GREMLIN Database
YWFO - Uncharacterized protein YwfO
UniProt: P39651 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (389)
Sequences: 1426 (1004)
Seq/√Len: 50.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_I309_C4.1991.00
43_R286_D3.8311.00
29_I95_L3.7541.00
75_M172_A3.5651.00
122_D126_G3.3671.00
178_L228_M3.3501.00
129_L150_A3.3451.00
32_L96_A3.3191.00
39_Q42_R3.2591.00
307_D311_R3.1631.00
284_K299_D3.1621.00
201_M210_I3.1271.00
36_R133_E3.0011.00
35_T137_V2.9071.00
251_R304_I2.8361.00
42_R62_F2.8331.00
73_R95_L2.7541.00
71_I172_A2.7521.00
100_L103_L2.7061.00
135_N139_R2.6781.00
77_D91_R2.6411.00
50_T238_T2.5741.00
17_P56_G2.5371.00
228_M233_Y2.5191.00
196_R235_H2.4201.00
106_G112_F2.3461.00
72_V94_C2.3091.00
125_R154_A2.2821.00
147_Q151_E2.2781.00
333_F336_T2.2491.00
298_E314_N2.2471.00
311_R316_Q2.2401.00
295_Q313_I2.2231.00
351_V356_S2.2071.00
72_V98_A2.1901.00
247_K250_H2.1301.00
332_Y336_T2.0781.00
52_L241_A2.0321.00
14_F24_V2.0221.00
127_I283_V2.0151.00
68_V172_A2.0001.00
196_R315_R1.9791.00
210_I218_V1.9691.00
105_H121_E1.9530.99
214_G217_A1.9390.99
14_F55_H1.9330.99
241_A317_L1.9100.99
108_F291_L1.8680.99
248_I294_F1.8560.99
306_S310_R1.8430.99
31_D140_K1.8310.99
348_Y360_Y1.8290.99
239_R357_D1.8070.99
29_I69_Y1.7760.99
27_K31_D1.7660.99
251_R255_L1.7290.99
93_L148_D1.7270.99
69_Y95_L1.6890.98
310_R316_Q1.6850.98
228_M232_V1.6830.98
356_S360_Y1.6630.98
150_A153_I1.6600.98
126_G130_G1.6490.98
37_E130_G1.6360.98
235_H315_R1.6130.98
18_V183_Y1.6070.98
20_R195_E1.6050.98
74_R77_D1.5980.98
278_T281_D1.5940.98
100_L128_I1.5870.98
352_V356_S1.5640.97
15_K21_Y1.5390.97
349_Y356_S1.5110.97
151_E156_T1.5090.97
398_G401_R1.4960.97
139_R146_P1.4850.97
251_R302_D1.4810.96
133_E137_V1.4800.96
244_I318_F1.4760.96
74_R195_E1.4730.96
148_D157_Y1.4670.96
351_V360_Y1.4570.96
34_G42_R1.4570.96
101_H120_H1.4410.96
13_V21_Y1.4320.96
105_H120_H1.4180.95
171_D174_R1.4090.95
363_Y367_E1.3980.95
102_D173_D1.3720.95
51_Y60_S1.3660.94
353_D356_S1.3640.94
32_L100_L1.3590.94
101_H121_E1.3580.94
89_S148_D1.3500.94
280_E337_S1.3390.94
175_M179_Q1.3360.94
139_R144_G1.3340.94
252_A297_W1.3330.94
75_M201_M1.3280.94
25_R29_I1.3230.93
343_G346_P1.3190.93
110_H173_D1.3190.93
151_E158_K1.3170.93
168_S175_M1.3150.93
310_R314_N1.3130.93
204_R209_V1.3120.93
101_H173_D1.3010.93
179_Q194_M1.2990.93
200_V214_G1.2940.93
352_V360_Y1.2930.93
121_E173_D1.2890.93
113_E219_E1.2850.92
152_V162_V1.2830.92
