MBL - BACSU - GREMLIN Contacts

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MBL - MreB-like protein

UniProt:	P39751	Sequences: MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAVGEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICCPTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTDIAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDARHEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIIDRGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	333 (314)
Sequences:	11094 (6380)
Seq/√Len:	360.0

ECOLI - MREB DNAK HSCC HSCA YEGD FTSA EUTJ
BACSU - MBL MREB MREBH DNAK FTSA
HALSA - DNAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
97_R	124_K	3.472	1.00
152_V	255_I	3.377	1.00
174_S	254_V	3.136	1.00
185_E	250_E	3.083	1.00
193_E	243_E	3.020	1.00
221_E	238_T	3.018	1.00
211_A	215_P	3.011	1.00
260_K	298_E	2.999	1.00
308_N	311_D	2.673	1.00
60_V	180_D	2.600	1.00
15_V	83_F	2.574	1.00
100_I	118_A	2.423	1.00
249_R	253_A	2.366	1.00
163_V	262_V	2.303	1.00
293_Q	297_E	2.301	1.00
84_I	88_N	2.216	1.00
296_A	302_P	2.205	1.00
101_C	317_T	2.188	1.00
285_G	288_L	2.185	1.00
112_K	116_E	2.147	1.00
186_I	239_V	2.136	1.00
77_E	120_K	2.113	1.00
205_D	209_K	2.105	1.00
240_N	243_E	2.076	1.00
256_V	298_E	2.050	1.00
34_L	78_A	2.045	1.00
82_H	86_K	1.994	1.00
21_G	24_I	1.984	1.00
18_H	318_G	1.980	1.00
243_E	246_E	1.966	1.00
294_L	297_E	1.965	1.00
148_G	165_S	1.961	1.00
292_D	305_V	1.944	1.00
182_F	251_S	1.908	1.00
287_L	310_M	1.874	1.00
13_A	156_G	1.858	1.00
189_Y	193_E	1.845	1.00
154_I	159_T	1.835	1.00
256_V	294_L	1.831	1.00
189_Y	247_A	1.819	1.00
223_S	238_T	1.796	1.00
252_V	290_G	1.765	1.00
12_T	157_G	1.752	1.00
15_V	30_S	1.736	1.00
248_L	288_L	1.735	1.00
70_I	75_V	1.721	1.00
78_A	81_K	1.715	1.00
182_F	248_L	1.699	1.00
115_K	119_E	1.687	1.00
163_V	266_T	1.679	1.00
244_V	288_L	1.661	1.00
18_H	314_A	1.646	1.00
17_I	83_F	1.645	1.00
241_S	245_E	1.644	1.00
46_E	50_R	1.634	1.00
311_D	315_I	1.625	1.00
150_M	163_V	1.612	1.00
190_I	210_V	1.595	1.00
185_E	188_N	1.591	1.00
97_R	126_V	1.584	1.00
73_F	116_E	1.566	1.00
187_L	207_K	1.554	1.00
248_L	252_V	1.549	1.00
249_R	294_L	1.544	1.00
190_I	237_I	1.530	1.00
107_T	110_E	1.526	1.00
116_E	119_E	1.514	1.00
154_I	182_F	1.507	1.00
223_S	236_T	1.507	1.00
261_Q	265_R	1.496	1.00
262_V	266_T	1.493	1.00
256_V	260_K	1.474	1.00
147_S	278_G	1.465	1.00
16_L	27_N	1.463	1.00
