GREMLIN Database
NADC - Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt: P39666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (245)
Sequences: 5693 (3315)
Seq/√Len: 211.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_R117_R3.6951.00
217_P220_T3.0791.00
246_P250_G3.0421.00
44_G268_L2.7971.00
201_R227_L2.7841.00
133_T140_E2.7701.00
112_T149_G2.6011.00
34_C88_A2.5731.00
70_K73_D2.5371.00
194_I200_L2.5131.00
172_S175_E2.4331.00
240_I248_F2.3671.00
35_E85_H2.3021.00
69_K79_E2.2091.00
68_H83_E2.2081.00
174_L202_E2.1741.00
228_T234_T2.1491.00
47_A146_A2.1191.00
174_L178_K2.1051.00
223_H226_K2.0301.00
46_F69_K2.0171.00
201_R205_A1.9951.00
64_Q85_H1.9591.00
43_E76_H1.9371.00
81_I270_I1.9331.00
195_E199_Q1.9271.00
33_S85_H1.8961.00
91_L272_M1.8741.00
59_L94_G1.8681.00
56_F98_V1.8661.00
174_L205_A1.7871.00
114_E242_L1.7561.00
175_E178_K1.7501.00
220_T223_H1.7231.00
144_V149_G1.7191.00
60_D90_A1.6821.00
127_C255_Y1.6771.00
247_A250_G1.6521.00
142_Y146_A1.6471.00
119_L126_I1.6241.00
104_R133_T1.6121.00
221_V236_A1.6021.00
119_L124_I1.5841.00
46_F75_L1.5841.00
52_I82_A1.5711.00
117_R120_D1.5611.00
35_E83_E1.5601.00
46_F49_A1.5311.00
43_E77_K1.5171.00
233_K255_Y1.5151.00
54_E58_L1.5141.00
225_A229_P1.4971.00
175_E179_K1.4901.00
115_A242_L1.4881.00
52_I98_V1.4871.00
104_R140_E1.4741.00
221_V248_F1.4671.00
115_A258_L1.4641.00
177_C192_V1.4591.00
115_A245_L1.4451.00
191_E210_V1.4281.00
38_I270_I1.4231.00
118_C242_L1.4061.00
111_M242_L1.4011.00
244_S247_A1.3971.00
87_P90_A1.3951.00
76_H79_E1.3881.00
118_C246_P1.3811.00
31_E87_P1.3721.00
46_F81_I1.3721.00
69_K73_D1.3641.00
125_K150_Y1.3641.00
126_I245_L1.3581.00
86_G91_L1.3571.00
111_M265_V1.3491.00
129_T137_R1.3381.00
53_K57_S1.3371.00
74_M113_R1.3351.00
47_A109_A1.3311.00
200_L228_T1.3271.00
50_A71_D1.3111.00
54_E57_S1.3101.00
45_I74_M1.3051.00
63_V86_G1.3021.00
160_I184_A1.2971.00
189_N209_D1.2801.00
121_D246_P1.2771.00
38_I52_I1.2751.00
36_A272_M1.2721.00
74_M117_R1.2571.00
200_L204_I1.2431.00
80_V83_E1.2401.00
210_V233_K1.2341.00
37_E83_E1.2221.00
164_D273_D1.2141.00
103_Q267_S1.1841.00
69_K75_L1.1801.00
233_K254_N1.1771.00
37_E80_V1.1751.00
112_T116_V1.1641.00
218_P248_F1.1581.00
41_K271_S1.1581.00
51_I142_Y1.1341.00
235_E255_Y1.1321.00
211_I224_F1.1321.00
178_K182_Q1.1261.00
198_E201_R1.1241.00
42_S266_K1.1241.00
225_A228_T1.1231.00
56_F94_G1.0991.00
121_D250_G1.0911.00
55_G94_G1.0851.00
45_I113_R1.0761.00
200_L211_I1.0741.00
249_K256_I1.0691.00
55_G97_V1.0641.00
38_I102_I1.0631.00
191_E212_M1.0591.00
108_I140_E1.0571.00
47_A142_Y1.0551.00
105_L143_A1.0541.00
38_I82_A1.0421.00
219_D222_R1.0391.00
37_E275_T1.0181.00
