GREMLIN Database
MBL - MreB-like protein
UniProt: P39751 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (314)
Sequences: 11094 (6380)
Seq/√Len: 360.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_R124_K3.4721.00
152_V255_I3.3771.00
174_S254_V3.1361.00
185_E250_E3.0831.00
193_E243_E3.0201.00
221_E238_T3.0181.00
211_A215_P3.0111.00
260_K298_E2.9991.00
308_N311_D2.6731.00
60_V180_D2.6001.00
15_V83_F2.5741.00
100_I118_A2.4231.00
249_R253_A2.3661.00
163_V262_V2.3031.00
293_Q297_E2.3011.00
84_I88_N2.2161.00
296_A302_P2.2051.00
101_C317_T2.1881.00
285_G288_L2.1851.00
112_K116_E2.1471.00
186_I239_V2.1361.00
77_E120_K2.1131.00
205_D209_K2.1051.00
240_N243_E2.0761.00
256_V298_E2.0501.00
34_L78_A2.0451.00
82_H86_K1.9941.00
21_G24_I1.9841.00
18_H318_G1.9801.00
243_E246_E1.9661.00
294_L297_E1.9651.00
148_G165_S1.9611.00
292_D305_V1.9441.00
182_F251_S1.9081.00
287_L310_M1.8741.00
13_A156_G1.8581.00
189_Y193_E1.8451.00
154_I159_T1.8351.00
256_V294_L1.8311.00
189_Y247_A1.8191.00
223_S238_T1.7961.00
252_V290_G1.7651.00
12_T157_G1.7521.00
15_V30_S1.7361.00
248_L288_L1.7351.00
70_I75_V1.7211.00
78_A81_K1.7151.00
182_F248_L1.6991.00
115_K119_E1.6871.00
163_V266_T1.6791.00
244_V288_L1.6611.00
18_H314_A1.6461.00
17_I83_F1.6451.00
241_S245_E1.6441.00
46_E50_R1.6341.00
311_D315_I1.6251.00
150_M163_V1.6121.00
190_I210_V1.5951.00
185_E188_N1.5911.00
97_R126_V1.5841.00
73_F116_E1.5661.00
187_L207_K1.5541.00
248_L252_V1.5491.00
249_R294_L1.5441.00
190_I237_I1.5301.00
107_T110_E1.5261.00
116_E119_E1.5141.00
154_I182_F1.5071.00
223_S236_T1.5071.00
261_Q265_R1.4961.00
262_V266_T1.4931.00
256_V260_K1.4741.00
147_S278_G1.4651.00
16_L27_N1.4631.00
74_E120_K1.4471.00
84_I123_G1.4431.00
76_T114_I1.4391.00
6_I17_I1.4371.00
64_P67_D1.4311.00
252_V294_L1.4271.00
81_K85_N1.4241.00
192_R195_K1.4221.00
269_E272_A1.4131.00
55_T58_N1.3991.00
185_E251_S1.3981.00
248_L251_S1.3971.00
246_E249_R1.3921.00
82_H85_N1.3801.00
161_I262_V1.3631.00
193_E196_L1.3561.00
245_E293_Q1.3401.00
308_N315_I1.3401.00
102_C128_L1.3391.00
259_A295_L1.3381.00
130_E133_K1.3361.00
61_A76_T1.3311.00
257_Q261_Q1.3281.00
186_I210_V1.3251.00
159_T255_I1.3241.00
150_M161_I1.3201.00
209_K212_T1.3191.00
173_S261_Q1.3181.00
152_V159_T1.3161.00
213_V224_I1.3101.00
189_Y243_E1.2971.00
163_V274_I1.2881.00
16_L314_A1.2871.00
147_S275_I1.2811.00
281_I295_L1.2771.00
7_G317_T1.2731.00
10_L76_T1.2691.00
184_M188_N1.2521.00
42_L78_A1.2511.00
97_R125_H1.2501.00
111_Q130_E1.2501.00
294_L298_E1.2311.00
