GREMLIN Database
FLID - Flagellar hook-associated protein 2
UniProt: P39738 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 498 (433)
Sequences: 1957 (1625)
Seq/√Len: 78.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_N238_E5.9041.00
103_S229_K4.7411.00
13_D16_D4.6791.00
103_S226_T4.3251.00
229_K236_E3.4641.00
381_I386_L3.4031.00
370_S376_R3.4011.00
290_D378_H3.1581.00
275_Y387_K3.1071.00
148_D156_K2.9121.00
279_K283_D2.8971.00
388_A392_E2.8441.00
393_D396_G2.8161.00
100_E231_T2.8041.00
279_K383_E2.7471.00
129_V133_G2.7201.00
148_D152_N2.7141.00
227_N240_L2.7121.00
229_K238_E2.6911.00
16_D20_K2.6561.00
230_V244_F2.6321.00
370_S378_H2.6291.00
109_T233_N2.6031.00
370_S380_E2.5261.00
14_I18_V2.5181.00
56_L288_L2.5141.00
276_N280_E2.4661.00
102_A229_K2.4361.00
106_T226_T2.4321.00
244_F253_I2.3731.00
157_L183_F2.3571.00
470_R474_K2.3031.00
154_I168_K2.2621.00
279_K381_I2.2041.00
59_Y284_K2.1811.00
382_N385_K2.1561.00
231_T236_E2.1361.00
99_V232_I2.1121.00
157_L166_A2.0991.00
471_Y475_F2.0801.00
468_E472_Y2.0631.00
365_F400_L2.0521.00
243_N252_S2.0331.00
26_R461_Q2.0291.00
84_L99_V2.0241.00
96_S266_S2.0101.00
20_K23_Q1.9881.00
278_I381_I1.9441.00
278_I386_L1.9231.00
165_S186_K1.9161.00
467_I470_R1.9071.00
22_M464_L1.8941.00
102_A231_T1.8831.00
491_Y495_L1.8771.00
467_I471_Y1.8761.00
84_L265_T1.8541.00
97_S233_N1.8491.00
386_L390_I1.8221.00
102_A236_E1.8101.00
15_D472_Y1.8041.00
147_A152_N1.7951.00
100_E262_P1.7871.00
83_V257_T1.7491.00
478_M482_I1.6951.00
461_Q465_N1.6871.00
369_T379_L1.6761.00
52_K291_S1.6691.00
230_V237_M1.6681.00
22_M467_I1.6541.00
32_L453_I1.6381.00
12_M478_M1.6341.00
145_T148_D1.6171.00
43_R446_I1.5951.00
283_D287_E1.5931.00
86_A265_T1.5901.00
275_Y383_E1.5891.00
25_E467_I1.5751.00
6_T14_I1.5600.99
282_V381_I1.5550.99
476_S480_S1.5540.99
257_T263_V1.5530.99
272_D276_N1.5450.99
272_D387_K1.5350.99
491_Y494_Q1.5350.99
390_I397_V1.5290.99
257_T262_P1.5260.99
84_L263_V1.5100.99
36_K454_S1.5080.99
473_S477_A1.5070.99
80_N83_V1.5060.99
168_K179_E1.5060.99
465_N469_N1.5020.99
99_V265_T1.4970.99
192_G225_G1.4940.99
400_L415_I1.4910.99
171_I180_T1.4800.99
107_A188_T1.4710.99
9_A479_D1.4660.99
30_D33_T1.4630.99
244_F251_Y1.4470.99
230_V253_I1.4330.99
155_S159_S1.4270.99
152_N156_K1.4250.99
360_Y364_E1.4020.99
257_T260_T1.4000.99
66_T420_T1.3930.99
24_T27_A1.3810.99
291_S295_K1.3780.99
191_G227_N1.3650.99
459_D462_D1.3610.99
151_D155_S1.3550.98
104_L253_I1.3520.98
455_T459_D1.3470.98
454_S458_T1.3460.98
230_V236_E1.3350.98
132_P139_T1.3280.98
39_L446_I1.3260.98
36_K457_I1.3240.98
221_A224_E1.3210.98
274_I390_I1.3150.98
239_K244_F1.3120.98
44_D47_R1.3090.98
290_D294_E1.3060.98
282_V379_L1.2910.98
460_M464_L1.2890.98
