GREMLIN Database
YWFM - Uncharacterized transporter YwfM
UniProt: P39649 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (274)
Sequences: 38998 (28751)
Seq/√Len: 1736.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_A153_A3.3261.00
9_F229_K2.9691.00
93_V150_V2.8561.00
229_K233_G2.7451.00
254_G260_E2.6811.00
38_A192_T2.5301.00
84_T152_M2.4951.00
45_G185_M2.4821.00
23_V214_Y2.4111.00
61_K64_A2.3691.00
125_A276_G2.3641.00
81_L155_G2.3131.00
229_K232_T2.2761.00
105_I157_G2.1601.00
81_L152_M2.1521.00
116_K168_K2.1001.00
109_L165_L2.0971.00
95_T250_A2.0851.00
25_A260_E2.0591.00
206_P210_G2.0401.00
43_I216_G2.0261.00
24_Q83_F1.9801.00
42_L188_A1.9491.00
10_V230_G1.9351.00
111_W118_P1.9101.00
18_G249_T1.9071.00
49_L181_A1.8461.00
107_G126_T1.8361.00
110_E116_K1.7991.00
119_R122_W1.7861.00
89_T150_V1.7801.00
77_C159_S1.7701.00
189_I193_P1.7341.00
88_E148_A1.7341.00
101_S105_I1.7301.00
205_T208_G1.7251.00
175_P178_A1.7141.00
106_A240_V1.7051.00
151_L155_G1.6991.00
89_T149_G1.6971.00
278_L282_A1.6721.00
18_G253_L1.6681.00
193_P196_W1.6581.00
216_G221_C1.6391.00
50_L53_W1.6331.00
235_P238_A1.6291.00
19_T214_Y1.6231.00
129_A244_L1.6191.00
64_A173_T1.6041.00
105_I161_A1.6011.00
81_L159_S1.5961.00
45_G188_A1.5951.00
63_W66_P1.5891.00
15_F249_T1.5581.00
263_S266_S1.5481.00
38_A188_A1.5091.00
84_T88_E1.4951.00
94_G153_A1.4951.00
125_A280_I1.4761.00
147_V150_V1.4421.00
49_L53_W1.4391.00
105_I158_A1.4351.00
27_A36_F1.4281.00
13_A230_G1.4211.00
167_S228_A1.4031.00
67_L71_A1.3841.00
264_P268_L1.3721.00
84_T87_K1.3601.00
44_G184_F1.3541.00
31_A208_G1.3461.00
125_A279_V1.3461.00
51_A55_S1.3351.00
16_F218_I1.3261.00
26_L211_T1.3231.00
110_E114_L1.3131.00
253_L257_F1.3131.00
9_F226_L1.3121.00
109_L113_V1.3091.00
147_V151_L1.3071.00
36_F215_I1.3031.00
91_I254_G1.3001.00
47_A221_C1.3001.00
120_N124_I1.2901.00
46_S50_L1.2881.00
129_A276_G1.2801.00
62_N66_P1.2791.00
89_T93_V1.2731.00
249_T253_L1.2731.00
267_W271_A1.2641.00
161_A165_L1.2611.00
207_R210_G1.2601.00
90_G93_V1.2551.00
135_L265_S1.2451.00
17_W223_A1.2431.00
135_L272_L1.2391.00
132_G269_G1.2371.00
206_P209_L1.2311.00
271_A275_L1.2301.00
92_A251_S1.2301.00
22_T253_L1.2301.00
121_S279_V1.2221.00
245_A249_T1.2201.00
50_L54_I1.2191.00
262_L267_W1.2021.00
88_E152_M1.2021.00
210_G214_Y1.1911.00
32_T35_A1.1851.00
30_S208_G1.1841.00
123_W127_V1.1781.00
7_S242_L1.1761.00
148_A152_M1.1711.00
207_R211_T1.1651.00
96_V270_I1.1621.00
86_V94_G1.1621.00
169_A173_T1.1571.00
168_K172_K1.1541.00
25_A29_E1.1521.00
34_L194_L1.1521.00
112_A115_K1.1481.00
132_G273_M1.1391.00
8_L12_I1.1331.00
168_K235_P1.1291.00
109_L162_G1.1271.00
169_A172_K1.1271.00
190_L193_P1.1201.00
106_A236_A1.1161.00
120_N123_W1.1151.00
127_V131_A1.1131.00
40_R220_T1.1111.00
74_C162_G1.1091.00
45_G181_A1.1041.00
30_S205_T1.1031.00
38_A195_L1.1011.00
88_E149_G1.0971.00
136_L269_G1.0951.00
89_T153_A1.0951.00
23_V211_T1.0911.00
82_F86_V1.0871.00