74_E	120_K	1.447	1.00
84_I	123_G	1.443	1.00
76_T	114_I	1.439	1.00
6_I	17_I	1.437	1.00
64_P	67_D	1.431	1.00
252_V	294_L	1.427	1.00
81_K	85_N	1.424	1.00
192_R	195_K	1.422	1.00
269_E	272_A	1.413	1.00
55_T	58_N	1.399	1.00
185_E	251_S	1.398	1.00
248_L	251_S	1.397	1.00
246_E	249_R	1.392	1.00
82_H	85_N	1.380	1.00
161_I	262_V	1.363	1.00
193_E	196_L	1.356	1.00
245_E	293_Q	1.340	1.00
308_N	315_I	1.340	1.00
102_C	128_L	1.339	1.00
259_A	295_L	1.338	1.00
130_E	133_K	1.336	1.00
61_A	76_T	1.331	1.00
257_Q	261_Q	1.328	1.00
186_I	210_V	1.325	1.00
159_T	255_I	1.324	1.00
150_M	161_I	1.320	1.00
209_K	212_T	1.319	1.00
173_S	261_Q	1.318	1.00
152_V	159_T	1.316	1.00
213_V	224_I	1.310	1.00
189_Y	243_E	1.297	1.00
163_V	274_I	1.288	1.00
16_L	314_A	1.287	1.00
147_S	275_I	1.281	1.00
281_I	295_L	1.277	1.00
7_G	317_T	1.273	1.00
10_L	76_T	1.269	1.00
184_M	188_N	1.252	1.00
42_L	78_A	1.251	1.00
97_R	125_H	1.250	1.00
111_Q	130_E	1.250	1.00
294_L	298_E	1.231	1.00
20_K	322_D	1.206	1.00
290_G	293_Q	1.206	1.00
213_V	222_I	1.197	1.00
278_G	304_L	1.187	1.00
10_L	114_I	1.184	1.00
84_I	98_M	1.182	1.00
279_V	299_L	1.180	1.00
14_N	310_M	1.180	1.00
7_G	314_A	1.179	1.00
5_D	321_L	1.178	1.00
293_Q	296_A	1.174	1.00
249_R	290_G	1.173	1.00
161_I	258_A	1.171	1.00
129_E	320_M	1.167	1.00
185_E	248_L	1.166	1.00
292_D	296_A	1.164	1.00
131_E	160_D	1.157	1.00
5_D	126_V	1.154	1.00
5_D	97_R	1.150	1.00
150_M	259_A	1.148	1.00
70_I	78_A	1.148	1.00
182_F	288_L	1.140	1.00
104_T	132_P	1.132	1.00
119_E	124_K	1.131	1.00
61_A	75_V	1.119	1.00
154_I	291_L	1.116	1.00
182_F	285_G	1.111	1.00
28_E	86_K	1.109	1.00
32_V	75_V	1.107	1.00
214_F	217_A	1.106	1.00
295_L	303_V	1.106	1.00
212_T	216_D	1.097	1.00
257_Q	260_K	1.097	1.00
184_M	207_K	1.096	1.00
281_I	286_A	1.096	1.00
190_I	224_I	1.094	1.00
225_R	236_T	1.089	1.00
85_N	89_V	1.089	1.00
148_G	268_P	1.087	1.00
182_F	244_V	1.080	1.00
253_A	257_Q	1.076	1.00
157_G	160_D	1.069	1.00
34_L	70_I	1.063	1.00
290_G	294_L	1.063	1.00
35_D	38_S	1.058	1.00
193_E	197_L	1.042	1.00
33_A	59_I	1.041	1.00
44_V	82_H	1.040	1.00
129_E	134_V	1.036	1.00
33_A	43_A	1.032	1.00
88_N	94_S	1.028	1.00
184_M	187_L	1.025	1.00
108_S	112_K	1.021	1.00
33_A	51_M	1.019	1.00
320_M	323_N	1.013	1.00
179_G	285_G	1.001	1.00
269_E	273_D	1.001	1.00
15_V	79_M	0.993	1.00
216_D	219_H	0.992	1.00
115_K	128_L	0.992	1.00
4_R	93_F	0.989	1.00
83_F	86_K	0.984	1.00
244_V	285_G	0.982	1.00
