GREMLIN Database
LIPL - Octanoyl-[GcvH]:protein N-octanoyltransferase
UniProt: P39648 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (234)
Sequences: 2380 (1667)
Seq/√Len: 108.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_K271_R4.1721.00
184_D225_S3.9291.00
222_A227_L3.4221.00
36_D40_M2.9521.00
127_E131_R2.8241.00
134_R139_K2.8171.00
77_S81_S2.6961.00
78_L82_E2.5671.00
135_P247_A2.5431.00
233_S236_D2.3771.00
258_S261_E2.3561.00
79_L86_V2.2781.00
135_P244_E2.2311.00
264_E267_K2.2271.00
82_E193_L2.2241.00
269_L274_E2.2081.00
54_W106_S2.0961.00
270_V274_E2.0501.00
201_A205_K2.0221.00
18_D238_M1.9861.00
40_M264_E1.9361.00
131_R247_A1.9321.00
266_E270_V1.9231.00
105_I179_I1.9081.00
260_D263_M1.9041.00
91_S169_R1.8961.00
98_L104_N1.8591.00
78_L81_S1.8021.00
255_A261_E1.7651.00
57_H85_R1.7561.00
38_L50_T1.7531.00
222_A226_E1.7331.00
136_Y240_A1.7091.00
35_D178_Q1.7061.00
268_N272_M1.6871.00
186_S189_E1.6631.00
76_I80_E1.6491.00
139_K159_N1.6351.00
103_L234_V1.6331.00
51_A245_L1.6311.00
41_S264_E1.6191.00
56_H98_L1.6111.00
62_L68_R1.6091.00
156_L163_F1.6061.00
36_D272_M1.6031.00
198_Y202_L1.6001.00
143_Y157_S1.5931.00
82_E192_D1.5591.00
239_F243_T1.5571.00
161_K226_E1.5341.00
49_A110_E1.5251.00
30_Q262_E1.5251.00
95_A194_I1.5221.00
103_L237_L1.5021.00
61_V98_L1.5011.00
78_L193_L1.4861.00
164_A180_Y1.4821.00
131_R134_R1.4651.00
167_S178_Q1.4611.00
192_D195_R1.4561.00
131_R244_E1.4551.00
77_S80_E1.4551.00
98_L102_V1.4401.00
183_A237_L1.4321.00
261_E264_E1.4311.00
123_E127_E1.4241.00
60_I79_L1.3821.00
161_K222_A1.3631.00
158_I163_F1.3541.00
225_S231_D1.3451.00
130_R140_I1.3401.00
111_D173_G1.3200.99
40_M171_V1.3180.99
267_K270_V1.3080.99
76_I86_V1.3060.99
158_I227_L1.3040.99
132_M244_E1.2890.99
201_A206_Q1.2860.99
32_F35_D1.2800.99
57_H100_D1.2790.99
166_I177_V1.2790.99
31_S56_H1.2760.99
61_V96_V1.2730.99
82_E189_E1.2560.99
255_A258_S1.2530.99
154_Y200_A1.2410.99
54_W61_V1.2350.99
269_L275_R1.2340.99
56_H104_N1.2310.99
200_A220_T1.2310.99
200_A204_D1.2290.99
37_T41_S1.2260.99
54_W177_V1.2180.99
154_Y220_T1.2170.99
78_L84_Y1.1980.99
163_F224_L1.1890.99
260_D264_E1.1750.99
31_S98_L1.1700.99
91_S178_Q1.1650.99
102_V180_Y1.1490.99
103_L238_M1.1490.99
30_Q34_M1.1460.99
140_I156_L1.1320.98
242_L246_K1.1300.98
266_E269_L1.1180.98
32_F61_V1.1060.98
257_L262_E1.1010.98
135_P240_A1.0990.98
42_V110_E1.0960.98
189_E192_D1.0950.98
32_F98_L1.0940.98
135_P243_T1.0890.98
268_N273_A1.0760.98
60_I194_I1.0700.98
94_L164_A1.0650.98
263_M267_K1.0630.98
27_D30_Q1.0590.97
201_A204_D1.0510.97
