GREMLIN Database
COMER - ComE operon protein 4
UniProt: P39696 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (260)
Sequences: 5200 (3876)
Seq/√Len: 240.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_Q140_A3.2311.00
75_I96_T2.8081.00
125_A211_K2.7741.00
218_Y226_K2.6671.00
176_M206_L2.4871.00
115_V128_S2.4581.00
179_L249_F2.4461.00
211_K215_T2.4411.00
180_I213_L2.4081.00
153_H200_L2.2061.00
4_G59_L2.1761.00
33_T56_L2.1651.00
177_S209_M2.0991.00
145_N156_Q2.0851.00
105_E133_G2.0821.00
194_S197_D2.0651.00
184_I199_I2.0191.00
127_V153_H2.0091.00
145_N149_Q1.9671.00
207_V211_K1.9601.00
141_K156_Q1.9371.00
155_L200_L1.8961.00
87_R90_H1.8751.00
211_K214_E1.8601.00
172_G205_M1.8441.00
8_T32_I1.8341.00
37_I41_L1.8221.00
222_A226_K1.7821.00
242_E246_Q1.7631.00
183_F253_F1.7591.00
120_T126_G1.7541.00
132_F141_K1.7501.00
149_Q154_P1.7451.00
218_Y222_A1.7331.00
129_L165_A1.7281.00
175_F237_G1.7271.00
179_L245_V1.7211.00
188_V195_K1.7051.00
34_N39_K1.6251.00
15_L151_I1.6211.00
137_G140_A1.6211.00
4_G63_N1.6071.00
41_L45_N1.5891.00
235_G239_K1.5871.00
93_I144_I1.5791.00
259_K262_E1.5711.00
163_R260_Y1.5561.00
130_V156_Q1.5471.00
31_T51_N1.5421.00
203_K214_E1.5381.00
92_L108_V1.5361.00
125_A207_V1.5191.00
222_A225_E1.5101.00
65_M91_I1.5001.00
228_C235_G1.4811.00
31_T53_T1.4741.00
11_M95_I1.4711.00
32_I50_I1.4711.00
245_V248_M1.4621.00
2_K29_N1.4571.00
191_T254_Q1.4421.00
243_S251_R1.4411.00
79_L108_V1.4401.00
35_R74_D1.4391.00
76_Y107_Y1.4381.00
94_S104_L1.4291.00
76_Y103_Q1.4191.00
138_E142_A1.4141.00
55_S58_K1.4091.00
185_D195_K1.3851.00
204_E207_V1.3691.00
180_I206_L1.3661.00
39_K42_H1.3591.00
100_Q103_Q1.3581.00
157_I162_T1.3541.00
240_A243_S1.3511.00
189_S254_Q1.3481.00
254_Q258_M1.3271.00
113_A144_I1.3211.00
176_M179_L1.3111.00
247_D251_R1.3091.00
189_S250_H1.3091.00
42_H46_R1.3061.00
127_V204_E1.3041.00
181_Q224_Q1.3021.00
13_T39_K1.3021.00
171_C233_V1.2891.00
245_V249_F1.2871.00
219_T222_A1.2861.00
17_E46_R1.2651.00
5_F12_G1.2581.00
257_H261_E1.2561.00
185_D246_Q1.2561.00
75_I99_V1.2481.00
96_T99_V1.2191.00
103_Q107_Y1.2121.00
69_C95_I1.2091.00
86_L92_L1.2071.00
167_D253_F1.2061.00
5_F16_I1.1971.00
130_V154_P1.1931.00
181_Q221_P1.1901.00
41_L44_K1.1841.00
26_D29_N1.1611.00
36_T39_K1.1601.00
237_G252_V1.1601.00
105_E134_T1.1571.00
145_N154_P1.1561.00
31_T62_E1.1471.00
142_A146_E1.1431.00
121_N126_G1.1401.00
105_E135_S1.1371.00
59_L63_N1.1371.00
125_A204_E1.1361.00
158_E161_I1.1301.00
15_L19_F1.1161.00
239_K243_S1.1151.00
12_G16_I1.1141.00
241_L252_V1.1131.00
65_M143_K1.1121.00
157_I165_A1.1111.00
101_T131_T1.1051.00
102_E106_Q1.1011.00
187_A193_V1.0981.00
236_E239_K1.0971.00
5_F67_F1.0761.00
130_V148_M1.0751.00
91_I140_A1.0751.00
127_V155_L1.0751.00
228_C238_I1.0721.00