261_Q	264_E	0.979	1.00
61_A	79_M	0.977	1.00
242_K	245_E	0.973	1.00
62_I	131_E	0.965	1.00
153_D	160_D	0.964	1.00
193_E	237_I	0.959	1.00
187_L	210_V	0.956	1.00
263_L	271_S	0.954	1.00
64_P	69_V	0.943	1.00
135_A	282_T	0.941	1.00
198_I	233_L	0.939	1.00
85_N	88_N	0.937	1.00
183_D	211_A	0.930	1.00
135_A	313_V	0.926	1.00
72_D	76_T	0.915	1.00
315_I	319_V	0.914	1.00
260_K	264_E	0.910	1.00
102_C	130_E	0.905	1.00
116_E	120_K	0.905	1.00
139_A	280_I	0.899	1.00
153_D	157_G	0.898	1.00
10_L	80_L	0.895	1.00
248_L	290_G	0.893	1.00
253_A	256_V	0.892	1.00
245_E	290_G	0.892	1.00
213_V	239_V	0.892	1.00
282_T	312_C	0.889	1.00
243_E	247_A	0.886	1.00
77_E	81_K	0.886	1.00
163_V	268_P	0.877	1.00
102_C	111_Q	0.875	1.00
203_A	207_K	0.869	1.00
73_F	113_A	0.868	1.00
153_D	156_G	0.866	1.00
51_M	55_T	0.866	1.00
296_A	303_V	0.866	1.00
189_Y	239_V	0.864	1.00
153_D	158_T	0.862	1.00
156_G	160_D	0.857	1.00
99_L	321_L	0.851	1.00
30_S	79_M	0.850	1.00
245_E	249_R	0.850	1.00
154_I	285_G	0.849	1.00
218_R	289_N	0.848	1.00
174_S	177_M	0.847	1.00
209_K	213_V	0.835	1.00
220_E	241_S	0.835	1.00
228_D	235_R	0.831	1.00
57_G	200_E	0.830	1.00
211_A	214_F	0.830	1.00
31_V	49_R	0.829	1.00
148_G	275_I	0.829	1.00
96_P	124_K	0.827	1.00
100_I	114_I	0.825	1.00
111_Q	115_K	0.823	1.00
6_I	87_L	0.822	1.00
253_A	294_L	0.822	1.00
108_S	111_Q	0.822	1.00
86_K	89_V	0.820	1.00
112_K	115_K	0.819	1.00
77_E	117_A	0.817	1.00
177_M	254_V	0.814	1.00
34_L	75_V	0.810	1.00
127_Y	320_M	0.808	1.00
138_G	312_C	0.804	1.00
216_D	222_I	0.802	1.00
188_N	192_R	0.799	1.00
258_A	262_V	0.795	1.00
221_E	240_N	0.794	1.00
189_Y	237_I	0.787	1.00
63_R	181_K	0.785	1.00
10_L	61_A	0.781	1.00
222_I	227_R	0.778	1.00
256_V	259_A	0.778	1.00
205_D	227_R	0.777	1.00
55_T	59_I	0.775	1.00
268_P	273_D	0.775	1.00
150_M	274_I	0.771	1.00
182_F	252_V	0.767	1.00
132_P	135_A	0.767	1.00
194_Y	198_I	0.766	1.00
19_V	91_G	0.766	1.00
214_F	218_R	0.764	1.00
138_G	315_I	0.764	1.00
65_L	76_T	0.763	1.00
8_I	80_L	0.763	1.00
136_A	164_I	0.762	1.00
6_I	98_M	0.761	1.00
61_A	65_L	0.758	1.00
26_L	90_K	0.757	1.00
189_Y	192_R	0.748	1.00
14_N	27_N	0.745	1.00
92_L	95_K	0.743	1.00
244_V	248_L	0.743	1.00
139_A	312_C	0.742	1.00
254_V	257_Q	0.740	1.00
187_L	191_K	0.735	1.00
7_G	318_G	0.733	1.00
56_P	59_I	0.729	1.00
187_L	203_A	0.727	1.00
98_M	123_G	0.724	1.00
33_A	55_T	0.724	1.00
239_V	247_A	0.722	0.99
176_K	181_K	0.721	0.99
132_P	160_D	0.720	0.99