235_Q239_F1.0460.97
55_V238_M1.0420.97
63_G155_D1.0290.97
72_L79_L1.0210.97
70_P215_E1.0210.97
257_L265_F1.0170.97
99_D189_E1.0170.97
271_R275_R0.9950.96
246_K252_L0.9940.96
98_L178_Q0.9900.96
157_S160_G0.9900.96
166_I179_I0.9890.96
262_E266_E0.9880.96
66_D71_F0.9680.96
122_Y125_M0.9650.96
272_M275_R0.9610.96
196_R200_A0.9480.95
143_Y152_G0.9420.95
152_G155_D0.9400.95
56_H102_V0.9330.95
133_L237_L0.9310.95
126_V166_I0.9310.95
132_M241_L0.9280.95
16_V242_L0.9250.95
97_V193_L0.9170.94
27_D85_R0.9060.94
130_R156_L0.9050.94
94_L180_Y0.9040.94
94_L155_D0.8950.94
32_F56_H0.8940.93
53_S238_M0.8920.93
78_L192_D0.8900.93
55_V234_V0.8880.93
154_Y204_D0.8870.93
131_R248_L0.8810.93
122_Y168_Q0.8810.93
190_R221_M0.8790.93
129_M241_L0.8780.93
28_A87_I0.8740.93
18_D242_L0.8730.93
42_V45_G0.8720.93
125_M128_L0.8710.93
243_T246_K0.8700.93
106_S177_V0.8660.92
187_G191_A0.8580.92
183_A232_I0.8540.92
96_V104_N0.8510.92
187_G223_S0.8480.92
90_N169_R0.8470.92
61_V104_N0.8440.91
73_Q81_S0.8370.91
232_I240_A0.8250.90
73_Q195_R0.8190.90
111_D175_V0.8190.90
70_P203_K0.8180.90
263_M266_E0.8180.90
56_H87_I0.8180.90
152_G220_T0.8170.90
134_R138_A0.8140.90
168_Q177_V0.8130.90
19_Q26_F0.8090.90
132_M240_A0.8050.89
156_L164_A0.8040.89
263_M270_V0.8030.89
32_F104_N0.8010.89
244_E247_A0.8000.89
126_V156_L0.8000.89
84_Y193_L0.7990.89
34_M265_F0.7970.89
159_N227_L0.7970.89
106_S178_Q0.7920.89
188_S218_P0.7900.88
164_A179_I0.7890.88
61_V102_V0.7880.88
35_D52_R0.7850.88
173_G252_L0.7660.87
35_D56_H0.7650.87
38_L49_A0.7620.87
109_F175_V0.7580.86
239_F253_Y0.7540.86
259_I263_M0.7500.86
61_V180_Y0.7490.86
155_D164_A0.7450.85
111_D170_R0.7430.85
189_E193_L0.7380.85
39_C176_A0.7330.84
16_V252_L0.7270.84
56_H61_V0.7200.83
158_I222_A0.7190.83
261_E265_F0.7190.83
32_F102_V0.7190.83
188_S191_A0.7140.83
96_V180_Y0.7130.83
225_S229_Q0.7110.83
182_C185_K0.7100.82
105_I152_G0.7090.82
188_S192_D0.7080.82
240_A243_T0.7080.82
72_L86_V0.7040.82
264_E270_V0.6920.81
96_V102_V0.6920.81
152_G200_A0.6860.80
140_I158_I0.6850.80
235_Q238_M0.6830.80
34_M257_L0.6820.80
54_W104_N0.6800.80
106_S168_Q0.6780.79
38_L42_V0.6780.79
164_A182_C0.6770.79
26_F100_D0.6770.79
35_D98_L0.6710.79
112_E263_M0.6690.79
68_R76_I0.6620.78
259_I262_E0.6560.77
39_C171_V0.6510.77
94_L221_M0.6510.77
36_D273_A0.6490.76
35_D91_S0.6440.76
37_T265_F0.6440.76
250_T260_D0.6430.76
34_M38_L0.6430.76
106_S167_S0.6430.76
61_V177_V0.6390.75
42_V48_P0.6380.75
50_T261_E0.6380.75
66_D88_V0.6360.75
31_S179_I0.6310.74
168_Q175_V0.6280.74
155_D221_M0.6240.74