179_K182_Q1.0171.00
197_E224_F1.0171.00
46_F102_I1.0141.00
43_E74_M1.0131.00
189_N210_V1.0021.00
111_M115_A1.0011.00
122_E246_P1.0011.00
168_A195_E1.0001.00
39_V273_D0.9931.00
59_L90_A0.9841.00
116_V150_Y0.9771.00
63_V90_A0.9771.00
122_E249_K0.9721.00
50_A53_K0.9681.00
200_L224_F0.9661.00
236_A253_V0.9661.00
111_M114_E0.9641.00
49_A67_L0.9621.00
245_L258_L0.9551.00
116_V121_D0.9551.00
122_E250_G0.9531.00
39_V271_S0.9501.00
71_D146_A0.9471.00
160_I180_A0.9390.99
107_G265_V0.9340.99
88_A169_A0.9330.99
118_C245_L0.9310.99
53_K67_L0.9300.99
51_I139_L0.9270.99
50_A142_Y0.9250.99
240_I244_S0.9230.99
124_I149_G0.9210.99
170_C179_K0.9120.99
229_P232_I0.9090.99
218_P247_A0.9070.99
36_A274_V0.9010.99
38_I98_V0.8980.99
61_E86_G0.8940.99
61_E67_L0.8940.99
33_S87_P0.8920.99
239_G269_D0.8900.99
75_L81_I0.8900.99
177_C206_A0.8890.99
40_A44_G0.8870.99
236_A251_T0.8870.99
245_L256_I0.8810.99
64_Q67_L0.8810.99
201_R204_I0.8790.99
68_H80_V0.8720.99
244_S248_F0.8680.99
49_A53_K0.8680.99
181_R190_I0.8660.99
127_C186_H0.8590.99
222_R226_K0.8430.99
105_L139_L0.8400.99
195_E273_D0.8350.99
213_F224_F0.8300.99
202_E205_A0.8260.99
151_N159_G0.8140.98
32_Q88_A0.8130.98
67_L73_D0.8080.98
94_G98_V0.8030.98
30_G89_A0.8030.98
61_E64_Q0.8030.98
258_L261_L0.8000.98
259_G262_T0.7940.98
222_R250_G0.7920.98
124_I256_I0.7920.98
101_L139_L0.7850.98
114_E117_R0.7850.98
119_L249_K0.7840.98
242_L260_F0.7830.98
116_V149_G0.7810.98
200_L227_L0.7780.98
228_T232_I0.7770.98
34_C91_L0.7760.98
236_A248_F0.7750.98
116_V120_D0.7740.98
28_I180_A0.7740.98
38_I99_L0.7710.98
28_I162_I0.7710.98
34_C274_V0.7700.98
122_E256_I0.7640.98
207_G231_N0.7640.98
167_I171_G0.7630.98
241_T244_S0.7590.98
225_A251_T0.7550.98
208_A232_I0.7520.97
172_S202_E0.7520.97
155_G158_D0.7500.97
128_D151_N0.7490.97
181_R209_D0.7450.97
55_G98_V0.7420.97
96_R129_T0.7420.97
101_L136_L0.7400.97
223_H227_L0.7400.97
216_C220_T0.7400.97
196_T199_Q0.7360.97
44_G106_S0.7350.97
194_I224_F0.7330.97
51_I105_L0.7260.97
218_P251_T0.7240.97
71_D142_Y0.7220.97
162_I180_A0.7180.97
168_A274_V0.7170.97
264_S267_S0.7170.97
46_F106_S0.7160.97
218_P244_S0.7160.97
204_I228_T0.7160.97
203_A208_A0.7110.96
204_I227_L0.7100.96
210_V255_Y0.7080.96
128_D144_V0.7050.96
191_E235_E0.7040.96
105_L140_E0.7030.96
259_G263_H0.6970.96
216_C224_F0.6940.96
224_F227_L0.6910.96
224_F228_T0.6910.96
191_E209_D0.6890.96
62_N87_P0.6880.96
239_G258_L0.6870.96
44_G75_L0.6860.96
185_G188_V0.6820.96
140_E265_V0.6800.95
104_R108_I0.6800.95
35_E275_T0.6800.95
201_R223_H0.6770.95
174_L206_A0.6730.95
49_A71_D0.6720.95
203_A232_I0.6680.95
116_V124_I0.6680.95
55_G101_L0.6660.95
211_I228_T0.6650.95
119_L245_L0.6650.95
