GREMLIN Database
YYXA - Uncharacterized serine protease YyxA
UniProt: P39668 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (319)
Sequences: 8238 (5554)
Seq/√Len: 311.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_N253_K5.3331.00
83_S183_K4.6921.00
350_E378_K4.2391.00
379_F388_V4.0651.00
178_N277_K3.6291.00
116_K121_S3.4371.00
352_D369_K3.3431.00
128_H154_S3.1811.00
175_D253_K3.0301.00
374_R389_D2.9971.00
378_K385_E2.9721.00
376_K387_S2.8211.00
178_N181_K2.7931.00
174_A254_V2.7571.00
88_A173_V2.6951.00
376_K389_D2.5511.00
150_D166_K2.4391.00
149_A163_L2.4141.00
137_I151_L2.4071.00
180_D277_K2.3981.00
379_F386_K2.2191.00
238_I271_G2.1911.00
162_V287_E2.1861.00
167_S170_I2.1261.00
350_E353_G2.0781.00
136_Q148_S2.0721.00
138_E146_R2.0151.00
113_V257_I2.0111.00
349_T380_Y1.9881.00
297_L390_I1.9561.00
374_R391_K1.9531.00
300_E330_G1.9211.00
378_K387_S1.9121.00
208_I232_L1.9091.00
357_N361_D1.9071.00
350_E355_K1.8901.00
79_T186_E1.8841.00
113_V246_A1.8821.00
95_I136_Q1.8811.00
113_V174_A1.8581.00
147_V165_V1.8571.00
113_V254_V1.8541.00
160_L257_I1.8531.00
342_L377_V1.8511.00
125_V279_V1.8501.00
176_F280_I1.8221.00
176_F276_S1.8201.00
82_V203_V1.8191.00
284_E288_R1.8181.00
334_F338_G1.8011.00
285_D289_Y1.7811.00
370_K373_D1.7441.00
293_K394_S1.7421.00
346_D381_R1.6981.00
301_M359_I1.6941.00
125_V283_I1.6821.00
289_Y293_K1.6741.00
187_P205_Q1.6371.00
303_S359_I1.6331.00
349_T385_E1.6261.00
339_K393_S1.6251.00
141_L147_V1.6221.00
342_L379_F1.6191.00
121_S164_R1.6181.00
138_E148_S1.5811.00
369_K373_D1.5621.00
174_A248_L1.5591.00
369_K392_L1.5391.00
79_T183_K1.5241.00
85_M174_A1.5231.00
78_V187_P1.5131.00
246_A254_V1.5051.00
123_Y164_R1.5031.00
354_Y365_R1.4991.00
358_D361_D1.4971.00
150_D164_R1.4701.00
85_M248_L1.4531.00
123_Y152_V1.4511.00
182_V255_I1.4241.00
296_F336_P1.4101.00
257_I279_V1.4091.00
94_N137_I1.4041.00
351_F369_K1.4031.00
296_F396_D1.4021.00
167_S171_K1.3971.00
349_T378_K1.3951.00
114_I141_L1.3871.00
381_R386_K1.3811.00
291_K394_S1.3761.00
328_V342_L1.3751.00
280_I284_E1.3741.00
123_Y287_E1.3701.00
324_N355_K1.3671.00
93_V140_S1.3471.00
88_A174_A1.3411.00
295_P371_V1.3381.00
380_Y385_E1.3351.00
115_Y283_I1.3231.00
333_A338_G1.3211.00
90_V124_V1.3071.00
77_A186_E1.2931.00
369_K375_V1.2901.00
342_L388_V1.2841.00
179_S277_K1.2831.00
336_P393_S1.2791.00
187_P250_M1.2691.00
212_E230_E1.2541.00
78_V205_Q1.2541.00
116_K123_Y1.2111.00
184_S211_T1.2091.00
147_V167_S1.2021.00
305_S308_A1.1931.00
375_V392_L1.1921.00
128_H132_E1.1851.00
195_L262_I1.1831.00
182_V232_L1.1801.00
182_V208_I1.1721.00