166_I178_Q0.6220.73
35_D104_N0.6220.73
60_I249_S0.6190.73
170_R175_V0.6180.73
234_V238_M0.6160.73
38_L108_I0.6160.73
128_L244_E0.6140.72
62_L95_A0.6120.72
205_K220_T0.6100.72
183_A234_V0.6080.72
223_S227_L0.6070.72
182_C223_S0.6030.71
37_T261_E0.6000.71
155_D177_V0.5980.70
229_Q233_S0.5970.70
141_E160_G0.5970.70
126_V142_A0.5960.70
217_R220_T0.5950.70
41_S258_S0.5930.70
78_L189_E0.5900.69
244_E248_L0.5870.69
121_G170_R0.5850.69
79_L84_Y0.5850.69
166_I169_R0.5840.69
237_L241_L0.5830.69
41_S261_E0.5820.68
98_L185_K0.5810.68
56_H106_S0.5800.68
66_D216_I0.5790.68
265_F268_N0.5750.67
105_I177_V0.5720.67
62_L86_V0.5720.67
71_F205_K0.5710.67
187_G190_R0.5700.67
29_K269_L0.5700.67
143_Y160_G0.5700.67
108_I163_F0.5690.67
28_A79_L0.5680.67
253_Y267_K0.5670.66
101_G223_S0.5670.66
238_M242_L0.5630.66
71_F182_C0.5620.66
95_A220_T0.5620.66
92_G165_G0.5600.65
58_D189_E0.5600.65
133_L163_F0.5580.65
94_L97_V0.5580.65
18_D55_V0.5570.65
101_G185_K0.5570.65
264_E268_N0.5560.65
194_I216_I0.5550.65
31_S102_V0.5540.65
177_V194_I0.5530.64
101_G184_D0.5520.64
108_I176_A0.5510.64
28_A85_R0.5510.64
255_A265_F0.5510.64
30_Q269_L0.5500.64
71_F216_I0.5480.64
222_A225_S0.5460.64
59_T85_R0.5450.63
187_G226_E0.5440.63
97_V189_E0.5430.63
125_M175_V0.5410.63
224_L237_L0.5400.63
38_L101_G0.5400.63
91_S218_P0.5370.62
60_I97_V0.5360.62
88_V94_L0.5360.62
59_T98_L0.5360.62
104_N166_I0.5350.62
110_E174_G0.5350.62
163_F227_L0.5340.62
39_C121_G0.5270.61
243_T251_H0.5270.61
203_K215_E0.5270.61
202_L205_K0.5260.61
39_C43_G0.5180.60
236_D239_F0.5180.60
250_T266_E0.5160.59
161_K227_L0.5150.59
31_S178_Q0.5150.59
112_E139_K0.5140.59
36_D171_V0.5130.59
256_G263_M0.5130.59
20_S256_G0.5130.59
249_S253_Y0.5130.59
36_D106_S0.5120.59
122_Y153_S0.5120.59
35_D61_V0.5120.59
97_V155_D0.5110.58
123_E141_E0.5100.58
81_S131_R0.5100.58
52_R125_M0.5080.58
101_G104_N0.5080.58
138_A158_I0.5080.58
154_Y196_R0.5080.58
180_Y221_M0.5070.58
129_M221_M0.5030.57
186_S223_S0.5020.57
71_F194_I0.5010.57
28_A98_L0.5010.57
169_R176_A0.5000.57
31_S35_D0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c8mA 1 0.8505 100 0.268 Contact Map
3a7rA 1 0.8505 100 0.283 Contact Map
2e5aA 1 0.8505 100 0.316 Contact Map
2p0lA 1 0.9004 100 0.321 Contact Map
1vqzA 1 0.8612 100 0.333 Contact Map
2p5iA 1 0.9253 100 0.347 Contact Map
2qhsA 1 0.7402 100 0.475 Contact Map
1w66A 1 0.7509 100 0.512 Contact Map
2eayA 2 0.6085 98.4 0.872 Contact Map
2dxuA 2 0.637 98.3 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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