GREMLIN Database
FLIS - Flagellar protein FliS
UniProt: P39739 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (118)
Sequences: 1671 (1261)
Seq/√Len: 116.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_A102_A3.2721.00
85_M104_V3.1141.00
65_N79_G2.9881.00
31_C108_V2.9721.00
88_R100_M2.8721.00
35_I101_L2.8671.00
88_R103_E2.8381.00
50_K96_N2.4911.00
46_D49_R2.3721.00
43_E98_T2.2411.00
29_N112_R2.1961.00
83_D87_R2.1871.00
73_E77_S2.1411.00
51_N55_I2.0931.00
112_R116_K2.0311.00
69_N72_I1.9041.00
85_M107_Y1.9011.00
40_Q44_N1.8391.00
32_L105_E1.7741.00
84_Y103_E1.7101.00
27_L60_I1.5461.00
21_G118_A1.5351.00
88_R91_Q1.5231.00
42_I50_K1.5171.00
70_R75_S1.4791.00
54_L101_L1.4251.00
85_M108_V1.4221.00
25_L116_K1.4101.00
54_L89_L1.3951.00
70_R79_G1.3831.00
42_I98_T1.3831.00
61_I85_M1.3431.00
21_G119_I1.3141.00
30_G34_F1.3041.00
97_D100_M1.3041.00
49_R52_E1.2740.99
39_A105_E1.2590.99
8_T11_Q1.2070.99
48_E52_E1.2000.99
31_C57_A1.1910.99
39_A98_T1.1790.99
84_Y88_R1.1780.99
34_F56_K1.1480.99
35_I105_E1.1440.99
28_Y111_F1.1190.99
37_L53_N1.1170.99
70_R76_A1.1080.98
77_S80_A1.1020.98
113_D117_Q1.0990.98
34_F53_N1.0980.98
26_M30_G1.0860.98
72_I75_S1.0680.98
24_T67_T1.0660.98
103_E107_Y1.0340.98
114_A117_Q1.0110.97
31_C61_I0.9920.97
99_G103_E0.9870.97
88_R104_V0.9830.97
47_M51_N0.9760.97
95_K100_M0.9730.97
111_F114_A0.9690.96
81_M85_M0.9650.96
62_Q66_F0.9590.96
105_E109_T0.9560.96
52_E56_K0.9480.96
41_A49_R0.9410.96
24_T118_A0.9270.95
30_G60_I0.9210.95
98_T102_A0.9150.95
78_M111_F0.9010.95
91_Q100_M0.8950.95
36_R105_E0.8810.94
51_N93_N0.8740.94
22_E29_N0.8660.94
19_T119_I0.8630.93
56_K59_N0.8580.93
41_A46_D0.8560.93
87_R91_Q0.8430.93
84_Y107_Y0.8410.92
51_N58_Q0.8250.92
81_M107_Y0.8040.91
65_N83_D0.8010.91
113_D116_K0.7980.90
35_I57_A0.7970.90
62_Q86_Y0.7890.90
54_L93_N0.7880.90
59_N62_Q0.7830.90
110_D113_D0.7820.89
33_K37_L0.7800.89
84_Y100_M0.7780.89
14_S22_E0.7720.89
43_E102_A0.7710.89
99_G102_A0.7620.88
59_N63_E0.7600.88
106_G110_D0.7600.88
91_Q95_K0.7580.88
51_N96_N0.7580.88
30_G56_K0.7520.88
25_L112_R0.7440.87
49_R53_N0.7420.87
90_V94_I0.7420.87
42_I96_N0.7390.87
39_A43_E0.7260.86
70_R74_L0.7180.85
53_N56_K0.7140.85
32_L36_R0.7140.85
65_N86_Y0.7130.85
38_A54_L0.7110.85
35_I89_L0.7050.84
80_A83_D0.7030.84
55_I59_N0.7000.84
41_A53_N0.6970.83
26_M60_I0.6940.83
62_Q65_N0.6910.83
13_N17_T0.6820.82
118_A122_E0.6820.82
24_T115_W0.6790.82
86_Y90_V0.6780.82
41_A44_N0.6750.81
109_T113_D0.6730.81
76_A80_A0.6680.81
17_T86_Y0.6510.79
47_M96_N0.6490.79
5_N8_T0.6480.79
117_Q121_S0.6430.78
27_L30_G0.6390.78
58_Q86_Y0.6360.77
71_N75_S0.6320.77
93_N96_N0.6300.77
31_C60_I0.6250.76
48_E51_N0.6240.76
7_Y11_Q0.6230.76
13_N16_N0.6220.76
63_E66_F0.6210.76
55_I58_Q0.6210.76
92_A101_L0.6200.76
37_L49_R0.6190.75
36_R109_T0.6140.75
52_E55_I0.6130.75
40_Q43_E0.6130.75
36_R39_A0.6030.74
26_M29_N0.6020.73
50_K55_I0.5980.73
32_L109_T0.5980.73
34_F37_L0.5860.71
9_A12_Q0.5760.70
42_I101_L0.5730.70
74_L77_S0.5720.70
74_L81_M0.5700.69
6_P9_A0.5680.69
47_M50_K0.5670.69
18_A26_M0.5610.68
66_F69_N0.5600.68
54_L92_A0.5560.67
28_Y74_L0.5530.67
18_A115_W0.5510.67
57_A89_L0.5500.67
47_M93_N0.5480.66
102_A106_G0.5430.66
110_D114_A0.5410.65
73_E76_A0.5400.65
87_R97_D0.5330.64
24_T119_I0.5330.64
20_P24_T0.5310.64
12_Q16_N0.5290.64
14_S37_L0.5260.63
20_P115_W0.5240.63
25_L119_I0.5220.63
18_A23_L0.5160.62
114_A121_S0.5140.61
23_L63_E0.5100.61
50_K58_Q0.5080.61
63_E67_T0.5080.61
107_Y110_D0.5070.60
22_E25_L0.5070.60
61_I89_L0.5040.60
24_T29_N0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh6A 2 0.812 100 0.082 Contact Map
3iqcA 2 0.8797 100 0.143 Contact Map
4iwbA 1 0.9173 100 0.198 Contact Map
2rklA 2 0.3609 16.1 0.93 Contact Map
3sjrA 2 0.5489 15.9 0.93 Contact Map
2za4B 1 0.594 13.3 0.933 Contact Map
4p3fA 2 0.6316 9.2 0.937 Contact Map
2rgnB 1 0.5639 8.5 0.938 Contact Map
2nrjA 1 0.812 8 0.939 Contact Map
2hsbA 2 0.7218 7.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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