81_I248_L1.1631.00
324_N357_N1.1541.00
124_V165_V1.1491.00
264_E268_E1.1441.00
177_G276_S1.1421.00
96_Q106_E1.1401.00
332_D335_S1.1321.00
352_D376_K1.1251.00
188_V208_I1.1241.00
296_F332_D1.1231.00
84_N175_D1.1211.00
92_V163_L1.1201.00
155_D158_M1.1171.00
302_K329_M1.1171.00
111_S246_A1.1121.00
211_T232_L1.1081.00
168_D171_K1.1061.00
80_K183_K1.1031.00
141_L145_S1.0931.00
81_I189_I1.0921.00
123_Y162_V1.0841.00
134_A137_I1.0791.00
140_S146_R1.0781.00
234_T247_L1.0781.00
189_I250_M1.0671.00
157_L395_A1.0651.00
177_G182_V1.0551.00
330_G344_E1.0531.00
116_K122_A1.0531.00
128_H156_Q1.0521.00
328_V348_I1.0481.00
82_V189_I1.0461.00
352_D365_R1.0441.00
165_V170_I1.0421.00
327_V345_L1.0341.00
190_A247_L1.0331.00
331_V335_S1.0331.00
151_L154_S1.0321.00
279_V283_I1.0191.00
92_V139_I1.0121.00
90_V112_G1.0101.00
112_G124_V1.0051.00
153_G286_L1.0031.00
77_A80_K1.0011.00
132_E156_Q0.9871.00
303_S358_D0.9861.00
78_V189_I0.9811.00
351_F377_V0.9761.00
283_I287_E0.9711.00
284_E287_E0.9691.00
305_S309_S0.9681.00
129_H159_D0.9661.00
122_A164_R0.9631.00
195_L267_V0.9611.00
203_V207_V0.9611.00
117_K173_V0.9611.00
281_P285_D0.9601.00
81_I85_M0.9591.00
380_Y383_G0.9551.00
351_F375_V0.9461.00
85_M191_I0.9431.00
261_K267_V0.9411.00
117_K170_I0.9401.00
351_F362_L0.9401.00
158_M294_R0.9321.00
129_H243_S0.9141.00
141_L165_V0.9011.00
158_M282_V0.8971.00
343_K381_R0.8961.00
190_A258_N0.8941.00
95_I105_G0.8871.00
86_S201_G0.8801.00
188_V255_I0.8751.00
193_N198_E0.8741.00
198_E201_G0.8721.00
356_V365_R0.8681.00
300_E332_D0.8661.00
95_I107_A0.8651.00
82_V86_S0.8611.00
155_D294_R0.8521.00
116_K287_E0.8511.00
89_V246_A0.8511.00
95_I138_E0.8471.00
139_I149_A0.8471.00
340_A390_I0.8461.00
353_G376_K0.8451.00
114_I171_K0.8451.00
295_P392_L0.8451.00
124_V163_L0.8441.00
98_S102_G0.8401.00
377_V390_I0.8391.00
247_L258_N0.8391.00
97_K103_E0.8341.00
94_N109_S0.8331.00
162_V283_I0.8311.00
301_M326_A0.8301.00
183_K186_E0.8261.00
182_V211_T0.8231.00
86_S142_K0.8221.00
127_N274_I0.8181.00
139_I165_V0.8171.00
261_K268_E0.8161.00
351_F366_L0.8151.00
238_I258_N0.8111.00
188_V250_M0.8091.00
176_F254_V0.8071.00
97_K135_S0.8051.00
350_E385_E0.8021.00
319_P322_V0.8021.00
80_K84_N0.7991.00
326_A356_V0.7991.00
236_A271_G0.7971.00
114_I165_V0.7951.00
78_V82_V0.7941.00
152_V164_R0.7931.00
331_V344_E0.7921.00
377_V388_V0.7911.00
195_L268_E0.7871.00
365_R369_K0.7831.00
218_D226_D0.7770.99
153_G162_V0.7750.99
331_V341_G0.7730.99
129_H241_G0.7710.99
300_E329_M0.7680.99
254_V276_S0.7680.99
298_G336_P0.7660.99
343_K382_G0.7650.99
263_A267_V0.7600.99
337_A340_A0.7580.99