232_I237_M1.2840.98
80_N255_N1.2830.98
226_T229_K1.2820.98
280_E283_D1.2800.98
228_A244_F1.2790.98
206_S209_L1.2740.98
183_F196_A1.2720.98
21_L475_F1.2700.98
79_S263_V1.2630.98
129_V135_T1.2600.98
26_R464_L1.2550.97
349_F379_L1.2490.97
330_G333_R1.2440.97
19_S23_Q1.2430.97
230_V239_K1.2420.97
85_T252_S1.2400.97
32_L457_I1.2320.97
129_V134_E1.2270.97
140_V162_L1.2240.97
299_E302_R1.2170.97
108_A194_I1.2170.97
86_A251_Y1.2150.97
77_T268_S1.2140.97
133_G137_A1.2130.97
154_I158_N1.2130.97
52_K287_E1.2120.97
256_T261_G1.2080.97
98_T262_P1.2020.97
45_S295_K1.1990.97
18_V22_M1.1990.97
130_V141_N1.1960.97
43_R47_R1.1930.97
447_G451_N1.1910.97
289_V342_T1.1880.96
271_V391_A1.1800.96
28_P460_M1.1800.96
33_T457_I1.1660.96
275_Y381_I1.1650.96
277_Q280_E1.1640.96
170_K179_E1.1630.96
70_T277_Q1.1630.96
127_F131_A1.1600.96
348_D422_T1.1580.96
43_R447_G1.1550.96
270_D273_G1.1540.96
29_L461_Q1.1540.96
276_N279_K1.1540.96
344_Q422_T1.1380.95
33_T36_K1.1380.95
32_L460_M1.1350.95
100_E257_T1.1230.95
298_E333_R1.1200.95
112_A115_Y1.1190.95
478_M485_M1.1170.95
395_Q399_N1.1140.95
292_L338_I1.1130.95
193_S225_G1.1110.95
335_D442_S1.1110.95
84_L251_Y1.1040.95
190_A227_N1.0960.94
274_I277_Q1.0930.94
39_L450_L1.0860.94
171_I178_V1.0850.94
452_S456_E1.0840.94
7_G11_G1.0820.94
228_A253_I1.0810.94
126_A129_V1.0750.94
257_T261_G1.0700.94
469_N473_S1.0660.94
154_I181_I1.0650.94
451_N455_T1.0630.94
341_G426_T1.0610.93
228_A242_N1.0550.93
361_Q364_E1.0540.93
278_I401_F1.0520.93
18_V468_E1.0510.93
150_I168_K1.0480.93
26_R30_D1.0450.93
22_M468_E1.0440.93
15_D19_S1.0420.93
64_T280_E1.0370.93
131_A137_A1.0300.92
49_V295_K1.0220.92
166_A183_F1.0200.92
37_Q41_W1.0180.92
108_A193_S1.0180.92
53_I423_L1.0160.92
345_M419_I1.0150.92
14_I478_M1.0100.92
129_V132_P1.0040.91
164_V183_F1.0040.91
287_E291_S1.0000.91
274_I381_I0.9980.91
6_T9_A0.9970.91
78_S81_E0.9950.91
421_N424_R0.9950.91
157_L164_V0.9920.91
149_T152_N0.9900.91
228_A239_K0.9890.91
121_G125_L0.9850.91
256_T262_P0.9830.91
190_A240_L0.9800.90
298_E303_D0.9760.90
301_Y329_S0.9750.90
462_D466_T0.9750.90
50_N54_K0.9750.90
133_G136_T0.9660.90
158_N166_A0.9650.90
39_L449_N0.9640.90
127_F133_G0.9530.89
389_K392_E0.9520.89
74_K88_G0.9510.89
256_T260_T0.9440.89
135_T139_T0.9380.88
73_S273_G0.9370.88
387_K391_A0.9370.88
100_E260_T0.9370.88
110_Y194_I0.9350.88
96_S264_T0.9340.88
28_P31_K0.9320.88
188_T240_L0.9270.88
108_A225_G0.9260.88
22_M26_R0.9220.88
296_L338_I0.9190.87
440_G444_Y0.9130.87
117_G120_Q0.9080.87
273_G276_N0.9070.87
371_S376_R0.9060.87
144_V148_D0.9030.86
144_V153_V0.9000.86
54_K57_Q0.8990.86
283_D378_H0.8990.86
10_S479_D0.8990.86
26_R460_M0.8970.86
35_K456_E0.8960.86
47_R50_N0.8950.86
121_G127_F0.8950.86
59_Y64_T0.8950.86