191_T257_H1.0641.00
180_I202_C1.0611.00
101_T112_V1.0551.00
130_V145_N1.0471.00
163_R261_E1.0401.00
224_Q228_C1.0361.00
70_V96_T1.0311.00
65_M93_I1.0241.00
168_I253_F1.0211.00
15_L95_I1.0171.00
132_F156_Q1.0171.00
207_V214_E1.0121.00
57_E81_R1.0081.00
115_V148_M1.0071.00
241_L249_F1.0061.00
10_N226_K1.0041.00
68_I75_I1.0011.00
240_A251_R0.9991.00
34_N40_A0.9971.00
40_A54_E0.9971.00
155_L197_D0.9951.00
13_T47_Y0.9931.00
40_A52_V0.9891.00
21_E124_L0.9881.00
101_T104_L0.9871.00
19_F147_L0.9851.00
169_V201_M0.9831.00
178_Y238_I0.9831.00
74_D77_P0.9761.00
17_E47_Y0.9741.00
131_T162_T0.9721.00
74_D78_L0.9691.00
165_A201_M0.9681.00
153_H204_E0.9681.00
240_A255_N0.9651.00
58_K62_E0.9501.00
16_I32_I0.9491.00
66_I90_H0.9491.00
136_C140_A0.9431.00
76_Y80_A0.9421.00
165_A169_V0.9361.00
236_E259_K0.9351.00
18_S151_I0.9321.00
177_S212_L0.9311.00
213_L220_L0.9171.00
57_E61_S0.9171.00
244_G247_D0.9171.00
164_V193_V0.9151.00
39_K43_I0.9151.00
99_V103_Q0.9131.00
67_F93_I0.9101.00
103_Q106_Q0.9041.00
203_K210_G0.9011.00
244_G248_M0.9001.00
178_Y242_E0.9001.00
13_T46_R0.8951.00
104_L112_V0.8951.00
33_T53_T0.8911.00
185_D188_V0.8881.00
255_N258_M0.8820.99
196_Q200_L0.8820.99
8_T43_I0.8770.99
197_D200_L0.8740.99
219_T225_E0.8730.99
3_I19_F0.8700.99
60_V66_I0.8620.99
184_I188_V0.8620.99
37_I40_A0.8610.99
17_E122_R0.8540.99
38_E41_L0.8520.99
168_I187_A0.8460.99
191_T253_F0.8450.99
113_A132_F0.8360.99
225_E235_G0.8350.99
258_M262_E0.8300.99
40_A44_K0.8300.99
61_S85_Y0.8280.99
75_I79_L0.8260.99
57_E85_Y0.8260.99
6_I78_L0.8260.99
20_I27_P0.8240.99
127_V201_M0.8220.99
42_H45_N0.8200.99
199_I203_K0.8170.99
4_G33_T0.8160.99
80_A107_Y0.8150.99
221_P225_E0.8140.99
80_A83_L0.8080.99
182_R246_Q0.8070.99
2_K31_T0.8020.99
91_I144_I0.7990.99
233_V260_Y0.7980.99
139_S142_A0.7960.99
167_D257_H0.7870.99
236_E240_A0.7840.99
121_N151_I0.7820.99
64_E90_H0.7810.99
13_T42_H0.7810.99
237_G240_A0.7790.99
136_C141_K0.7670.99
238_I242_E0.7640.98
207_V210_G0.7620.98
10_N229_V0.7620.98
75_I94_S0.7610.98
34_N37_I0.7590.98
187_A202_C0.7590.98
43_I47_Y0.7590.98
31_T63_N0.7540.98
132_F138_E0.7470.98
76_Y99_V0.7430.98
237_G256_T0.7370.98
25_A29_N0.7370.98
181_Q185_D0.7330.98
239_K251_R0.7310.98
189_S239_K0.7280.98
83_L109_P0.7270.98
2_K62_E0.7260.98
114_R159_S0.7250.98
178_Y246_Q0.7230.98
60_V82_A0.7200.98
44_K52_V0.7180.98
16_I30_M0.7180.98
132_F136_C0.7170.98
123_A211_K0.7140.98
12_G69_C0.7120.98
56_L81_R0.7090.98
166_S260_Y0.7090.98
203_K213_L0.7080.98
95_I115_V0.7080.98
193_V201_M0.7070.98
142_A145_N0.7070.98
163_R264_I0.7050.97
185_D189_S0.7050.97
51_N62_E0.7020.97
79_L96_T0.7020.97
258_M261_E0.6970.97
146_E149_Q0.6970.97
133_G136_C0.6960.97
116_I170_S0.6950.97
169_V205_M0.6930.97
171_C256_T0.6930.97
13_T17_E0.6910.97
58_K61_S0.6900.97
