GREMLIN Database
FLHO - Flagellar hook-basal body complex protein FlhO
UniProt: P39752 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (240)
Sequences: 5726 (4187)
Seq/√Len: 270.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_Y132_F3.6531.00
95_I164_V3.3431.00
135_N139_Q3.2011.00
165_S169_T3.1971.00
126_Y185_A3.0891.00
194_D200_S3.0501.00
86_L224_V2.9781.00
141_T145_R2.9441.00
117_P183_R2.8481.00
139_Q146_P2.8371.00
86_L96_A2.7901.00
113_A184_M2.4881.00
192_K200_S2.4311.00
169_T176_T2.3521.00
120_T125_R2.3071.00
221_K224_V2.2491.00
81_F115_F2.2441.00
192_K202_A2.1091.00
37_D193_R2.0881.00
87_K227_L2.0711.00
118_V127_S2.0661.00
201_T207_L2.0551.00
95_I220_L2.0511.00
36_A235_A2.0381.00
258_K261_D2.0221.00
125_R194_D2.0171.00
88_S224_V2.0131.00
117_P124_I1.9931.00
18_R242_A1.9891.00
19_T239_M1.9531.00
183_R210_A1.8941.00
119_Q148_L1.8941.00
125_R198_L1.8721.00
98_I221_K1.8691.00
4_G256_Y1.8601.00
97_L182_V1.8561.00
26_I232_V1.8101.00
129_S197_D1.7941.00
187_D190_N1.7801.00
165_S171_T1.7801.00
22_L242_A1.7331.00
140_L147_I1.7221.00
132_F147_I1.6971.00
18_R238_E1.6921.00
171_T176_T1.6841.00
153_Q156_T1.6751.00
97_L218_Y1.6661.00
120_T123_G1.6561.00
164_V170_V1.6451.00
251_K254_Q1.6431.00
93_T162_F1.6401.00
19_T242_A1.6201.00
14_A72_V1.5781.00
118_V141_T1.5781.00
231_D234_S1.5741.00
113_A188_V1.5671.00
89_T94_D1.5461.00
95_I180_I1.5401.00
99_E114_L1.5261.00
32_S225_S1.5101.00
169_T179_Q1.5011.00
79_P193_R1.4981.00
238_E241_E1.4881.00
15_Q245_S1.4541.00
234_S238_E1.4541.00
154_P157_V1.4531.00
116_Y180_I1.4481.00
120_T145_R1.4471.00
32_S129_S1.4451.00
185_A201_T1.4221.00
166_E219_S1.4181.00
121_A145_R1.4071.00
95_I116_Y1.4031.00
8_A252_V1.3951.00
85_S227_L1.3921.00
22_L239_M1.3821.00
149_S153_Q1.3751.00
179_Q211_A1.3731.00
125_R200_S1.3721.00
36_A234_S1.3631.00
21_M39_G1.3271.00
235_A238_E1.3241.00
254_Q257_D1.3071.00
16_Q20_E1.3061.00
184_M217_A1.2851.00
117_P148_L1.2621.00
129_S142_I1.2621.00
91_Q94_D1.2581.00
36_A80_L1.2571.00
118_V198_L1.2551.00
213_N219_S1.2501.00
29_A232_V1.2461.00
93_T140_L1.2241.00
37_D79_P1.1941.00
38_Q78_K1.1451.00
115_F188_V1.1421.00
17_R74_M1.1331.00
118_V125_R1.1311.00
149_S181_D1.1261.00
145_R198_L1.1221.00
32_S131_T1.1141.00
34_Y37_D1.1111.00
24_N34_Y1.1101.00
95_I222_Q1.1071.00
11_A249_N1.1041.00
118_V132_F1.0931.00
117_P210_A1.0921.00
81_F199_Y1.0751.00
44_F48_L1.0691.00
153_Q157_V1.0641.00
39_G74_M1.0491.00
152_R155_I1.0431.00
117_P181_D1.0421.00
15_Q242_A1.0371.00
149_S178_G1.0311.00
194_D198_L1.0291.00
205_N208_P1.0281.00
143_N196_N1.0211.00
202_A205_N1.0201.00
150_T179_Q1.0181.00