299_E303_D0.8950.86
43_R450_L0.8940.86
83_V255_N0.8840.85
60_M419_I0.8820.85
163_G186_K0.8810.85
86_A249_V0.8790.85
114_N178_V0.8790.85
30_D34_Q0.8790.85
471_Y474_K0.8750.85
98_T264_T0.8740.85
482_I486_N0.8730.85
109_T184_S0.8700.84
342_T346_R0.8690.84
136_T139_T0.8690.84
149_T153_V0.8690.84
299_E333_R0.8670.84
455_T458_T0.8640.84
230_V251_Y0.8640.84
486_N490_S0.8600.84
75_T268_S0.8560.83
465_N468_E0.8560.83
239_K253_I0.8540.83
383_E387_K0.8530.83
64_T67_Y0.8530.83
140_V161_D0.8500.83
18_V476_S0.8500.83
292_L295_K0.8500.83
399_N403_S0.8480.83
5_I9_A0.8470.83
36_K450_L0.8450.83
104_L256_T0.8440.82
365_F397_V0.8400.82
76_V86_A0.8390.82
385_K388_A0.8350.82
198_D201_T0.8350.82
5_I8_L0.8340.82
457_I479_D0.8340.82
425_S428_K0.8330.82
19_S468_E0.8310.81
453_I460_M0.8270.81
191_G240_L0.8250.81
82_S254_K0.8250.81
187_A192_G0.8230.81
59_Y280_E0.8220.81
106_T223_K0.8220.81
144_V205_M0.8220.81
424_R428_K0.8210.81
109_T182_A0.8160.80
428_K440_G0.8160.80
106_T256_T0.8150.80
285_Y289_V0.8100.80
188_T227_N0.8100.80
298_E302_R0.8100.80
82_S255_N0.8090.80
367_I379_L0.8080.80
396_G399_N0.8050.79
108_A221_A0.8040.79
205_M210_G0.8030.79
85_T254_K0.8020.79
132_P141_N0.8020.79
133_G164_V0.8010.79
99_V251_Y0.7970.79
78_S84_L0.7950.79
274_I394_P0.7940.78
26_R468_E0.7940.78
135_T138_K0.7930.78
436_N440_G0.7860.78
362_L367_I0.7850.78
52_K288_L0.7850.78
158_N164_V0.7820.77
205_M212_S0.7800.77
28_P32_L0.7800.77
87_T250_T0.7770.77
250_T418_R0.7770.77
171_I177_Y0.7760.77
21_L25_E0.7710.76
246_V249_V0.7700.76
134_E139_T0.7680.76
289_V293_N0.7680.76
462_D465_N0.7660.76
78_S83_V0.7630.76
168_K181_I0.7610.75
284_K287_E0.7550.75
7_G479_D0.7540.75
39_L43_R0.7510.74
450_L454_S0.7500.74
80_N254_K0.7470.74
282_V386_L0.7460.74
464_L468_E0.7440.74
7_G10_S0.7430.74
28_P463_R0.7420.74
291_S294_E0.7410.73
21_L471_Y0.7390.73
111_K180_T0.7360.73
49_V341_G0.7340.73
11_G479_D0.7320.73
9_A14_I0.7300.72
81_E85_T0.7300.72
6_T472_Y0.7300.72
359_T400_L0.7290.72
94_N269_T0.7290.72
367_I401_F0.7280.72
55_E284_K0.7270.72
381_I390_I0.7240.72
370_S379_L0.7180.71
151_D168_K0.7170.71
108_A185_S0.7170.71
492_L495_L0.7140.71
152_N155_S0.7110.70
346_R369_T0.7110.70
249_V267_V0.7110.70
14_I479_D0.7100.70
35_K42_Q0.7090.70
367_I381_I0.7090.70
56_L284_K0.7090.70
74_K94_N0.7070.70
365_F385_K0.7050.70
388_A391_A0.7030.70
92_A95_S0.6960.69
205_M209_L0.6950.69
485_M488_Q0.6940.69
125_L129_V0.6940.69
353_V418_R0.6920.68
275_Y279_K0.6920.68
6_T15_D0.6920.68
448_K451_N0.6880.68
359_T365_F0.6880.68
103_S238_E0.6870.68
457_I461_Q0.6860.68
339_S343_N0.6850.68
443_S447_G0.6850.68
463_R467_I0.6840.67
347_T350_Y0.6840.67
357_G396_G0.6810.67
29_L460_M0.6800.67
99_V244_F0.6800.67
158_N165_S0.6790.67
348_D418_R0.6790.67