285_D290_G0.7560.99
304_L309_S0.7490.99
299_I326_A0.7420.99
182_V188_V0.7400.99
301_M362_L0.7400.99
213_R233_Q0.7390.99
115_Y287_E0.7380.99
91_G108_G0.7350.99
110_G130_V0.7340.99
94_N135_S0.7330.99
374_R392_L0.7310.99
205_Q235_D0.7310.99
325_G347_V0.7270.99
91_G198_E0.7260.99
215_I231_V0.7250.99
365_R368_Q0.7250.99
160_L283_I0.7210.99
304_L323_T0.7190.99
74_V77_A0.7170.99
282_V286_L0.7150.99
240_P264_E0.7150.99
297_L377_V0.7150.99
116_K173_V0.7120.99
94_N134_A0.7100.99
352_D375_V0.7100.99
371_V393_S0.7090.99
217_V231_V0.7090.99
145_S169_K0.7060.99
74_V187_P0.7020.99
332_D338_G0.7010.99
114_I173_V0.6930.99
179_S182_V0.6930.99
239_N242_N0.6910.99
361_D365_R0.6910.99
117_K121_S0.6910.99
93_V138_E0.6900.99
297_L392_L0.6870.99
285_D292_V0.6840.99
230_E278_L0.6840.99
159_D243_S0.6820.99
233_Q272_L0.6810.99
162_V286_L0.6760.99
351_F365_R0.6750.99
373_D392_L0.6740.99
366_L369_K0.6730.99
339_K391_K0.6730.99
277_K280_I0.6720.99
115_Y162_V0.6720.99
91_G193_N0.6670.98
381_R388_V0.6660.98
58_Q61_N0.6650.98
306_D314_E0.6650.98
125_V160_L0.6630.98
218_D229_A0.6620.98
276_S279_V0.6620.98
353_G378_K0.6620.98
94_N108_G0.6600.98
126_T161_A0.6560.98
115_Y125_V0.6550.98
379_F387_S0.6530.98
256_G273_S0.6520.98
331_V338_G0.6510.98
92_V149_A0.6440.98
263_A266_A0.6440.98
296_F395_A0.6430.98
114_I170_I0.6430.98
109_S197_L0.6420.98
302_K327_V0.6420.98
328_V388_V0.6420.98
356_V377_V0.6410.98
142_K201_G0.6410.98
297_L362_L0.6390.98
81_I84_N0.6390.98
96_Q135_S0.6370.98
93_V146_R0.6360.98
93_V109_S0.6350.98
381_R384_K0.6340.98
97_K105_G0.6330.98
121_S173_V0.6320.98
289_Y292_V0.6320.98
229_A259_S0.6320.98
113_V160_L0.6310.98
348_I356_V0.6300.98
335_S338_G0.6280.98
285_D288_R0.6270.98
359_I363_R0.6270.98
213_R272_L0.6260.98
375_V390_I0.6250.98
195_L261_K0.6200.98
209_S233_Q0.6200.98
308_A316_L0.6200.98
91_G109_S0.6180.97
131_I154_S0.6180.97
301_M363_R0.6170.97
351_F356_V0.6170.97
127_N130_V0.6170.97
372_G391_K0.6140.97
77_A187_P0.6120.97
159_D241_G0.6110.97
343_K386_K0.6100.97
386_K389_D0.6100.97
384_K389_D0.6080.97
356_V362_L0.6080.97
247_L273_S0.6070.97
246_A258_N0.6040.97
319_P380_Y0.6030.97
189_I205_Q0.6020.97
330_G333_A0.6010.97
276_S280_I0.6010.97
94_N106_E0.5990.97
127_N159_D0.5990.97
137_I163_L0.5970.97
336_P340_A0.5940.97
193_N196_G0.5910.97
237_A267_V0.5910.97
304_L318_L0.5890.97
117_K122_A0.5880.97
228_N367_Y0.5850.97
130_V243_S0.5840.96
113_V125_V0.5840.96
81_I191_I0.5820.96
148_S166_K0.5800.96
127_N258_N0.5780.96
215_I227_W0.5780.96
188_V205_Q0.5760.96
178_N280_I0.5760.96
363_R366_L0.5750.96
302_K308_A0.5740.96