20_K322_D1.2061.00
290_G293_Q1.2061.00
213_V222_I1.1971.00
278_G304_L1.1871.00
10_L114_I1.1841.00
84_I98_M1.1821.00
279_V299_L1.1801.00
14_N310_M1.1801.00
7_G314_A1.1791.00
5_D321_L1.1781.00
293_Q296_A1.1741.00
249_R290_G1.1731.00
161_I258_A1.1711.00
129_E320_M1.1671.00
185_E248_L1.1661.00
292_D296_A1.1641.00
131_E160_D1.1571.00
5_D126_V1.1541.00
5_D97_R1.1501.00
150_M259_A1.1481.00
70_I78_A1.1481.00
182_F288_L1.1401.00
104_T132_P1.1321.00
119_E124_K1.1311.00
61_A75_V1.1191.00
154_I291_L1.1161.00
182_F285_G1.1111.00
28_E86_K1.1091.00
32_V75_V1.1071.00
214_F217_A1.1061.00
295_L303_V1.1061.00
212_T216_D1.0971.00
257_Q260_K1.0971.00
184_M207_K1.0961.00
281_I286_A1.0961.00
190_I224_I1.0941.00
225_R236_T1.0891.00
85_N89_V1.0891.00
148_G268_P1.0871.00
182_F244_V1.0801.00
253_A257_Q1.0761.00
157_G160_D1.0691.00
34_L70_I1.0631.00
290_G294_L1.0631.00
35_D38_S1.0581.00
193_E197_L1.0421.00
33_A59_I1.0411.00
44_V82_H1.0401.00
129_E134_V1.0361.00
33_A43_A1.0321.00
88_N94_S1.0281.00
184_M187_L1.0251.00
108_S112_K1.0211.00
33_A51_M1.0191.00
320_M323_N1.0131.00
179_G285_G1.0011.00
269_E273_D1.0011.00
15_V79_M0.9931.00
216_D219_H0.9921.00
115_K128_L0.9921.00
4_R93_F0.9891.00
83_F86_K0.9841.00
244_V285_G0.9821.00
261_Q264_E0.9791.00
61_A79_M0.9771.00
242_K245_E0.9731.00
62_I131_E0.9651.00
153_D160_D0.9641.00
193_E237_I0.9591.00
187_L210_V0.9561.00
263_L271_S0.9541.00
64_P69_V0.9431.00
135_A282_T0.9411.00
198_I233_L0.9391.00
85_N88_N0.9371.00
183_D211_A0.9301.00
135_A313_V0.9261.00
72_D76_T0.9151.00
315_I319_V0.9141.00
260_K264_E0.9101.00
102_C130_E0.9051.00
116_E120_K0.9051.00
139_A280_I0.8991.00
153_D157_G0.8981.00
10_L80_L0.8951.00
248_L290_G0.8931.00
253_A256_V0.8921.00
245_E290_G0.8921.00
213_V239_V0.8921.00
282_T312_C0.8891.00
243_E247_A0.8861.00
77_E81_K0.8861.00
163_V268_P0.8771.00
102_C111_Q0.8751.00
203_A207_K0.8691.00
73_F113_A0.8681.00
153_D156_G0.8661.00
51_M55_T0.8661.00
296_A303_V0.8661.00
189_Y239_V0.8641.00
153_D158_T0.8621.00
156_G160_D0.8571.00
99_L321_L0.8511.00
30_S79_M0.8501.00
245_E249_R0.8501.00
154_I285_G0.8491.00
218_R289_N0.8481.00
174_S177_M0.8471.00
209_K213_V0.8351.00
220_E241_S0.8351.00
228_D235_R0.8311.00
57_G200_E0.8301.00
211_A214_F0.8301.00
31_V49_R0.8291.00
148_G275_I0.8291.00
96_P124_K0.8271.00
100_I114_I0.8251.00
111_Q115_K0.8231.00
6_I87_L0.8221.00
253_A294_L0.8221.00
108_S111_Q0.8221.00
86_K89_V0.8201.00
112_K115_K0.8191.00
77_E117_A0.8171.00
177_M254_V0.8141.00
34_L75_V0.8101.00
127_Y320_M0.8081.00