98_I219_S1.0111.00
93_T134_L1.0111.00
160_E172_T1.0081.00
22_L235_A1.0061.00
126_Y208_P1.0001.00
124_I148_L1.0001.00
211_A214_N0.9991.00
201_T205_N0.9941.00
157_V173_N0.9761.00
257_D260_M0.9711.00
67_S193_R0.9471.00
182_V218_Y0.9451.00
15_Q18_R0.9441.00
92_P161_N0.9441.00
96_A224_V0.9441.00
244_R247_E0.9431.00
21_M34_Y0.9411.00
97_L114_L0.9391.00
141_T147_I0.9381.00
23_S252_V0.9301.00
18_R22_L0.9261.00
119_Q146_P0.9161.00
38_Q43_A0.9161.00
38_Q80_L0.9151.00
190_N202_A0.9061.00
166_E221_K0.9051.00
19_T259_S0.9001.00
141_T198_L0.9001.00
25_N235_A0.8921.00
9_T12_M0.8811.00
36_A229_N0.8751.00
46_E49_L0.8651.00
95_I132_F0.8651.00
91_Q133_S0.8601.00
19_T243_Y0.8591.00
114_L218_Y0.8521.00
150_T155_I0.8521.00
182_V217_A0.8441.00
185_A191_L0.8381.00
51_R54_S0.8361.00
260_M264_A0.8330.99
261_D265_N0.8260.99
124_I181_D0.8220.99
152_R156_T0.8200.99
190_N206_D0.8160.99
131_T142_I0.8120.99
157_V172_T0.8110.99
94_D131_T0.8080.99
193_R199_Y0.8040.99
233_T236_Y0.8000.99
147_I180_I0.7980.99
184_M188_V0.7750.99
133_S142_I0.7710.99
2_L260_M0.7690.99
8_A253_I0.7630.99
256_Y259_S0.7630.99
12_M250_Q0.7620.99
150_T181_D0.7590.99
170_V178_G0.7590.99
172_T175_R0.7540.99
118_V145_R0.7520.99
158_D172_T0.7510.99
18_R241_E0.7500.99
45_P73_Y0.7440.99
119_Q124_I0.7430.99
151_D156_T0.7420.99
3_K70_T0.7390.99
135_N146_P0.7380.99
43_A78_K0.7370.99
119_Q122_D0.7310.99
11_A15_Q0.7200.99
156_T159_N0.7100.98
122_D125_R0.7030.98
180_I220_L0.7030.98
7_T71_G0.7020.98
16_Q246_F0.7020.98
148_L152_R0.7000.98
244_R257_D0.7000.98
32_S227_L0.6990.98
182_V212_G0.6980.98
8_A249_N0.6970.98
151_D178_G0.6940.98
254_Q258_K0.6900.98
43_A76_E0.6900.98
255_A258_K0.6890.98
13_I231_D0.6890.98
149_S155_I0.6880.98
5_L260_M0.6870.98
97_L220_L0.6830.98
47_M51_R0.6820.98
190_N205_N0.6820.98
86_L221_K0.6800.98
236_Y254_Q0.6770.98
246_F250_Q0.6740.98
116_Y130_S0.6740.98
139_Q154_P0.6690.98
46_E69_N0.6690.98
5_L253_I0.6660.98
71_G74_M0.6640.97
167_N179_Q0.6620.97
151_D154_P0.6570.97
92_P222_Q0.6570.97
139_Q156_T0.6550.97
55_K65_I0.6550.97
83_Q99_E0.6540.97
10_S14_A0.6530.97
212_G216_V0.6520.97
127_S141_T0.6510.97
34_Y38_Q0.6490.97
38_Q44_F0.6470.97
2_L259_S0.6470.97
213_N217_A0.6440.97
4_G252_V0.6440.97
6_Y241_E0.6420.97
233_T241_E0.6420.97
95_I147_I0.6420.97
235_A243_Y0.6410.97
83_Q98_I0.6380.97
247_E251_K0.6340.97
99_E113_A0.6330.97
212_G217_A0.6310.97
25_N34_Y0.6280.96
178_G181_D0.6260.96
148_L153_Q0.6250.96
12_M15_Q0.6230.96
115_F199_Y0.6220.96
49_L69_N0.6220.96
170_V177_A0.6200.96
84_G147_I0.6190.96
117_P180_I0.6180.96
118_V147_I0.6170.96
232_V247_E0.6130.96
230_V235_A0.6130.96
