GREMLIN Database
COMEA - ComE operon protein 1
UniProt: P39694 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (194)
Sequences: 1627 (1473)
Seq/√Len: 105.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_T153_E4.4941.00
94_T100_E4.2151.00
166_E170_A3.6451.00
164_K167_A3.5651.00
107_E113_T3.4951.00
151_L166_E3.3041.00
185_T192_E3.1851.00
151_L155_Q3.1831.00
185_T195_F3.0271.00
183_D186_K3.0111.00
61_T77_E2.8351.00
155_Q162_P2.7501.00
158_S201_S2.7241.00
67_K114_V2.6421.00
151_L169_I2.4371.00
79_R82_D2.4351.00
83_R111_D2.4331.00
78_M87_A2.4181.00
164_K194_S2.3371.00
69_A119_K2.2531.00
63_V77_E2.2111.00
78_M82_D2.1501.00
103_V117_I2.0951.00
171_Y186_K2.0921.00
116_Y122_E2.0641.00
170_A174_E2.0481.00
157_I201_S2.0231.00
65_D114_V1.9921.00
145_N203_T1.9881.00
145_N148_T1.9641.00
75_V85_S1.8231.00
78_M90_K1.7691.00
146_I202_I1.7291.00
66_I87_A1.7041.00
181_I195_F1.6581.00
102_Q118_P1.6321.00
69_A95_S1.6081.00
195_F199_K1.5751.00
184_I202_I1.5451.00
193_K196_E1.5261.00
76_Y91_A1.4931.00
145_N204_V1.4801.00
65_D105_L1.4721.00
184_I198_I1.4551.00
157_I202_I1.4331.00
192_E196_E1.4271.00
179_Q183_D1.4231.00
65_D101_A1.3771.00
67_K116_Y1.3771.00
85_S89_E1.3641.00
143_L200_S1.3561.00
160_V164_K1.3501.00
62_I109_L1.3460.99
151_L162_P1.3320.99
180_T183_D1.3300.99
181_I204_V1.2990.99
146_I177_R1.2930.99
87_A109_L1.2880.99
152_E155_Q1.2770.99
119_K122_E1.2730.99
157_I198_I1.2730.99
109_L115_V1.2260.99
167_A197_K1.2250.99
167_A194_S1.2150.99
196_E199_K1.2140.99
182_E195_F1.2120.99
181_I202_I1.2100.99
171_Y175_N1.2100.99
81_G108_I1.2010.99
144_V156_G1.1940.99
167_A170_A1.1870.99
97_Q119_K1.1850.99
78_M109_L1.1630.98
88_I94_T1.1420.98
69_A97_Q1.1350.98
67_K164_K1.1100.98
84_V115_V1.1080.98
98_A121_G1.1030.98
190_I195_F1.0940.98
121_G124_T1.0900.98
143_L203_T1.0900.98
151_L170_A1.0770.98
70_V87_A1.0630.97
24_M28_A1.0450.97
82_D86_Q1.0290.97
21_T24_M1.0190.97
64_I87_A1.0050.96
60_E80_T0.9970.96
108_I112_G0.9960.96
94_T98_A0.9940.96
163_S167_A0.9900.96
99_D121_G0.9860.96
170_A173_E0.9820.96
94_T105_L0.9790.96
65_D164_K0.9710.95
94_T103_V0.9500.95
191_G194_S0.9480.95
194_S198_I0.9450.95
159_G197_K0.9390.95
162_P166_E0.9260.94
182_E199_K0.9210.94
23_I26_F0.9180.94
193_K197_K0.9150.94
71_Q95_S0.9050.93
110_Q113_T0.9000.93
83_R112_G0.8970.93
159_G194_S0.8960.93
146_I150_T0.8830.92
66_I84_V0.8820.92
185_T199_K0.8750.92
23_I27_L0.8720.92
101_A116_Y0.8700.92
184_I195_F0.8680.92
65_D75_V0.8680.92
146_I195_F0.8650.92
67_K191_G0.8610.92
164_K187_V0.8570.91
69_A98_A0.8530.91
19_V27_L0.8440.91
188_S193_K0.8430.91
99_D119_K0.8420.91
163_S189_G0.8410.91
155_Q158_S0.8390.90
65_D194_S0.8380.90
106_A112_G0.8210.89
66_I117_I0.8120.89
82_D90_K0.8110.89
63_V85_S0.8040.89
107_E114_V0.7940.88
175_N183_D0.7930.88
88_I105_L0.7900.88
158_S167_A0.7900.88
163_S188_S0.7860.87
194_S197_K0.7850.87
163_S193_K0.7770.87
187_V191_G0.7750.87
99_D102_Q0.7660.86
153_E156_G0.7650.86
167_A187_V0.7610.86
118_P122_E0.7600.86
70_V117_I0.7590.85
82_D112_G0.7440.84
62_I81_G0.7350.84
22_A26_F0.7300.83
191_G196_E0.7280.83
69_A122_E0.7260.83
164_K188_S0.7200.82
21_T36_V0.7140.82
103_V114_V0.7100.81
65_D167_A0.7100.81
63_V75_V0.7070.81
76_Y87_A0.7070.81