19_H179_Q1.2810.92
33_I38_F1.2770.92
29_I96_A1.2750.92
175_M192_F1.2740.92
369_E372_L1.2630.92
39_Q235_H1.2620.92
70_E73_R1.2610.92
244_I317_L1.2570.92
39_Q62_F1.2460.91
271_S274_E1.2370.91
62_F235_H1.2350.91
267_V270_Y1.2240.90
178_L224_S1.2210.90
24_V30_W1.2210.90
32_L138_L1.2180.90
110_H121_E1.2160.90
70_E74_R1.2110.90
61_R64_H1.2080.90
207_Q375_H1.2080.90
50_T54_F1.2080.90
386_L390_S1.2060.90
356_S363_Y1.2050.90
348_Y353_D1.2000.90
349_Y353_D1.2000.90
17_P183_Y1.1980.89
48_G171_D1.1900.89
339_F350_L1.1870.89
166_I174_R1.1840.89
32_L58_E1.1780.89
15_K54_F1.1760.89
80_F91_R1.1750.89
53_T94_C1.1650.88
87_D159_N1.1640.88
348_Y356_S1.1580.88
42_R52_L1.1540.88
384_K389_Q1.1520.88
111_S242_E1.1510.88
101_H105_H1.1420.87
301_E306_S1.1340.87
356_S361_D1.1320.87
378_T384_K1.1280.86
43_R314_N1.1270.86
174_R222_I1.1260.86
364_R371_R1.1250.86
134_V137_V1.1170.86
347_S352_V1.1160.86
305_L308_L1.1120.86
251_R305_L1.1050.85
102_D120_H1.1000.85
111_S238_T1.0840.84
316_Q334_E1.0820.84
120_H173_D1.0750.84
47_L50_T1.0740.84
76_V80_F1.0710.83
146_P150_A1.0710.83
103_L124_T1.0700.83
391_A396_I1.0690.83
330_S334_E1.0640.83
90_E157_Y1.0620.83
62_F196_R1.0610.83
75_M165_L1.0590.83
102_D110_H1.0560.83
298_E313_I1.0530.82
297_W302_D1.0510.82
12_K30_W1.0500.82
185_T232_V1.0500.82
18_V22_V1.0460.82
119_D122_D1.0390.82
32_L134_V1.0360.81
302_D305_L1.0340.81
61_R67_G1.0310.81
78_D194_M1.0220.80
46_Q59_H1.0200.80
178_L182_A1.0190.80
24_V29_I1.0160.80
248_I308_L1.0160.80
102_D121_E0.9980.79
34_G235_H0.9970.79
289_I295_Q0.9900.78
356_S359_P0.9860.78
121_E124_T0.9850.78
353_D363_Y0.9850.78
348_Y351_V0.9830.78
76_V249_L0.9830.78
48_G109_S0.9780.77
34_G39_Q0.9770.77
64_H67_G0.9740.77
229_Y234_F0.9720.77
315_R319_Q0.9720.77
371_R376_L0.9650.76
106_G282_Y0.9590.76
189_Y226_Y0.9570.76
48_G238_T0.9550.76
224_S228_M0.9550.76
187_V190_G0.9520.75
72_V172_A0.9520.75
184_Y238_T0.9520.75
18_V56_G0.9520.75
212_E378_T0.9470.75
110_H120_H0.9440.75
192_F222_I0.9430.75
90_E148_D0.9410.75
123_F238_T0.9400.75
237_V315_R0.9390.74
65_S95_L0.9380.74
311_R318_F0.9370.74
17_P184_Y0.9370.74
145_F155_K0.9360.74
36_R280_E0.9340.74
174_R225_R0.9340.74
126_G160_K0.9300.74
49_T245_L0.9300.74
106_G233_Y0.9290.74
345_D348_Y0.9250.73
101_H110_H0.9240.73
352_V355_S0.9230.73
210_I214_G0.9160.73
357_D360_Y0.9160.73
331_A334_E0.9160.73
388_R394_E0.9150.73
66_L218_V0.9130.72
187_V228_M0.9110.72
378_T381_G0.9100.72
49_T242_E0.9070.72