221_V225_A0.6620.95
62_N85_H0.6590.95
197_E201_R0.6560.94
189_N233_K0.6530.94
40_A75_L0.6520.94
34_C169_A0.6460.94
52_I55_G0.6390.94
193_E197_E0.6380.94
197_E227_L0.6380.94
152_H191_E0.6370.94
61_E90_A0.6350.93
111_M260_F0.6350.93
181_R207_G0.6350.93
38_I272_M0.6340.93
259_G264_S0.6330.93
36_A84_L0.6330.93
119_L122_E0.6320.93
84_L94_G0.6320.93
39_V80_V0.6260.93
195_E271_S0.6250.93
40_A81_I0.6230.93
42_S268_L0.6220.93
102_I270_I0.6210.93
43_E113_R0.6190.93
212_M221_V0.6180.93
177_C203_A0.6100.92
44_G110_T0.6100.92
43_E117_R0.6090.92
48_G106_S0.6070.92
219_D247_A0.6070.92
203_A206_A0.6050.92
199_Q202_E0.6030.92
161_M164_D0.6020.92
145_R156_L0.5960.91
116_V126_I0.5950.91
63_V67_L0.5930.91
193_E198_E0.5930.91
120_D246_P0.5890.91
247_A251_T0.5870.91
178_K206_A0.5860.90
103_Q270_I0.5850.90
63_V84_L0.5810.90
136_L139_L0.5800.90
154_F157_Y0.5800.90
127_C210_V0.5770.90
96_R137_R0.5770.90
127_C257_S0.5740.90
63_V87_P0.5740.90
60_D63_V0.5740.90
136_L140_E0.5740.90
125_K255_Y0.5720.89
56_F63_V0.5660.89
123_Q254_N0.5620.89
49_A52_I0.5620.89
177_C208_A0.5590.88
164_D215_N0.5590.88
236_A240_I0.5580.88
204_I232_I0.5570.88
184_A188_V0.5490.87
198_E202_E0.5480.87
225_A252_G0.5470.87
180_A184_A0.5450.87
106_S270_I0.5450.87
103_Q128_D0.5450.87
240_I256_I0.5440.87
56_F84_L0.5440.87
169_A274_V0.5420.87
167_I170_C0.5400.87
260_F264_S0.5390.86
186_H255_Y0.5390.86
111_M118_C0.5380.86
119_L149_G0.5360.86
126_I258_L0.5350.86
164_D195_E0.5350.86
31_E89_A0.5330.86
168_A273_D0.5320.86
50_A54_E0.5310.86
221_V251_T0.5310.86
49_A70_K0.5290.85
236_A252_G0.5280.85
193_E199_Q0.5270.85
67_L70_K0.5270.85
62_N182_Q0.5260.85
263_H267_S0.5250.85
213_F216_C0.5240.85
235_E238_G0.5220.85
262_T267_S0.5210.85
194_I211_I0.5210.85
229_P234_T0.5210.85
59_L93_S0.5200.84
216_C221_V0.5170.84
126_I256_I0.5170.84
49_A82_A0.5160.84
116_V147_G0.5150.84
173_I202_E0.5130.84
194_I227_L0.5130.84
110_T268_L0.5130.84
200_L234_T0.5110.83
197_E223_H0.5110.83
180_A183_A0.5090.83
115_A240_I0.5080.83
192_V208_A0.5060.83
171_G175_E0.5060.83
207_G232_I0.5040.83
190_I193_E0.5020.82
38_I84_L0.5020.82
241_T258_L0.5010.82
42_S77_K0.5000.82
190_I208_A0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l0gA 3 0.9412 100 0.169 Contact Map
3pajA 2 0.9516 100 0.191 Contact Map
1qapA 2 0.9481 100 0.198 Contact Map
3gnnA 2 0.8651 100 0.2 Contact Map
2b7nA 6 0.9343 100 0.212 Contact Map
2jbmA 5 0.9516 100 0.213 Contact Map
1qpoA 2 0.9446 100 0.214 Contact Map
3tqvA 2 0.9446 100 0.218 Contact Map
1o4uA 2 0.9066 100 0.232 Contact Map
3c2eA 5 0.872 100 0.24 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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