GREMLIN Database
FLHP - Flagellar hook-basal body complex protein FlhP
UniProt: P39753 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (245)
Sequences: 5618 (4206)
Seq/√Len: 268.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_Y122_L3.5791.00
97_I163_I3.2791.00
164_N168_T3.2081.00
125_T135_Q3.1261.00
196_E202_S3.0421.00
116_Y187_V3.0131.00
88_I226_S2.9261.00
171_A179_R2.9251.00
213_N220_I2.7751.00
88_I98_A2.7281.00
138_T142_Y2.7161.00
106_L185_V2.6381.00
135_Q143_P2.5381.00
102_P186_Q2.5211.00
194_K202_S2.3301.00
223_Q226_S2.2921.00
168_T178_Q2.2461.00
125_T133_Q2.2091.00
109_N115_Q2.1701.00
260_Q263_G2.1611.00
194_K204_D2.1571.00
109_N113_N2.1501.00
126_P133_Q2.0921.00
83_S104_Q2.0871.00
36_A237_Q2.0651.00
107_Q117_T2.0591.00
89_Q229_M2.0361.00
203_I209_F2.0091.00
37_K195_S1.9921.00
90_K226_S1.9701.00
185_V212_L1.9581.00
97_I222_M1.9301.00
18_Q244_S1.9091.00
125_T137_V1.8991.00
115_Q200_L1.8921.00
115_Q196_E1.8731.00
106_L114_R1.8691.00
4_S258_G1.8651.00
119_D199_N1.8431.00
141_G144_V1.8401.00
19_I241_L1.8011.00
18_Q240_D1.7881.00
22_I244_S1.7771.00
164_N170_T1.7751.00
189_N192_E1.7211.00
99_F184_V1.7171.00
253_R256_T1.7121.00
26_L234_I1.7011.00
163_I169_L1.6791.00
100_T223_Q1.6331.00
108_V145_L1.6201.00
107_Q138_T1.5951.00
19_I244_S1.5911.00
233_D236_E1.5491.00
95_L161_I1.5491.00
170_T178_Q1.5341.00
91_T96_D1.5241.00
236_E240_D1.5191.00
102_P190_P1.5111.00
32_T227_L1.5081.00
14_Q75_A1.4971.00
136_L144_V1.4971.00
240_D243_T1.4721.00
122_L144_V1.4701.00
168_T181_N1.4641.00
181_N214_G1.4601.00
87_S229_M1.4401.00
41_F45_V1.4311.00
135_Q153_N1.4221.00
97_I105_Y1.4121.00
15_L247_S1.4101.00
187_V203_I1.4071.00
21_T39_T1.3941.00
32_T119_D1.3791.00
22_I241_L1.3621.00
146_D150_N1.3571.00
97_I182_L1.3461.00
110_V142_Y1.3461.00
115_Q202_S1.3431.00
8_A254_T1.3321.00
81_L195_S1.3251.00
29_S234_I1.3231.00
158_M171_A1.3161.00
107_Q122_L1.3141.00
16_Q20_D1.3101.00
36_A236_E1.2831.00
186_Q220_I1.2671.00
109_N142_Y1.2651.00
141_G145_L1.2531.00
237_Q240_D1.2461.00
107_Q200_L1.2421.00
154_I158_M1.2221.00
256_T259_D1.2141.00
170_T176_A1.2111.00
113_N202_S1.1871.00
119_D139_G1.1821.00
32_T121_A1.1771.00
95_L136_L1.1751.00
17_Q77_M1.1711.00
147_E181_N1.1671.00
105_Y182_L1.1651.00
104_Q190_P1.1601.00
107_Q115_Q1.1401.00
97_I224_Q1.1391.00
146_D183_G1.1371.00
34_Y37_K1.1371.00
204_D207_A1.1371.00
83_S201_F1.1271.00
140_N198_N1.1221.00
207_A210_E1.1171.00
99_F221_G1.1111.00
36_A82_V1.1081.00
37_K81_L1.0921.00
38_D80_R1.0791.00
39_T77_M1.0731.00
106_L145_L1.0691.00
196_E200_L1.0651.00
11_T251_N1.0531.00
203_I207_A1.0441.00
152_V155_D1.0421.00
24_S34_Y1.0351.00
93_R96_D1.0301.00