177_M	181_K	0.718	0.99
106_I	110_E	0.717	0.99
217_A	241_S	0.715	0.99
209_K	222_I	0.715	0.99
27_N	311_D	0.713	0.99
155_G	284_G	0.713	0.99
239_V	244_V	0.713	0.99
88_N	95_K	0.713	0.99
44_V	79_M	0.712	0.99
148_G	274_I	0.711	0.99
172_S	261_Q	0.710	0.99
51_M	54_R	0.709	0.99
259_A	298_E	0.709	0.99
172_S	258_A	0.708	0.99
144_F	147_S	0.708	0.99
45_G	48_A	0.705	0.99
111_Q	128_L	0.704	0.99
154_I	255_I	0.700	0.99
193_E	235_R	0.699	0.99
71_A	74_E	0.697	0.99
74_E	77_E	0.697	0.99
131_E	313_V	0.694	0.99
43_A	47_E	0.692	0.99
106_I	114_I	0.689	0.99
104_T	114_I	0.688	0.99
242_K	246_E	0.685	0.99
131_E	158_T	0.685	0.99
118_A	121_S	0.681	0.99
281_I	305_V	0.681	0.99
152_V	259_A	0.680	0.99
102_C	114_I	0.680	0.99
74_E	78_A	0.679	0.99
118_A	128_L	0.678	0.99
304_L	312_C	0.677	0.99
8_I	98_M	0.676	0.99
46_E	49_R	0.675	0.99
183_D	214_F	0.674	0.99
133_K	164_I	0.669	0.99
137_I	320_M	0.668	0.99
117_A	121_S	0.665	0.99
73_F	120_K	0.663	0.99
47_E	50_R	0.662	0.99
61_A	67_D	0.659	0.99
219_H	222_I	0.657	0.99
131_E	156_G	0.657	0.99
274_I	278_G	0.654	0.99
195_K	198_I	0.653	0.99
65_L	114_I	0.651	0.99
73_F	77_E	0.650	0.99
62_I	158_T	0.647	0.99
271_S	298_E	0.645	0.99
194_Y	243_E	0.644	0.99
132_P	158_T	0.642	0.99
70_I	74_E	0.641	0.99
241_S	289_N	0.637	0.99
135_A	156_G	0.636	0.99
16_L	311_D	0.635	0.99
9_D	12_T	0.634	0.99
34_L	42_L	0.633	0.99
6_I	95_K	0.630	0.99
101_C	313_V	0.629	0.99
180_D	183_D	0.625	0.99
138_G	141_M	0.624	0.99
118_A	123_G	0.624	0.99
224_I	227_R	0.624	0.99
188_N	191_K	0.619	0.98
60_V	65_L	0.615	0.98
114_I	117_A	0.611	0.98
172_S	262_V	0.608	0.98
81_K	84_I	0.607	0.98
12_T	158_T	0.607	0.98
258_A	261_Q	0.605	0.98
49_R	211_A	0.605	0.98
80_L	118_A	0.602	0.98
152_V	161_I	0.601	0.98
103_P	131_E	0.599	0.98
263_L	266_T	0.596	0.98
186_I	247_A	0.594	0.98
9_D	153_D	0.594	0.98
10_L	79_M	0.593	0.98
79_M	83_F	0.588	0.98
65_L	68_G	0.588	0.98
205_D	234_P	0.587	0.98
76_T	80_L	0.586	0.98
28_E	82_H	0.586	0.98
150_M	299_L	0.582	0.98
156_G	284_G	0.582	0.98
252_V	288_L	0.580	0.98
161_I	172_S	0.576	0.98
136_A	140_G	0.575	0.98
251_S	254_V	0.574	0.97
218_R	241_S	0.574	0.97
194_Y	235_R	0.572	0.97
245_E	288_L	0.571	0.97
281_I	303_V	0.571	0.97
200_E	204_E	0.571	0.97
113_A	116_E	0.570	0.97
253_A	298_E	0.569	0.97
52_V	59_I	0.569	0.97
42_L	81_K	0.566	0.97
151_V	280_I	0.565	0.97
155_G	158_T	0.565	0.97
103_P	106_I	0.564	0.97
241_S	244_V	0.564	0.97
223_S	226_G	0.564	0.97