281_D284_K0.9060.72
53_T123_F0.9050.72
78_D198_L0.9040.72
152_V156_T0.9020.71
390_S394_E0.9000.71
35_T38_F0.9000.71
118_L123_F0.8860.70
188_S191_H0.8840.70
236_P320_Y0.8770.69
115_V127_I0.8770.69
391_A400_R0.8760.69
221_Y282_Y0.8710.69
43_R288_S0.8690.69
140_K303_A0.8690.69
353_D360_Y0.8680.68
181_D233_Y0.8650.68
332_Y343_G0.8650.68
39_Q315_R0.8620.68
91_R95_L0.8580.68
36_R314_N0.8550.67
216_H231_Q0.8540.67
280_E301_E0.8520.67
339_F344_I0.8480.67
335_L339_F0.8480.67
55_H59_H0.8480.67
76_V95_L0.8450.66
136_Q139_R0.8450.66
405_K409_P0.8420.66
76_V91_R0.8410.66
94_C166_I0.8400.66
393_V399_K0.8390.66
55_H58_E0.8350.65
163_V166_I0.8340.65
47_L318_F0.8320.65
76_V94_C0.8320.65
14_F33_I0.8280.65
30_W34_G0.8270.65
113_E223_M0.8230.64
164_S170_I0.8220.64
334_E338_L0.8200.64
109_S171_D0.8200.64
21_Y242_E0.8170.64
42_R185_T0.8140.63
318_F349_Y0.8130.63
122_D154_A0.8120.63
109_S242_E0.8110.63
216_H230_W0.8100.63
240_S318_F0.8090.63
127_I282_Y0.8080.63
66_L71_I0.8070.63
94_C162_V0.8050.63
343_G348_Y0.8050.63
109_S286_D0.8040.63
48_G242_E0.8040.63
140_K336_T0.8030.62
176_D181_D0.8000.62
72_V165_L0.7970.62
72_V123_F0.7950.62
103_L127_I0.7920.61
221_Y236_P0.7920.61
170_I210_I0.7900.61
62_F315_R0.7880.61
58_E63_N0.7860.61
373_P406_L0.7860.61
47_L111_S0.7850.61
52_L317_L0.7830.60
360_Y363_Y0.7810.60
165_L172_A0.7810.60
106_G285_L0.7790.60
105_H110_H0.7780.60
386_L392_I0.7780.60
244_I248_I0.7770.60
348_Y359_P0.7760.60
63_N196_R0.7750.60
168_S373_P0.7710.59
202_R209_V0.7690.59
129_L147_Q0.7610.58
323_F407_Y0.7530.57
78_D199_R0.7520.57
19_H42_R0.7510.57
190_G214_G0.7490.57
250_H310_R0.7490.57
74_R138_L0.7480.57
109_S174_R0.7470.57
88_D350_L0.7450.57
38_F103_L0.7440.57
387_S395_S0.7440.57
90_E93_L0.7430.56
13_V25_R0.7410.56
17_P21_Y0.7400.56
14_F18_V0.7370.56
53_T57_A0.7350.56
106_G124_T0.7350.56
23_H199_R0.7340.56
48_G111_S0.7330.55
337_S341_E0.7300.55
71_I194_M0.7290.55
170_I192_F0.7290.55
330_S340_K0.7280.55
72_V84_P0.7270.55
159_N162_V0.7270.55
140_K280_E0.7270.55
16_D19_H0.7270.55
359_P362_F0.7250.55
348_Y354_S0.7240.55
248_I252_A0.7230.54
201_M214_G0.7220.54
179_Q183_Y0.7220.54
41_L46_Q0.7210.54
165_L222_I0.7210.54
105_H173_D0.7190.54
29_I92_E0.7160.54
139_R142_S0.7150.54
102_D105_H0.7150.54
68_V149_V0.7130.53
253_K273_F0.7130.53
110_H177_Y0.7120.53
54_F232_V0.7120.53
17_P234_F0.7110.53
80_F87_D0.7100.53
107_P291_L0.7100.53
403_D407_Y0.7100.53
75_M198_L0.7090.53
238_T242_E0.7080.53
189_Y228_M0.7080.53