138_G312_C0.8041.00
216_D222_I0.8021.00
188_N192_R0.7991.00
258_A262_V0.7951.00
221_E240_N0.7941.00
189_Y237_I0.7871.00
63_R181_K0.7851.00
10_L61_A0.7811.00
222_I227_R0.7781.00
256_V259_A0.7781.00
205_D227_R0.7771.00
55_T59_I0.7751.00
268_P273_D0.7751.00
150_M274_I0.7711.00
182_F252_V0.7671.00
132_P135_A0.7671.00
194_Y198_I0.7661.00
19_V91_G0.7661.00
214_F218_R0.7641.00
138_G315_I0.7641.00
65_L76_T0.7631.00
8_I80_L0.7631.00
136_A164_I0.7621.00
6_I98_M0.7611.00
61_A65_L0.7581.00
26_L90_K0.7571.00
189_Y192_R0.7481.00
14_N27_N0.7451.00
92_L95_K0.7431.00
244_V248_L0.7431.00
139_A312_C0.7421.00
254_V257_Q0.7401.00
187_L191_K0.7351.00
7_G318_G0.7331.00
56_P59_I0.7291.00
187_L203_A0.7271.00
98_M123_G0.7241.00
33_A55_T0.7241.00
239_V247_A0.7220.99
176_K181_K0.7210.99
132_P160_D0.7200.99
177_M181_K0.7180.99
106_I110_E0.7170.99
217_A241_S0.7150.99
209_K222_I0.7150.99
27_N311_D0.7130.99
155_G284_G0.7130.99
239_V244_V0.7130.99
88_N95_K0.7130.99
44_V79_M0.7120.99
148_G274_I0.7110.99
172_S261_Q0.7100.99
51_M54_R0.7090.99
259_A298_E0.7090.99
172_S258_A0.7080.99
144_F147_S0.7080.99
45_G48_A0.7050.99
111_Q128_L0.7040.99
154_I255_I0.7000.99
193_E235_R0.6990.99
71_A74_E0.6970.99
74_E77_E0.6970.99
131_E313_V0.6940.99
43_A47_E0.6920.99
106_I114_I0.6890.99
104_T114_I0.6880.99
242_K246_E0.6850.99
131_E158_T0.6850.99
118_A121_S0.6810.99
281_I305_V0.6810.99
152_V259_A0.6800.99
102_C114_I0.6800.99
74_E78_A0.6790.99
118_A128_L0.6780.99
304_L312_C0.6770.99
8_I98_M0.6760.99
46_E49_R0.6750.99
183_D214_F0.6740.99
133_K164_I0.6690.99
137_I320_M0.6680.99
117_A121_S0.6650.99
73_F120_K0.6630.99
47_E50_R0.6620.99
61_A67_D0.6590.99
219_H222_I0.6570.99
131_E156_G0.6570.99
274_I278_G0.6540.99
195_K198_I0.6530.99
65_L114_I0.6510.99
73_F77_E0.6500.99
62_I158_T0.6470.99
271_S298_E0.6450.99
194_Y243_E0.6440.99
132_P158_T0.6420.99
70_I74_E0.6410.99
241_S289_N0.6370.99
135_A156_G0.6360.99
16_L311_D0.6350.99
9_D12_T0.6340.99
34_L42_L0.6330.99
6_I95_K0.6300.99
101_C313_V0.6290.99
180_D183_D0.6250.99
138_G141_M0.6240.99
118_A123_G0.6240.99
224_I227_R0.6240.99
188_N191_K0.6190.98
60_V65_L0.6150.98
114_I117_A0.6110.98
172_S262_V0.6080.98
81_K84_I0.6070.98
12_T158_T0.6070.98
258_A261_Q0.6050.98
49_R211_A0.6050.98
80_L118_A0.6020.98
152_V161_I0.6010.98
103_P131_E0.5990.98
263_L266_T0.5960.98
186_I247_A0.5940.98
9_D153_D0.5940.98
10_L79_M0.5930.98
79_M83_F0.5880.98
65_L68_G0.5880.98
205_D234_P0.5870.98
76_T80_L0.5860.98
28_E82_H0.5860.98
150_M299_L0.5820.98