212_G220_L0.6120.96
184_M215_Q0.6120.96
133_S136_E0.6110.96
52_I56_S0.6110.96
150_T153_Q0.6040.96
181_D210_A0.6010.95
83_Q86_L0.6000.95
151_D155_I0.6000.95
116_Y127_S0.5970.95
13_I17_R0.5950.95
91_Q225_S0.5950.95
134_L147_I0.5950.95
45_P75_Q0.5930.95
35_K226_E0.5920.95
132_F140_L0.5920.95
149_S152_R0.5920.95
252_V256_Y0.5910.95
253_I257_D0.5890.95
250_Q259_S0.5890.95
185_A206_D0.5870.95
165_S176_T0.5860.95
140_L149_S0.5860.95
3_K20_E0.5810.95
33_G199_Y0.5810.95
213_N218_Y0.5800.95
9_T15_Q0.5790.94
21_M74_M0.5790.94
186_E189_R0.5780.94
15_Q237_T0.5720.94
124_I210_A0.5700.94
155_I159_N0.5700.94
21_M77_L0.5680.94
213_N216_V0.5640.94
17_R21_M0.5640.94
114_L128_K0.5610.94
13_I234_S0.5600.93
120_T146_P0.5590.93
84_G229_N0.5580.93
32_S87_K0.5580.93
4_G7_T0.5570.93
28_N31_T0.5530.93
74_M77_L0.5530.93
140_L180_I0.5520.93
243_Y250_Q0.5500.93
71_G249_N0.5490.93
182_V220_L0.5480.93
131_T225_S0.5470.93
114_L184_M0.5440.92
201_T206_D0.5430.92
159_N172_T0.5410.92
22_L238_E0.5410.92
152_R181_D0.5410.92
17_R20_E0.5380.92
157_V176_T0.5380.92
176_T179_Q0.5370.92
254_Q261_D0.5360.92
7_T20_E0.5360.92
150_T154_P0.5340.92
39_G77_L0.5330.92
139_Q152_R0.5330.92
44_F47_M0.5320.92
146_P154_P0.5320.92
81_F188_V0.5310.92
249_N265_N0.5310.92
69_N77_L0.5300.91
26_I235_A0.5290.91
204_G207_L0.5280.91
55_K67_S0.5270.91
116_Y129_S0.5270.91
127_S130_S0.5260.91
140_L155_I0.5250.91
87_K225_S0.5250.91
12_M253_I0.5240.91
2_L7_T0.5200.91
194_D197_D0.5200.91
49_L67_S0.5190.91
153_Q170_V0.5190.91
10_S72_V0.5180.91
164_V222_Q0.5180.91
153_Q159_N0.5170.90
117_P126_Y0.5160.90
5_L11_A0.5150.90
51_R55_K0.5150.90
3_K12_M0.5140.90
251_K255_A0.5140.90
20_E24_N0.5140.90
232_V248_A0.5130.90
17_R68_V0.5120.90
43_A47_M0.5110.90
148_L181_D0.5100.90
252_V255_A0.5100.90
97_L116_Y0.5090.90
14_A74_M0.5090.90
251_K262_K0.5070.90
46_E195_G0.5070.90
148_L154_P0.5060.90
134_L140_L0.5050.89
78_K189_R0.5050.89
247_E254_Q0.5050.89
160_E173_N0.5040.89
135_N138_N0.5040.89
241_E260_M0.5030.89
190_N204_G0.5030.89
247_E250_Q0.5030.89
48_L52_I0.5030.89
240_T243_Y0.5030.89
52_I55_K0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a69A 3 0.6593 100 0.186 Contact Map
1wlgA 2 0.4593 99.9 0.644 Contact Map
4ut1A 1 0.5222 99.8 0.725 Contact Map
1oryB 2 0.1481 7.4 0.964 Contact Map
2x5pA 1 0.3556 5.4 0.966 Contact Map
4zcnA 3 0.3111 5.4 0.966 Contact Map
2d4yA 1 0.6852 5 0.967 Contact Map
4tqlA 1 0.2037 2 0.973 Contact Map
3k8wA 1 0.1815 1.6 0.975 Contact Map
2j9uA 1 0.163 1.4 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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