13_A226_L1.0821.00
194_L198_L1.0731.00
121_S282_A1.0711.00
62_N65_W1.0711.00
76_A190_L1.0681.00
38_A42_L1.0681.00
148_A151_L1.0681.00
168_K236_A1.0601.00
114_L165_L1.0491.00
88_E146_D1.0431.00
109_L161_A1.0401.00
118_P123_W1.0381.00
231_L239_A1.0351.00
111_W117_R1.0311.00
57_E175_P1.0281.00
71_A74_C1.0241.00
13_A17_W1.0241.00
12_I226_L1.0231.00
121_S283_A1.0191.00
24_Q86_V1.0171.00
37_G83_F1.0161.00
97_I150_V1.0111.00
116_K122_W1.0091.00
19_T253_L1.0081.00
16_F226_L1.0071.00
193_P197_Q1.0031.00
107_G118_P1.0021.00
17_W227_F0.9971.00
76_A191_L0.9931.00
91_I258_I0.9881.00
106_A164_T0.9881.00
210_G213_L0.9861.00
134_W138_S0.9781.00
97_I157_G0.9761.00
33_P37_G0.9761.00
149_G153_A0.9691.00
41_L187_S0.9561.00
264_P267_W0.9561.00
101_S133_C0.9541.00
213_L216_G0.9491.00
34_L80_P0.9441.00
27_A211_T0.9381.00
106_A161_A0.9381.00
42_L192_T0.9331.00
128_L276_G0.9321.00
14_A18_G0.9311.00
157_G161_A0.9291.00
234_V239_A0.9291.00
119_R123_W0.9191.00
35_A195_L0.9151.00
109_L158_A0.9141.00
138_S263_S0.9131.00
231_L235_P0.9061.00
27_A208_G0.9041.00
72_A190_L0.9041.00
75_M163_Y0.9021.00
209_L213_L0.9011.00
53_W57_E0.8981.00
22_T257_F0.8951.00
97_I153_A0.8901.00
235_P239_A0.8851.00
91_I260_E0.8801.00
146_D150_V0.8761.00
14_A249_T0.8711.00
194_L197_Q0.8711.00
24_Q28_P0.8701.00
109_L112_A0.8691.00
80_P84_T0.8631.00
66_P69_F0.8561.00
64_A174_Q0.8521.00
185_M189_I0.8511.00
96_V134_W0.8481.00
234_V238_A0.8471.00
255_V262_L0.8471.00
212_S216_G0.8421.00
117_R121_S0.8411.00
74_C163_Y0.8331.00
49_L185_M0.8311.00
47_A217_L0.8311.00
47_A50_L0.8291.00
117_R120_N0.8231.00
251_S262_L0.8231.00
230_G239_A0.8191.00
196_W199_D0.8131.00
53_W56_R0.8101.00
131_A135_L0.8031.00
162_G166_I0.7991.00
205_T209_L0.7991.00
131_A272_L0.7941.00
133_C137_F0.7901.00
248_L270_I0.7891.00
251_S270_I0.7871.00
153_A157_G0.7861.00
197_Q200_I0.7841.00
72_A186_I0.7831.00
89_T94_G0.7811.00
270_I274_M0.7781.00
74_C159_S0.7721.00
186_I189_I0.7711.00
22_T254_G0.7711.00
245_A248_L0.7641.00
74_C166_I0.7631.00
265_S268_L0.7631.00
181_A185_M0.7621.00
132_G276_G0.7601.00
78_Y163_Y0.7581.00
48_M221_C0.7551.00
144_R147_V0.7551.00
213_L217_L0.7511.00
204_L209_L0.7431.00
54_I57_E0.7431.00
10_V242_L0.7381.00
135_L268_L0.7351.00
35_A39_F0.7341.00
45_G49_L0.7341.00
111_W115_K0.7321.00
104_I129_A0.7321.00
78_Y159_S0.7311.00
11_L249_T0.7271.00
268_L272_L0.7231.00
76_A80_P0.7231.00
118_P122_W0.7221.00
39_F43_I0.7191.00
21_G82_F0.7191.00
222_A226_L0.7181.00
218_I222_A0.7151.00
22_T91_I0.7111.00
124_I128_L0.7111.00
255_V261_M0.7101.00
14_A245_A0.7031.00
37_G191_L0.7031.00
72_A76_A0.7031.00
67_L72_A0.7031.00
160_F164_T0.7021.00
72_A75_M0.7021.00
42_L46_S0.7011.00
186_I190_L0.6991.00
275_L279_V0.6991.00
51_A177_R0.6961.00
116_K237_S0.6911.00
241_T280_I0.6871.00
101_S104_I0.6861.00
211_T214_Y0.6851.00
70_L74_C0.6831.00
52_V181_A0.6821.00
108_T112_A0.6811.00
68_V186_I0.6781.00
254_G258_I0.6751.00
188_A192_T0.6751.00