126_A133_G0.6760.67
445_S449_N0.6760.67
34_Q38_T0.6750.66
10_S478_M0.6750.66
475_F478_M0.6730.66
187_A241_T0.6720.66
171_I239_K0.6720.66
103_S256_T0.6720.66
75_T272_D0.6720.66
488_Q491_Y0.6720.66
204_F207_G0.6710.66
458_T461_Q0.6710.66
245_T250_T0.6700.66
57_Q420_T0.6700.66
84_L101_V0.6680.66
142_I162_L0.6670.65
281_F362_L0.6670.65
61_S420_T0.6660.65
172_W179_E0.6660.65
134_E137_A0.6650.65
192_G227_N0.6650.65
53_I341_G0.6640.65
64_T277_Q0.6620.65
49_V92_A0.6620.65
396_G400_L0.6600.65
401_F414_G0.6580.64
56_L415_I0.6550.64
421_N425_S0.6530.64
401_F416_M0.6520.64
102_A256_T0.6510.64
5_I14_I0.6510.64
239_K334_N0.6500.63
472_Y476_S0.6500.63
368_T382_N0.6490.63
154_I166_A0.6490.63
73_S277_Q0.6480.63
459_D463_R0.6470.63
15_D468_E0.6450.63
18_V464_L0.6430.63
76_V264_T0.6390.62
131_A134_E0.6380.62
49_V338_I0.6370.62
288_L292_L0.6370.62
278_I414_G0.6370.62
80_N246_V0.6360.62
38_T42_Q0.6360.62
482_I485_M0.6350.62
112_A180_T0.6350.62
188_T296_L0.6350.62
40_E450_L0.6340.62
490_S493_S0.6340.62
50_N440_G0.6340.62
481_A485_M0.6340.62
456_E459_D0.6330.61
347_T351_T0.6320.61
365_F381_I0.6310.61
197_A200_A0.6290.61
428_K436_N0.6280.61
16_D19_S0.6280.61
97_S267_V0.6260.61
426_T438_T0.6250.60
243_N250_T0.6240.60
278_I300_K0.6240.60
61_S241_T0.6230.60
148_D153_V0.6210.60
486_N489_A0.6200.60
296_L333_R0.6200.60
58_D64_T0.6200.60
453_I457_I0.6180.60
58_D61_S0.6180.60
18_V471_Y0.6170.59
190_A238_E0.6170.59
365_F389_K0.6160.59
485_M489_A0.6150.59
477_A481_A0.6150.59
210_G213_L0.6150.59
391_A394_P0.6140.59
36_K40_E0.6140.59
84_L400_L0.6130.59
133_G139_T0.6130.59
193_S196_A0.6130.59
351_T423_L0.6120.59
427_V439_M0.6120.59
169_D182_A0.6100.59
251_Y265_T0.6090.58
128_N133_G0.6080.58
380_E384_E0.6060.58
32_L39_L0.6050.58
276_N283_D0.6050.58
296_L339_S0.6040.58
359_T393_D0.6040.58
71_Y402_T0.6040.58
269_T274_I0.6030.58
352_Q418_R0.6020.58
278_I367_I0.6010.57
441_A444_Y0.6000.57
475_F496_L0.5990.57
61_S64_T0.5960.57
146_S152_N0.5950.57
244_F252_S0.5950.57
29_L457_I0.5940.57
293_N378_H0.5940.57
14_I472_Y0.5930.56
153_V157_L0.5930.56
77_T266_S0.5910.56
31_K468_E0.5890.56
27_A30_D0.5890.56
37_Q40_E0.5880.56
54_K427_V0.5880.56
393_D448_K0.5880.56
53_I288_L0.5870.56
126_A149_T0.5860.56
57_Q427_V0.5860.56
20_K25_E0.5850.55
444_Y447_G0.5830.55
346_R363_T0.5820.55
489_A493_S0.5810.55
36_K453_I0.5810.55
150_I154_I0.5790.55
177_Y180_T0.5780.55
48_E295_K0.5780.55
358_K396_G0.5770.54
368_T380_E0.5770.54
211_F214_D0.5760.54
103_S190_A0.5760.54
103_S236_E0.5750.54
20_K475_F0.5740.54
121_G136_T0.5740.54
452_S455_T0.5730.54
341_G364_E0.5720.54
60_M281_F0.5720.54
413_K421_N0.5720.54
195_Q198_D0.5720.54
144_V156_K0.5700.54
131_A135_T0.5700.54
5_I479_D0.5700.54
166_A181_I0.5690.53