63_N184_Y0.7070.53
255_L305_L0.7060.53
60_S103_L0.7040.52
39_Q108_F0.7040.52
206_D250_H0.7030.52
52_L291_L0.7000.52
138_L141_V0.6960.52
406_L410_K0.6950.52
351_V355_S0.6940.51
172_A197_I0.6920.51
231_Q286_D0.6920.51
129_L154_A0.6900.51
68_V98_A0.6890.51
104_G109_S0.6890.51
379_Q382_Q0.6890.51
121_E177_Y0.6840.50
17_P22_V0.6810.50
46_Q61_R0.6800.50
24_V33_I0.6760.50
297_W305_L0.6740.49
190_G219_E0.6740.49
45_K248_I0.6720.49
284_K295_Q0.6710.49
349_Y359_P0.6700.49
126_G129_L0.6690.49
100_L165_L0.6650.48
36_R136_Q0.6640.48
56_G184_Y0.6640.48
399_K409_P0.6620.48
386_L393_V0.6610.48
86_W242_E0.6610.48
307_D349_Y0.6600.48
19_H93_L0.6590.48
304_I307_D0.6590.48
38_F100_L0.6580.48
284_K298_E0.6580.48
175_M199_R0.6570.48
169_Q251_R0.6560.47
226_Y230_W0.6540.47
182_A367_E0.6540.47
13_V199_R0.6520.47
54_F235_H0.6520.47
340_K344_I0.6520.47
18_V157_Y0.6510.47
31_D51_Y0.6470.47
79_V82_G0.6460.46
51_Y107_P0.6460.46
36_R298_E0.6460.46
150_A213_S0.6460.46
42_R315_R0.6450.46
366_G370_E0.6430.46
219_E302_D0.6430.46
398_G409_P0.6420.46
153_I182_A0.6420.46
178_L232_V0.6420.46
120_H124_T0.6410.46
109_S225_R0.6410.46
244_I308_L0.6400.46
46_Q64_H0.6380.46
356_S362_F0.6380.46
77_D381_G0.6360.45
31_D34_G0.6350.45
65_S68_V0.6350.45
42_R235_H0.6330.45
133_E136_Q0.6320.45
79_V107_P0.6300.45
59_H181_D0.6300.45
176_D180_R0.6290.45
394_E400_R0.6290.45
37_E98_A0.6290.45
196_R200_V0.6270.45
24_V38_F0.6270.45
13_V23_H0.6240.44
77_D81_K0.6240.44
240_S407_Y0.6240.44
241_A247_K0.6210.44
303_A307_D0.6200.44
165_L168_S0.6200.44
174_R223_M0.6190.44
170_I221_Y0.6180.44
347_S354_S0.6170.43
16_D41_L0.6170.43
124_T208_I0.6150.43
23_H36_R0.6150.43
407_Y410_K0.6150.43
349_Y357_D0.6140.43
202_R377_L0.6130.43
17_P186_G0.6120.43
189_Y217_A0.6100.43
103_L128_I0.6100.43
224_S376_L0.6090.43
338_L341_E0.6080.43
196_R237_V0.6080.43
34_G62_F0.6080.43
240_S244_I0.6070.42
206_D232_V0.6070.42
321_V326_N0.6050.42
123_F282_Y0.6050.42
49_T53_T0.6040.42
79_V86_W0.6030.42
173_D177_Y0.6030.42
59_H197_I0.6010.42
34_G315_R0.6000.42
217_A315_R0.5970.41
112_F165_L0.5960.41
130_G140_K0.5960.41
183_Y187_V0.5960.41
139_R341_E0.5960.41
198_L228_M0.5940.41
55_H196_R0.5930.41
23_H307_D0.5930.41
45_K287_E0.5930.41
23_H240_S0.5920.41
34_G179_Q0.5910.41
354_S361_D0.5900.41
366_G369_E0.5860.40
51_Y238_T0.5820.40
84_P203_P0.5760.39
133_E138_L0.5750.39
190_G232_V0.5750.39
134_V280_E0.5750.39
195_E218_V0.5740.39
396_I401_R0.5740.39
211_K376_L0.5740.39