70_R195_S1.0281.00
15_L18_Q1.0271.00
94_D160_N1.0211.00
192_E204_D1.0031.00
15_L244_S0.9971.00
195_S201_F0.9771.00
99_F103_Y0.9761.00
95_L124_V0.9731.00
155_D158_M0.9711.00
138_T144_V0.9711.00
48_Q51_Q0.9621.00
22_I237_Q0.9551.00
246_R249_Q0.9541.00
259_D262_L0.9351.00
142_Y200_L0.9321.00
187_V193_L0.9271.00
106_L183_G0.9251.00
116_Y210_E0.9211.00
98_A226_S0.9191.00
214_G217_R0.9121.00
74_G77_M0.9091.00
42_S76_M0.9041.00
172_S176_A0.8991.00
23_S254_T0.8961.00
136_L152_V0.8911.00
106_L212_L0.8871.00
146_D180_F0.8851.00
165_K223_Q0.8851.00
38_D82_V0.8841.00
93_R123_Y0.8781.00
18_Q22_I0.8741.00
152_V156_S0.8691.00
9_S12_L0.8681.00
41_F44_L0.8631.00
25_N237_Q0.8621.00
153_N156_S0.8491.00
121_A139_G0.8491.00
21_T34_Y0.8391.00
19_I261_M0.8370.99
262_L266_N0.8330.99
145_L151_T0.8300.99
151_T154_I0.8280.99
123_Y139_G0.8220.99
114_R183_G0.8200.99
154_I157_S0.8180.99
2_L262_L0.8140.99
43_E46_R0.8120.99
108_V143_P0.8110.99
184_V220_I0.8100.99
97_I122_L0.8020.99
96_D121_A0.8010.99
263_G267_S0.7990.99
108_V112_G0.7920.99
19_I245_Q0.7850.99
36_A231_N0.7840.99
156_S172_S0.7830.99
11_T15_L0.7810.99
8_A255_I0.7780.99
180_F183_G0.7770.99
155_D171_A0.7760.99
44_L48_Q0.7730.99
235_S238_M0.7650.99
18_Q243_T0.7650.99
144_V182_L0.7610.99
16_Q248_Y0.7590.99
12_L252_S0.7480.99
192_E208_A0.7400.99
3_R73_V0.7390.99
109_N112_G0.7360.99
258_G261_M0.7340.99
146_D152_V0.7340.99
114_R145_L0.7330.99
246_R259_D0.7250.99
238_M256_T0.7230.99
138_T200_L0.7230.99
256_T260_Q0.7210.98
107_Q142_Y0.7180.98
5_M255_I0.7150.98
186_Q190_P0.7140.98
99_F105_Y0.7130.98
140_N144_V0.7090.98
171_A175_N0.7050.98
108_V114_R0.7050.98
13_N233_D0.6990.98
149_G152_V0.6960.98
232_V237_Q0.6940.98
40_N80_R0.6920.98
125_T143_P0.6920.98
43_E72_G0.6910.98
32_T229_M0.6900.98
215_A222_M0.6900.98
105_Y120_G0.6830.98
125_T134_L0.6830.98
257_M260_Q0.6790.98
85_Q88_I0.6770.98
54_E72_G0.6760.98
5_M262_L0.6720.98
255_I259_D0.6710.98
88_I223_Q0.6680.98
4_S254_T0.6640.97
217_R221_G0.6610.97
187_V208_A0.6580.97
103_Y118_R0.6530.97
235_S243_T0.6530.97
4_S7_T0.6450.97
187_V210_E0.6430.97
248_Y252_S0.6400.97
156_S173_D0.6350.97
8_A251_N0.6350.97
2_L261_M0.6330.97
215_A220_I0.6310.97
42_S45_V0.6300.96
252_S261_M0.6300.96
143_P151_T0.6300.96
135_Q151_T0.6300.96
254_T258_G0.6280.96
6_L243_T0.6270.96
40_N44_L0.6260.96
85_Q100_T0.6260.96
85_Q101_S0.6260.96
25_N34_Y0.6240.96
12_L15_L0.6210.96
94_D224_Q0.6190.96
234_I249_Q0.6190.96
35_K86_G0.6170.96
264_L267_S0.6150.96
40_N79_S0.6120.96
10_T14_Q0.6110.96
33_G201_F0.6100.96
156_S178_Q0.6090.96
237_Q245_Q0.6090.96
38_D41_F0.6080.96
72_G75_A0.6080.96
99_F222_M0.6070.96
178_Q181_N0.6070.96
192_E206_A0.6070.96