101_T133_G0.6900.97
161_I164_V0.6870.97
97_S233_V0.6850.97
66_I92_L0.6840.97
129_L162_T0.6830.97
166_S172_G0.6820.97
127_V200_L0.6800.97
3_I25_A0.6770.97
77_P80_A0.6760.97
162_T260_Y0.6740.97
111_Q136_C0.6690.97
97_S263_D0.6660.96
16_I43_I0.6650.96
195_K199_I0.6640.96
16_I50_I0.6640.96
37_I54_E0.6590.96
187_A198_A0.6580.96
239_K242_E0.6550.96
101_T105_E0.6540.96
77_P81_R0.6500.96
125_A153_H0.6460.96
100_Q264_I0.6450.96
221_P224_Q0.6440.96
113_A136_C0.6430.96
143_K146_E0.6400.96
111_Q133_G0.6360.95
184_I202_C0.6340.95
67_F148_M0.6330.95
56_L60_V0.6320.95
184_I220_L0.6300.95
56_L59_L0.6240.95
91_I113_A0.6230.95
140_A143_K0.6190.95
33_T55_S0.6180.95
247_D250_H0.6180.95
186_A253_F0.6180.95
164_V191_T0.6170.95
177_S223_L0.6150.94
53_T59_L0.6120.94
14_I18_S0.6100.94
105_E112_V0.6060.94
168_I183_F0.6050.94
254_Q257_H0.6050.94
4_G66_I0.6040.94
253_F256_T0.6020.94
71_K229_V0.5980.94
65_M147_L0.5950.93
235_G238_I0.5950.93
129_L155_L0.5940.93
78_L81_R0.5940.93
31_T59_L0.5910.93
161_I197_D0.5910.93
43_I46_R0.5900.93
54_E58_K0.5860.93
128_S151_I0.5860.93
4_G31_T0.5840.93
32_I43_I0.5840.93
112_V133_G0.5830.93
2_K64_E0.5800.93
177_S213_L0.5790.93
180_I220_L0.5790.93
174_A234_T0.5780.92
33_T59_L0.5760.92
153_H214_E0.5760.92
120_T173_P0.5760.92
172_G256_T0.5750.92
166_S171_C0.5730.92
249_F253_F0.5710.92
229_V233_V0.5690.92
128_S152_S0.5660.92
113_A141_K0.5650.92
60_V90_H0.5640.92
34_N95_I0.5610.91
161_I194_S0.5600.91
131_T159_S0.5580.91
129_L169_V0.5570.91
174_A237_G0.5530.91
162_T165_A0.5500.91
172_G253_F0.5490.90
68_I82_A0.5470.90
206_L245_V0.5450.90
124_L151_I0.5420.90
119_I226_K0.5420.90
10_N71_K0.5420.90
175_F256_T0.5410.90
123_A212_L0.5410.90
68_I96_T0.5400.90
86_L108_V0.5400.90
241_L245_V0.5390.90
6_I33_T0.5380.90
164_V187_A0.5360.89
186_A250_H0.5360.89
35_R40_A0.5350.89
92_L110_C0.5310.89
116_I162_T0.5310.89
22_S124_L0.5300.89
85_Y90_H0.5280.89
82_A86_L0.5270.89
138_E141_K0.5260.89
15_L148_M0.5250.88
60_V85_Y0.5240.88
157_I161_I0.5210.88
118_S170_S0.5140.87
91_I111_Q0.5140.87
108_V112_V0.5110.87
239_K250_H0.5100.87
60_V63_N0.5080.87
70_V78_L0.5070.87
184_I195_K0.5070.87
170_S233_V0.5060.87
121_N128_S0.5060.87
91_I143_K0.5060.87
184_I187_A0.5050.86
100_Q104_L0.5040.86
149_Q153_H0.5040.86
63_N90_H0.5000.86
180_I210_G0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2izzA 5 0.978 100 0.382 Contact Map
2rcyA 5 0.9341 100 0.399 Contact Map
1yqgA 2 0.9487 100 0.409 Contact Map
2ahrA 5 0.9267 100 0.411 Contact Map
3triA 2 0.9707 100 0.422 Contact Map
3gt0A 3 0.7802 100 0.46 Contact Map
4kqwA 2 0.956 100 0.475 Contact Map
4wjiA 2 0.9524 100 0.516 Contact Map
3fr7A 2 0.9414 100 0.531 Contact Map
2i76A 2 0.8462 100 0.571 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0259 seconds.