118_P157_I0.7050.81
178_F189_G0.7040.81
58_S61_T0.7000.81
71_Q88_I0.6930.80
82_D85_S0.6920.80
61_T79_R0.6900.80
37_K40_V0.6890.79
107_E112_G0.6830.79
89_E115_V0.6780.78
27_L30_G0.6770.78
163_S166_E0.6750.78
37_K44_T0.6680.77
37_K46_N0.6650.77
71_Q92_G0.6640.77
76_Y160_V0.6620.77
171_Y177_R0.6620.77
86_Q89_E0.6590.76
74_G83_R0.6530.76
85_S105_L0.6520.76
178_F187_V0.6500.75
164_K189_G0.6490.75
88_I92_G0.6450.75
181_I199_K0.6450.75
99_D158_S0.6430.75
173_E179_Q0.6410.74
84_V117_I0.6360.74
155_Q185_T0.6340.74
60_E138_G0.6310.73
45_E49_V0.6310.73
188_S197_K0.6310.73
160_V198_I0.6300.73
164_K197_K0.6260.73
20_F135_Q0.6220.72
23_I28_A0.6220.72
43_E47_T0.6170.72
67_K101_A0.6170.72
164_K171_Y0.6140.71
164_K191_G0.6130.71
37_K41_P0.6110.71
65_D116_Y0.6100.71
20_F24_M0.6100.71
45_E48_V0.6050.70
157_I187_V0.6040.70
67_K76_Y0.6040.70
66_I88_I0.6020.70
145_N177_R0.6020.70
146_I184_I0.6010.70
195_F202_I0.5950.69
69_A183_D0.5940.69
159_G171_Y0.5940.69
47_T53_A0.5930.69
130_G134_V0.5920.69
163_S197_K0.5900.68
39_A44_T0.5890.68
76_Y164_K0.5870.68
107_E110_Q0.5840.67
100_E105_L0.5830.67
50_K56_D0.5810.67
160_V167_A0.5810.67
87_A90_K0.5800.67
99_D123_E0.5790.67
67_K194_S0.5780.67
141_G203_T0.5780.67
159_G186_K0.5780.67
69_A120_K0.5760.66
114_V164_K0.5750.66
14_A20_F0.5730.66
65_D112_G0.5730.66
69_A116_Y0.5730.66
164_K179_Q0.5730.66
164_K190_I0.5710.66
88_I100_E0.5680.65
18_A21_T0.5660.65
36_V53_A0.5640.65
160_V194_S0.5610.64
187_V190_I0.5600.64
157_I195_F0.5600.64
62_I87_A0.5590.64
19_V23_I0.5580.64
43_E55_N0.5580.64
18_A22_A0.5580.64
65_D85_S0.5570.64
167_A188_S0.5570.64
162_P195_F0.5550.64
16_S21_T0.5520.63
91_A115_V0.5510.63
118_P121_G0.5500.63
21_T25_I0.5470.62
107_E167_A0.5460.62
173_E177_R0.5450.62
175_N186_K0.5430.62
164_K170_A0.5420.62
48_V51_Q0.5420.62
65_D193_K0.5410.62
49_V53_A0.5410.62
182_E185_T0.5380.61
10_A21_T0.5360.61
192_E201_S0.5350.61
104_N190_I0.5340.61
14_A18_A0.5330.60
154_L168_I0.5330.60
162_P192_E0.5320.60
133_S136_S0.5310.60
41_P50_K0.5300.60
105_L191_G0.5260.59
171_Y202_I0.5260.59
181_I185_T0.5260.59
105_L193_K0.5230.59
20_F27_L0.5220.59
171_Y197_K0.5220.59
69_A192_E0.5210.59
66_I101_A0.5210.59
53_A56_D0.5200.59
112_G163_S0.5190.58
40_V56_D0.5170.58
158_S198_I0.5160.58
74_G78_M0.5160.58
88_I93_G0.5160.58
62_I78_M0.5160.58
88_I180_T0.5160.58
159_G201_S0.5140.58
110_Q117_I0.5110.57
147_N176_G0.5110.57
18_A50_K0.5100.57
169_I177_R0.5090.57
17_A20_F0.5090.57
157_I197_K0.5090.57
144_V150_T0.5090.57
13_L28_A0.5080.57
109_L134_V0.5070.57
30_G144_V0.5060.57
127_Q137_D0.5050.56
67_K105_L0.5040.56
163_S194_S0.5040.56
88_I117_I0.5030.56
63_V99_D0.5030.56
125_A136_S0.5020.56
49_V55_N0.5020.56
75_V122_E0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3psiA 1 0.8683 100 0.574 Contact Map
3psfA 1 0.8683 100 0.588 Contact Map
3bzcA 1 0.8244 100 0.61 Contact Map
2i5hA 1 0.6829 99.8 0.717 Contact Map
4pj0U 1 0.361 99.7 0.729 Contact Map
3wu2U 1 0.3659 99.7 0.744 Contact Map
2j58A 5 0.9659 99.5 0.767 Contact Map
2duyA 1 0.3171 99.5 0.771 Contact Map
3ci0K 1 0.9024 99.5 0.771 Contact Map
2eduA 1 0.4537 99.4 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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