185_E	247_A	0.562	0.97
62_I	157_G	0.562	0.97
217_A	222_I	0.562	0.97
190_I	194_Y	0.561	0.97
271_S	299_L	0.561	0.97
178_A	181_K	0.560	0.97
119_E	125_H	0.559	0.97
63_R	66_K	0.557	0.97
114_I	128_L	0.557	0.97
7_G	321_L	0.556	0.97
78_A	82_H	0.554	0.97
197_L	227_R	0.554	0.97
156_G	179_G	0.553	0.97
222_I	228_D	0.551	0.97
254_V	258_A	0.551	0.97
148_G	273_D	0.550	0.97
43_A	51_M	0.548	0.97
208_I	212_T	0.548	0.97
191_K	194_Y	0.548	0.97
88_N	96_P	0.547	0.97
212_T	215_P	0.546	0.97
222_I	226_G	0.546	0.97
186_I	244_V	0.546	0.97
248_L	285_G	0.545	0.97
202_T	206_I	0.545	0.97
214_F	285_G	0.544	0.97
148_G	163_V	0.543	0.97
226_G	229_M	0.543	0.97
219_H	242_K	0.542	0.96
151_V	282_T	0.541	0.96
247_A	250_E	0.540	0.96
260_K	299_L	0.538	0.96
207_K	210_V	0.537	0.96
61_A	64_P	0.537	0.96
154_I	286_A	0.537	0.96
81_K	122_G	0.535	0.96
158_T	178_A	0.533	0.96
49_R	208_I	0.532	0.96
76_T	79_M	0.532	0.96
252_V	256_V	0.532	0.96
88_N	91_G	0.530	0.96
19_V	90_K	0.527	0.96
220_E	289_N	0.526	0.96
223_S	227_R	0.526	0.96
204_E	208_I	0.526	0.96
105_N	160_D	0.524	0.96
89_V	92_L	0.524	0.96
65_L	113_A	0.524	0.96
201_R	234_P	0.524	0.96
204_E	207_K	0.523	0.96
87_L	91_G	0.522	0.96
91_G	95_K	0.522	0.96
16_L	25_V	0.519	0.96
172_S	175_I	0.519	0.96
43_A	46_E	0.518	0.95
105_N	174_S	0.518	0.95
191_K	195_K	0.517	0.95
259_A	299_L	0.516	0.95
227_R	232_G	0.514	0.95
131_E	157_G	0.514	0.95
245_E	252_V	0.514	0.95
7_G	101_C	0.514	0.95
279_V	295_L	0.513	0.95
219_H	241_S	0.512	0.95
173_S	265_R	0.511	0.95
228_D	232_G	0.510	0.95
138_G	280_I	0.510	0.95
71_A	79_M	0.509	0.95
225_R	228_D	0.509	0.95
6_I	91_G	0.508	0.95
278_G	306_A	0.508	0.95
29_P	46_E	0.508	0.95
192_R	196_L	0.507	0.95
181_K	184_M	0.506	0.95
4_R	96_P	0.504	0.95
295_L	299_L	0.502	0.95
9_D	157_G	0.502	0.95
194_Y	230_V	0.501	0.95
256_V	297_E	0.501	0.95
151_V	156_G	0.501	0.95
210_V	213_V	0.501	0.95
232_G	235_R	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fl9A	1	0.958	100	0.212	Contact Map
4jneA	2	0.982	100	0.217	Contact Map
3d2fA	1	0.976	100	0.218	Contact Map
2v7yA	1	0.979	100	0.225	Contact Map
4rtfD	1	0.9459	100	0.243	Contact Map
3i33A	1	0.9489	100	0.256	Contact Map
4kboA	1	0.952	100	0.261	Contact Map
4j8fA	2	0.982	100	0.281	Contact Map
4gniA	2	0.9489	100	0.305	Contact Map
1jceA	1	0.964	100	0.339	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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