17_Q21_T0.6060.96
173_D176_A0.6060.96
13_N236_E0.6050.96
34_Y38_D0.6040.96
213_N216_N0.6030.96
3_R20_D0.6030.96
243_T262_L0.6000.95
145_L183_G0.6000.95
166_N181_N0.5990.95
104_Q201_F0.5990.95
192_E207_A0.5980.95
106_L182_L0.5980.95
172_S175_N0.5970.95
161_I171_A0.5970.95
73_V76_M0.5950.95
173_D177_V0.5940.95
122_L136_L0.5920.95
183_G212_L0.5910.95
153_N175_N0.5870.95
215_A219_N0.5870.95
12_L255_I0.5870.95
188_N191_Q0.5870.95
121_A227_L0.5850.95
50_D53_D0.5810.95
9_S15_L0.5780.94
213_N217_R0.5750.94
117_T138_T0.5740.94
182_L222_M0.5730.94
14_Q41_F0.5720.94
45_V49_F0.5710.94
21_T77_M0.5710.94
169_L180_F0.5690.94
159_K172_S0.5680.94
99_F104_Q0.5660.94
184_V187_V0.5650.94
164_N178_Q0.5640.94
89_Q227_L0.5630.94
103_Y184_V0.5620.93
15_L239_T0.5610.93
32_T89_Q0.5600.93
249_Q253_R0.5600.93
49_F53_D0.5590.93
238_M264_L0.5570.93
180_F185_V0.5560.93
256_T263_G0.5560.93
102_P219_N0.5550.93
250_L254_T0.5550.93
245_Q252_S0.5550.93
249_Q256_T0.5550.93
211_E220_I0.5540.93
26_L237_Q0.5540.93
257_M261_M0.5500.93
196_E199_N0.5500.93
48_Q70_R0.5490.93
20_D24_S0.5480.93
217_R220_I0.5470.93
150_N153_N0.5450.92
2_L7_T0.5440.92
163_I224_Q0.5430.92
42_S78_S0.5400.92
83_S190_P0.5380.92
20_D73_V0.5350.92
216_N219_N0.5350.92
48_Q52_V0.5320.92
7_T12_L0.5320.92
206_A209_F0.5320.92
248_Y258_G0.5320.92
99_F122_L0.5280.91
49_F52_V0.5270.91
203_I208_A0.5250.91
97_I225_G0.5240.91
7_T20_D0.5240.91
13_N17_Q0.5240.91
5_M11_T0.5230.91
186_Q211_E0.5220.91
46_R72_G0.5210.91
146_D149_G0.5210.91
258_G265_I0.5210.91
142_Y145_L0.5200.91
35_K228_E0.5200.91
123_Y126_P0.5170.90
163_I182_L0.5170.90
108_V151_T0.5170.90
239_T243_T0.5160.90
176_A205_N0.5160.90
248_Y261_M0.5160.90
157_S172_S0.5150.90
74_G251_N0.5140.90
184_V222_M0.5130.90
156_S171_A0.5130.90
250_L253_R0.5120.90
165_K169_L0.5110.90
234_I250_L0.5110.90
254_T257_M0.5090.90
100_T221_G0.5090.90
11_T75_A0.5080.90
249_Q252_S0.5080.90
147_E150_N0.5070.90
150_N154_I0.5060.89
122_L139_G0.5060.89
124_V136_L0.5040.89
136_L182_L0.5040.89
138_T141_G0.5030.89
238_M254_T0.5020.89
5_M9_S0.5020.89
105_Y119_D0.5010.89
6_L10_T0.5010.89
253_R264_L0.5010.89
24_S37_K0.5000.89
111_N115_Q0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a69A 3 0.6877 100 0.127 Contact Map
1wlgA 2 0.487 100 0.584 Contact Map
4ut1A 1 0.7695 99.3 0.791 Contact Map
1oryB 2 0.145 10.8 0.961 Contact Map
2x5pA 1 0.3717 8.5 0.963 Contact Map
3j9aA 1 0.2082 4.8 0.967 Contact Map
3zqeA 1 0.2305 3.7 0.969 Contact Map
2m4eA 1 0.0669 2.4 0.971 Contact Map
3eabG 1 0.1524 1.4 0.975 Contact Map
4tkcA 2 0.4164 1.3 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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