106_A165_L0.6741.00
182_V186_I0.6741.00
10_V234_V0.6741.00
276_G280_I0.6731.00
107_G122_W0.6711.00
189_I192_T0.6691.00
225_F229_K0.6671.00
262_L266_S0.6601.00
67_L166_I0.6581.00
195_L199_D0.6571.00
85_A149_G0.6541.00
47_A216_G0.6521.00
97_I154_L0.6501.00
100_G103_P0.6481.00
43_I47_A0.6441.00
26_L258_I0.6431.00
77_C81_L0.6421.00
174_Q179_T0.6421.00
60_V64_A0.6411.00
160_F227_F0.6411.00
44_G221_C0.6411.00
75_M224_Y0.6371.00
251_S255_V0.6361.00
100_G133_C0.6341.00
128_L279_V0.6341.00
114_L169_A0.6321.00
180_S228_A0.6311.00
61_K65_W0.6301.00
214_Y218_I0.6291.00
252_L256_F0.6291.00
31_A36_F0.6271.00
107_G111_W0.6251.00
61_K66_P0.6241.00
20_T219_A0.6201.00
182_V185_M0.6201.00
21_G95_T0.6171.00
16_F223_A0.6141.00
12_I16_F0.6141.00
196_W200_I0.6091.00
208_G211_T0.6041.00
85_A94_G0.6021.00
152_M155_G0.6021.00
277_L280_I0.6001.00
178_A182_V0.5991.00
75_M183_V0.5981.00
7_S238_A0.5971.00
266_S270_I0.5951.00
180_S183_V0.5941.00
261_M265_S0.5941.00
56_R59_H0.5931.00
263_S267_W0.5911.00
103_P244_L0.5901.00
105_I154_L0.5891.00
101_S157_G0.5881.00
83_F87_K0.5871.00
82_F94_G0.5821.00
185_M188_A0.5811.00
82_F156_A0.5781.00
16_F219_A0.5781.00
176_P180_S0.5761.00
163_Y228_A0.5741.00
74_C78_Y0.5731.00
122_W235_P0.5721.00
205_T210_G0.5711.00
32_T198_L0.5701.00
34_L198_L0.5691.00
55_S175_P0.5681.00
253_L256_F0.5681.00
53_W58_L0.5651.00
150_V154_L0.5631.00
244_L277_L0.5611.00
137_F150_V0.5601.00
243_S246_E0.5571.00
76_A194_L0.5561.00
187_S191_L0.5561.00
204_L208_G0.5551.00
144_R148_A0.5531.00
39_F212_S0.5531.00
52_V178_A0.5531.00
70_L166_I0.5521.00
56_R175_P0.5501.00
145_I148_A0.5491.00
14_A246_E0.5451.00
7_S11_L0.5421.00
96_V136_L0.5381.00
43_I46_S0.5341.00
252_L255_V0.5341.00
11_L14_A0.5341.00
100_G157_G0.5331.00
10_V227_F0.5321.00
65_W68_V0.5321.00
164_T240_V0.5311.00
139_D265_S0.5311.00
31_A35_A0.5281.00
214_Y217_L0.5271.00
114_L168_K0.5271.00
95_T100_G0.5271.00
110_E237_S0.5271.00
190_L194_L0.5241.00
55_S177_R0.5201.00
230_G234_V0.5201.00
51_A54_I0.5181.00
163_Y167_S0.5171.00
255_V267_W0.5171.00
21_G25_A0.5161.00
113_V162_G0.5161.00
255_V259_G0.5101.00
158_A162_G0.5101.00
63_W173_T0.5101.00
164_T227_F0.5101.00
25_A258_I0.5091.00
37_G80_P0.5091.00
81_L156_A0.5081.00
42_L45_G0.5071.00
11_L15_F0.5071.00
132_G272_L0.5071.00
32_T199_D0.5061.00
108_T126_T0.5051.00
46_S49_L0.5051.00
28_P86_V0.5031.00
85_A89_T0.5031.00
69_F72_A0.5021.00
130_L244_L0.5001.00
192_T196_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2601 98.8 0.758 Contact Map
3b5dA 2 0.3412 98.3 0.793 Contact Map
1pw4A 1 0.9764 44.4 0.924 Contact Map
4pypA 1 0.9493 37.3 0.927 Contact Map
4he8J 1 0.5135 29.5 0.931 Contact Map
1u7gA 3 0.7872 24.5 0.933 Contact Map
4j05A 3 0.9628 21.7 0.935 Contact Map
2kluA 1 0.152 20.2 0.936 Contact Map
3b9wA 3 0.8074 18.9 0.937 Contact Map
2cfqA 1 0.6047 18.8 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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