380_N388_R0.5730.39
11_E27_K0.5720.39
57_A185_T0.5700.39
378_T382_Q0.5690.39
346_P360_Y0.5650.38
207_Q336_T0.5650.38
108_F164_S0.5640.38
59_H64_H0.5630.38
112_F249_L0.5620.38
108_F406_L0.5620.38
197_I218_V0.5620.38
269_F272_I0.5620.38
329_M332_Y0.5600.38
51_Y58_E0.5590.38
386_L395_S0.5590.38
352_V363_Y0.5590.38
49_T238_T0.5580.38
300_E396_I0.5580.38
255_L302_D0.5560.37
398_G406_L0.5550.37
223_M227_Q0.5550.37
27_K96_A0.5540.37
162_V291_L0.5540.37
335_L341_E0.5510.37
84_P202_R0.5490.37
21_Y35_T0.5490.37
165_L169_Q0.5490.37
93_L149_V0.5480.37
156_T198_L0.5470.37
78_D82_G0.5460.36
363_Y368_E0.5460.36
337_S340_K0.5440.36
317_L353_D0.5420.36
122_D327_E0.5400.36
336_T340_K0.5400.36
87_D133_E0.5400.36
306_S346_P0.5400.36
140_K338_L0.5380.36
384_K388_R0.5370.36
301_E366_G0.5370.36
240_S312_F0.5370.36
400_R409_P0.5370.36
372_L378_T0.5360.36
187_V224_S0.5360.36
345_D352_V0.5360.36
168_S312_F0.5340.35
255_L297_W0.5340.35
46_Q102_D0.5340.35
278_T292_Y0.5330.35
216_H226_Y0.5330.35
94_C197_I0.5310.35
389_Q399_K0.5300.35
68_V170_I0.5300.35
393_V396_I0.5290.35
219_E390_S0.5290.35
187_V210_I0.5280.35
357_D361_D0.5270.35
357_D363_Y0.5260.35
29_I32_L0.5250.34
303_A325_P0.5230.34
25_R95_L0.5230.34
351_V362_F0.5220.34
396_I399_K0.5210.34
344_I349_Y0.5210.34
112_F172_A0.5210.34
221_Y286_D0.5200.34
330_S336_T0.5200.34
189_Y218_V0.5200.34
151_E250_H0.5190.34
170_I211_K0.5190.34
103_L134_V0.5180.34
98_A305_L0.5180.34
195_E336_T0.5170.34
351_V354_S0.5170.34
160_K316_Q0.5160.34
328_E332_Y0.5160.34
53_T62_F0.5160.34
166_I222_I0.5150.34
15_K200_V0.5130.33
47_L218_V0.5120.33
230_W286_D0.5120.33
369_E376_L0.5110.33
88_D91_R0.5110.33
266_P296_A0.5110.33
33_I69_Y0.5100.33
179_Q191_H0.5080.33
15_K217_A0.5080.33
89_S254_Q0.5080.33
223_M392_I0.5080.33
12_K31_D0.5070.33
175_M243_V0.5070.33
301_E333_F0.5040.33
69_Y73_R0.5030.32
399_K406_L0.5020.32
349_Y354_S0.5010.32
373_P385_E0.5010.32
358_L362_F0.5000.32
404_H407_Y0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz7A 4 0.9838 100 0.247 Contact Map
4lrlA 4 0.9954 100 0.258 Contact Map
2q14A 4 0.8961 100 0.337 Contact Map
2hekA 4 0.8337 100 0.358 Contact Map
3bg2A 4 0.642 100 0.743 Contact Map
2pgsA 4 0.6443 100 0.747 Contact Map
2dqbA 4 0.6374 100 0.75 Contact Map
4x9eA 4 0.6905 100 0.761 Contact Map
2pq7A 2 0.3857 98.4 0.917 Contact Map
3gw7A 2 0.4573 98.4 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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