303_S326_A0.5720.96
131_I137_I0.5720.96
334_F339_K0.5720.96
258_N273_S0.5700.96
362_L377_V0.5700.96
193_N260_M0.5690.96
191_I248_L0.5690.96
262_I267_V0.5690.96
326_A359_I0.5690.96
153_G282_V0.5680.96
176_F283_I0.5650.96
217_V260_M0.5640.96
209_S239_N0.5640.96
179_S276_S0.5640.96
354_Y368_Q0.5640.96
303_S360_V0.5630.96
64_R67_I0.5620.96
299_I342_L0.5610.96
217_V229_A0.5600.96
132_E154_S0.5590.95
209_S213_R0.5590.95
114_I124_V0.5580.95
227_W363_R0.5570.95
231_V259_S0.5560.95
304_L327_V0.5560.95
86_S184_S0.5550.95
115_Y123_Y0.5540.95
343_K346_D0.5540.95
78_V207_V0.5530.95
295_P373_D0.5530.95
60_N63_G0.5530.95
189_I203_V0.5530.95
286_L292_V0.5520.95
249_N255_I0.5510.95
76_N80_K0.5490.95
304_L347_V0.5460.95
363_R367_Y0.5460.95
124_V171_K0.5450.95
260_M263_A0.5450.95
216_P226_D0.5450.95
145_S167_S0.5440.95
124_V170_I0.5440.95
110_G129_H0.5420.95
130_V241_G0.5400.95
348_I362_L0.5400.95
177_G255_I0.5400.95
188_V247_L0.5390.95
282_V292_V0.5390.95
229_A278_L0.5390.95
371_V392_L0.5360.94
174_A276_S0.5360.94
69_T72_V0.5350.94
81_I174_A0.5350.94
261_K270_I0.5340.94
87_P142_K0.5290.94
296_F301_M0.5280.94
338_G341_G0.5270.94
304_L308_A0.5270.94
186_E249_N0.5260.94
58_Q62_N0.5260.94
158_M278_L0.5250.94
96_Q107_A0.5250.94
194_P197_L0.5250.94
80_K83_S0.5240.94
160_L276_S0.5240.94
361_D364_K0.5230.94
281_P370_K0.5230.94
293_K392_L0.5220.94
352_D373_D0.5210.93
96_Q133_G0.5210.93
113_V248_L0.5200.93
326_A362_L0.5200.93
127_N242_N0.5200.93
195_L202_S0.5190.93
78_V203_V0.5190.93
209_S242_N0.5180.93
127_N246_A0.5170.93
129_H233_Q0.5160.93
180_D211_T0.5160.93
122_A165_V0.5160.93
76_N187_P0.5150.93
234_T273_S0.5150.93
96_Q108_G0.5150.93
71_N75_N0.5140.93
204_T209_S0.5120.93
329_M344_E0.5110.93
177_G181_K0.5110.93
278_L282_V0.5100.93
89_V155_D0.5100.93
353_G387_S0.5100.93
337_A342_L0.5090.93
214_A231_V0.5080.93
326_A363_R0.5080.93
71_N74_V0.5070.93
364_K368_Q0.5060.92
240_P261_K0.5060.92
115_Y173_V0.5050.92
74_V78_V0.5030.92
145_S170_I0.5010.92
61_N65_E0.5010.92
232_L247_L0.5010.92
109_S193_N0.5000.92
340_A388_V0.5000.92
166_K170_I0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ky9A 5 0.755 100 0.359 Contact Map
3stjA 6 0.745 100 0.376 Contact Map
3pv2A 6 0.73 100 0.38 Contact Map
4a8cA 5 0.76 100 0.383 Contact Map
1lcyA 3 0.73 100 0.411 Contact Map
4ri0A 3 0.7625 100 0.426 Contact Map
3numA 3 0.475 100 0.43 Contact Map
4ic6A 4 0.775 100 0.432 Contact Map
3qo6A 5 0.7825 100 0.433 Contact Map
1te0A 6 0.7825 100 0.438 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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