200.99
242_H247_N0.5180.99
319_I385_A0.5180.99
372_W377_G0.5170.99
456_L466_V0.5170.99
38_V53_L0.5160.99
31_P40_I0.5150.99
420_A424_F0.5150.99
211_V265_A0.5150.99
36_S44_I0.5150.99
104_K108_L0.5150.99
438_I442_V0.5140.99
202_E206_I0.5140.99
202_E205_G0.5140.99
70_L78_T0.5130.99
245_L248_A0.5120.99
264_I268_I0.5090.99
87_I451_I0.5090.99
21_S29_L0.5090.99
326_L378_D0.5090.99
454_C459_G0.5070.99
263_G266_S0.5040.99
368_G456_L0.5030.99
42_I52_S0.5030.99
220_Q223_F0.5020.99
42_I47_L0.5010.99
352_T429_L0.5000.99
448_A455_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoL 1 0.9644 100 0.259 Contact Map
4he8L 1 0.9644 100 0.267 Contact Map
3rkoM 1 0.9168 100 0.268 Contact Map
3rkoN 1 0.903 100 0.278 Contact Map
4he8M 1 0.8752 100 0.311 Contact Map
4he8N 1 0.8376 100 0.342 Contact Map
4he8K 1 0.1842 46.4 0.963 Contact Map
3rkoK 1 0.1921 39.4 0.965 Contact Map
4he8J 1 0.297 15.4 0.971 Contact Map
3e4oA 2 0.0594 3.7 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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