156_G284_G0.5820.98
252_V288_L0.5800.98
161_I172_S0.5760.98
136_A140_G0.5750.98
251_S254_V0.5740.97
218_R241_S0.5740.97
194_Y235_R0.5720.97
245_E288_L0.5710.97
281_I303_V0.5710.97
200_E204_E0.5710.97
113_A116_E0.5700.97
253_A298_E0.5690.97
52_V59_I0.5690.97
42_L81_K0.5660.97
151_V280_I0.5650.97
155_G158_T0.5650.97
103_P106_I0.5640.97
241_S244_V0.5640.97
223_S226_G0.5640.97
185_E247_A0.5620.97
62_I157_G0.5620.97
217_A222_I0.5620.97
190_I194_Y0.5610.97
271_S299_L0.5610.97
178_A181_K0.5600.97
119_E125_H0.5590.97
63_R66_K0.5570.97
114_I128_L0.5570.97
7_G321_L0.5560.97
78_A82_H0.5540.97
197_L227_R0.5540.97
156_G179_G0.5530.97
222_I228_D0.5510.97
254_V258_A0.5510.97
148_G273_D0.5500.97
43_A51_M0.5480.97
208_I212_T0.5480.97
191_K194_Y0.5480.97
88_N96_P0.5470.97
212_T215_P0.5460.97
222_I226_G0.5460.97
186_I244_V0.5460.97
248_L285_G0.5450.97
202_T206_I0.5450.97
214_F285_G0.5440.97
148_G163_V0.5430.97
226_G229_M0.5430.97
219_H242_K0.5420.96
151_V282_T0.5410.96
247_A250_E0.5400.96
260_K299_L0.5380.96
207_K210_V0.5370.96
61_A64_P0.5370.96
154_I286_A0.5370.96
81_K122_G0.5350.96
158_T178_A0.5330.96
49_R208_I0.5320.96
76_T79_M0.5320.96
252_V256_V0.5320.96
88_N91_G0.5300.96
19_V90_K0.5270.96
220_E289_N0.5260.96
223_S227_R0.5260.96
204_E208_I0.5260.96
105_N160_D0.5240.96
89_V92_L0.5240.96
65_L113_A0.5240.96
201_R234_P0.5240.96
204_E207_K0.5230.96
87_L91_G0.5220.96
91_G95_K0.5220.96
16_L25_V0.5190.96
172_S175_I0.5190.96
43_A46_E0.5180.95
105_N174_S0.5180.95
191_K195_K0.5170.95
259_A299_L0.5160.95
227_R232_G0.5140.95
131_E157_G0.5140.95
245_E252_V0.5140.95
7_G101_C0.5140.95
279_V295_L0.5130.95
219_H241_S0.5120.95
173_S265_R0.5110.95
228_D232_G0.5100.95
138_G280_I0.5100.95
71_A79_M0.5090.95
225_R228_D0.5090.95
6_I91_G0.5080.95
278_G306_A0.5080.95
29_P46_E0.5080.95
192_R196_L0.5070.95
181_K184_M0.5060.95
4_R96_P0.5040.95
295_L299_L0.5020.95
9_D157_G0.5020.95
194_Y230_V0.5010.95
256_V297_E0.5010.95
151_V156_G0.5010.95
210_V213_V0.5010.95
232_G235_R0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fl9A 1 0.958 100 0.212 Contact Map
4jneA 2 0.982 100 0.217 Contact Map
3d2fA 1 0.976 100 0.218 Contact Map
2v7yA 1 0.979 100 0.225 Contact Map
4rtfD 1 0.9459 100 0.243 Contact Map
3i33A 1 0.9489 100 0.256 Contact Map
4kboA 1 0.952 100 0.261 Contact Map
4j8fA 2 0.982 100 0.281 Contact Map
4gniA 2 0.9489 100 0.305 Contact Map
1jceA 1 0.964 100 0.339 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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