351_T418_R0.5690.53
48_E291_S0.5690.53
141_N451_N0.5680.53
49_V292_L0.5680.53
232_I477_A0.5670.53
6_T17_I0.5670.53
20_K24_T0.5670.53
170_K415_I0.5660.53
110_Y221_A0.5660.53
354_N357_G0.5650.53
178_V239_K0.5630.53
147_A338_I0.5630.53
22_M461_Q0.5620.53
26_R29_L0.5620.53
92_A249_V0.5610.52
271_V387_K0.5610.52
292_L296_L0.5600.52
50_N427_V0.5590.52
395_Q398_A0.5590.52
287_E290_D0.5590.52
120_Q388_A0.5590.52
460_M463_R0.5550.52
256_T263_V0.5550.52
420_T424_R0.5520.51
15_D18_V0.5510.51
23_Q26_R0.5510.51
207_G211_F0.5490.51
466_T470_R0.5490.51
423_L427_V0.5480.51
384_E388_A0.5480.51
108_A191_G0.5480.51
17_I24_T0.5460.51
350_Y482_I0.5450.50
294_E297_K0.5450.50
478_M481_A0.5430.50
476_S485_M0.5420.50
239_K245_T0.5420.50
167_F231_T0.5420.50
235_F368_T0.5420.50
14_I491_Y0.5410.50
228_A241_T0.5400.50
298_E329_S0.5390.50
181_I349_F0.5390.50
22_M478_M0.5380.49
444_Y448_K0.5380.49
345_M423_L0.5380.49
30_D457_I0.5380.49
100_E261_G0.5370.49
91_S94_N0.5370.49
6_T479_D0.5370.49
132_P135_T0.5360.49
474_K477_A0.5350.49
422_T426_T0.5350.49
476_S482_I0.5340.49
429_S437_S0.5340.49
65_L181_I0.5340.49
17_I283_D0.5330.49
235_F239_K0.5330.49
88_G249_V0.5320.49
185_S192_G0.5320.49
264_T455_T0.5310.49
482_I489_A0.5300.48
23_Q27_A0.5290.48
155_S168_K0.5280.48
478_M495_L0.5280.48
205_M208_Q0.5280.48
78_S263_V0.5250.48
420_T427_V0.5250.48
70_T73_S0.5240.48
116_T240_L0.5230.48
45_S331_L0.5220.47
68_P71_Y0.5210.47
129_V137_A0.5200.47
102_A230_V0.5190.47
292_L342_T0.5190.47
54_K58_D0.5190.47
185_S194_I0.5190.47
76_V97_S0.5180.47
135_T140_V0.5180.47
172_W177_Y0.5180.47
192_G343_N0.5170.47
437_S442_S0.5170.47
459_D494_Q0.5160.47
206_S210_G0.5160.47
42_Q449_N0.5160.47
137_A196_A0.5150.47
101_V272_D0.5140.46
192_G240_L0.5140.46
389_K397_V0.5130.46
22_M25_E0.5120.46
81_E84_L0.5120.46
272_D275_Y0.5120.46
369_T380_E0.5120.46
231_T452_S0.5100.46
16_D490_S0.5090.46
438_T442_S0.5090.46
232_I343_N0.5090.46
329_S333_R0.5080.46
189_G227_N0.5080.46
429_S469_N0.5060.45
279_K484_K0.5050.45
131_A139_T0.5050.45
329_S335_D0.5040.45
74_K91_S0.5040.45
56_L330_G0.5040.45
88_G92_A0.5040.45
189_G242_N0.5030.45
132_P197_A0.5030.45
353_V415_I0.5010.45
295_K386_L0.5010.45
120_Q141_N0.5000.45
142_I156_K0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bhqA 2 0.0281 65.3 0.965 Contact Map
3ghgA 2 0.2691 59.9 0.966 Contact Map
4ll8A 1 0 53.7 0.967 Contact Map
3c9iA 5 0.255 47.9 0.968 Contact Map
1deqA 1 0.245 40.4 0.97 Contact Map
4cgkA 3 0.1667 39.8 0.97 Contact Map
3swyA 3 0.0924 39.5 0.97 Contact Map
4nqiA 2 0.3253 36.2 0.97 Contact Map
2z5iA 3 0.1004 35.7 0.971 Contact Map
1x8yA 2 0.0843 32.4 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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