GREMLIN Database
YVYC - Uncharacterized protein YvyC
UniProt: P39737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 109 (93)
Sequences: 388 (348)
Seq/√Len: 36.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_K99_E4.0961.00
62_L69_Y3.0671.00
63_H92_D3.0191.00
57_H76_D2.8851.00
96_A99_E2.5491.00
96_A100_F2.3771.00
56_V73_V2.2430.99
58_L71_V2.2060.99
73_V83_R2.1670.99
43_M90_W1.9040.98
66_L98_T1.8650.97
16_Y40_L1.8410.97
63_H95_A1.6690.95
89_R105_V1.6300.94
53_P94_Y1.6090.94
61_E70_Y1.5850.94
66_L70_Y1.5800.93
85_I89_R1.4680.91
89_R108_K1.4620.90
66_L69_Y1.4560.90
72_K90_W1.4550.90
26_N33_H1.4440.90
60_F68_E1.4370.90
49_K52_E1.3880.88
91_L95_A1.3260.86
68_E94_Y1.3140.85
35_V40_L1.2580.82
61_E72_K1.2540.82
42_E45_G1.2490.82
66_L88_K1.2070.80
70_Y97_M1.2060.80
69_Y88_K1.1930.79
58_L83_R1.1840.78
47_M51_L1.1800.78
69_Y94_Y1.1750.78
94_Y98_T1.1740.78
18_T21_H1.1580.77
17_D25_D1.1480.76
28_N38_T1.1430.76
48_N60_F1.1090.74
82_I87_P1.0990.73
92_D95_A1.0460.69
66_L97_M1.0370.68
21_H24_K1.0340.68
75_E80_E1.0120.66
27_D30_V1.0080.66
24_K28_N1.0050.66
93_F104_F0.9900.65
66_L94_Y0.9900.65
64_D91_L0.9800.64
19_Q26_N0.9480.61
96_A107_E0.9470.61
87_P90_W0.9470.61
91_L106_D0.9320.60
41_A60_F0.9270.60
93_F98_T0.9220.59
74_I81_V0.9190.59
22_N104_F0.8970.57
16_Y26_N0.8960.57
46_E53_P0.8950.57
61_E88_K0.8690.55
77_S107_E0.8550.53
39_N101_L0.8280.51
94_Y97_M0.8190.50
69_Y98_T0.8180.50
20_I28_N0.7970.48
62_L88_K0.7880.48
39_N49_K0.7830.47
23_Q40_L0.7810.47
25_D36_S0.7790.47
16_Y22_N0.7780.47
17_D30_V0.7750.46
54_S75_E0.7750.46
19_Q30_V0.7730.46
90_W93_F0.7620.45
52_E77_S0.7560.45
18_T28_N0.7430.44
69_Y101_L0.7410.44
99_E107_E0.7300.43
90_W94_Y0.7220.42
98_T101_L0.7210.42
65_K103_L0.7200.42
54_S83_R0.7200.42
79_N107_E0.7180.42
59_K72_K0.7120.41
47_M59_K0.7090.41
80_E97_M0.7060.41
46_E50_L0.7040.40
93_F99_E0.7020.40
91_L98_T0.6930.39
19_Q36_S0.6910.39
60_F71_V0.6900.39
18_T25_D0.6790.38
53_P98_T0.6750.38
98_T104_F0.6750.38
28_N36_S0.6730.38
21_H28_N0.6720.38
28_N40_L0.6700.38
43_M67_N0.6690.37
49_K101_L0.6650.37
33_H49_K0.6620.37
87_P91_L0.6610.37
35_V87_P0.6540.36
50_L88_K0.6530.36
46_E51_L0.6420.35
63_H70_Y0.6400.35
58_L73_V0.6380.35
37_Y41_A0.6360.35
60_F74_I0.6270.34
29_E38_T0.6260.34
78_T92_D0.6250.34
32_V35_V0.6060.32
50_L66_L0.6040.32
80_E92_D0.6040.32
71_V90_W0.6000.32
27_D39_N0.6000.32
22_N25_D0.5990.32
42_E57_H0.5960.32
19_Q23_Q0.5870.31
61_E83_R0.5770.30
23_Q30_V0.5720.30
21_H32_V0.5720.30
17_D27_D0.5710.30
19_Q22_N0.5690.30
32_V36_S0.5660.30
19_Q29_E0.5640.29
57_H74_I0.5620.29
17_D32_V0.5590.29
81_V100_F0.5530.29
52_E74_I0.5470.28
72_K106_D0.5410.28
44_V48_N0.5410.28
70_Y82_I0.5390.28
23_Q35_V0.5340.27
78_T85_I0.5300.27
51_L89_R0.5290.27
58_L65_K0.5250.27
36_S100_F0.5240.27
16_Y23_Q0.5190.26
68_E83_R0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hc5A 1 1 99.9 0.265 Contact Map
3nw0A 1 0.8899 38.3 0.904 Contact Map
2qupA 1 0.789 26 0.912 Contact Map
1zatA 1 0.4404 11.4 0.925 Contact Map
4jbuA 1 0.367 10.2 0.927 Contact Map
4exrA 2 0.7339 7.1 0.932 Contact Map
2p61A 1 0.7523 4.2 0.939 Contact Map
4tr6A 2 0.7248 3.9 0.94 Contact Map
4bh6I 1 0.422 3.8 0.94 Contact Map
3t0pA 2 0.7156 3.2 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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